Diagnostic and prognostic relevance of expression of human telomerase subunits in oral cancer.

abstract：:This study aimed to analyze expression of Müllerian inhibiting substance type II receptor (MISRII) protein and mRNA in cervical neoplasia, to demonstrate the growth inhibition of cervical cancer cells by administration of highly purified recombinant human Müllerian inhibiting substa...

journal_title：International journal of oncology

authors： Song JY,Jo HH,Kim MR,Lew YO,Ryu KS,Cha JH,Kang CS,Donahoe PK,MacLaughlin DT,Kim JH

更新日期：2012-06-01 00:00:00

abstract：:Renal cell carcinoma (RCC) is resistant to chemo-therapy partly due to the overexpression of the P-glycoprotein. Several tumor suppressor genes have been reported to be silenced by hypermethylation of the promoter region in RCC. We recently reported that the in vitro cytotoxicity of vinblastine (VBL) was enhanced by p...

journal_title：International journal of oncology

authors： Iwata H,Sato H,Suzuki R,Yamada R,Ichinomiya S,Yanagihara M,Okabe H,Sekine Y,Yano T,Ueno K

更新日期：2011-06-01 00:00:00

abstract：:Stromal cells isolated from lymph nodes of adult T-cell leukemia/lymphoma (ATL) patients were cultured. Such lymph node stromal cells (LNSC) could be maintained for more than one year, whereas LNSC from other lymphoproliferative disorders ceased to proliferate within months. The rate of human T lymphotropic virus type...

journal_title：International journal of oncology

authors： Joh T,Yamada Y,Seto M,Nakamura S,Ohmoto Y,Kamihira S,Tomonaga M,Shiku H

更新日期：1996-10-01 00:00:00

abstract：:Malignant pleural mesothelioma (MPM) is a rare and aggressive form of cancer commonly associated with asbestos exposure that stems from the thoracic mesothelium with high mortality rate. Currently, treatment options for MPM are limited, and new molecular targets for treatments are urgently needed. Using quantitative r...

journal_title：International journal of oncology

authors： Kato T,Lee D,Wu L,Patel P,Young AJ,Wada H,Hu HP,Ujiie H,Kaji M,Kano S,Matsuge S,Domen H,Kaga K,Matsui Y,Kanno H,Hatanaka Y,Hatanaka KC,Matsuno Y,de Perrot M,Yasufuku K

更新日期：2016-08-01 00:00:00

abstract：:IGF-2 mRNA binding protein 3 (IGF2BP3, IMP-3) is a well-known post-transcriptional regulatory factor of gene expression, mainly involved in embryonic development and oncogenesis. We have previously demonstrated that a subset of IMP-3 targets, such as the mRNAs of cyclins D1, D3 and G1, are positively regulated by IMP-...

journal_title：International journal of oncology

authors： Deforzh E,Vargas TR,Kropp J,Vandamme M,Pinna G,Polesskaya A

更新日期：2016-12-01 00:00:00

abstract：:Normal cells produce energy either through OXPHOS in the presence of oxygen or glycolysis in its absence. Cancer cells produce energy preferably through glycolysis even in the presence of oxygen, thereby, acquiring survival and proliferative advantages. Oncogenes and tumour suppressors control these metabolic pathways...

journal_title：International journal of oncology

authors： Rajendran R,Garva R,Ashour H,Leung T,Stratford I,Krstic-Demonacos M,Demonacos C

更新日期：2013-06-01 00:00:00

abstract：:Twenty-one patients with isolated colorectal liver metastases underwent hepatic artery infusion (HAI) port implantation for regional chemotherapy with bolus injections of 5-FU, LV and fast drip of cisplatin. Ten of the 21 patients had previously failed systemic chemotherapy before HAI. Toxicity was moderate and no nee...

journal_title：International journal of oncology

authors： Lyass S,Lyass O,Gabizon A,Peretz T,Eid A,Muggiasullam M,Durst A,Shiloni E

