Sentinel node localisation: A new prospective in the treatment of nodal melanoma metastases.

abstract：:Prostate cancer (CaP), the most common malignancy in American men, presents its greatest challenge to clinicians when the cancer progresses to the hormone-refractory state. In the present investigation, we studied the combined effects of interferon (IFN) and onconase, each of which has reported antitumor activity, on ...

journal_title：International journal of oncology

authors： Tsai SY,Hsieh TC,Ardelt B,Darzynkiewicz Z,Wu JM

更新日期：2002-05-01 00:00:00

abstract：:The hematogenous metastasis of cancer consists of a multistep process. It is surmised that a number of interactions between cancer and endothelial cells occur, with cell adhesion molecules playing certain roles in this process. The authors conducted an investigation on the interaction between human cancer cells and cu...

journal_title：International journal of oncology

authors： Sato M,Narita T,Kimura N,Nakashio T,Hashimoto T,Manabe T,Kannagi R

更新日期：1997-06-01 00:00:00

abstract：:Claudin 6 (CLDN6), a member of tight junction protein claudin (CLDN) family, inhibits proliferation and induces apoptosis of MCF-7 breast cancer cells. However, these molecular mechanisms of CLDN6-induced apoptosis remain largely elusive. We previously found that restoration of human CLDN6 gene expression was correlat...

journal_title：International journal of oncology

authors： Guo Y,Lin D,Zhang M,Zhang X,Li Y,Yang R,Lu Y,Jin X,Yang M,Wang M,Zhao S,Quan C

更新日期：2016-06-01 00:00:00

abstract：:Peroxisome proliferator-activated receptor gamma (PPARγ) agonists have been demonstrated to exert an inhibitory effect on cell growth in several tumor models, including clear cell renal cell carcinoma (CCRCC). PPARγ has therefore been proposed to be a potential therapeutic target. Thus, the PPARγ gene must be expresse...

journal_title：International journal of oncology

authors： Collet N,Théoleyre S,Rageul J,Mottier S,Jouan F,Rioux-Leclercq N,Fergelot P,Patard JJ,Masson D,Denis MG

更新日期：2011-03-01 00:00:00

abstract：:Despite the introduction of 13-cis-retinoic acid (13-cis-RA) into the current chemotherapy, more than half of high-risk neuroblastoma patients have experienced tumor relapses driven by chemoresistant cancer stem cells (CSCs) that can be isolated by their ability to grow as spheres. Although aldehyde dehydrogenase (ALD...

journal_title：International journal of oncology

authors： Hartomo TB,Van Huyen Pham T,Yamamoto N,Hirase S,Hasegawa D,Kosaka Y,Matsuo M,Hayakawa A,Takeshima Y,Iijima K,Nishio H,Nishimura N

更新日期：2015-03-01 00:00:00

abstract：:Evidence from the literature widely supports the efficacy of screening for colorectal cancer (CRC) in reducing mortality. A blood-based assay, potentially, represents a more accessible early detection tool for the identification of circulating tumour cells originating from a primary tumour site in the body. The presen...

journal_title：International journal of oncology

authors： Lauriola M,Ugolini G,Rosati G,Zanotti S,Montroni I,Manaresi A,Zattoni D,Rivetti S,Mattei G,Coppola D,Strippoli P,Taffurelli M,Solmi R

更新日期：2010-08-01 00:00:00

abstract：:The development of resistance to anticancer agents during treatment is a major obstacle in the chemotherapy of cancer. Cells expressing high levels of the P-glycoprotein exhibit a multidrug resistance phenotype. The P-glycoprotein is a membrane phosphoprotein which serves as a drug efflux pump to reduce intracellular ...

journal_title：International journal of oncology

authors： Srivastava R,Srivastava A,Chochung Y

更新日期：1996-11-01 00:00:00

abstract：:The exact mechanism behind the effect of hypoxia-inducible factor-1alpha (HIF-1alpha) on the proliferation and/or apoptosis of carcinoma cells is still a matter of debate. We treated a human gastric carcinoma cell line, MKN-1 (mutant P53), with 500 microM CoCl(2). A dual-phase pattern of HIF-1alpha expression with an ...

journal_title：International journal of oncology

authors： Ardyanto TD,Osaki M,Tokuyasu N,Nagahama Y,Ito H

更新日期：2006-09-01 00:00:00

abstract：:Advanced castration-resistant prostate cancer has high mortality rates and limited treatment options. Novel therapies are needed to better contend with this disease. Polysaccharide-K® (PSK), an extract of the mushroom Trametes versicolor, has immunomodulatory and tumor suppressive a...

journal_title：International journal of oncology

authors： Wenner CA,Martzen MR,Lu H,Verneris MR,Wang H,Slaton JW

更新日期：2012-04-01 00:00:00

abstract：:Glutathione S-transferase (GST) enzymes catalyse the detoxification of by-products of reactive oxygen species and are thus important in cellular defence mechanisms. The GSTs are polymorphic with allelic variants encoding isoforms with functional differences. GST polymorphism has been associated with susceptibility and...

