Different intracellular compartmentalization of TA and DeltaNp73 in non-small cell lung cancer.

abstract：:The cell cycle was analyzed using double staining with an anti-bromodeoxyuridine (BrdU) monoclonal antibody and propidium iodide (PI). Changes in cell kinetics after irradiation were compared with those seen by the conventional PI-based DNA histogram method. The effect of irradiation on cell kinetics has been studied ...

journal_title：International journal of oncology

authors： Murata T,Akagi K,Nasu R,Kimura H,Tanaka Y

更新日期：1998-02-01 00:00:00

abstract：:The purpose of this present study was to investigate the role of inhibitor of apoptosis proteins (IAPs), their inhibitor, Smac, and the focal adhesion kinase (FAK) in the laminin enhancement of cisplatin-induced apoptosis in a testicular tumor germ cell line, NCCIT. We demonstrated that specifically in laminin-adheren...

journal_title：International journal of oncology

authors： Andjilani M,Droz JP,Benahmed M,Tabone E

更新日期：2006-02-01 00:00:00

abstract：:Meningiomas are benign brain tumors thought to arise by multi-step tumorigenesis, involving both the activation of oncogenes and the loss of tumor suppressor genes. The cell cycle regulator proto-oncogene cyclin D1 has been implicated in the pathogenesis of several types of cancer. Northern blot analysis revealed expr...

journal_title：International journal of oncology

authors： Maxwell M,Galanopoulos T,Antoniades H

更新日期：1996-12-01 00:00:00

abstract：:Large granular lymphocyte (LGL) leukemia is a lymphoproliferative disease often associated with autoimmune disorders such as rheumatoid arthritis. High levels of soluble Fas ligand have been implicated in development of chronic neutropenia. However, a comprehensive analysis of constitutive chemokine and lymphokine pro...

journal_title：International journal of oncology

authors： Kothapalli R,Nyland SB,Kusmartseva I,Bailey RD,McKeown TM,Loughran TP Jr

更新日期：2005-02-01 00:00:00

abstract：:The Drosophila ras2 and rop gene pair are governed by a common promoter. Characterisation of the Drosophila ras2/rop bidirectional promoter has revealed that a single major protein complex (M), composed of two subunits (factors A and B) interacts with two central promoter domains (regions A and B). To define the trans...

journal_title：International journal of oncology

authors： Lightfoot K,Tai A,Segev O

更新日期：1995-11-01 00:00:00

abstract：:Aberrant glycosylation is a universal feature of cancer cells, and certain glycan structures are well-known markers for tumor progression. Availability and composition of sugars in the microenvironment may affect cell glycosylation. Recent studies of human breast tumor cell lines indicate their ability to take up and ...

journal_title：International journal of oncology

authors： Monzavi-Karbassi B,Hine RJ,Stanley JS,Ramani VP,Carcel-Trullols J,Whitehead TL,Kelly T,Siegel ER,Artaud C,Shaaf S,Saha R,Jousheghany F,Henry-Tillman R,Kieber-Emmons T

更新日期：2010-09-01 00:00:00

abstract：:Rat C6 glioma is a chemo-resistant experimental brain tumor that is difficult to treat with various drug combinations. Previous studies suggested that imatinib mesylate (Gleevec) is effective in pre-clinical trials for glioblastoma. Also, chlorimipramine (Anafranil) is an anti-depressant drug in use in the clinic and ...

journal_title：International journal of oncology

authors： Bilir A,Erguven M,Oktem G,Ozdemir A,Uslu A,Aktas E,Bonavida B

更新日期：2008-04-01 00:00:00

abstract：:Vascular endothelial growth factor (VEGF), a secreted endothelial-specific growth factor, and microvessel density was examined in 204 primary non-small cell lung carcinomas. The expression of VEGF was evaluated by immunohistochemical staining using an anti-VEGF antibody. Positive staining was obtained in 125 out of 20...

journal_title：International journal of oncology

authors： Mattern J,Koomagi R,Volm M

更新日期：1995-05-01 00:00:00

abstract：:Radioiodinated meta-iodobenzylguanidine (MIBG), an analogue of norepinephrine, has been used in management of neuroendocrine tumors. Recent studies reveal that distribution of radioiodinated MIBG in animals depends on the specific activity of this radiopharmaceutical. In order to clarify the effect of specific activit...

journal_title：International journal of oncology

authors： Farahati J,Lassmann M,Scheubeck M,Bier D,Hanscheid H,Schelper L,Grelle I,Biko J,Werner E,Graefe K,Reiners C

更新日期：1997-04-01 00:00:00

abstract：:The P-glycoprotein (P-gp) multidrug transporter is present at the luminal face of the brain capillary endothelial cells that contribute to the blood-brain barrier. To study its role in transendothelial anticancer drug transport, we made use of a co-culture system formed of bovine brain capillary endothelial cells and ...

