miR-148a increases the sensitivity to cisplatin by targeting Rab14 in renal cancer cells.

abstract：:Docetaxel is one of the most commonly used chemotherapeutic agents in breast cancer. To avert from significant toxicities with no clinical benefit, identification of predictive markers for response is one of the most important unsolved clinical needs. Therefore, the potential associ...

journal_title：International journal of oncology

authors： Gil EY,Jo UH,Jeong H,Whang YM,Woo OH,Cho KR,Seo JH,Kim A,Lee ES,Koh I,Kim YH,Park KH

更新日期：2012-08-01 00:00:00

abstract：:To investigate the usefulness of oral doxifluridine (5'-DFUR), an active intermediate metabolite of capecitabine (XELODA), in gastric cancer patients after curative resection, we conducted a phase III randomized controlled study to compare oral 5'-DFUR and oral 5-fluorouracil (5-FU). 485 gastric cancer patients with S...

journal_title：International journal of oncology

authors： Takiguchi N,Nakajima N,Saitoh N,Fujimoto S,Nakazato H

更新日期：2000-05-01 00:00:00

abstract：:The homeobox transcription factor orthodenticle homeobox 2 (OTX2) plays a critical role in very early neurogenesis, but can become oncogenic when aberrantly expressed later in life. We previously discovered its novel oncogenic role in the malignant childhood brain tumor medulloblastoma and hypothesize an oncogenic rol...

journal_title：International journal of oncology

authors： Li J,Di C,Jing J,Di Q,Nakhla J,Adamson DC

更新日期：2015-11-01 00:00:00

abstract：:Although radiation therapy is a powerful anticancer modality, radiation- induced stress response and gene expression with adaptive resistance may severely compromise the effectiveness of radiation. The function of rotundic acid (RA) on inducing apoptosis in the human breast cancer cell line MCF-7 has been investigated...

journal_title：International journal of oncology

authors： Wang ZF,Sun WY,Yu DH,Zhao Y,Xu HM,He YF,Li HJ

更新日期：2018-11-01 00:00:00

abstract：:Nasopharyngeal carcinoma (NPC) is a major cause of cancer deaths. Concurrent administration of radiation and chemotherapy is the treatment of choice for advanced NPC. Previously, we showed that apogossypolone (ApoG2) induced apoptosis by blocking the binding of Bcl-2 to Bax, arresting the cell cycle in the S phase, in...

journal_title：International journal of oncology

authors： He JH,Liao XL,Wang W,Li DD,Chen WD,Deng R,Yang D,Han ZP,Jiang JW,Zhu XF

更新日期：2014-09-01 00:00:00

abstract：:The cell cycle was analyzed using double staining with an anti-bromodeoxyuridine (BrdU) monoclonal antibody and propidium iodide (PI). Changes in cell kinetics after irradiation were compared with those seen by the conventional PI-based DNA histogram method. The effect of irradiation on cell kinetics has been studied ...

journal_title：International journal of oncology

authors： Murata T,Akagi K,Nasu R,Kimura H,Tanaka Y

更新日期：1998-02-01 00:00:00

abstract：:Inhibin and activin, members of transforming growth factor beta (TGF beta) superfamily, have been localized immunohistochemically in fetal bovine heart endothelial cells (FBHE), suggesting that these cells produce inhibin/activin proteins. In addition, the mRNAs coding for alpha-, and beta A-subunits of inhibin/activi...

journal_title：International journal of oncology

authors： Ying S,Zhang Z

更新日期：1995-10-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is difficult to diagnose early, resulting in only 30% resection rate. HCC is a relatively chemo-resistant tumor, molecular targeted therapy can only benefit approximately 30% patients with liver cancer. Bufalin (Bu) is one of the topoisomerase II inhibitors, many studies have recently fo...

journal_title：International journal of oncology

authors： Sheng X,Sun X,Sun K,Sui H,Qin J,Li Q

更新日期：2016-10-01 00:00:00

abstract：:Telomerase activity and its subunits (hTERC, hTERT mRNA) were evaluated in ovarian tumours in relation to the expression of p53, c-Myc and estrogen receptor (ER). Furthermore, relations between telomerase activity, hTERC and hTERT with known clinicopathologic prognostic factors and survival in patients with malignant ...

journal_title：International journal of oncology

authors： Wisman GB,Hollema H,Helder MN,Knol AJ,Van der Meer GT,Krans M,De Jong S,De Vries EG,Van der Zee AG

更新日期：2003-11-01 00:00:00

abstract：:After the publication of the article, the authors noted that they had made the following errors. In Fig. 5B, total PDK1 is incorrect in the published paper. The corrected version of Fig. 5B is shown below. Also in Fig. 6B, the DMSO-treated group and the brassinin (400 µM)-treated group are incorrect, and the corrected...

journal_title：International journal of oncology

authors： Izutani Y,Yogosawa S,Sowa Y,Sakai T

更新日期：2016-03-01 00:00:00

abstract：:RhKGF is developed for prevention and treatment of chemotherapy- and radiation-induced epithelial damage in cancer patients. Little information exists on growth modulation of malignant cells by KGF. We have tested the anchorage-independent clonal growth of 35 human tumor and 22 lymphoma and leukemia cell lines in semi...