更新日期：1996-12-01 00:00:00

abstract：:Periostin (POSTN) is a protein involved in multiple processes important for cancer development, both at the stage of cancer initiation and progression, as well as metastasis. The aim of this study was to determine the expression of POSTN in the cells of non-invasive ductal breast carcinoma in situ (DCIS) and invasive ...

journal_title：International journal of oncology

authors： Ratajczak-Wielgomas K,Grzegrzolka J,Piotrowska A,Matkowski R,Wojnar A,Rys J,Ugorski M,Dziegiel P

更新日期：2017-10-01 00:00:00

abstract：:One of the early events of apoptosis is proteolysis. The enzyme(s) involved in this event appear to be the serine protease(s), inasmuch as the reversible or irreversible inhibitors of serine proteases prevent DNA degradation and abrogate other signs of apoptosis in several cell systems (Gorczyca et al, Int J Oncol 1: ...

journal_title：International journal of oncology

authors： Gorczyca W,Ardelt B,Darzynkiewicz Z

更新日期：1993-10-01 00:00:00

abstract：:Long non-coding RNAs (lncRNAs) are involved in cancer progression. In the present study, we analyzed the lncRNA profiles in adriamycin-resistant and -sensitive breast cancer cells and found a group of dysregulated lncRNAs in the adriamycin-resistant cells. Expression of the dysregulated lncRNAs was correlated with dys...

journal_title：International journal of oncology

authors： He DX,Zhang GY,Gu XT,Mao AQ,Lu CX,Jin J,Liu DQ,Ma X

更新日期：2016-10-01 00:00:00

abstract：:Phosphatase of regenerating liver-3 (PRL-3) has been found to be overexpressed in liver metastases of colorectal cancer and rarely expressed in primary tumors, which plays an important role in the metastasis of colorectal cancer cells. Metabolism reprogramming has been found to be a hallmark of cancer cells, and aerob...

journal_title：International journal of oncology

authors： Xu H,Zeng Y,Liu L,Gao Q,Jin S,Lan Q,Lai W,Luo X,Wu H,Huang Y,Chu Z

更新日期：2017-10-01 00:00:00

abstract：:Human chorionic gonadotropin (hCG) inhibits the growth of human breast epithelial cells MCF-7. Differential display was utilized for analyzing RNA of hCG-treated MCF-7 cells in order to determine whether this effect was mediated by specific gene activation or repression. Three cDNA clones, 19, 29 and 44, were differen...

journal_title：International journal of oncology

authors： Srivastava P,Silva ID,Russo J,Mgbonyebi OP,Russo IH

更新日期：1998-09-01 00:00:00

abstract：:Extracellular matrix breakdown as well as increased expression in cancer cells and tumor microvascular endothelial cells make matrix metalloproteinase 2 (MMP2) an attractive target for cancer treatment. By taking advantage of MMP2's properties, an MMP2 cleavable melittin/avidin conjugate was designed. Melittin alone i...

journal_title：International journal of oncology

authors： Holle L,Song W,Holle E,Wei Y,Wagner T,Yu X

更新日期：2003-01-01 00:00:00

abstract：:KRAS‑mutant colorectal cancer (CRC) is a highly malignant cancer with a poor prognosis, however specific therapies targeting KRAS mutations do not yet exist. Anti‑epidermal growth factor receptor (EGFR) agents, including cetuximab and panitumumab, are effective for the treatment of certain patients with CRC. However, ...

journal_title：International journal of oncology

authors： Koyama M,Kitazawa M,Nakamura S,Matsumura T,Miyazaki S,Miyagawa Y,Muranaka F,Tokumaru S,Okumura M,Yamamoto Y,Ehara T,Hondo N,Takahata S,Takeoka M,Miyagawa SI,Soejima Y

更新日期：2020-11-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is one the most common malignancies and has poor prognosis in patients. The aim of the present study is to explore the clinical significance of the main genes involved in the Janus kinase (JAK)‑signal transducer and activator of transcription (STAT) pathway in HCC. GSE14520, a training c...