journal_title：International journal of oncology

authors： Joly B,Lecureur V,Puozzo C,Guillouzo A,Fardel O

更新日期：1996-11-01 00:00:00

abstract：:A 60 year old man had two tumours resected from his liver which were shown histologically to be a well differentiated hepatocellular carcinoma and the fibrolamellar variant. Both are considered clinically distinct and of different pathogenesis and have not been previously reported occurring synchronously. DNA analysis...

journal_title：International journal of oncology

authors： Ding S,Wong K,Davidson B,Dooley J,Dhillon A,Wood C,Habib N

更新日期：1992-07-01 00:00:00

abstract：:Prostate cancer (CaP), the most common malignancy in American men, presents its greatest challenge to clinicians when the cancer progresses to the hormone-refractory state. In the present investigation, we studied the combined effects of interferon (IFN) and onconase, each of which has reported antitumor activity, on ...

journal_title：International journal of oncology

authors： Tsai SY,Hsieh TC,Ardelt B,Darzynkiewicz Z,Wu JM

更新日期：2002-05-01 00:00:00

abstract：:Following the publication of this article, the authors noted that there was an error in the affiliations. Specifically, the affiliation of the first author JUAN XU should be: Jinhua Municipal Central Hospital, Jinhua Hospital of Zhejiang University, Jinhua, Zhejiang 321000, P.R. China. [the original article was publis...

journal_title：International journal of oncology

authors： Xu J,Jiang N,Shi H,Zhao S,Yao S,Shen H

更新日期：2017-06-01 00:00:00

abstract：:CA IX is a tumor-associated transmembrane isoform of the carbonic anhydrase with a high enzyme activity and a functional involvement in the pH regulation and cell adhesion. Expression of CA9 gene in tumor cells is principally regulated by the high cell density and the hypoxia-related VHL-HIF pathway. In renal cell car...

journal_title：International journal of oncology

authors： Jakubicková L,Biesová Z,Pastoreková S,Kettmann R,Pastorek J

更新日期：2005-04-01 00:00:00

abstract：:Squamous cell carcinoma antigen (SCCA) is overexpressed in many squamous cell cancers and SCCA‑derived peptide-specific CD8(+) cytotoxic T lymphocytes can display cytotoxicity against tumor cells. In the present study, we screened the SCCA amino acid sequence for potential HLA-A*0201-binding CD8(+) T‑cell epitopes usi...

journal_title：International journal of oncology

authors： Duan ZL,Wang ZB,Guo JL,Liu WQ,Hu J,Li J,Wang SN,Li Q,Wen JS

更新日期：2013-04-01 00:00:00

abstract：:The Equiguard is a dietary supplement comprised of standardized extracts from nine herbs, respectively, Herba epimedium brevicornum Maxim (stem and leaves), Radix morindae officinalis (root), Fructus rosa laevigatae michx (fruit), Rubus chingii Hu (fruit), Schisandra chinensis (Turz.) Baill (fruit), Ligustrum lucidum ...

journal_title：International journal of oncology

authors： Hsieh TC,Lu X,Guo J,Xiong W,Kunicki J,Darzynkiewicz Z,Wu JM

更新日期：2002-04-01 00:00:00

abstract：:Thirty-three adult patients with anaplastic astrocytoma or glioblastoma multiforme, verified between 1990 and 1997, received postoperative intra-arterial ACNU chemotherapy and irradiation. Since our previous strategies to malignant gliomas had included intra-venous ACNU, the purpose of the present study is to evaluate...

journal_title：International journal of oncology

authors： Hirano Y,Mineura K,Mizoi K,Tomura N

更新日期：1998-09-01 00:00:00

abstract：:Initiation of protein translation by the 5' mRNA cap is a tightly regulated step in cell growth and proliferation. Aberrant activation of cap-dependent translation is a hallmark of many cancers including non-small cell lung cancer. The canonical signaling mechanisms leading to trans...

journal_title：International journal of oncology

authors： Patel MR,Sadiq AA,Jay-Dixon J,Jirakulaporn T,Jacobson BA,Farassati F,Bitterman PB,Kratzke RA

更新日期：2012-02-01 00:00:00

abstract：:Quantitative nuclear morphometry (QNM) provides a reliable, reproducible method for measuring the degree of nuclear pleomorphism, a qualitative parameter widely incorporated into histopathological grading schemes. Nuclear shape has successfully been shown to predict primary prostate adenocarcinoma metastatic potential...

journal_title：International journal of oncology

authors： Donat T,Sakr W,Pienta K

更新日期：1995-09-01 00:00:00

abstract：:Irvalec® (elisidepsin trifluoroacetate, PM02734) is a novel marine-derived cyclic peptide belonging to the Kahaladide family of compounds, currently in clinical trials with preliminary evidence of antitumor activity. Previous studies have shown a correlation between elisidepsin sens...

journal_title：International journal of oncology

authors： Teixidó C,Arguelaguet E,Pons B,Aracil M,Jimeno J,Somoza R,Marés R,Ramón Y Cajal S,Hernández-Losa J

