Suppression of lysyl-tRNA synthetase, KRS, causes incomplete epithelial-mesenchymal transition and ineffective cell‑extracellular matrix adhesion for migration.

abstract：:Bile acids serve a critical role in the induction of gastric intestinal metaplasia (IM) and gastric carcinogenesis. The present study investigated the effects of bile acids on the induction of gastric IM formation. The results demonstrated that the expression levels of caudal‑related homeobox transcription factor 2 (C...

journal_title：International journal of oncology

authors： Yu JH,Zheng JB,Qi J,Yang K,Wu YH,Wang K,Wang CB,Sun XJ

更新日期：2019-03-01 00:00:00

abstract：:Cervical cancer constitutes the second most common cancer in women. It is evident from earlier studies that epidermal growth factor (EGF) is a mitogen, in that it mimics the function of estrogen by mediating cross-talk with other oncoproteins. Although epidermal growth factor recept...

journal_title：International journal of oncology

authors： Narayanan R,Kim HN,Narayanan NK,Nargi D,Narayanan B

更新日期：2012-01-01 00:00:00

abstract：:Cytokine expression in a tumor microenvironment can impact both host defense against the tumor and tumor cell survival. In this study, we sought to clarify whether the cytokine gene expression profile could have clinical associations with ovarian cancer. We analyzed the expression of 16 cytokine genes (IL-1α, IL-1β, I...

journal_title：International journal of oncology

authors： Yanaihara N,Anglesio MS,Ochiai K,Hirata Y,Saito M,Nagata C,Iida Y,Takakura S,Yamada K,Tanaka T,Okamoto A

更新日期：2012-09-01 00:00:00

abstract：:Newcastle disease virus (NDV) is an avian paramyxovirus with oncolytic properties which shows promising effects in the treatment of cancer. Anti-cancer effects are due to the virus ability: i) to replicate in and kill tumor cells, leading finally to their selective elimination; and ...

journal_title：International journal of oncology

authors： Fournier P,Wilden H,Schirrmacher V

更新日期：2012-01-01 00:00:00

abstract：:Cholangiocarcinoma (CCA) is a lethal malignancy which occurs with relatively high incidence in Thailand. This cancer is often difficult to diagnose and associated with high mortality. The secretome, containing the secreted proteins from cells, are potentially useful as biomarkers of cancers. Since three-dimensional (3...

journal_title：International journal of oncology

authors： Tit-Oon P,Chokchaichamnankit D,Khongmanee A,Sawangareetrakul P,Svasti J,Srisomsap C

更新日期：2014-11-01 00:00:00

abstract：:Conventional chemotherapy produces varying degrees of response in patients with many advanced cancers and has significant side effects. Receptors for luteinizing hormone-releasing hormone (LH-RH) are present in a high percentage of human ovarian, prostatic, breast and endometrial tumors and targeted chemotherapy based...

journal_title：International journal of oncology

authors： Lamharzi N,Halmos G,Armatis P,Schally AV

更新日期：1998-03-01 00:00:00

abstract：:Histone deacetylase inhibitors (HDACIs) are involved in cell growth, apoptosis and differentiation. This study aimed to investigate the effects of HDACI scriptaid on histone modification, demethylation, cell growth, cell cycle and apoptosis in the RKO colorectal cancer cell line and screening for scriptaid-induced gen...

journal_title：International journal of oncology

authors： Lee EJ,Lee BB,Kim SJ,Park YD,Park J,Kim DH

更新日期：2008-10-01 00:00:00

abstract：:Mesenchymal stem cells (MSCs) can be used as a delivery vehicle for gene therapy against brain tumors, because these cells have a migratory capacity toward glioma cells. Soluble factors including chemokines or growth factors expressed and released by glioma cells mediate the tropism of MSCs for gliomas. Among them, st...

