Abstract:
:Some diseases and drugs have previously been associated with increased risk for colon cancer. A case-control study on colon adenocarcinoma was conducted encompassing 329 cases and 658 controls. History of previous diseases and drug intake was assessed by questionnaire. Appendectomy was associated with a protective effect with odds ratio (OR) 0.5 and 95% confidence interval (CI) 0.2-0.9. Cholecystectomy was associated with increased risk, especially in females, for right sided and transverse colon cancer, OR 1.5 (CI 0.9-2.5) and OR 1.8 (CI 0.8-3.5), respectively. Ulcerative colitis increased the risk, OR 11 (CI 3.5-38). Also hyperplasia of the prostate gland and diabetes in men were related to an increased risk with OR 4.4 (CI 1.5-13) and OR 2.9 (CI 1.4-6.0), respectively. For men and women together diabetes mellitus yielded an increased OR of 1.7 (1.0-3.0). Regarding drugs somewhat increased risks were found for beta-2-stimulating agents, OR 1.9 (CI 0.6-5.4), benzodiazepine, OR 1.7 (CI 0.9-3.3), iron, OR 1.9 (CI 0.5-6.7), and paracetamol, OR 2.5 (0.6-8.5). Increased risks were found for hydralazine in men, OR 2.3 (CI 0.7-7.0), methyldopa in men, OR 4.3 (1.1-18), sulfonylurea, OR 2.9 (CI 1.2-6.7), and verapamil, OR 22 (CI 2.4-480). Somewhat decreased risk was found for indometacin, OR 0.6 (0.2-1.6).
journal_name
Int J Oncoljournal_title
International journal of oncologyauthors
Hardell L,Fredrikson M,Axelson Odoi
10.3892/ijo.8.3.439subject
Has Abstractpub_date
1996-03-01 00:00:00pages
439-44issue
3eissn
1019-6439issn
1791-2423journal_volume
8pub_type
杂志文章abstract::Although a number of recent studies have reported the involvement of leptin in colorectal carcinogenesis, findings are contradictory and difficult to interpret. Our group has previously reported that leptin signaling might have an important role in the development of colorectal adenomas. In this study, we investigated...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2011.1105
更新日期:2011-10-01 00:00:00
abstract::Prevention of chemotherapy induced nausea and vomiting in an outpatient population requires an antiemetic regimen which is reliable and safe and easy to administer. In this study the use of oral ondansetron was investigated in 45 patients receiving 143 courses of non-cisplatin containing chemotherapy regimens on an ou...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.4.6.1283
更新日期:1994-06-01 00:00:00
abstract::The promising benefits of cancer gene therapy have been limited by the inability to deliver therapeutic genes homogeneously throughout the tumor mass and to control gene expression within the tumor cells. Transcriptional targeting, the use of DNA regulatory promoter sequences to localize transgene expression, has been...
journal_title:International journal of oncology
pub_type: 杂志文章,评审
doi:
更新日期:2004-03-01 00:00:00
abstract::Lisofylline, a dimethylxanthine derivative, has been shown to block the induction of hematopoietic growth inhibitors produced in response to cytotoxic anticancer therapy. In the current study, mice bearing established EMT-6 mammary carcinoma were treated with high dose cyclophosphamide, melphalan, BCNU, 5-fluorouracil...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.11.2.265
更新日期:1997-08-01 00:00:00
abstract::Although the hematopoietic reconstituting ability of human umbilical cord blood cells (UCBC) is well documented, their antitumor cytotoxic potential has not been well studied. Therefore, UCBC were compared to normal peripheral blood stem cells (PBSC) and bone marrow (BM) stem cell harvests for cytomorphology, antitumo...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.13.4.791
更新日期:1998-10-01 00:00:00
abstract::Nasopharyngeal carcinoma (NPC) is a major cause of cancer deaths. Concurrent administration of radiation and chemotherapy is the treatment of choice for advanced NPC. Previously, we showed that apogossypolone (ApoG2) induced apoptosis by blocking the binding of Bcl-2 to Bax, arresting the cell cycle in the S phase, in...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2014.2497
更新日期:2014-09-01 00:00:00
abstract::Mesothelioma is an aggressive tumor which is mainly derived from the pleura of lung. In the present study, we evaluated the anticancer effect of suberoylanilide hydroxamic acid (SAHA), a histone deacetylase (HDAC) inhibitor on human mesothelioma cells in relation to the levels of HDAC1, reactive oxygen species (ROS) a...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2016.3402
更新日期:2016-05-01 00:00:00
abstract::The aim of the present work is to investigate whether microtubule-affecting drugs including vincristine, vinblastine, vindesine and vinorelbine are able to produce an anti-angiogenic effect at non-cytotoxic doses in the same way of taxol. The cytotoxic effects were determined by means of the colorimetric MTT assay, an...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:
更新日期:2002-08-01 00:00:00
abstract::In antibody-directed enzyme-prodrug therapy (ADEPT), an antibody-bound enzyme localizes to tumor tissue, where it selectively converts a subsequently administered non-toxic prodrug into a cytotoxic drug. A33scFv::CDy is a bifunctional fusion construct comprising a single chain antibody against the gpA33 antigen and th...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:
更新日期:2008-04-01 00:00:00
abstract::Linear accelerator-based radiotherapy has little effect on tumors such as malignant melanoma, various types of sarcoma, and most locally-advanced neoplasms that have grown to several centimeters or more. These tumors contain many hypoxic cancer cells or large amounts of anti-oxidative enzymes, and are therefore resist...
