Abstract:
:Functional defects in DNA mismatch repair genes have been shown to be associated mainly with hereditary human malignancies. We examined genomic DNA from 88 sporadic transitional cell carcinomas (TCCs) of the urinary tract for mutations in hMSH6 gene by polymerase chain reaction and direct sequencing analysis. Mutational status of p53 gene was also studied as a potential target of genetic instability secondary to hMSH6 dysfunction. A total of 5 cases (5.7%: 5/88) displayed hMSH6 mutations all consisted of transition and located in exon 4, including three cases with missense mutation and two without change of corresponding amino acid. These three tumors with hMSH6 missense mutation had no microsatellite instability with five microsatellite markers tested. p53 gene mutations were detected in 22 cases (25.0%: 22/88). No tumors with p53 mutation had any hMSH6 missense mutations. Compared to the cases without hMSH6 alterations, the three patients with hMSH6 alterations had more frequent additional primary cancer (P<0.05). These findings provide the first in vivo evidence for the type of alterations and frequency of possible involvement of the hMSH6 mutations in sporadic type urothelial TCCs.
journal_name
Int J Oncoljournal_title
International journal of oncologyauthors
Furihata M,Shuin T,Takeuchi T,Sonobe H,Ohtsuki Y,Akiyama Y,Yuasa Ykeywords:
subject
Has Abstractpub_date
2000-03-01 00:00:00pages
491-6issue
3eissn
1019-6439issn
1791-2423journal_volume
16pub_type
杂志文章abstract::A novel amphibian oocyte RNase, ONCONASE(R) (ONC), has been previously shown to have synergistic tumor cell growth inhibitory activity when combined with tamoxifen (TMX) and/or trifluoperazine (TFP) in human ASPC-1 pancreatic and A-549 lung carcinoma cells, respectively. It has recently been reported that several drug...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2.5.807
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abstract::Neuroblastoma is a childhood malignancy originating from cells of the sympathetic nervous system, exhibiting a marked diversity in outcome, with spontaneous regression at one end of the spectrum and severe disease and death at the other end. Features associated with frequent recurrence, a poor prognosis, and high tumo...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.16.5.943
更新日期:2000-05-01 00:00:00
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journal_title:International journal of oncology
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doi:
更新日期:2005-06-01 00:00:00
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journal_title:International journal of oncology
pub_type: 杂志文章
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更新日期:2019-07-01 00:00:00
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journal_title:International journal of oncology
pub_type: 杂志文章
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更新日期:2014-11-01 00:00:00
abstract::Dose is a critical determinant of the efficacy of chemotherapy. The dose response curve for virtually all anticancer agents is steep in both in vitro and in vivo experimental studies. However the application of the steep dose-response curve in the clinic has been troublesome for many years because of dose limiting bon...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:
更新日期:1995-04-01 00:00:00
abstract::We have previously shown that growth of the oral squamous cell carcinoma cell line SAS, is resistant to cetuximab in monolayer culture conditions, even though epidermal growth factor receptor (EGFR) was phosphorylated, but the growth of SAS aggregates was sensitive to cetuximab. In the present study, we demonstrate di...
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pub_type: 杂志文章
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更新日期:2015-12-01 00:00:00
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journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2.1.89
更新日期:1993-01-01 00:00:00
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journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2.2.161
更新日期:1993-02-01 00:00:00
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journal_title:International journal of oncology
pub_type: 临床试验,杂志文章
doi:
更新日期:2002-06-01 00:00:00
abstract::Antisense oligonucleotides that selectively inhibit gene expression are a genetic approach for disease treatment and prevention. However, their use as therapeutic agents is complicated by their low rate of transport across cellular membranes and their sequestration within endocytic-like vesicles. We report that the ad...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.17.4.841
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journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2017.4018
更新日期:2017-07-01 00:00:00
abstract::Telomerase activity (TA) is associated with most malignant human tumors but is not detected in normal somatic cells with a few exceptions. Three major subunits (hTR, hTP1 and hTERT) of telomerase have been identified. To investigate the clinical implications of the mRNA detection of these components as useful diagnost...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.19.5.1063
更新日期:2001-11-01 00:00:00
abstract::Telomerase activity was studied in 51 penile carcinomas, and detected in all samples from 3 patients with verrucous carcinoma, in 85.4% (41/48) of invasive carcinomas, in 81.8% (9/11) of adjacent non-cancerous skin and in 80% (8/10) of adjacent non-cancerous corpus cavernosum. All skin and corpus cavernosum samples fr...
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pub_type: 杂志文章
doi:10.3892/ijo.18.1.67
更新日期:2001-01-01 00:00:00
abstract::Long non-coding RNAs (lncRNAs) are involved in cancer progression. In the present study, we analyzed the lncRNA profiles in adriamycin-resistant and -sensitive breast cancer cells and found a group of dysregulated lncRNAs in the adriamycin-resistant cells. Expression of the dysregulated lncRNAs was correlated with dys...
journal_title:International journal of oncology
pub_type: 杂志文章
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更新日期:2016-10-01 00:00:00
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journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2014.2631
更新日期:2014-11-01 00:00:00
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journal_title:International journal of oncology
pub_type: 杂志文章
doi:
更新日期:1999-08-01 00:00:00
abstract::A precise diagnosis of peritoneal dissemination is necessary to determine the appropriate treatment strategy for colorectal cancer. However, small peritoneal dissemination is difficult to diagnose. 5-aminolevulinic acid (5-ALA) is an intermediate substrate of heme metabolism. The administration of 5-ALA to cancer pati...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2014.2417
更新日期:2014-07-01 00:00:00
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journal_title:International journal of oncology
pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2013.1819
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journal_title:International journal of oncology
pub_type: 杂志文章
doi:
更新日期:1993-08-01 00:00:00
abstract::Postoperative adjuvant chemotherapy reportedly improves advanced colorectal cancer patients' survival, however, it is necessary to assess what regimens are useful. Doxifluridine (5'-DFUR) is an intermediate of capecitabine approved in Europe and USA to treat metastatic colorectal cancer. 5'-DFUR is metabolized to 5-fl...
journal_title:International journal of oncology
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:2003-07-01 00:00:00
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pub_type: 杂志文章
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journal_title:International journal of oncology
pub_type: 杂志文章
doi:
更新日期:2005-02-01 00:00:00
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pub_type: 杂志文章
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journal_title:International journal of oncology
pub_type: 杂志文章
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journal_title:International journal of oncology
pub_type: 杂志文章
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更新日期:2013-11-01 00:00:00
abstract::The non-invasive treatment of tumors with preserved fertility holds great promise. The application of pulsed electric field (PEF) is a new biomedical engineering technique for tumor therapy. Picosecond pulsed electric fields (psPEF) can be transferred to target deep tissue non-invas...
journal_title:International journal of oncology
pub_type: 杂志文章
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