Abstract:
:Depletion of glutathione (GSH) by buthionine sulfoximine (BSO) has been reported to be toxic against some cancer cells and to sensitize many tumours including neuroblastoma (NB) to anticancer drugs. The balance between the production rate of reactive oxygen species (ROS) and the function of GSH affects the intracellular reduction-oxidation status, which is crucial for the regulation of several cellular physiological functions. To assess the role of glutathione in neuroblastoma therapy, the effect of sublethal concentrations of BSO was studied in a panel of neuroblastoma cell lines characterized by different MYCN status. We found that GSH depletion per se not accompanied by ROS overproduction, does not affect cell survival, and is not genotoxic but induces HO-1 expression in GI-ME-N cell line, a representative example of MYCN non-amplified NB cells, having the highest basal levels of GSH among the tested NB lines. These observations might open a novel therapeutic window based on the possibility of modulating the cellular 'activity' of GSH.
journal_name
Int J Oncoljournal_title
International journal of oncologyauthors
Marengo B,Balbis E,Patriarca S,De Ciucis C,Furfaro A,Nitti M,Marinari UM,Pronzato MA,Traverso N,Domenicotti Csubject
Has Abstractpub_date
2008-01-01 00:00:00pages
121-7issue
1eissn
1019-6439issn
1791-2423journal_volume
32pub_type
杂志文章abstract::Human papillomavirus 16 (HPV-16) is strongly associated with the development of 50% of cervical cancers. The E6 and E7 proteins encoded by high-risk HPV types are associated with the immune evasion of cervical cancer cells, but the mechanism is poorly understood. The purpose of this study was to investigate whether ce...
journal_title:International journal of oncology
pub_type: 杂志文章
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更新日期:2011-11-01 00:00:00
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journal_title:International journal of oncology
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journal_title:International journal of oncology
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journal_title:International journal of oncology
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journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2011.978
更新日期:2011-06-01 00:00:00
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journal_title:International journal of oncology
pub_type: 杂志文章,评审
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pub_type: 杂志文章
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journal_title:International journal of oncology
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journal_title:International journal of oncology
pub_type: 杂志文章
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journal_title:International journal of oncology
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更新日期:2007-09-01 00:00:00
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journal_title:International journal of oncology
pub_type: 杂志文章
doi:
更新日期:2003-12-01 00:00:00
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pub_type: 杂志文章
doi:10.3892/ijo.7.6.1405
更新日期:1995-12-01 00:00:00
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pub_type: 杂志文章
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journal_title:International journal of oncology
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journal_title:International journal of oncology
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doi:
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journal_title:International journal of oncology
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doi:
更新日期:2008-03-01 00:00:00
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journal_title:International journal of oncology
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更新日期:2006-05-01 00:00:00
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journal_title:International journal of oncology
pub_type: 杂志文章,评审
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journal_title:International journal of oncology
pub_type: 杂志文章
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