journal_title：International journal of oncology

authors： Wang X,Liao X,Yu T,Gong Y,Zhang L,Huang J,Yang C,Han C,Yu L,Zhu G,Qin W,Liu Z,Zhou X,Liu J,Han Q,Peng T

更新日期：2019-10-01 00:00:00

abstract：:Over-expression of p21Waf-1 was performed in 5 human glioma cell lines (U251MG, U87MG, T98G, NMC-G1, and KALS-1). p53 gene status was examined by PCR-SSCP and direct sequence method. The endogenous p21Waf-1 expression was evaluated by RT-PCR. Adenovirus-mediated over-expression of p21Waf-1 inhibited the proliferation ...

journal_title：International journal of oncology

authors： Terasaki M,Kato S,Sugita Y,Shigemori M,Morimatsu M

更新日期：1999-01-01 00:00:00

abstract：:Invasiveness and metastatic potential are the two most important properties defining malignancy. The adeno-virus E1A (Ad-E1A) gene has a dual effect as a proliferative gene and as a tumor-suppressor gene, decreasing tumor growth and the metastatic potential of malignant cells. In order to study genes related with the ...

journal_title：International journal of oncology

authors： Fernández-Soria V,Lleonart ME,Diaz-Fuertes M,Villuendas R,Sánchez-Prieto R,Fabra A,Ramón Y Cajal S

更新日期：2006-01-01 00:00:00

abstract：:One of the major obstacles in curing prostate cancer is the development of drug resistance. It is not only imperative to discover the molecular basis of resistance but also to find therapeutic agents that can disrupt the resistant pathways. Tumor necrosis factor TNF-related apoptosis-inducing ligand TRAIL-like ligands...

journal_title：International journal of oncology

authors： Festuccia C,Gravina GL,D'Alessandro AM,Millimaggi D,Di Rocco C,Dolo V,Ricevuto E,Vicentini C,Bologna M

更新日期：2008-08-01 00:00:00

abstract：:MicroRNA (miRNA or miR)-506 is a novel miRNA related to the survival of breast cancer patients. However, the mechanism underlying miRNA-506 involvement in breast carcinogenesis remains unclear. In the present study, we found that miR-506 was downregulated in human breast malignant tissues and breast cancer cell lines ...

journal_title：International journal of oncology

authors： Sun G,Liu Y,Wang K,Xu Z

更新日期：2015-11-01 00:00:00

abstract：:The intention of a surveillance program to monitor prostate cancer patients is to detect recurrence of disease as soon as possible and institute therapy at the time of recurrence in order to improve the chance of cure or extend survival. We analyzed the cost of four surveillance programs for prostate cancer. As PSA le...

journal_title：International journal of oncology

authors： Schapira D,Jarrett A

更新日期：1993-03-01 00:00:00

abstract：:Hsp90α is a molecular chaperone protein involved in the structural maturation of oncogenic signaling proteins. Hsp90 was recently identified as an anticancer target; various studies are ongoing to find ways for managing cancer through Hsp90α. However, this approach is limited by reported side-effects. Hypoxia is a hal...

journal_title：International journal of oncology

authors： Pak SH,Joung YH,Park JH,Lim EJ,Darvin P,Na YM,Hong DY,Lee B,Hwang TS,Park T,Ye SK,Moon ES,Cho BW,Park KD,Lee HK,Chung IM,Yang YM

更新日期：2012-07-01 00:00:00

abstract：:Whether elderly patients with metastatic esophageal, gastroesophageal, and gastric cancer do as well with chemotherapy as their younger counterparts was investigated in this pooled analysis. In total, 367 patients from 8 consecutive, first-line trials were included: i) etoposide + cisplatin; ii) 5-fluorourucil + leuco...

journal_title：International journal of oncology

authors： Jatoi A,Foster NR,Egner JR,Burch PA,Stella PJ,Rubin J,Dakhil SR,Sargent DJ,Murphy BR,Alberts SR

