Abstract:
:Ionizing radiation (IR) is frequently unsuccessful in the treatment of cancer because of local failure or distant metastases. The efficacy of systemically administered cytokines for cancer therapy is often limited by toxicity. We report that intratumoral injection of an adenoviral vector with interleukin-12 (IL-12) enhances local anti-tumor effects of irradiation (IR). We demonstrate that microscopic tumor growth at a distant site is suppressed following treatment of the primary tumor with adeno-murine IL-12 (Adm.IL-12). The results support a model in which the anti-angiogenic effects of IL-12 contribute to the local anti-tumor effects of radiation, while IL-12 induced immunity suppresses growth of microscopic tumors distant from the primary irradiated site. These data suggest that combining radiotherapy with IL-12 improves both local and distant tumor control compared to either treatment alone. Immunoradiotherapy may be employed in addition to or in place of current conventional therapies to increase local control and decrease distant tumor growth.
journal_name
Int J Oncoljournal_title
International journal of oncologyauthors
Seetharam S,Staba MJ,Schumm LP,Schreiber K,Schreiber H,Kufe DW,Weichselbaum RRdoi
10.3892/ijo.15.4.769keywords:
subject
Has Abstractpub_date
1999-10-01 00:00:00pages
769-73issue
4eissn
1019-6439issn
1791-2423journal_volume
15pub_type
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