Abstract:
:The human teratocarcinoma cell line (Tera 2) could be stimulated to a moderate increase in cell number in serum-free medium by addition of 5 ng leukemia inhibitory factor (LIF)/ml. However this effect was only observed in short term (24 h) cultures. By comparing cell numbers with thymidine incorporation data and proportion intact cell nuclei, we concluded that this short term increase in cell number was due to enhanced cell survival rather than a real increase in the proportion of cells traversing the cell cycle. When increased concentrations of LIF were added a preferential effect on clonal cell locomotion was observed. 50-200 ng of LIF stimulated cell movement but exerted no effect on Tera 2 cell proliferation at any time interval studied.
journal_name
Int J Oncoljournal_title
International journal of oncologyauthors
Granerus M,Bierke P,Engstrom Wdoi
10.3892/ijo.5.6.1419subject
Has Abstractpub_date
1994-12-01 00:00:00pages
1419-23issue
6eissn
1019-6439issn
1791-2423journal_volume
5pub_type
杂志文章abstract::Some diseases and drugs have previously been associated with increased risk for colon cancer. A case-control study on colon adenocarcinoma was conducted encompassing 329 cases and 658 controls. History of previous diseases and drug intake was assessed by questionnaire. Appendectomy was associated with a protective eff...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.8.3.439
更新日期:1996-03-01 00:00:00
abstract::Targeting protein kinases as a therapeutic approach to treat various diseases, especially cancer is currently a fast growing business. Although many inhibitors are available, exhibiting remarkable potency, the major challenge is their selectivity. Here we show that the protein kinase CK2 inhibitors DMAT, TBB and resor...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo_00000431
更新日期:2009-11-01 00:00:00
abstract::Knowledge of the presence and extent of disease plays a major role in clinical management of prostate cancer, as it provides meaningful information as to which therapy to choose and who might benefit from this therapy. The wide expression of androgen receptor (AR) in primary and metastatic prostate tumors offers a cel...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:
更新日期:2010-01-01 00:00:00
abstract::Sphingosine-1-phosphate (S1P) is a bioactive phospholipid that transmits signals through G-protein-coupled receptors to control cellular differentiation, survival, and several functions of immune cells. S1P is a chemoattractant for NK cells, which are critical members of the immunological tumor surveillance machinery....
journal_title:International journal of oncology
pub_type: 杂志文章
doi:
更新日期:2009-01-01 00:00:00
abstract::Tamoxifen (Tam), a selective estrogen receptor modulator, is in wide clinical use for the treatment and prevention of breast cancer. However, extended TAM administration for breast cancer induces increased VEGF levels in patients, promoting new blood vessel formation and thereby limiting its efficacy and highlighting ...
journal_title:International journal of oncology
pub_type: 杂志文章
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更新日期:2014-04-01 00:00:00
abstract::We evaluated the effect of intravenous thermosensitive liposomal doxorubicin (TL-DOX) together with local hyperthermia on primary tumors in highly metastatic hamster osteosarcoma. This combination resulted in higher DOX concentrations in plasma, primary tumors and lungs than standard DOX under the same conditions. Tum...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.19.3.585
更新日期:2001-09-01 00:00:00
abstract::Hypoxia, a common phenomenon during the development of malignant solid tumors including breast cancer, serves to propagate a cascade of molecular pathways triggered by hypoxia-inducible factor-1α (HIF-1α). Carbonic anhydrase IX (CA IX), one of the target genes of HIF-1α, has been reported to be involved in progression...
