FcγR polymorphisms and clinical outcome in colorectal cancer patients receiving passive or active antibody treatment.

abstract：:Angiogenesis is increased in various human cancers, including head and neck squamous cell carcinoma (HNSCC), and correlates with tumor progression and metastasis. Vascular endothelial growth factor (VEGF) has been shown to be a key regulator of angiogenesis. We determined whether VEGF antisense oligonucleotide treatme...

journal_title：International journal of oncology

authors： Riedel F,Götte K,Li M,Hörmann K,Grandis JR

更新日期：2003-09-01 00:00:00

abstract：:The aim was to compare the efficacy of ondansetron and a combination of ondansetron plus dexamethasone in the prophylaxis of cisplatin-induced delayed emesis over three consecutive courses of chemotherapy. Cancer patients scheduled to receive for the first time cisplatin (>50 mg/m(2)) in combination with other cytotox...

journal_title：International journal of oncology

authors： Gridelli C,Ianniello G,Ambrosini G,Mustacchi G,Pedicini T,Farris A,Iacobelli S,Rossi G,Moretti G,Angelini F,Delena M,Dicarlo A,Bonsignori M,Sabbatini R,Catalano G,Rossi A,Olivieri A,Fina P,Bianco A

更新日期：1997-02-01 00:00:00

abstract：:Telomerase (T) is a ribonucleoprotein complex that includes the telomerase RNA component (hTR), telomerase associated protein (TP1) and the telomerase catalytic subunit (hTERT). Telomerase has been shown in stem cells and found to be activated in tumor tissues and immortalized cells. We wanted to test whether the expr...

journal_title：International journal of oncology

authors： Hoang-Vu C,Boltze C,Gimm O,Poremba C,Dockhorn-Dworniczak B,Köhrle J,Rath FW,Dralle H

更新日期：2002-08-01 00:00:00

abstract：:In a recent study, we evaluated the efficacy and toxicity of 5-fluorouracil (5-FU), cisplatin (CDDP), and 5-FU plus CDDP (FP treatment) in gastric cancer cell lines and examined the relationship between the response to FP treatment and apoptosis. Our study indicated that there may be prognostic value in measuring p53 ...

journal_title：International journal of oncology

authors： Matsuhashi N,Saio M,Matsuo A,Sugiyama Y,Saji S

更新日期：2005-06-01 00:00:00

abstract：:Chemotherapeutic treatment with combinations of drugs is front-line therapy for many types of cancer. Combining drugs that target different signaling pathways often lessens adverse side-effects while increasing the efficacy of treatment and reducing patient morbidity. Histone deacetylase (HDAC) inhibitors represent a ...

journal_title：International journal of oncology

authors： Sato T,Suzuki M,Sato Y,Echigo S,Rikiishi H

更新日期：2006-05-01 00:00:00

abstract：:TGF-β-induced epithelial-mesenchymal transition (EMT) plays an important role in tumor progression. We assessed whether the TGF-β-induced EMT contributed to vasculogenic mimicry (VM) formation in glioma, we established an SHG44 cell line stably transfected with TGF-β cDNA loaded lentivirus. SB203580 was employed to in...

journal_title：International journal of oncology

authors： Ling G,Ji Q,Ye W,Ma D,Wang Y

更新日期：2016-12-01 00:00:00

abstract：:Over the past few decades, there has been a tremendous increase in cancer biology data and treatment. Cancer research has opened exciting new areas of cellular and molecular biology. Month by month, new genes which regulate the carcinogenesis process are being discovered. The result is an incredible knowledge of cance...

journal_title：International journal of oncology

authors： Kanduc D,Bannasch P,Farber E

更新日期：1999-12-01 00:00:00

abstract：:Previous studies have revealed that protein kinase C (PKC) is responsible for malignant progression. In the present study, we investigated the potent inhibitory effects of an antiestrogen, toremifene, on PKC-mediated cellular adhesion. A phorbol ester, phorbol 12-myristate 13-acetate (PMA), significantly enhanced alph...

journal_title：International journal of oncology

authors： Maemura M,Iino Y,Horiguchi J,Takei H,Horii Y,Koibuchi Y,Yokoe T,Takeyoshi I,Ohwada S,Morishita Y

更新日期：1998-11-01 00:00:00

abstract：:Melanoma, the most aggressive human skin tumor, has a very short survival time, and there are currently no effective treatments. Alterations in cell metabolism, such as enhanced aerobic glycolysis, have been identified as hallmarks of cancer cells. In the present study, bioinformatics studies using online databases re...

journal_title：International journal of oncology

authors： Dong Z,Yang J,Li L,Tan L,Shi P,Zhang J,Zhong X,Ge L,Wu Z,Cui H

更新日期：2020-03-01 00:00:00

abstract：:We previously developed a new microscopic observation system that enables time-lapse quantitative analysis of apoptosis and necrosis. With this system we quantitatively analyzed adriamycin (ADR)-induced cell death using manganese superoxide dismutase (MnSOD)- and wild-type p53-gene transfectants on SaOS(2), a p53-defi...

journal_title：International journal of oncology

authors： Wang Y,Kuroda M,Gao XS,Asaumi J,Shibuya K,Kawasaki S,Akaki S,St Clair D,Hiraki Y,Kanazawa S

更新日期：2005-05-01 00:00:00

abstract：:Aberrant glycosylation is a universal feature of cancer cells, and certain glycan structures are well-known markers for tumor progression. Availability and composition of sugars in the microenvironment may affect cell glycosylation. Recent studies of human breast tumor cell lines indicate their ability to take up and ...