journal_title：International journal of oncology

authors： Oelmann E,Haghgu S,Kulimova E,Mesters RM,Kienast J,Herbst H,Schmitmann C,Kolkmeyer A,Serve H,Berdel WE

更新日期：2004-10-01 00:00:00

abstract：:Expression of the tumor suppressor gene p53 and the ras oncogene were examined in 46 tumor and nodal specimens of non-small cell lung cancer (NSCLC) using the antibodies p53 pAb 240 and ras Y13-259 respectively. p53 expression was elevated in 46% and ras p21 was over-expressed in 85% of the tumor specimens analyzed. F...

journal_title：International journal of oncology

authors： Papadakis E,Malliri A,Linardopoulos S,Karaiossifidi H,Field J,Spandidos D

更新日期：1992-09-01 00:00:00

abstract：:Multi-drug resistance (MDR) limits the effectiveness of chemotherapy. P-glycoprotein encoded by the MDR1 gene, is known to be implicated in MDR phenotype, but other factors could be determinant in MDR. The aim of this study was to investigate new molecular factors potentially associated with the MDR phenotype using a ...

journal_title：International journal of oncology

authors： Visentin M,Simula MP,Sartor F,Petrucco A,De Re V,Toffoli G

更新日期：2009-05-01 00:00:00

abstract：:Overexpression of TMPRSS4, a cell surface-associated transmembrane serine protease, has been reported in pancreatic, colorectal and thyroid cancers, and has been implicated in tumor cell migration and metastasis. Few reports have investigated both TMPRSS4 gene expression levels and ...

journal_title：International journal of oncology

authors： Nguyen TH,Weber W,Havari E,Connors T,Bagley RG,McLaren R,Nambiar PR,Madden SL,Teicher BA,Roberts B,Kaplan J,Shankara S

更新日期：2012-09-01 00:00:00

abstract：:Early detection and treatment are critical in the management of renal cell carcinoma (RCC). However, there is no standard serum biomarker to facilitate early diagnosis or prognostic stratification in patients with RCC. Recent reports suggest that circulating microRNAs (miRNAs) have great potential as biomarkers for di...

journal_title：International journal of oncology

authors： Iwamoto H,Kanda Y,Sejima T,Osaki M,Okada F,Takenaka A

更新日期：2014-01-01 00:00:00

abstract：:Tripartite motif 16 (TRIM16), a member of the RING B-box coiled-coil (RBCC)/tripartite totif (TRIM) protein family, has been demonstrated to have significant effects on tumor migration by previous studies, but its specific contribution to hepatocellular carcinoma (HCC) is currently unknown. The aim of this study was t...

journal_title：International journal of oncology

authors： Li L,Dong L,Qu X,Jin S,Lv X,Tan G

更新日期：2016-04-01 00:00:00

abstract：:Cognate interactions between naïve tumor antigen (TA)-specific T cells and TA-presenting dendritic cells (DCs) are facilitated by secondary lymphoid organs such as lymph nodes or the spleen. These can result either in TA-specific tolerance or, depending on environmental costimulatory signals, in TA-specific immune res...

journal_title：International journal of oncology

authors： Schirrmacher V

更新日期：2015-12-01 00:00:00

abstract：:Erlotinib, an epidermal growth factor receptor tyrosine kinase inhibitor (EGFR‑TKI), is widely applied as a first‑line treatment for non‑small cell lung cancer (NSCLC) and greatly improves the clinical outcomes of patients. However, acquired resistance to EGFR‑TKIs remains a major clinical challenge. Here, we identifi...

journal_title：International journal of oncology

authors： Cheng L,Gou L,Wei T,Zhang J

更新日期：2020-09-01 00:00:00

abstract：:The biological processes of cancer cells such as tumorigenesis, proliferation, angiogenesis, apoptosis and invasion are greatly influenced by the surrounding microenvironment. The ability of solid malignant tumors to alter the microenvironment represents an important characteristic through which tumor cells are able t...

journal_title：International journal of oncology

authors： Zhang X,Huang S,Guo J,Zhou L,You L,Zhang T,Zhao Y

更新日期：2016-05-01 00:00:00

abstract：:Most malignant tumors have a defect in the Rb pathway that allows them to proliferate autonomously, unrestricted by the availability of mitogens and growth factors. This defect preconditions tumor cells to be less sensitive to inhibitors of growth factor receptors and/or signal transduction pathways that arrest normal...

journal_title：International journal of oncology

authors： Du L,Smolewski P,Bedner E,Traganos F,Darzynkiewicz Z

更新日期：2001-10-01 00:00:00

abstract：:Cancer stem cells (CSC) exhibit therapy resistance and drive self-renewal of the tumour, making cancer stem cells an important target for therapy. The PI3K signalling pathway has been the focus of considerable research effort, including in glioblastoma (GBM), a cancer that is notoriously resistant to conventional ther...

