miR-506 regulates breast cancer cell metastasis by targeting IQGAP1.

abstract：:Acquired drug resistance to chemotherapy is a major problem in the treatment of cancer. After primary surgical intervention, followed by chemotherapy treatments, the majority of patients develop disease recurrence. This is due to tumor cell heterogeneity and genetic instability. In contrast to tumor cells, proliferati...

journal_title：International journal of oncology

authors： Benouchan M,Colombo BM

更新日期：2005-08-01 00:00:00

abstract：:Rhabdomyosarcoma (RMS) is a malignant tumour of skeletal muscle origin which includes two major histological subtypes: alveolar rhabdomyosarcoma (ARMS), the more aggressive, and embryonal rhabdomyosarcoma (ERMS). In order to establish whether the higher metastatic potential of ARMS cells may depend on differential exp...

journal_title：International journal of oncology

authors： Onisto M,Slongo ML,Gregnanin L,Gastaldi T,Carli M,Rosolen A

更新日期：2005-09-01 00:00:00

abstract：:E-cadherins are homophilic adhesion molecules the expression of which is tightly linked to the invasiveness and the differentiated state of the cells. E-cadherin expression seems also inversely related to the expression of vimentin, an intermediate filament implicated in the metastatic potential of some cells. In brea...

journal_title：International journal of oncology

authors： Vandewalle B,Revillion F,Doutrelant P,Granier A,Lefebvre J

更新日期：1994-01-01 00:00:00

abstract：:We have reported that ONO-4007, a novel synthetic lipid A derivative with low toxic activities, produced large amount of tumor necrosis factor (TNF)-alpha selectively in the tumor tissues and brought about complete cures in about 60% of rats bearing TNF-alpha sensitive KDH-8 cells, which also secreted a large amount o...

journal_title：International journal of oncology

authors： Matsushita K,Kuramitsu Y,Ohiro Y,Kobayashi I,Watanabe T,Kobayashi M,Hosokawa M

更新日期：2003-08-01 00:00:00

abstract：:The naturally occurring photosensitizer, hypericin, with its high quantum yield of singlet oxygen photogeneration was studied for its ability to differentiate between glioblastoma cells and fetal rat neurons using fluorescence microscopy. Eight human glioma cell lines and twelve primary human glioma cell cultures were...

journal_title：International journal of oncology

authors： Ritz R,Müller M,Weller M,Dietz K,Kuci S,Roser F,Tatagiba M

更新日期：2005-12-01 00:00:00

abstract：:Salinomycin (SAL) is a polyether ionophore antibiotic that has recently been shown to regulate a variety of cellular responses in various human cancer cells. However, the effects of SAL on metastatic capacity of HT1080 human fibrosarcoma cells have not been elucidated. We investigated the effect of SAL on migration an...

journal_title：International journal of oncology

authors： Yu SM,Kim SJ

更新日期：2016-06-01 00:00:00

abstract：:Although CD138 expression is a hallmark of plasma cells and myeloma cells, reduced CD138 expression is occasionally found. However, the mechanisms underlying CD138 downregulation in myeloma cells remain unclear. Previous reports suggest that the bone marrow microenvironment may contribute to CD138 downregulation. Amon...

journal_title：International journal of oncology

authors： Kawano Y,Kikukawa Y,Fujiwara S,Wada N,Okuno Y,Mitsuya H,Hata H

更新日期：2013-12-01 00:00:00

abstract：:Depletion of glutathione (GSH) by buthionine sulfoximine (BSO) has been reported to be toxic against some cancer cells and to sensitize many tumours including neuroblastoma (NB) to anticancer drugs. The balance between the production rate of reactive oxygen species (ROS) and the function of GSH affects the intracellul...

journal_title：International journal of oncology

authors： Marengo B,Balbis E,Patriarca S,De Ciucis C,Furfaro A,Nitti M,Marinari UM,Pronzato MA,Traverso N,Domenicotti C