journal_title:International journal of oncology
pub_type: 临床试验,杂志文章
doi:10.3892/ijo.2011.1069
更新日期:2011-09-01 00:00:00
abstract::Mos is a germ cell-specific serine/threonine protein kinase that plays an important role during meiotic divisions of oocytes. Upon expression in somatic cells, Mos causes cell cycle perturbations leading to neoplastic transformation. Mos activates the MAP kinase pathway in both oocytes and transformed somatic cells. T...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.12.5.1199
更新日期:1998-05-01 00:00:00
abstract::Colon cancer represents one of the most common solid tumors in adults. Although 5-fluorouracil (5-FU) and irinotecan have been frequently administered in colon cancer patients, low response rates to these single drug therapies were reported. It is therefore imperative to search for new targeted combination therapies t...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo_00000465
更新日期:2009-12-01 00:00:00
abstract::A p53 functional analysis system, which can identify the types of abnormality of p53, such as loss of function, dominant negative function, or gain of oncogenic function, is now required. In this study, we examined the functional diversity of several mutations of p53 derived from human head and neck cancer cells. The ...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:
更新日期:2007-05-01 00:00:00
abstract::Although active targeting of anticancer drugs using magnetically responsive carriers is a very attractive treatment approach for solid tumors, successful results are limited. In particular, the therapeutic utility of intravenously administered magnetically responsive carriers has to date not been clearly established. ...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.17.2.309
更新日期:2000-08-01 00:00:00
abstract::Thymidylate synthase (TS) is known to have polymorphisms in the 5' and 3' untranslated region (UTR). These polymorphisms have been reported to be associated with high TS expression and chemoresistance to 5-FU. The aim of this study was to examine the prognostic roles of the 5'-UTR and 3'-UTR TS polymorphisms in esopha...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:
更新日期:2008-01-01 00:00:00
abstract::Ionizing radiation (IR) is frequently unsuccessful in the treatment of cancer because of local failure or distant metastases. The efficacy of systemically administered cytokines for cancer therapy is often limited by toxicity. We report that intratumoral injection of an adenoviral vector with interleukin-12 (IL-12) en...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.15.4.769
更新日期:1999-10-01 00:00:00
abstract::The mitogen-activated protein kinase (MAPK) cascade is a critical component in the regulation of cell survival and proliferation decisions. In breast carcinoma cells, activation of the p38-MAPK member of this family occurs in response to pro-inflammatory cytokines and cellular stress. The involvement of p38-MAPK in th...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:
更新日期:2004-06-01 00:00:00
abstract::Hypoxia regulates the expression of genes that promote tumor growth, angiogenesis and invasion. We previously studied hypoxic tumor cells in vitro and from hepatic metastases of colorectal cancer and determined several potential prognostic factors for hepatocellular carcinoma (HCC). In this study, we evaluated the pro...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2014.2519
更新日期:2014-09-01 00:00:00
abstract::Malignant peripheral nerve sheath tumors (MPNSTs) are aggressive soft tissue tumors arising sporadically although more frequently in patients with Neurofibromatosis type 1. Prognosis remains dismal as chemo- and radiotherapy have not been shown to be successful. The heparin-binding growth factor, Midkine (MK), is impl...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:
更新日期:2005-11-01 00:00:00
abstract::WNT signaling pathway is implicated in carcinogenesis and embryogenesis. We have previously cloned and characterized WNT10A, and demonstrated up-regulation of WNT10A in gastric cancer. Here, we investigated expression of WNT10A mRNA in various types of human cancer. WNT10A mRNA was detected in 10 out of 12 esophageal ...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.19.5.997
更新日期:2001-11-01 00:00:00
abstract::Targeted cancer therapies are used to inhibit the growth, progression, and metastasis of the tumor by interfering with specific molecular targets and are currently the focus of anticancer drug development. Protein kinase B, also known as Akt, plays a central role in many types of cancer and has been validated as a the...