journal_title：International journal of oncology

authors： Holley SL,Rajagopal R,Hoban PR,Deakin M,Fawole AS,Elder JB,Elder J,Smith V,Strange RC,Fryer AA

更新日期：2006-01-01 00:00:00

abstract：:Cervical cancer is a potentially preventable disease; however, it is the third most commonly diagnosed cancer and the fourth leading cause of cancer deaths in women worldwide. Cervical cancer is thought to develop through a multistep process involving virus, tumor suppressor genes, proto-oncogenes and immunological fa...

journal_title：International journal of oncology

authors： Xiao S,Zhou Y,Yi W,Luo G,Jiang B,Tian Q,Li Y,Xue M

更新日期：2015-04-01 00:00:00

abstract：:Most malignant tumors have a defect in the Rb pathway that allows them to proliferate autonomously, unrestricted by the availability of mitogens and growth factors. This defect preconditions tumor cells to be less sensitive to inhibitors of growth factor receptors and/or signal transduction pathways that arrest normal...

journal_title：International journal of oncology

authors： Du L,Smolewski P,Bedner E,Traganos F,Darzynkiewicz Z

更新日期：2001-10-01 00:00:00

abstract：:Pristimerin (PM), a quinonemethide triterpenoid, is a promising anticancer agent with potent antiproliferative and apoptosis-inducing activities against cancer cell lines. However, the anticancer activity and mechanisms of PM in prostate cancer cells have not been adequately investigated. Here we report that the degra...

journal_title：International journal of oncology

authors： Liu YB,Gao X,Deeb D,Brigolin C,Zhang Y,Shaw J,Pindolia K,Gautam SC

更新日期：2014-10-01 00:00:00

abstract：:Protein kinase C (PKC) designates a family of kinases that regulate many essential functions including cell growth and differentiation. The tight regulation of PKC activity is crucial for maintaining normal cellular proliferation and excessive activity leads to abnormal or uncontrolled cell growth. Recent reports indi...

journal_title：International journal of oncology

authors： Sharif TR,Sharif M

更新日期：1999-02-01 00:00:00

abstract：:Accumulating evidence indicates that microRNAs (miRNAs) have a critical role in cell proliferation and metastasis in hepatocellular carcinoma (HCC). However, the effect of miR‑300 on the development and progression of HCC remains unclear. In the present study, it was observed that miRNA (miR)‑300 expression was signif...

journal_title：International journal of oncology

authors： Chen Y,Guo Y,Li Y,Yang J,Liu J,Wu Q,Wang R

更新日期：2019-04-01 00:00:00

abstract：:We examined the relationships among nuclear DNA content, tumor origin, nuclear size, and prognosis in squamous cell lung cancer. Central tumors had significantly higher DNA aneuploidy (83%, p<0.01) and DNA indices (1.65+/-0.40, p<0.01) than did peripheral tumors (40%, 1.29+/-0.37, respectively). All six women in the s...

journal_title：International journal of oncology

authors： Miyamoto H,Isobe H,Akita H,Ishiguro A,Endo T,Inoue S,Kawakami Y

更新日期：1992-08-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is one of the most malignant types of cancer, and is associated with high recurrence rates and a poor response to chemotherapy. Immune signatures in the microenvironment of HCC have not been well explored systematically. The aim of the present study was to identify prognostic immune sign...

journal_title：International journal of oncology

authors： Huang R,Chen Z,Li W,Fan C,Liu J

更新日期：2020-05-01 00:00:00

abstract：:There is increasing evidence that different types of breast cancers are related to distinct risk factors. We analyzed the risk of breast cancer with respect to circulating insulin-like growth factor (IGF)-I, IGF-binding protein (IGFBP)-3, 17beta-estradiol, estrone, testosterone, androstenedione and sex hormone-binding...

journal_title：International journal of oncology

authors： Kahán Z,Gardi J,Nyári T,Földesi I,Hajnal-Papp R,Ormándi K,Lázár G,Thurzó L,Schally AV

更新日期：2006-07-01 00:00:00

abstract：:The purpose of this study was to determine whether the synthesis of endogenous nitric oxide (NO) is involved in the apoptosis of murine L929 transformed fibroblasts. L929 parental cells and L929 cells selected for resistance to tumor necrosis factor (TNF-alpha) were incubated in vitro with various concentrations of TN...

journal_title：International journal of oncology

authors： Xie K,Huang S,Dong Z,Fidler I

更新日期：1993-12-01 00:00:00

abstract：:Mxi1 protein is a basic helix-loop-helix, leucine zipper (bHLHZIP) transcriptional factor, which dimerizes with the Max protein. This heterodimer binds a specific DNA sequence (E-box) and suppresses transcription of target genes. On the other hand, c-Myc protein is also a bHLHZIP protein that dimerizes with Max, binds...

