Collagen triple helix repeat containing 1 is overexpressed in hepatocellular carcinoma and promotes cell proliferation and motility.

abstract：:In order to realise the full potential of gene therapy as a rational approach to the treatment of cancer, it will be necessary to achieve delivery of the therapeutic gene selectively to target tumour cells. Such cancer cell-specific gene delivery is mandated in the context of locoregional or compartmentalised carcinom...

journal_title：International journal of oncology

authors： Douglas J,Curiel D

更新日期：1997-08-01 00:00:00

abstract：:To compare the oncosuppressive activity of integrated and episomal adeno-associated virus (AAV), two Epstein-Barr virus (EBV) derived episomal form vectors, p205 and p220, were used to generate plasmids containing episomal AAV. HeLa cells transfected with p205, p220, and the plasmids with forward (pA205-1, pA220-1) an...

journal_title：International journal of oncology

authors： Wu FY,Wu CY,Lin CH,Wu CH

更新日期：1999-07-01 00:00:00

abstract：:Side population (SP) cells may play a crucial role in tumorigenesis and the recurrence of cancer. Many types of cell lines and tissues have demonstrated the presence of SP cells, including colon cancer cell lines. This study aimed to identify cancer stem cells (CSCs) in the SP of the colon cancer cell line SW480. SP c...

journal_title：International journal of oncology

authors： Xiong B,Ma L,Hu X,Zhang C,Cheng Y

更新日期：2014-09-01 00:00:00

abstract：:RLIP76, a stress-responsive, multi-functional protein with multi-specific transport activity towards glutathione-conjugates (GS-E) and chemotherapeutic agents is frequently overexpressed in malignant cells. Our recent studies suggest that it plays a prominent anti-apoptotic role selectively in cancer cells. The presen...

journal_title：International journal of oncology

authors： Singhal SS,Sehrawat A,Mehta A,Sahu M,Awasthi S

更新日期：2009-01-01 00:00:00

abstract：:An altered expression of microRNAs (miRNAs) contributes both to the development of cancer and to the progression of the disease. Malignant tumours and tumour cell lines have widespread deregulated expressions of miRNAs compared to normal tissues. In this study, we investigated the expression profiles of 340 mammalian ...

journal_title：International journal of oncology

authors： D'Urso PI,D'Urso OF,Storelli C,Mallardo M,Gianfreda CD,Montinaro A,Cimmino A,Pietro C,Marsigliante S

更新日期：2012-07-01 00:00:00

abstract：:We have demonstrated anti-proliferation and anti-metastasis effects of both interferon-alpha and a histone deacetylase inhibitor, sodium butyrate, on human liver cancer cell lines. In this study, invasive ability of human liver cancer cell lines through the matrix-coated membrane was examined and inhibitory effect of ...

journal_title：International journal of oncology

authors： Kaneko F,Saito H,Saito Y,Wakabayashi K,Nakamoto N,Tada S,Suzuki H,Tsunematsu S,Kumagai N,Ishii H

更新日期：2004-04-01 00:00:00

abstract：:Degradation of the extracellular matrix is a prerequisite for the invasive phenotype in glioma cells. Several proteases released by invading tumor cells seem to participate in the focal degradation of extracellular matrix proteins. Using enzymatic assays, Western blotting, and Northern blotting techniques, we investig...

journal_title：International journal of oncology

authors： Konduri S,Lakka SS,Tasiou A,Yanamandra N,Gondi CS,Dinh DH,Olivero WC,Gujrati M,Rao JS

更新日期：2001-09-01 00:00:00

abstract：:Recent studies demonstrated an epigenetic inactivation of the runt-related transcription factor 3 (RUNX3) gene in human colon cancer. However, it remains unclear whether RUNX3 is tumor suppressive in colon cancer and, if so, the underlying molecular mechanisms of this activity are still unknown. In the present study, ...

journal_title：International journal of oncology

authors： Peng Z,Tang H,Wang X,Zhou C,Fan J,Wang L,Jia Z,Li Q,Le X,Wei D,Xie K

更新日期：2008-11-01 00:00:00

abstract：:Cancer progression has been associated with an increase in genomic instability indicated by inactivation of tumor suppressor genes and activation of oncogenes. Epidemiological and experimental evidence has implicated estrogens in the etiology of breast cancer. To study environmental organophosphorous pesticides is of ...

journal_title：International journal of oncology

authors： Calaf GM,Echiburu-Chau C,Roy D

更新日期：2009-11-01 00:00:00

abstract：:We investigated three clonally related human keratinocyte cell lines of different biological behaviour, HaCaT (non-tumorigenic), A5 (benign, tumorigenic) and II-4RT (malignant, tumorigenic), with regard to the cell-associated localization of the major MMPs -1, -2, -3, -9, -10 and -11. These observations were correlate...

journal_title：International journal of oncology

authors： Bachmeier BE,Nerlich AG

更新日期：2002-03-01 00:00:00

abstract：:Golgi phosphoprotein 2 (GP73) is a type II Golgi protein, which was found on examination of the fucosylated proteome as a potential tumor marker for hepatocellular carcinoma (HCC). The serum levels of both total and fucosylated GP73 were increased in the sera of patients with HCC. Fucosylation is one of the most impor...