journal_title：International journal of oncology

authors： Park SA,Ryu CH,Kim SM,Lim JY,Park SI,Jeong CH,Jun JA,Oh JH,Park SH,Oh W,Jeun SS

更新日期：2011-01-01 00:00:00

abstract：:Metformin is a commonly used oral anti-hyperglycemic agent of the biguanide family. Recent studies suggest that metformin may reduce cancer risk and improve prognosis. However, the antitumor mechanism of metformin in several types of cancers, including hepatocellular carcinoma (HCC), has not been elucidated. The goal ...

journal_title：International journal of oncology

authors： Miyoshi H,Kato K,Iwama H,Maeda E,Sakamoto T,Fujita K,Toyota Y,Tani J,Nomura T,Mimura S,Kobayashi M,Morishita A,Kobara H,Mori H,Yoneyama H,Deguchi A,Himoto T,Kurokohchi K,Okano K,Suzuki Y,Murao K,Masaki T

更新日期：2014-07-01 00:00:00

abstract：:The purpose of the study was to determine whether the organ environment can influence the response of colon cancer cells to chemotherapy. The highly metastatic human colon cancer cell line KM12L4, previously selected for production of liver metastases in nude mice, was injected into the cecal wall and into the spleen ...

journal_title：International journal of oncology

authors： Wilmanns C,Fan D,Obrian C,Radinsky R,Bucana C,Tsan R,Fidler I

更新日期：1993-09-01 00:00:00

abstract：:A normal human lymphocyte-derived 54 kDa polypeptide, capable of regulating cell growth has been identified as an isoform variant (abbreviated as NP54) of protein neuroleukin-phosphoglucose isomerase (PGI). Since distinct PGI variants undetectable in normal tissues had been identified in breast cancer tissues, the eff...

journal_title：International journal of oncology

authors： Chiao JW,Xu W,Yang YM,Kancherla R,Seiter K,Ahmed T,Mittelman A

更新日期：1999-10-01 00:00:00

abstract：:Cancer stem cells (CSCs) in glioma are often responsible for relapse and resistance to therapy. The purpose of the present study was to confirm the self-renewal and migration inhibitory effects of tetrandrine (Tet), which is a compound extracted from the dried root of Stephania tetrandra S. Moore, toward glioma stem-l...

journal_title：International journal of oncology

authors： Zhang Y,Wen YL,Ma JW,Ye JC,Wang X,Huang JX,Meng CY,Xu XZ,Wang SX,Zhong XY

更新日期：2017-01-01 00:00:00

abstract：:Although it is well established that ras genes contribute to tumourigenesis either through the accumulation of mutations or by aberrant expression in a wide range of human cancers, little is known regarding their involvement in human nasal polyps (NPs). In the present study, the occurrence of mutations in codons 11 an...

journal_title：International journal of oncology

authors： Zaravinos A,Bizakis J,Soufla G,Sourvinos G,Spandidos DA

更新日期：2007-11-01 00:00:00

abstract：:The p53 homologue p73 is overexpressed in many tumors, including lung cancer. We have evaluated the differential expression and subcellular localization of the functionally distinct apoptotic (TA) and anti-apoptotic (DeltaN) isoforms of p73 in non-small cell lung cancer (NSCLC), their possible association with p53 exp...

journal_title：International journal of oncology

authors： Di Vinci A,Sessa F,Casciano I,Banelli B,Franzi F,Brigati C,Allemanni G,Russo P,Dominioni L,Romani M

更新日期：2009-02-01 00:00:00

abstract：:To examine the possibility that chemical inducers of cytochrome P450 may have effects on the expression of oncogenes and a tumor suppressor gene, human colon LS174T cells were treated with different cytochrome P450 inducers such as benzanthracene (Ba), pyrazole (Pyr) and phenobarbital-hydrocortisone (Pb-Hc). Three for...

