Abstract:
:The aim of the present review was to summarize the current knowledge of the involvement of nestin in breast cancer (BC) pathogenesis. Nestin is a member of the class VI family of intermediate filament proteins, originally identified as a marker of neural stem cells and subsequently demonstrated to be expressed in BC and other cancer types. In normal breast tissue, nestin is expressed in the basal/myoepithelial cells of the mammary gland. In BC, nestin identifies basal-like tumours and predicts aggressive behaviour and poor prognosis. Nestin expression has also been detected in BC stem cells and newly-formed tumour vessels, being a factor in promoting invasion and metastasis. The present review provides an up-to-date overview of the involvement of nestin in processes facilitating BC pathogenesis and progression.
journal_name
Int J Oncoljournal_title
International journal of oncologyauthors
Nowak A,Dziegiel Pdoi
10.3892/ijo.2018.4441subject
Has Abstractpub_date
2018-08-01 00:00:00pages
477-487issue
2eissn
1019-6439issn
1791-2423journal_volume
53pub_type
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