journal_title：International journal of oncology

authors： Kawamoto S,Moriwaki K,Nakagawa T,Terao M,Shinzaki S,Yamane-Ohnuki N,Satoh M,Mehta AS,Block TM,Miyoshi E

更新日期：2011-07-01 00:00:00

abstract：:Thymic epithelial tumors comprise thymoma, thymic carcinoma and neuroendocrine tumors of the thymus. Recent studies have revealed that the incidence of somatic non‑synonymous mutations is significantly higher in thymic carcinoma than in thymoma. However, limited information is currently available on epigenetic alterat...

journal_title：International journal of oncology

authors： Kishibuchi R,Kondo K,Soejima S,Tsuboi M,Kajiura K,Kawakami Y,Kawakita N,Sawada T,Toba H,Yoshida M,Takizawa H,Tangoku A

更新日期：2020-01-01 00:00:00

abstract：:Rhabdomyosarcoma (RMS) is a malignant tumour of skeletal muscle origin which includes two major histological subtypes: alveolar rhabdomyosarcoma (ARMS), the more aggressive, and embryonal rhabdomyosarcoma (ERMS). In order to establish whether the higher metastatic potential of ARMS cells may depend on differential exp...

journal_title：International journal of oncology

authors： Onisto M,Slongo ML,Gregnanin L,Gastaldi T,Carli M,Rosolen A

更新日期：2005-09-01 00:00:00

abstract：:The p53 homologue p73 is overexpressed in many tumors, including lung cancer. We have evaluated the differential expression and subcellular localization of the functionally distinct apoptotic (TA) and anti-apoptotic (DeltaN) isoforms of p73 in non-small cell lung cancer (NSCLC), their possible association with p53 exp...

journal_title：International journal of oncology

authors： Di Vinci A,Sessa F,Casciano I,Banelli B,Franzi F,Brigati C,Allemanni G,Russo P,Dominioni L,Romani M

更新日期：2009-02-01 00:00:00

abstract：:The molecular mechanism playing a role in the development of benign prostate hypertrophy (BPH) and prostate cancer (PC) is not well defined. We performed microarray analysis to assess the gene expression change in BPH and PC, and performed network analysis. Normal prostate, BPH and PC tissues were obtained from patien...

journal_title：International journal of oncology

authors： Endo T,Uzawa K,Suzuki H,Tanzawa H,Ichikawa T

更新日期：2009-09-01 00:00:00

abstract：:Thermal ablation of solid tumors using conductive interstitial thermal therapy (CITT) produces coagulative necrosis in the center of ablation. Local changes in homeostasis for surviving tumor and systemic changes in circulation and distant organs must be understood and monitored in order to prevent tumor re-growth and...

journal_title：International journal of oncology

authors： Przybyla BD,Shafirstein G,Vishal SJ,Dennis RA,Griffin RJ

更新日期：2014-02-01 00:00:00

abstract：:Fanconi anemia complementation group D2 (FANCD2) is involved in the key steps of the Fanconi anemia (FA) pathway, which plays a role in the repair of DNA crosslink damage. However, the role of FANCD2 during radiotherapy for head and neck squamous cell carcinoma (HNSCC) is unclear. In this study, the HNSCC cell line HS...

journal_title：International journal of oncology

authors： Feng HJ,Bao YL,Liang ZP,Zhao FP,Xu SE,Xu W,Zhao C,Qin G

更新日期：2017-03-07 00:00:00

abstract：:Breast cancer cells can switch from estrogen receptor α (ER)- to human epidermal growth factor receptor (HER)-driven cell growth upon acquiring antiestrogen resistance. HER ligands are cleaved by metalloproteinases leading to release of active HER ligands, activation of HER receptors and consequently increased cell gr...

journal_title：International journal of oncology

authors： Kirkegaard T,Yde CW,Kveiborg M,Lykkesfeldt AE

更新日期：2014-07-01 00:00:00

abstract：:The effects of prostaglandin E2 and indomethacin on carcinogenesis were studied in male Wistar rats. Of the rats, those treated with MNNG (MNNG group) were given 1 ml of 0.1% solution of MNNG in distilled water by intrarectal instillation every day for 14 days. The diet for the rats treated with Indomethacin and MNNG ...

journal_title：International journal of oncology

authors： Yamaguchi A,Goi T,Nakagawara G,Ishida T,Miyazaki I

更新日期：1993-08-01 00:00:00

abstract：:Baicalein is a flavonoid derived originally from the root of Scutellaria baicalensis Georgi, which has been used in Oriental medicines for treating various diseases. Although this compound has been reported to have anticancer activities in several human cancer cell lines, the therapeutic effects of baicalein on human ...