journal_title：International journal of oncology

authors： Kawamata N,Sugimoto KJ,Sakajiri S,Oshimi K,Koeffler HP

更新日期：2005-05-01 00:00:00

abstract：:To test the effects of combined transduction of a suicide gene and genes coding for various immunostimulatory factors on the oncogenicity and immunogenicity of TC-1 cells (HPV-16 transformed C57BL/6 mouse cells), several bicistronic recombinant adeno-associated viruses (rAAV) were constructed. Each of these constructs...

journal_title：International journal of oncology

authors： Janousková O,Síma P,Kunke D

更新日期：2003-03-01 00:00:00

abstract：:Cervical cancer constitutes the second most common cancer in women. It is evident from earlier studies that epidermal growth factor (EGF) is a mitogen, in that it mimics the function of estrogen by mediating cross-talk with other oncoproteins. Although epidermal growth factor recept...

journal_title：International journal of oncology

authors： Narayanan R,Kim HN,Narayanan NK,Nargi D,Narayanan B

更新日期：2012-01-01 00:00:00

abstract：:One hundred five patients with clinical stage T2-T4 transitional cell bladder carcinoma who completed either low-dose (20-26 Gy) or high dose (40-50 Gy) preoperative radiotherapy (RT) followed by cystectomy were reviewed. Five-year actuarial survival was 42%, 52%, and 17% for stages T2, T3, and T4, respectively. Five-...

journal_title：International journal of oncology

authors： Cox J,Greven K,Anscher M,Morgan T

更新日期：1992-10-01 00:00:00

abstract：:Raman spectroscopy is a vibrational spectroscopic technique that can be used to probe molecular changes associated with tissue malignancy. In this report, the effect of formalin fixation on human bronchial tissues was studied by near-infrared (NIR) Raman spectroscopy to determine if the variations of Raman spectra cau...

journal_title：International journal of oncology

authors： Huang Z,McWilliams A,Lam S,English J,McLean DI,Lui H,Zeng H

更新日期：2003-09-01 00:00:00

abstract：:The development of clinical agents remains a costly and time-consuming process. Although identification of new uses of existing drugs has been recognized as a more efficient approach for drug discovery than development of novel drugs, little screening of drugs that might be used for a rare malignant tumor such as oste...

journal_title：International journal of oncology

authors： Oi T,Asanuma K,Matsumine A,Matsubara T,Nakamura T,Iino T,Asanuma Y,Goto M,Okuno K,Kakimoto T,Yada Y,Sudo A

更新日期：2016-12-01 00:00:00

abstract：:The protease-activated receptor-2 (PAR-2) is a G protein-coupled receptor that is cleaved and activated by trypsin and tryptase. The purpose of this study was to clarify the role of PAR-2 in proliferation of human pancreatic cancer cells. PAR-2 mRNA and protein expression were detected by RT-PCR and Western blotting i...

journal_title：International journal of oncology

authors： Shimamoto R,Sawada T,Uchima Y,Inoue M,Kimura K,Yamashita Y,Yamada N,Nishihara T,Ohira M,Hirakawa K

更新日期：2004-06-01 00:00:00

abstract：:Lymph node metastasis of tumors is a crucial early step in the metastatic process. Tumor lymphangiogenesis plays an important role in promoting tumor metastasis to regional lymph nodes. Norcantharidin (NCTD) has been reported to possess potent anti-angiogenesis and antitumor propert...

journal_title：International journal of oncology

authors： Liu ZY,Qiu HO,Yuan XJ,Ni YY,Sun JJ,Jing W,Fan YZ

更新日期：2012-11-01 00:00:00

abstract：:Using a transdisciplinary methodological approach we have conducted a multifactorial analysis in Martinique and Guadeloupe in order to elucidate the aetiology of prostate cancer. In 2002, world age standardized rates of prostate cancer were 152 new cases per 100,000 person-years in the two islands; one of the highest ...

journal_title：International journal of oncology

authors： Belpomme D,Irigaray P,Ossondo M,Vacque D,Martin M

更新日期：2009-04-01 00:00:00

abstract：:Invasiveness and metastatic potential are the two most important properties defining malignancy. The adeno-virus E1A (Ad-E1A) gene has a dual effect as a proliferative gene and as a tumor-suppressor gene, decreasing tumor growth and the metastatic potential of malignant cells. In order to study genes related with the ...

journal_title：International journal of oncology

authors： Fernández-Soria V,Lleonart ME,Diaz-Fuertes M,Villuendas R,Sánchez-Prieto R,Fabra A,Ramón Y Cajal S

更新日期：2006-01-01 00:00:00

abstract：:We have previously reported that Insulin-like growth factor (IGF-I) is a cellular growth factor of human transformed T-lymphocytes. To evaluate the role of IGF-I for nontransformed T-cells we investigated synthesis of IGF-I and the influence of an IGF-I antiserum, UBK487, during proliferation process. IGF-I is synthes...

journal_title：International journal of oncology

authors： Hartmann K,Teckentrup R,Nixdorf D,Meuer S,Papa V,Heinrich U

更新日期：1993-06-01 00:00:00