更新日期：2012-07-01 00:00:00

abstract：:Dexamethasone is a synthetic glucocorticoid frequently used to suppress side-effects of anticancer chemotherapy. In the present study, we showed that dexamethasone treatment leads to concentration-dependent downregulation of cancer-associated marker, carbonic anhydrase IX (CA IX), at the level of promoter activity, mR...

journal_title：International journal of oncology

authors： Simko V,Takacova M,Debreova M,Laposova K,Ondriskova-Panisova E,Pastorekova S,Csaderova L,Pastorek J

更新日期：2016-10-01 00:00:00

abstract：:Alternative polyadenylation and microRNA regulation are both mechanisms of post-transcriptional regulation of gene expression. Alternative polyadenylation often results in mRNA isoforms with the same coding sequence but different lengths of 3' UTRs, while microRNAs regulate gene expression by binding to specific mRNA ...

journal_title：International journal of oncology

authors： An J,Zhu X,Wang H,Jin X

更新日期：2013-10-01 00:00:00

abstract：:Cell synchrony was induced in AGF cells by blocking of the cell cycle at GI-S boundary with high concentrations (2 mM) of thymidine for 11 h. Prolonged arrest of cells in GI-S (15 h-20 h) induced progressive and time dependent apoptosis. Early morphological changes in cellular and nuclear morphology (blebbing) were mo...

journal_title：International journal of oncology

authors： Gazitt Y,Lavia M,Erdos G

更新日期：1993-09-01 00:00:00

abstract：:The development of resistance to anticancer agents during treatment is a major obstacle in the chemotherapy of cancer. Cells expressing high levels of the P-glycoprotein exhibit a multidrug resistance phenotype. The P-glycoprotein is a membrane phosphoprotein which serves as a drug efflux pump to reduce intracellular ...

journal_title：International journal of oncology

authors： Srivastava R,Srivastava A,Chochung Y

更新日期：1996-11-01 00:00:00

abstract：:The active metabolite of vitamin D, 1alpha,25-dihydroxyvitamin D3, can induce differentiation in breast cancer cells; however, it is hypercalcemic in vivo. Therefore, development of non-calcemic analogs of vitamin D has received considerable attention. Recently, we synthesized an analog of vitamin D [1alpha(OH)D5] tha...

journal_title：International journal of oncology

authors： Mehta RR,Bratescu L,Graves JM,Green A,Mehta RG

更新日期：2000-01-01 00:00:00

abstract：:The inhibitory effects of macrolide antibiotics including clarithromycin (CAM) on autophagy flux have been reported. Although a macrolide antibiotic exhibits no cytotoxicity, its combination with bortezomib (BZ), a proteasome inhibitor, for the simultaneous blocking of the ubiquitin (Ub)‑proteasome and autophagy‑lysos...

journal_title：International journal of oncology

authors： Moriya S,Komatsu S,Yamasaki K,Kawai Y,Kokuba H,Hirota A,Che XF,Inazu M,Gotoh A,Hiramoto M,Miyazawa K

更新日期：2015-02-01 00:00:00

abstract：:Lamins are the major components of the nuclear lamina and play important roles in many cellular processes. The role of lamins in cancer development and progression is still unclear but it is known that reduced expression of lamin B1 has been observed in colon cancer. Thus, the aim of the present study was to elucidate...

journal_title：International journal of oncology

authors： Izdebska M,Gagat M,Grzanka A

更新日期：2018-01-01 00:00:00

abstract：:The aim of this study was to determine the prevalence of human papillomavirus (HPV) in patients with laryngeal benign lesions (LBLs) and laryngeal squamous cell carcinomas (LSCCs) using a sensitive E6/E7 type-specific PCR. Paraffin-embedded samples from LBL (n=39) and LSCC patients (n=67) were evaluated for the presen...

journal_title：International journal of oncology

authors： Duray A,Descamps G,Arafa M,Decaestecker C,Remmelink M,Sirtaine N,Ernoux-Neufcoeur P,Mutijima E,Somja J,Depuydt CE,Delvenne P,Saussez S

更新日期：2011-07-01 00:00:00

abstract：:Abnormal accumulation and activation of the recepteur d'origine nantais (RON) has been implicated in epithelial tumor carcinogenesis. In the present study, we examined the effect of epigallocatechin-3-gallate (EGCG), the major green tea catechin, on the induction of RON and tumor growth in human gastric cancer. EGCG i...

journal_title：International journal of oncology

authors： Park JS,Khoi PN,Joo YE,Lee YH,Lang SA,Stoeltzing O,Jung YD

更新日期：2013-03-01 00:00:00

abstract：:Polymerase chain reaction (PCR) has been reported as one of the most efficient techniques to detect hepatitis C virus (HCV) RNA. The determination of the specificity of PCR products is usually based on 'nested' PCR, Southern blotting and hybridization of the amplified DNA to radioactive oligonucleotide probes recogniz...

journal_title：International journal of oncology

authors： Bianchi N,Mischiati C,Feriotto G,Gambari R

更新日期：1994-04-01 00:00:00