journal_title：International journal of oncology

authors： Vasquez H,Strobel H

更新日期：1996-09-01 00:00:00

abstract：:The human immunodeficiency virus (HIV) protein negative factor (Nef) is important for AIDS pathogenesis. An anti-Nef single-domain antibody (sdAb19) derived from camelids has been previously generated and shown to effectively block the physiological functions of Nef in vitro and in vivo in nef-transgenic mice. However...

journal_title：International journal of oncology

authors： Fan X,Wei J,Xiong H,Liu X,Benichou S,Gao X,Liu L

更新日期：2015-10-01 00:00:00

abstract：:Tumour growth is frequently associated with massive loss of body weight and negative nitrogen balance leading to cachexia, one of the worst features of malignancy accounting for nearly two thirds of cancer deaths. At the metabolic level, cachexia is associated with depletion of body lipid stores as well as loss of ske...

journal_title：International journal of oncology

authors： Argilés JM,Costelli P,Carbó N,Pallarés-Trujillo J,López-Soriano FJ

更新日期：1999-03-01 00:00:00

abstract：:Advanced metastatic melanoma is a malignant tumor for which there is currently no effective treatment due to resistance development. Ginsenoside Rg3, a saponin component extracted from ginseng roots, has been shown to reduce melanoma cell proliferation by decreasing histone deacetylase 3 and increasing p53 acetylation...

journal_title：International journal of oncology

authors： Meng L,Ji R,Dong X,Xu X,Xin Y,Jiang X

更新日期：2019-06-01 00:00:00

abstract：:Cholangiocarcinoma (CC) is an aggressive liver tumor with limited therapeutic options. Natrium‑iodide symporter (NIS) mediates the uptake of iodine by the thyroid, representing a key component in metabolic radiotherapy using iodine‑131 (131I) for the treatment of thyroid cancer. NIS expression is increased in CC, prov...

journal_title：International journal of oncology

authors： Brito AF,Abrantes AM,Teixo R,Pires AS,Ribeiro AC,Ferreira RF,Mascarenhas A,Puga T,Laranjo M,Caramelo F,Boin I,Jefferson DM,Gonçalves C,Martins R,Tavares I,Ribeiro IP,Sarmento-Ribeiro AB,Carreira IM,Souza D,Tralhão J

更新日期：2020-03-01 00:00:00

abstract：:We previously developed a new microscopic observation system that enables time-lapse quantitative analysis of apoptosis and necrosis. With this system we quantitatively analyzed adriamycin (ADR)-induced cell death using manganese superoxide dismutase (MnSOD)- and wild-type p53-gene transfectants on SaOS(2), a p53-defi...

journal_title：International journal of oncology

authors： Wang Y,Kuroda M,Gao XS,Asaumi J,Shibuya K,Kawasaki S,Akaki S,St Clair D,Hiraki Y,Kanazawa S

更新日期：2005-05-01 00:00:00

abstract：:The MUC1 heterodimeric protein is aberrantly overexpressed in diverse human carcinomas and contributes to the malignant phenotype. The MUC1-C transmembrane subunit contains a CQC motif in the cytoplasmic domain that has been implicated in the formation of dimers and in its oncogenic function. The present study demonst...

journal_title：International journal of oncology

authors： Raina D,Ahmad R,Rajabi H,Panchamoorthy G,Kharbanda S,Kufe D

更新日期：2012-05-01 00:00:00

abstract：:On the basis of immunological results, it is not in doubt that the immune system is able to recognize and eliminate transformed cells. A plethora of studies have investigated the immune system of patients with cancer and how it is prone to immunosuppression, due in part to the decrease in lymphocyte proliferation and ...

journal_title：International journal of oncology

authors： Scutti JAB

更新日期：2018-04-01 00:00:00

abstract：:Metastatic disease commonly occurs in the spine and incidence is likely to increase secondary to improved survival rates in many cancer patients. Despite published research on instability in patients with metastatic disease of the thoracolumbar spine, controversy exists regarding risk factors for instability and indic...