journal_title：International journal of oncology

authors： Jones NM,Rowe MR,Shepherd PR,McConnell MJ

更新日期：2016-07-01 00:00:00

abstract：:High-mobility group AT-hook protein 2 (HMGA 2) is a transcription factor associated with malignancy and poor prognosis in a variety of human cancers. We correlated HMGA 2 expression with clinical parameters, survival, and O-6-methylguanine-DNA methyltransferase methylation status (MGMT) in glioblastoma patients. HMGA ...

journal_title：International journal of oncology

authors： Schwarm FP,Uhle F,Schänzer A,Acker T,Stein M,Reinges MH,Weischer C,Weigand MA,Uhl E,Kolodziej MA

更新日期：2016-04-01 00:00:00

abstract：:Loss of chromosome sequences at 13q14 (Rbl) and 17p13 (p53) associated with squamous cell carcinoma of head and neck (SCCHN) was evaluated in 12 recurrent tumors and 51 primary tumors from 63 patients. The incidence of LOH at 17p13 was 19 of 50 (38%) tumors, and at 13q14 was 21 of 57 (37%). LOH affecting Rbl and/or p5...

journal_title：International journal of oncology

authors： Li Y,Pavelic Z,Wang L,Wang X,Gleich L,Biddinger P,Gartside P,Wilson K,Gluckman J,Stambrook P

更新日期：1997-06-01 00:00:00

abstract：:Glioblastoma multiforme (GBM) is characterized by extensive angiogenesis that is mostly orchestrated by the hypoxia inducible factor HIF-1. Deregulation of HIF-1 is believed to contribute to cancer initiation and progression. However, instances have been described in which loss of HIF-1 leads to more aggressive tumors...

journal_title：International journal of oncology

authors： Fiorenzo P,Mongiardi MP,Dimitri D,Cozzolino M,Ferri A,Montano N,Trevisi G,Maira G,Battistini L,Falchetti ML,Levi A,Pallini R

更新日期：2010-04-01 00:00:00

abstract：:Neoadjuvant chemotherapy with docetaxel for advanced breast cancer can improve the radicality for a subset of patients, but some patients suffer from severe adverse drug reactions without any benefit. To establish a method for predicting responses to docetaxel, we analyzed gene expression profiles of biopsy materials ...

journal_title：International journal of oncology

authors： Zembutsu H,Suzuki Y,Sasaki A,Tsunoda T,Okazaki M,Yoshimoto M,Hasegawa T,Hirata K,Nakamura Y

更新日期：2009-02-01 00:00:00

abstract：:The relationship between mucin markers and several clinical and pathological characteristics was investigated in breast cancer tissue. CA549, CA15.3 and MCA were measured using commercially available assay methods in 82 primary breast carcinomas and 47 normal glandular breast tissue samples. Similarly to CA15.3 and MC...

journal_title：International journal of oncology

authors： Gion M,Plebani M,Mione R,Capitanio G,Penzo C,Meo S

更新日期：1993-10-01 00:00:00

abstract：:The support mechanisms that are involved in lymph-node metastasis of oral squamous cell carcinoma (OSCC) remain largely unknown. Recent studies have demonstrated that tumor cells express chemokine receptors and use chemokines to metastasize to the target organ in many malignancies in humans. In this study, we examined...

journal_title：International journal of oncology

authors： Ishikawa T,Nakashiro K,Hara S,Klosek SK,Li C,Shintani S,Hamakawa H

更新日期：2006-01-01 00:00:00

abstract：:It has previously been suggested that some tumours may elaborate substances which can suppress the functional activity of lymphokine activated killer (LAK) cells. We have investigated the effects of secreted products from the colorectal cancer cell line LoVo on the pattern of expression of T lymphocyte subsets and nat...

journal_title：International journal of oncology

authors： Johnston D,Allen P,Newland A,Williams N

更新日期：1993-10-01 00:00:00

abstract：:Oncogenic drivers of osteosarcoma remain controversial due to the complexity of the genomic background of the disease. There are limited novel therapeutic options, and the survival rate of patients with osteosarcoma has not improved in decades. Genomic instability leads to complexity in various pathways, which is pote...

journal_title：International journal of oncology

authors： Chaiyawat P,Sungngam P,Teeyakasem P,Sirikaew N,Klangjorhor J,Settakorn J,Diskul-Na-Ayudthaya P,Chokchaichamnankit D,Srisomsap C,Svasti J,Pruksakorn D

更新日期：2019-05-01 00:00:00

abstract：:Recently, ultrasound-guided percutaneous ethanol injection therapy (PEIT) has been widely performed in the treatment of hepatocellular carcinoma. Histopathologic examinations after the therapy have revealed that PEIT can destroy the tumor completely in most cases. Findings in imaging modalities and serum tumor marker ...

journal_title：International journal of oncology

authors： Shiina S,Niwa Y,Shiratori Y,Terano A,Omata M

更新日期：1993-04-01 00:00:00