Abstract:
:We have utilized a series of glioma cell lines to study the effects of ionizing radiation on the regulation of proteins that contribute to cell cycle progression. While no alterations of cyclin E or cdk4 were detected, a high percentage of glioma cell lines exhibited constitutive overexpression of cdk2 protein and aberrant patterns of cyclin D1 protein. The fraction of glioma cells expressing cdk2 was similar to that observed in normal astrocytes, but individual glioma cells overexpressed cdk2. In response to ionizing radiation, both cyclin D1 and cdk2 accumulated in control cells but not in gliomas with overexpressed cdk2 or aberrant cyclin D1. These novel findings provide the first evidence of altered cyclin-cdk regulation in gliomas in response to ionizing radiation.
journal_name
Int J Oncoljournal_title
International journal of oncologyauthors
Pykett M,Azzam E,Little Jdoi
10.3892/ijo.10.1.93subject
Has Abstractpub_date
1997-01-01 00:00:00pages
93-9issue
1eissn
1019-6439issn
1791-2423journal_volume
10pub_type
杂志文章abstract::The Leydig cell tumor, derived from interstitial cells, is a rare neoplasm. In most cases, Leydig cell tumors are benign, however, if the tumor is malignant, no effective treatments are currently available. In this study, we aimed to evaluate the effects of icariin on the growth of the mouse Leydig tumor cell line MLT...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2011.1086
更新日期:2011-10-01 00:00:00
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journal_title:International journal of oncology
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journal_title:International journal of oncology
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journal_title:International journal of oncology
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journal_title:International journal of oncology
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journal_title:International journal of oncology
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journal_title:International journal of oncology
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doi:
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journal_title:International journal of oncology
pub_type: 杂志文章
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journal_title:International journal of oncology
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pub_type: 杂志文章
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journal_title:International journal of oncology
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doi:10.3892/ijo.8.5.875
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journal_title:International journal of oncology
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doi:
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