journal_title:International journal of oncology
pub_type: 杂志文章
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更新日期:2016-01-01 00:00:00
abstract::Specific RE protein species modulated by autocrine TGF alpha are unknown. HCT116 cells transfected with TGF alpha antisense expression vector were compared with control HCT116 NEO for mitogenesis and modulation of high MW (130, 120 kD) and low MW (116, 110, 105 kD) RE species. Nutrients alone (N) induced maximal mitog...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.8.6.1025
更新日期:1996-06-01 00:00:00
abstract::Polypyrimidine tract-binding protein 1 (PTBP1), a heterogeneous nuclear ribonucleoprotein, is a multi-functional RNA-binding protein. PTBP1 participates in a number of biological processes, including maintaining cell structure and motility, immunity, protein metabolism and the cell cycle. The present study aimed to in...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2018.4296
更新日期:2018-05-01 00:00:00
abstract::By setting the cut-off line at the level as used in a negative control study without primary antibody in the same sample, the Ki-67 labeling rate was calculated by the Ki67-DNA dual fluorescence analysis. The mean Ki-67 labeling rate of 28 advanced gastric cancer was 45.1% (13.9-76.3%). The Ki-67 labeling rates were s...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.1.3.265
更新日期:1992-08-01 00:00:00
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journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2015.3006
更新日期:2015-07-01 00:00:00
abstract::We performed interventional treatments on 50 patients with hepatocellular carcinoma (HCC) and analyzed the relationship between these treatments and the exacerbation of liver function after treatment. The different treatments included transcatheter arterial embolization (TAE), percutaneous ethanol injection therapy (P...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.19.6.1279
更新日期:2001-12-01 00:00:00
abstract::MicroRNA‑301a (miRNA/miR‑301a) and nuclear factor (NF)‑κB signaling play important roles in tumor invasion, migration and progression. However, the role of miRNA‑301a‑3p in human gastric cancer (GC), and specifically in the activation of NF‑κB signaling, remains unclear. The aim of the present study was to investigate...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2020.5072
更新日期:2020-08-01 00:00:00
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journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.10.6.1103
更新日期:1997-06-01 00:00:00
abstract::Pancreatic cancer is one of the most aggressive solid malignancies with a dismal survival rate. Recent studies have shown that high expression levels of histone deacetylase 3 (HDAC3) correlate with malignant phenotype. However, the expression patterns and biological role of HDAC3 in pancreatic cancer remain unclear. I...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2014.2568
更新日期:2014-10-01 00:00:00
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journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2012.1603
更新日期:2012-11-01 00:00:00
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journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.14.2.327
更新日期:1999-02-01 00:00:00
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journal_title:International journal of oncology
pub_type: 杂志文章,评审
doi:
更新日期:2003-03-01 00:00:00
abstract::Chromosomal alterations are a major genomic force contributing to the development of lung cancer. We subjected 22 cases of squamous cell carcinoma of the lung (SCC) to whole-genome microarray-CGH (resolution, 1 Mb) to identify critical genetic landmarks that might be important mediators in the formation or progression...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:
更新日期:2010-08-01 00:00:00
abstract::We assessed Stanniocalcin-1 (STC-1) mRNA expression in human normal tissues, various types of human cancer cell lines, and cancer tissues obtained during surgery. Using a reverse transcriptase-polymerase chain reaction (RT-PCR) assay developed to detect STC-1 mRNA, the transcripts were detected in 20 out of 21 cancer ...
journal_title:International journal of oncology
pub_type: 杂志文章
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更新日期:2000-04-01 00:00:00
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pub_type: 杂志文章
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更新日期:1999-12-01 00:00:00
abstract::Expression and functions of interleukin (IL)-8, a pro-inflammatory cytokine with angiogenesis action, was examined in 23 surgically resected hepatocellular carcinoma (HCC) specimens and 7 HCC cell lines. In all HCC tissues, IL-8 expression was confirmed with reverse-transcription polymerase chain reaction method and e...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.18.2.257
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journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.4.4.839
更新日期:1994-04-01 00:00:00
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journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2017.4063
更新日期:2017-09-01 00:00:00
abstract::Long non-coding RNAs (lncRNAs) are involved in cancer progression. In the present study, we analyzed the lncRNA profiles in adriamycin-resistant and -sensitive breast cancer cells and found a group of dysregulated lncRNAs in the adriamycin-resistant cells. Expression of the dysregulated lncRNAs was correlated with dys...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2016.3665
更新日期:2016-10-01 00:00:00
abstract::Growth and inflammatory factors are associated with poor prognosis in gastric adenocarcinoma (GA); however, the additive effects of growth and inflammatory factors in GA remain unclear. In this study, we investigated the ability of epidermal growth factor (EGF) and interleukin (IL-1β) to activate extracellular signal-...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2014.2401
更新日期:2014-07-01 00:00:00
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journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2012.1557
更新日期:2012-10-01 00:00:00
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journal_title:International journal of oncology
pub_type: 杂志文章
doi:
更新日期:2003-09-01 00:00:00
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journal_title:International journal of oncology
pub_type: 杂志文章
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journal_title:International journal of oncology
pub_type: 临床试验,杂志文章
doi:
更新日期:2004-12-01 00:00:00