Abstract:
:The GTPase activity of purified dimeric tubulin (alpha+beta) at 5 mu M was insensitive to methyl-3,5-diiodo-4-(4'-methoxyphenoxy) benzoate (DIME), in contrast to nocodazole which activated GTPase. Cellular motility of MDA-MB-231 (human mammary cancer) cells migrating through 12-mu m pores was inhibited by DIME similar to nocodazole in a drug concentration-and DIME structure-dependent manner. An increase of cytoplasmic ATPase activity of DIME-treated cells without a decrease in ATP contents of intact cells suggests that DIME may also influence additional as yet unidentified ATP-dependent system(s) probably also involved in cell motility. These results show that DIME not only arrests cells in M phase but also inhibits cell motility in interphase. However the cellular mode of action of DIME is different from the action of other toxic tubulin-targeted drugs, despite the fact that DIME in a concentration-dependent manner disrupts microtubule structures in intact cells.
journal_name
Int J Oncoljournal_title
International journal of oncologyauthors
Buki K,Kirsten E,Bauer P,Vidair C,Kun A,Mendeleyev J,Kun Edoi
10.3892/ijo.11.6.1247subject
Has Abstractpub_date
1997-12-01 00:00:00pages
1247-50issue
6eissn
1019-6439issn
1791-2423journal_volume
11pub_type
杂志文章abstract::Temozolomide (TMZ) is an alkylating chemotherapeutic agent widely used in anti-glioma treatment. However, acquired TMZ resistance represents a major clinical challenge that leads to tumor relapse or progress. This study investigated the genomic profiles including long non-coding RNA (lncRNA) and mRNA expression associ...
journal_title:International journal of oncology
pub_type: 杂志文章
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abstract::Sialyl Le(a) antigen (CA19-9), a member of a family of high molecular weight glycoproteins, was originally described as a gastrointestinal- and pancreatic-specific tumor marker. Recent studies have demonstrated that sialyl Le(a) is a ligand for E-selectin and may play an important role in tumor metastasis. However, ex...
journal_title:International journal of oncology
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更新日期:2000-10-01 00:00:00
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journal_title:International journal of oncology
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journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2015.2904
更新日期:2015-05-01 00:00:00
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pub_type: 杂志文章
doi:10.3892/ijo.2017.4018
更新日期:2017-07-01 00:00:00
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更新日期:1993-05-01 00:00:00
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journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.11.4.819
更新日期:1997-10-01 00:00:00
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journal_title:International journal of oncology
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更新日期:2008-11-01 00:00:00
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更新日期:1994-09-01 00:00:00
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journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2011.1014
更新日期:2011-07-01 00:00:00
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pub_type: 杂志文章
doi:10.3892/ijo.2019.4692
更新日期:2019-03-01 00:00:00
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journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2010.884
更新日期:2011-03-01 00:00:00
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journal_title:International journal of oncology
pub_type: 杂志文章
doi:
更新日期:2007-02-01 00:00:00
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journal_title:International journal of oncology
pub_type: 杂志文章
doi:
更新日期:2004-01-01 00:00:00
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journal_title:International journal of oncology
pub_type: 杂志文章
doi:
更新日期:2006-04-01 00:00:00
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journal_title:International journal of oncology
pub_type: 杂志文章,评审
doi:10.3892/ijo.2018.4441
更新日期:2018-08-01 00:00:00
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pub_type: 杂志文章
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journal_title:International journal of oncology
pub_type: 杂志文章
doi:
更新日期:2004-07-01 00:00:00
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doi:
更新日期:2000-07-01 00:00:00
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journal_title:International journal of oncology
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更新日期:2005-03-01 00:00:00
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pub_type: 杂志文章
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更新日期:1998-05-01 00:00:00
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journal_title:International journal of oncology
pub_type: 杂志文章
doi:
更新日期:1994-01-01 00:00:00
abstract::Human marrow-derived mesenchymal stem cells (MSC), which have the potential to differentiate into mesenchymal tissues, such as bone, cartilage, adipose and bone marrow stroma, were transduced with a retroviral vector carrying the simian virus 40 large T antigen, hygromycin-resistant gene and herpes simplex virus thymi...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:
更新日期:2003-10-01 00:00:00
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journal_title:International journal of oncology
pub_type: 杂志文章
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更新日期:2015-09-01 00:00:00
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journal_title:International journal of oncology
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doi:
更新日期:2007-01-01 00:00:00
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journal_title:International journal of oncology
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journal_title:International journal of oncology
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doi:
更新日期:2002-07-01 00:00:00
abstract::DNA replication is a vital process in cell division where anomalies can lead to tumorigenesis. Minichromosome maintenance complex component 10 (MCM10) plays a crucial role in this process. However, the role of MCM10 in lung cancer pathogenesis remains to be elucidated. In current study, using the publicly available lu...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2019.4899
更新日期:2019-12-01 00:00:00