更新日期：2008-01-01 00:00:00

abstract：:This study examined whether the soluble tumor-associated antigens (sTAA) of 66 kDa and 51 kDa could promote suppression of chemically-induced rat mammary tumorigenesis by the hormone-related anticancer drug tamoxifen and prevent the drug's toxic side-effects. Dimethylbenzanthracene (DMBA, 10 mg/rat, 3 administrations)...

journal_title：International journal of oncology

authors： Ben-Hur H,Kossoy G,Zusman I

更新日期：2002-02-01 00:00:00

abstract：:The peptide hormone, GnRH has been hypothesized to play a direct antitumoral role in certain kinds of breast cancer. This direct effect is considered to function via high affinity membrane receptors to GnRH that have been demonstrated in tumors. However, no routine assay for GnRH receptors exist limiting further resea...

journal_title：International journal of oncology

authors： Reshkin S,Pezzetta A,Albarani V,Schittulli F,Paradiso A

更新日期：1995-08-01 00:00:00

abstract：:SOX2, a SRY-related HMG box protein, is thought to be an important transcription factor during organogenesis, including the stomach although the expression and function are unclear. We investigated SOX2 protein expression to clarify its roles in differentiation and carcinogenesis of the stomach. Using polyclonal SOX2 ...

journal_title：International journal of oncology

authors： Li XL,Eishi Y,Bai YQ,Sakai H,Akiyama Y,Tani M,Takizawa T,Koike M,Yuasa Y

更新日期：2004-02-01 00:00:00

abstract：:Polypyrimidine tract-binding protein 1 (PTBP1), a heterogeneous nuclear ribonucleoprotein, is a multi-functional RNA-binding protein. PTBP1 participates in a number of biological processes, including maintaining cell structure and motility, immunity, protein metabolism and the cell cycle. The present study aimed to in...

journal_title：International journal of oncology

authors： Shan H,Hou P,Zhang M,Li L,Pan Y,Chen F,Jiang T,Bai J,Zheng J

更新日期：2018-05-01 00:00:00

abstract：:Cholangiocarcinoma (CC) is an aggressive liver tumor with limited therapeutic options. Natrium‑iodide symporter (NIS) mediates the uptake of iodine by the thyroid, representing a key component in metabolic radiotherapy using iodine‑131 (131I) for the treatment of thyroid cancer. NIS expression is increased in CC, prov...

journal_title：International journal of oncology

authors： Brito AF,Abrantes AM,Teixo R,Pires AS,Ribeiro AC,Ferreira RF,Mascarenhas A,Puga T,Laranjo M,Caramelo F,Boin I,Jefferson DM,Gonçalves C,Martins R,Tavares I,Ribeiro IP,Sarmento-Ribeiro AB,Carreira IM,Souza D,Tralhão J

更新日期：2020-03-01 00:00:00

abstract：:The human teratocarcinoma cell line (Tera 2) could be stimulated to a moderate increase in cell number in serum-free medium by addition of 5 ng leukemia inhibitory factor (LIF)/ml. However this effect was only observed in short term (24 h) cultures. By comparing cell numbers with thymidine incorporation data and propo...

journal_title：International journal of oncology

authors： Granerus M,Bierke P,Engstrom W

更新日期：1994-12-01 00:00:00

abstract：:Three novel isoforms of the neurofibromatosis 2 (NF2) gene transcripts generated from alternative splicing were identified from normal human brain, schwannoma and glioma tissues. The 3 novel transcripts lack exon 2, exons 2 and 3, exons 2-4, respectively. Recombinant isoform proteins encoded by those new transcripts h...

journal_title：International journal of oncology

authors： Nishi T,Takeshima H,Hamada K,Yoshizato K,Koga H,Sato K,Yamamoto K,Kitamura I,Kochi M,Kuratsu J,Saya H,Ushio Y