journal_title:International journal of oncology
pub_type: 杂志文章,评审
doi:10.3892/ijo.2015.3306
更新日期:2016-03-01 00:00:00
abstract::p57KIP2, the second class of KIP family protein, is one of the negative regulators of the cell cycle. To elucidate the role of p57KIP2 in colorectal normal mucosa and cancer, we examined the expression of p57KIP2 protein in 110 pairs of colorectal non-tumor and cancer tissues. Immunohistochemical analysis showed that ...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.19.1.39
更新日期:2001-07-01 00:00:00
abstract::We have developed a new type of drug delivery system (DDS) comprising a complex of porous hydroxyapatite (HAP) with the anticancer drug doxorubicin hydrochloride (DOX) and the glutathione inhibitor buthionine sulfoximine (BSO) (DOX and BSO-HAP complex). We then studied the antitumour effect of DOX and BSO-HAP combined...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.10.5.961
更新日期:1997-05-01 00:00:00
abstract::This study aimed to analyze expression of Müllerian inhibiting substance type II receptor (MISRII) protein and mRNA in cervical neoplasia, to demonstrate the growth inhibition of cervical cancer cells by administration of highly purified recombinant human Müllerian inhibiting substa...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2012.1370
更新日期:2012-06-01 00:00:00
abstract::ATP-dependent transport of doxorubicin (DOX) by recombinant human RLIP76 has been demonstrated previously in reconstituted proteoliposomes. In the preceding communication, we demonstrated that the ATPase activity of RLIP76 was 2-fold higher in NSCLC as compared with SCLC, and it correlated with their inherent DOX resi...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:
更新日期:2003-04-01 00:00:00
abstract::Primary cilia are microtubule-based organelles that regulate smoothened-dependent activation of the GLI transcription factors in canonical hedgehog signaling. In many cancers, primary cilia are markedly decreased or absent. The lack of primary cilia may inhibit or alter canonical hedgehog signaling and, thereby, inter...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2015.3006
更新日期:2015-07-01 00:00:00
abstract::Despite the introduction of 13-cis-retinoic acid (13-cis-RA) into the current chemotherapy, more than half of high-risk neuroblastoma patients have experienced tumor relapses driven by chemoresistant cancer stem cells (CSCs) that can be isolated by their ability to grow as spheres. Although aldehyde dehydrogenase (ALD...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2014.2801
更新日期:2015-03-01 00:00:00
abstract::Although several therapeutic options are available for hepatocellular carcinoma (HCC), the outcome is still very poor. One reason is the complexity of signal transduction in the pathogenesis of HCC. The aim of this study was to identify new HCC-related genes and to investigate the functions of these genes in the patho...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2014.2445
更新日期:2014-08-01 00:00:00
abstract::Mantle cell lymphoma (MCL) is typified by translocation t(11;14)(q13;q32) causing upregulation of cyclin D1 and deregulation of cell cycle. The cyclin D1 activation plays a critical role in MCL pathogenesis but additional oncogenic events, such as aberrations of the ARF/MDM2/p53 pathway are also necessary for progress...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo_00000545
更新日期:2010-03-01 00:00:00
abstract::New drugs that inhibit the osteoprotegerin (OPG)/receptor activator of NF-κB ligand (RANKL)/RANK pathway have demonstrated efficacy for the treatment of bone metastasis. Toxicities induced by these drugs, however, including osteonecrosis of the jaw and hypocalcemia, may adversely affect therapy. The aim of this study ...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2013.1954
更新日期:2013-08-01 00:00:00