更新日期：2010-03-01 00:00:00

abstract：:Although the hematopoietic reconstituting ability of human umbilical cord blood cells (UCBC) is well documented, their antitumor cytotoxic potential has not been well studied. Therefore, UCBC were compared to normal peripheral blood stem cells (PBSC) and bone marrow (BM) stem cell harvests for cytomorphology, antitumo...

journal_title：International journal of oncology

authors： Joshi SS,Babushkina-Patz NN,Verbik DJ,Gross TG,Tarantolo SR,Kuszynski CA,Pirruccello SJ,Bishop MR,Kessinger A

更新日期：1998-10-01 00:00:00

abstract：:The GTPase activity of purified dimeric tubulin (alpha+beta) at 5 mu M was insensitive to methyl-3,5-diiodo-4-(4'-methoxyphenoxy) benzoate (DIME), in contrast to nocodazole which activated GTPase. Cellular motility of MDA-MB-231 (human mammary cancer) cells migrating through 12-mu m pores was inhibited by DIME similar...

journal_title：International journal of oncology

authors： Buki K,Kirsten E,Bauer P,Vidair C,Kun A,Mendeleyev J,Kun E

更新日期：1997-12-01 00:00:00

abstract：:Recent studies have shown that chromosome 8p21-22 is the main site of frequent loss of heterozygosity (LOH) in breast cancers. However, the detailed molecular analysis of chromosome 8 so far in breast cancer has been variable. Most of the literature pertaining to LOH in breast cancer is mainly on short arm of chromoso...

journal_title：International journal of oncology

authors： Dahiya R,Perinchery G,Deng G,Lee C

更新日期：1998-04-01 00:00:00

abstract：:A chromosomal break indicates a double-stranded DNA break of the chromatin fiber. Cytogenetic observations can enumerate chromosome breaks but cannot detect single-stranded DNA breaks (nicks). When a high frequency of chromosomal breaks occurs in a cell population, whether spontaneously occurred or mutagen induced, a ...

journal_title：International journal of oncology

authors： Wang R,Hsu T,Liang J

更新日期：1993-06-01 00:00:00

abstract：:The aim of this study was to investigate STK15 amplification in histologically benign urothelium and invasive tumor tissue of urothelial bladder cancer patients in relation to clinicopathologic and molecular characteristics, and to analyze a hypothesized association between the STK15 single nucleotide polymorphism at ...

journal_title：International journal of oncology

authors： Denzinger S,Stoehr R,Schwarz S,Eichenseher N,Brockhoff G,Obermann EC,Knuechel R,Blaszyk H,Hartmann A,Wild PJ

更新日期：2007-10-01 00:00:00

abstract：:Signal transducers and activators of transcription 3 (STAT3) signaling is persistently activated in many types of cancer cells, and represents a valid target for anticancer drug design. However, few reports have described the constitutive activation of STAT3 in human sarcoma cells. In this study, we demonstrate that t...

journal_title：International journal of oncology

authors： Wei CC,Ball S,Lin L,Liu A,Fuchs JR,Li PK,Li C,Lin J

更新日期：2011-01-01 00:00:00

abstract：:The two-kringle domain of tissue-type plasminogen activator (TK1-2) has been identified as a novel angiogenesis inhibitor. In the previous study, purified Pichia-derived TK1-2 has been shown to suppress in vivo growth of human lung and colon cancer cells. Here, we demonstrate that E. coli-derived non-glycosylated TK1-...

journal_title：International journal of oncology

authors： Kang BH,Shim BS,Lee SY,Lee SK,Hong YK,Joe YA

更新日期：2006-02-01 00:00:00

abstract：:Regulatory T cells (CD4+CD25+FoxP3+, Treg) have been shown to play a major role in suppression of the immune response to malignant gliomas. In this study, we investigated the kinetics of Treg infiltration in metastatic brain tumor models, including melanoma, breast and colon cancers. Our data indicate that both CD4+ a...

journal_title：International journal of oncology

authors： Sugihara AQ,Rolle CE,Lesniak MS

更新日期：2009-06-01 00:00:00