更新日期：1997-05-01 00:00:00

abstract：:On the basis of immunological results, it is not in doubt that the immune system is able to recognize and eliminate transformed cells. A plethora of studies have investigated the immune system of patients with cancer and how it is prone to immunosuppression, due in part to the decrease in lymphocyte proliferation and ...

journal_title：International journal of oncology

authors： Scutti JAB

更新日期：2018-04-01 00:00:00

abstract：:Pancreatic neuroendocrine neoplasms (p-NENs) are slowly growing tumors with frequent liver metastasis. There is a variety of approaches to treat non-functional p-NENs with synchronous liver metastasis (LM) which complicates the determination of optimal treatment. Based on updated literature review, we discussed the tr...

journal_title：International journal of oncology

authors： Jin K,Xu J,Chen J,Chen M,Chen R,Chen Y,Chen Z,Cheng B,Chi Y,Feng ST,Fu D,Hou B,Huang D,Huang H,Huang Q,Li J,Li Y,Liang H,Lin R,Liu A,Liu J,Liu X,Lu M,Luo J,Mai G,Ni Q,Qiu M,Shao C,Shen B,Sheng W

更新日期：2016-11-01 00:00:00

abstract：:Ninety-four human non-small cell lung carcinomas (NSCLC) of previously untreated patients were analyzed for the presence of metallothionein (MT) expression by means of immunohistochemistry. Of the tumors investigated, expression of MT was detected in 63%. The expression of MT was correlated with the results of doxorub...

journal_title：International journal of oncology

authors： Mattern J,Volm M

更新日期：1992-11-01 00:00:00

abstract：:The retinoic acid receptor (RAR) beta gene is located in a region on chromosome 3p, which is frequently deleted in renal cell carcinoma. Since retinoic acid (RA) can inhibit cell proliferation and tumor formation, loss of RAR beta might contribute to oncogenesis of the kidney. This prompted us to examine RAR beta expr...

journal_title：International journal of oncology

authors： Vanderleede B,Opdenoordt T,Vandenbrink C,Ebert T,Vandersaag P

更新日期：1995-02-01 00:00:00

abstract：:Accumulating evidence has demonstrated the crucial roles of long non‑coding RNAs (lncRNAs) in various human cancers, including non‑small cell lung cancer (NSCLC). However, to the best of our knowledge, the role of the lncRNA cancer susceptibility candidate 7 (CASC7) in NSCLC has not been clearly determined. The aim of...

journal_title：International journal of oncology

authors： Chen L,Li X,Lu C,Zhao Y,Zhu J,Yang L

更新日期：2020-08-01 00:00:00

abstract：:Five retinoblastoma tumours from patients treated in the King Khaled Eye Specialist Hospital in Riyadh were analysed for mutations in the RB1 gene using single strand conformation polymorphism analysis and mutations were found in all of them. In one tumour the mutation in exon 11 was homozygous demonstrating the role ...

journal_title：International journal of oncology

authors： Su G,Senft S,Cowell J

更新日期：1995-03-01 00:00:00

abstract：:Phosphatase of regenerating liver-3 (PRL-3) has been found to be overexpressed in liver metastases of colorectal cancer and rarely expressed in primary tumors, which plays an important role in the metastasis of colorectal cancer cells. Metabolism reprogramming has been found to be a hallmark of cancer cells, and aerob...

journal_title：International journal of oncology

authors： Xu H,Zeng Y,Liu L,Gao Q,Jin S,Lan Q,Lai W,Luo X,Wu H,Huang Y,Chu Z

更新日期：2017-10-01 00:00:00

abstract：:Percutaneous nephrostomy (PN) will rapidly correct renal failure due to ureteral obstruction. Complications of the procedure are few and the procedure can be quickly accomplished on an outpatient basis using local anesthesia. A retrospective review of fifty patients who underwent PN led to derivation of a formula whic...