journal_title：International journal of oncology

authors： Choi EO,Park C,Hwang HJ,Hong SH,Kim GY,Cho EJ,Kim WJ,Choi YH

更新日期：2016-09-01 00:00:00

abstract：:Solid tumors can generate a plethora of neurogenesis-related molecules that enhance their growth and metastasis. Among them, we have identified axonal guidance molecule Semaphorin 7A (SEMA7A) in breast cancer. The goal of this study was to determine the therapeutic effect of suppressing SEMA7A levels in the 4T1 murine...

journal_title：International journal of oncology

authors： Garcia-Areas R,Libreros S,Simoes M,Castro-Silva C,Gazaniga N,Amat S,Jaczewska J,Keating P,Schilling K,Brito M,Wojcikiewicz EP,Iragavarpu-Charyulu V

更新日期：2017-11-01 00:00:00

abstract：:Anisi stellati fructus (ASF), commonly known as star anise, has long been used as a traditional Chinese medicine to treat inflammation, nervousness, insomnia and pain. In recent studies, it has been demonstrated that ASF possesses anti-bacterial, anti-fungal and anti-oxidant activities, as well as exhibits inhibitory ...

journal_title：International journal of oncology

authors： Kim A,Im M,Ma JY

更新日期：2014-11-01 00:00:00

abstract：:The purpose of the study was to assess response rate, clinical outcome, organ/function preservation and toxicity in head and neck cancer patients treated with induction chemotherapy followed by concomitant chemoradiotherapy and, when necessary, limited surgery. The study design was a phase II non-randomized trial in h...

journal_title：International journal of oncology

authors： Mantovani G,Maccio A,Massa E,Mulas C,Mudu MC,Massidda S,Massa D,Murgia V,Ferreli L,Succu G,Astara G,Proto E,Tore G,Mura M,Maxia G

更新日期：2000-06-01 00:00:00

abstract：:Fcγ receptors (FcγRs) on effector cells are of importance for mediating antibody-dependent cellular cytotoxicity (ADCC). FcγRIIIa158valine (V)/phenylalanine (F) and FcγRIIa131histidine (H)/arginine(R) polymorphisms have been shown to relate to prognosis in antibody-treated patients. The aim of the present study was to...

journal_title：International journal of oncology

authors： Wang B,Kokhaei P,Mellstedt H,Liljefors M

更新日期：2010-12-01 00:00:00

abstract：:Quinazolinone derivatives are known to possess anticancer activities on cell metastasis and cell death in different human cancer cell lines. Here, we studied the anti-metastasis activity and the underlying mechanisms of the novel quinazoline derivative MJ-56 (6-pyrrolidinyl-2-(3-bromostyryl)quinazolin-4-one). MJ-56 in...

journal_title：International journal of oncology

authors： Chen HJ,Jiang YL,Lin CM,Tsai SC,Peng SF,Fushiya S,Hour MJ,Yang JS

更新日期：2013-07-01 00:00:00

abstract：:Mos is a germ cell-specific serine/threonine protein kinase that plays an important role during meiotic divisions of oocytes. Upon expression in somatic cells, Mos causes cell cycle perturbations leading to neoplastic transformation. Mos activates the MAP kinase pathway in both oocytes and transformed somatic cells. T...

journal_title：International journal of oncology

authors： Yang Y,Pham CD,Arlinghaus RB,Khillan JS,Singh B

更新日期：1998-05-01 00:00:00

abstract：:MUC16 (CA125) is a transmembrane mucin that contributes to the progression of epithelial ovarian cancer (EOC). Expression of MUC16 is not detectable in the epithelial surface of normal ovaries. MUC16 expression is, however, common in serous EOC as well as in metastatic and recurrent tumors. Despite these observations,...

journal_title：International journal of oncology

authors： Giannakouros P,Matte I,Rancourt C,Piché A

更新日期：2015-01-01 00:00:00

abstract：:The failure of androgen deprivation therapy in prostate cancer treatment mainly results from drug resistance to androgen receptor antagonists. Although an aberrant caveolin‑1 (Cav‑1) expression has been reported in multiple tumor cell lines, it is unknown whether it is responsible for the progression of castration‑res...

journal_title：International journal of oncology

authors： Gao Y,Li L,Li T,Ma L,Yuan M,Sun W,Cheng HL,Niu L,Du Z,Quan Z,Fan Y,Fan J,Luo C,Wu X

更新日期：2019-06-01 00:00:00

abstract：:Oral squamous cell carcinoma (OSCC) is the sixth most common cancer and frequently metastasizes to the cervical lymph nodes, leading to poor survival of patients with OSCC. However, the mechanism of lymph node metastasis is not fully understood. To clarify the molecular mechanism un...

journal_title：International journal of oncology

authors： Morita Y,Hata K,Nakanishi M,Nishisho T,Yura Y,Yoneda T

更新日期：2012-09-01 00:00:00

abstract：:Total body irradiation (TBI), given in low to moderate doses as a single modality, can enhance leukocyte populations and immune modifiers, resulting in slowed tumor progression. The aim of this study was to evaluate natural killer (NK) cell involvement in mediating the antitumor effect of TBI by depleting NK populatio...

journal_title：International journal of oncology

authors： Miller GM,Andres ML,Gridley DS

更新日期：2003-12-01 00:00:00