journal_title：International journal of oncology

authors： Weber MH,Burch S,Buckley J,Schmidt MH,Fehlings MG,Vrionis FD,Fisher CG

更新日期：2011-01-01 00:00:00

abstract：:In the present study, we investigated the effects and molecular mechanism of 5-caffeoylquinic acid (5-CQA), a natural phenolic compound isolated from Ligularia fischeri, on cell invasion, proliferation and adhesion in p53 wild-type A549 and p53-deficient H1299 non-small cell lung cancer (NSCLC) cells. 5-CQA abrogated ...

journal_title：International journal of oncology

authors： In JK,Kim JK,Oh JS,Seo DW

更新日期：2016-05-01 00:00:00

abstract：:We previously reported in a retrospective study that CEA-based RT-PCR was useful for predicting the prognosis of patients with node-negative colorectal cancer. RT-PCR is well established for laboratory use, but many issues remain to be resolved prior to its clinical application. In addition to the false positive rate ...

journal_title：International journal of oncology

authors： Takayama O,Yamamoto H,Ikeda K,Ishida H,Kato T,Okuyama M,Kanou T,Fukunaga M,Tominaga S,Morita S,Fujie Y,Fukunaga H,Ikenaga M,Ikeda M,Ohue M,Sekimoto M,Kikkawa N,Monden M

更新日期：2004-09-01 00:00:00

abstract：:The aim of the present study was to assess whether (-)-epigallocatechin 3-gallate (EGCG) via epigenetic modifications, regulates Raf kinase inhibitor protein (RKIP) expression and invasive metastatic activity in AsPC-1 pancreatic adenocarcinoma cells. Basal levels of RKIP were examined in various human pancreatic canc...

journal_title：International journal of oncology

authors： Kim SO,Kim MR

更新日期：2013-01-01 00:00:00

abstract：:3F8 is an IgG3 murine monoclonal antibody directed against the ganglioside GD2. In a phase II study, 3F8 was administered i.v. to 16 patients (pts) who had stage 4 neuroblastoma. Response was seen in bony lesions (2 of 7 pts) and marrow (3 of 8 pts). Acute toxicities of pain, fever, urticaria, hypertension, hypotensio...

journal_title：International journal of oncology

authors： Cheung NK,Kushner BH,Yeh SD,Larson SM

更新日期：1998-06-01 00:00:00

abstract：:A monoclonal antibody (MSN-3) was raised using HEC-108 cells derived from poorly differentiated endometrial carcinoma as the immunogen. The immunoglobulin subclass of MSN-3 was IgGr1. The target antigen of MSN-3 was a protein with a molecular weight of 77 kDa, and it was shown to be localized in the cytoplasm. MSN-3 o...

journal_title：International journal of oncology

authors： Hasegawa K,Tsukazaki K,Kubushiro K,Kobayashi Y,Kobiki K,Udagawa Y,Nozawa S

更新日期：1997-10-01 00:00:00

abstract：:Intrinsic resistance of glioma cells to radiation and chemotherapy is currently hypothesized to be partially attributed to the existence of cancer stem cells. Emerging studies suggest that mesenchymal stem cells may serve as a potential carrier for delivery of therapeutic genes to disseminated glioma cells. However, t...

journal_title：International journal of oncology

authors： Liu Z,Jiang Z,Huang J,Huang S,Li Y,Sheng F,Yu S,Yu S,Liu X

更新日期：2014-04-01 00:00:00

abstract：:Hepatocellular carcinoma is the most frequent liver cancer and hepatitis B virus is included among the risk factors for the development of this type of neoplasia. Direct detection of this virus is difficult due to the lack of a simple tissue culture system for growing the virus. Amplification of HBV nucleic acid seque...

journal_title：International journal of oncology

authors： Haliassos A,Arvanitis D,Parliaras J,Spandidos D

更新日期：1992-07-01 00:00:00