journal_title：International journal of oncology

authors： McKenna B,Chalas E,Ferretti J,Rothpearl A,Mann W

更新日期：1994-04-01 00:00:00

abstract：:DNA replication is a vital process in cell division where anomalies can lead to tumorigenesis. Minichromosome maintenance complex component 10 (MCM10) plays a crucial role in this process. However, the role of MCM10 in lung cancer pathogenesis remains to be elucidated. In current study, using the publicly available lu...

journal_title：International journal of oncology

authors： Wang M,Xie S,Yuan W,Xie T,Jamal M,Huang J,Yin Q,Song H,Zhang Q

更新日期：2019-12-01 00:00:00

abstract：:Cytochrome P450 1A1 (CYP1A1) is a member of the cytochrome p450 enzyme family, which is involved in the metabolisms of carcinogenic metabolites, such as benzo(a)pyrene. In this study, we identified miR-892a as a negative regulator of CYP1A1 expression. Luciferase assays revealed a s...

journal_title：International journal of oncology

authors： Choi YM,An S,Lee EM,Kim K,Choi SJ,Kim JS,Jang HH,An IS,Bae S

更新日期：2012-07-01 00:00:00

abstract：:Expressions of p53 protein and epidermal growth factor receptor (EGFR) were immunohistochemically investigated in 111 patients with papillary thyroid carcinomas (PTC) in order to evaluate their co-expression in relation to lymph node metastases (LNM), tumor size and clinicopathologic stage. In PTC, positive staining f...

journal_title：International journal of oncology

authors： Chen BK,Ohtsuki Y,Furihata M,Takeuchi T,Iwata J,Liang SB,Sonobe H

更新日期：1999-11-01 00:00:00

abstract：:5-Fluorouracil (5-FU), a fluoropyrimidine analogue, is one of the most commonly used anticancer drugs for the treatment of gastrointestinal malignancies. Some studies reported that the cytotoxicity of fluoropyrimidines is mediated, in large part, by inhibition of the thymidylate synthase (TS), an essential DNA synthet...

journal_title：International journal of oncology

authors： Matsuoka K,Tsukuda K,Suda M,Kobayashi K,Ota T,Okita A,Watanabe K,Suzuki E,Murakami M,Doihara H,Shimizu N

更新日期：2004-01-01 00:00:00

abstract：:Endometrial cancer (EC) is one of the most common malignancies of the female reproductive system, and metastasis is a major cause of mortality. In this study, we aimed to explore the role of CP‑31398 in the migration, invasion and apoptosis of EC cells by its regulation of the expression of the murine double minute 2 ...

journal_title：International journal of oncology

authors： Liu L,Yang L,Chang H,Chen YN,Zhang F,Feng S,Peng J,Ren CC,Zhang XA

更新日期：2019-03-01 00:00:00

abstract：:Changes in the expression of the putative p53-inducible inhibitor p21 of cyclin-dependent kinase (CDK) and p21-associated CDK activity were examined in relation to the DNA synthesis-associated nuclear exclusion of p53 after stimulating growth arrested human breast cancer MCF7 cells with serum. Following stimulation, p...

journal_title：International journal of oncology

authors： Takahashi K,Suzuki K

更新日期：1994-11-01 00:00:00

abstract：:Malignant pleural mesothelioma (MPM) is a rare and aggressive form of cancer commonly associated with asbestos exposure that stems from the thoracic mesothelium with high mortality rate. Currently, treatment options for MPM are limited, and new molecular targets for treatments are urgently needed. Using quantitative r...

journal_title：International journal of oncology

authors： Kato T,Lee D,Wu L,Patel P,Young AJ,Wada H,Hu HP,Ujiie H,Kaji M,Kano S,Matsuge S,Domen H,Kaga K,Matsui Y,Kanno H,Hatanaka Y,Hatanaka KC,Matsuno Y,de Perrot M,Yasufuku K

更新日期：2016-08-01 00:00:00