Abstract:
:Sixty-four colorectal carcinomas were evaluated for allelic loss of chromosomes 17p and 5q, as well as point mutation of the p53 tumor suppressor gene. Allelic loss of chromosomes 5q and 17p were found to be weakly associated, whereas point mutation of the p53 gene was found to be more strongly associated with chromosome 5q allelic loss. Carcinomas in which both alleles of p53 had been inactivated showed a strong association with allelic loss of chromosome 5q (p=2.3x10(-4)), a relationship confirmed by an association between allelic loss of chromosome 5q and immunostaining with the p53 monoclonal antibody pAb 1801 (p=9.4x10(-3)). In contrast, allelic loss of chromosome 5q was not associated with either the activation of the c-Ki-ras proto-oncogene, or with DNA aneuploidy. The association between allelic loss of chromosome 5q and the inactivation of both alleles of p53 was significantly associated with tumor dissemination (p=7.2x10(-3)). These results suggest that dissemination of colorectal neoplasia may require the coordinate inactivation of at least two suppressor genes.
journal_name
Int J Oncoljournal_title
International journal of oncologyauthors
Smith D,Khine K,Chan C,Goh Hdoi
10.3892/ijo.5.3.539subject
Has Abstractpub_date
1994-09-01 00:00:00pages
539-46issue
3eissn
1019-6439issn
1791-2423journal_volume
5pub_type
杂志文章abstract::This study defines the role of WWOX in the regulation of epithelial to mesenchymal transition. A group of 164 endometrial adenocarcinoma patients was studied as well as an ECC1 well-differentiated steroid-responsive endometrial cell line, which was transducted with WWOX cDNA by a retroviral system. The relationship be...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2015.2964
更新日期:2015-01-01 00:00:00
abstract::Malignant peripheral nerve sheath tumors (MPNSTs) are aggressive soft tissue tumors arising sporadically although more frequently in patients with Neurofibromatosis type 1. Prognosis remains dismal as chemo- and radiotherapy have not been shown to be successful. The heparin-binding growth factor, Midkine (MK), is impl...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:
更新日期:2005-11-01 00:00:00
abstract::The purpose of this study was to determine whether DU145, a human prostate cancer cell line: (a) transcribes mRNAs coding for beta A- and beta B-subunits of activin, a member of transforming growth factor beta (TGF beta) superfamily, and activin receptors I, II, and IIB; and (b) produces activin proteins. The expressi...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.7.2.239
更新日期:1995-08-01 00:00:00
abstract::On the basis of immunological results, it is not in doubt that the immune system is able to recognize and eliminate transformed cells. A plethora of studies have investigated the immune system of patients with cancer and how it is prone to immunosuppression, due in part to the decrease in lymphocyte proliferation and ...
journal_title:International journal of oncology
pub_type: 杂志文章,评审
doi:10.3892/ijo.2018.4283
更新日期:2018-04-01 00:00:00
abstract::Overexpression of TMPRSS4, a cell surface-associated transmembrane serine protease, has been reported in pancreatic, colorectal and thyroid cancers, and has been implicated in tumor cell migration and metastasis. Few reports have investigated both TMPRSS4 gene expression levels and ...
journal_title:International journal of oncology
pub_type: 杂志文章
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abstract::Glutathione S-transferase (GST) enzymes catalyse the detoxification of by-products of reactive oxygen species and are thus important in cellular defence mechanisms. The GSTs are polymorphic with allelic variants encoding isoforms with functional differences. GST polymorphism has been associated with susceptibility and...
journal_title:International journal of oncology
pub_type: 杂志文章
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更新日期:2006-01-01 00:00:00
abstract::Newcastle disease virus (NDV) is an avian paramyxovirus with oncolytic properties which shows promising effects in the treatment of cancer. Anti-cancer effects are due to the virus ability: i) to replicate in and kill tumor cells, leading finally to their selective elimination; and ...
journal_title:International journal of oncology
pub_type: 杂志文章
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更新日期:2012-01-01 00:00:00
abstract::We have previously reported that Insulin-like growth factor (IGF-I) is a cellular growth factor of human transformed T-lymphocytes. To evaluate the role of IGF-I for nontransformed T-cells we investigated synthesis of IGF-I and the influence of an IGF-I antiserum, UBK487, during proliferation process. IGF-I is synthes...
journal_title:International journal of oncology
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doi:10.3892/ijo.2.6.1003
更新日期:1993-06-01 00:00:00
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journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2016.3383
更新日期:2016-04-01 00:00:00
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pub_type: 杂志文章
doi:10.3892/ijo.4.3.703
更新日期:1994-03-01 00:00:00
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pub_type: 杂志文章
doi:10.3892/ijo.2.6.873
更新日期:1993-06-01 00:00:00
abstract::Clear cell renal cell carcinoma (ccRCC) is the most common renal malignancy in adults, the incidence of which continues to increase. The lipid droplet protein perilipin 2 (PLIN2), which was originally considered an RNA transcript, is markedly expressed during adipocyte differentiation. In addition, it has been observe...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2018.4384
更新日期:2018-07-01 00:00:00
abstract::Primary hyperparathyroidism is a common endocrine disease with a multifaceted genetic background, the elucidation of which has only begun. Among others, loss of the short arm of chromosome 1 and somatic inactivation of the multiple endocrine neoplasia type 1 gene (MEN1) in 11q13 represent significant alterations in th...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:
更新日期:2002-10-01 00:00:00
abstract::Meningiomas are benign brain tumors thought to arise by multi-step tumorigenesis, involving both the activation of oncogenes and the loss of tumor suppressor genes. The cell cycle regulator proto-oncogene cyclin D1 has been implicated in the pathogenesis of several types of cancer. Northern blot analysis revealed expr...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.9.6.1213
更新日期:1996-12-01 00:00:00
abstract::In four previous case-control studies we have shown an association between exposure to phenoxyacetic acids or chlorophenols and soft-tissue sarcoma (STS). These chemicals are contaminated by dioxins and dibenzofurans, some of which are known carcinogens in experimental animals. In a meta-analysis of our four studies w...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.6.4.847
更新日期:1995-04-01 00:00:00
abstract::Chemotherapy (CT) resistance in ovarian cancer is related to multiple factors, and assessment of these factors is necessary for the development of new drugs and therapeutic regimens. In an effort to identify such determinants, we evaluated the expression of approximately 21,000 genes using DNA microarray screening in ...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:
更新日期:2006-07-01 00:00:00
abstract::Transforming growth factor beta1 (TGF-beta1) has been shown to exhibit anti-proliferative activity for mammary gland epithelial cells and for human breast cancer cells. Insulin-like growth factor I (IGF-I), in contrast, is a well-characterized mitogenic and anti-apoptotic factor involved in mammary gland physiology. I...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.16.2.277
更新日期:2000-02-01 00:00:00
abstract::Nanoparticles are promising novel drug delivery carriers that allow tumor targeting and controlled drug release. In the present study, we prepared poly butyl-cyanoacrylate nanoparticles (PBCA-NP) entrapped with hypocrellin B (HB) to improve the effect of photodynamic therapy (PDT) in ovarian cancer. An ovarian cancer ...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2015.3079
更新日期:2015-09-01 00:00:00
abstract::Knowledge of the presence and extent of disease plays a major role in clinical management of prostate cancer, as it provides meaningful information as to which therapy to choose and who might benefit from this therapy. The wide expression of androgen receptor (AR) in primary and metastatic prostate tumors offers a cel...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:
更新日期:2010-01-01 00:00:00
abstract::To determine the relation between apoptosis and cytotoxicity the number of apoptotic (AP) cells was measured in MOLT-4 and HL-60 cultures treated with adriamycin, etoposide, cisplatin and 1-B-D-arabinofuranosylcytosine (ara-C) in the dose range inducing 20-95% growth inhibition. DNA degradation in individual AP cells ...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.4.2.481
更新日期:1994-02-01 00:00:00
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journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2014.2539
更新日期:2014-10-01 00:00:00
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journal_title:International journal of oncology
pub_type: 杂志文章
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更新日期:2012-04-01 00:00:00
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journal_title:International journal of oncology
pub_type: 杂志文章,评审
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更新日期:1999-07-01 00:00:00
abstract::We have examined six patients with multiple low grade, low stage superficial multifocal bladder tumors with surrounding tissues for loss of heterozygosity (LOH) and microsatellite instability at chromosome 3, totaling 76 samples. The majority (4/5) of the patients had LOH at or close to the fragile histidine triad (FH...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.18.1.203
更新日期:2001-01-01 00:00:00
abstract::Tumor cell invasion and metastasis requires precise coordination of adherence to the extracellular matrix (ECM) and controlled degradation of its components. lnvasive cells secrete proteolytic enzymes known as matrix metalloproteinases which degrade specific basement membrane molecules. Expression of these enzymes is ...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.13.6.1127
更新日期:1998-12-01 00:00:00
abstract::The biological processes of cancer cells such as tumorigenesis, proliferation, angiogenesis, apoptosis and invasion are greatly influenced by the surrounding microenvironment. The ability of solid malignant tumors to alter the microenvironment represents an important characteristic through which tumor cells are able t...
journal_title:International journal of oncology
pub_type: 杂志文章,评审
doi:10.3892/ijo.2016.3400
更新日期:2016-05-01 00:00:00
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journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2013.2187
更新日期:2014-02-01 00:00:00
abstract::Paclitaxel (PTX) is an anticancer drug currently in phase II clinical trials. This study shows for the first time that low doses of PTX (5 nM) potently induce apoptosis in human retinoblastoma Y79 cells. The effect of PTX is accompanied by a potent induction of E2F1 which appears to play a critical role in the effects...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:
更新日期:2008-10-01 00:00:00
abstract::Cadherins play a crucial role in epithelial morphogenesis and mediate intercellular adhesion. These receptors bind catenins and are involved in signal transduction pathways that regulate cell growth and apoptosis, and are frequently down-regulated in invasive and metastatic carcinomas. In order to assess the role of E...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:
更新日期:2002-07-01 00:00:00
abstract::Microsatellite instability (MSI) is an indicator of DNA instability and is caused by abnormalities in DNA mismatch repair (MMR) genes such as hMLH1, hMSH2 and hMSH6. MSI occurs frequently in endometrial cancer (in approximately 30% of cases), and accumulation of gene mutations due to MSI may therefore have a major rol...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo_00000411
更新日期:2009-11-01 00:00:00