journal_title：International journal of oncology

authors： Monzavi-Karbassi B,Hine RJ,Stanley JS,Ramani VP,Carcel-Trullols J,Whitehead TL,Kelly T,Siegel ER,Artaud C,Shaaf S,Saha R,Jousheghany F,Henry-Tillman R,Kieber-Emmons T

更新日期：2010-09-01 00:00:00

abstract：:With a view to identifying markers reflecting not the evidence of, but the potential for, neoplastic progression of the breast we have compared the normal invasive mammary epithelial cell growth seen at puberty with invasive and non-invasive carcinogenesis using the mouse as a model. We have analyzed cell proliferatio...

journal_title：International journal of oncology

authors： Djonov V,Altermatt H,Arnold A,Gerber H,Andres A

更新日期：1995-08-01 00:00:00

abstract：:The isolation of circulating tumor cells (CTCs) from the blood of patients afflicted with solid malignant tumors becomes increasingly important as it may serve as a 'liquid biopsy' with the potential of monitoring the course of the cancer disease and its response to cancer therapy, with subsequent molecular characteri...

journal_title：International journal of oncology

authors： Saucedo-Zeni N,Mewes S,Niestroj R,Gasiorowski L,Murawa D,Nowaczyk P,Tomasi T,Weber E,Dworacki G,Morgenthaler NG,Jansen H,Propping C,Sterzynska K,Dyszkiewicz W,Zabel M,Kiechle M,Reuning U,Schmitt M,Lücke K

更新日期：2012-10-01 00:00:00

abstract：:The process of cell dissemination from the primary tumors to distant sites is the most harmful event during cancer progression, and the leading cause of cancer death. We have previously demonstrated that restoration of DLC1 tumor suppressor gene expression in the DLC1-negative Focus and 7703K human hepatocellular carc...

journal_title：International journal of oncology

authors： Zhou X,Zimonjic DB,Park SW,Yang XY,Durkin ME,Popescu NC

更新日期：2008-06-01 00:00:00

abstract：:Recent investigations have demonstrated that polyphenolic catechins inhibit cancer cell proliferation and tumor growth. However, how the major active component of tea catechins, epigallocatechin-3 gallate (EGCG), mediates anticancerous effects has not been extensively examined. We have investigated the cell growth inh...

journal_title：International journal of oncology

authors： Tang Y,Zhao DY,Elliott S,Zhao W,Curiel TJ,Beckman BS,Burow ME

更新日期：2007-10-01 00:00:00

abstract：:Carcinoma‑associated fibroblasts (CAFs) secrete factors that increase the expression and/or activities of proteins in breast cancer cells and induce resistance to anti‑estrogens, such as fulvestrant. A major factor is interleukin‑6 (IL‑6). This study demonstrated that, across estrogen receptor (ER)α‑positive and ‑nega...

journal_title：International journal of oncology

authors： Dittmer A,Lange T,Leyh B,Dittmer J

更新日期：2020-01-01 00:00:00

abstract：:The promising benefits of cancer gene therapy have been limited by the inability to deliver therapeutic genes homogeneously throughout the tumor mass and to control gene expression within the tumor cells. Transcriptional targeting, the use of DNA regulatory promoter sequences to localize transgene expression, has been...

journal_title：International journal of oncology

authors： Lopez CA,Park JO,Mauceri HJ,Beckett MA,Weichselbaum RR,Posner MC

更新日期：2004-03-01 00:00:00

abstract：:The expression of proinflammatory cytokines in various malignant neoplasms is widely considered to represent the host immune response to tumor development. The role of interferon (IFN)γ in head and neck squamous cell carcinoma, and its association with endoplasmic reticulum (ER) stress pathways, remains a subject of o...

journal_title：International journal of oncology

authors： Gkouveris I,Nikitakis NG,Aseervatham J,Ogbureke KUE

更新日期：2018-12-01 00:00:00

abstract：:A slowly proliferating cell fraction in tumors shows reduced sensitivity to cell cycle-dependent anticancer agents. To understand the molecular basis of drug resistance observed in brain tumors, we examined the relationship between alteration of p16, a cyclin dependent kinase inhibitor whose functions are frequently l...

journal_title：International journal of oncology

authors： Iwadate Y,Mochizuki S,Fujimoto S,Namba H,Sakiyama S,Tagawa M,Yamaura A

更新日期：2000-09-01 00:00:00

abstract：:Recombinant adenovirus-associated vector serotype 2 (rAAV2) is one of the most promising gene transfer vectors due to its advantage of causing non-pathogenic infection, low immunogenicity, and long-term gene expression in human clinical trials. Human interleukin 15 (hIL15) has been implicated in modulation of antitumo...

journal_title：International journal of oncology

authors： Yu YL,Wei CW,Chen YL,Chen MH,Yiang GT

更新日期：2010-02-01 00:00:00

abstract：:The presence of S-100 protein positive dendritic cells (S-100(+)DC) in primary hepatocellular carcinoma (HCC) were immunohistochemically investigated in relation to clinicopathological factors. The patients who showed a marked infiltration of S-100(+)DC survived longer especially in the group of non-curative resection...

journal_title：International journal of oncology

authors： Ido E,Furihata M,Ohtsuki Y,Iwata J,Sonobe H

更新日期：1994-08-01 00:00:00

abstract：:Overexpression of p185erbB2/neu has been demonstrated in approximately 30% of prostatic carcinomas and has been shown to induce tumorigenesis and metastasis in a prostatic epithelial cell line, NbE. To metastasize successfully, cells must be able to proliferate, degrade and be motile on a variety of substrates; thus a...

journal_title：International journal of oncology

authors： Vafa A,Zhang Y,Sikes RA,Marengo SR

更新日期：1998-12-01 00:00:00

abstract：:Although histone deacetylase (HDAC) inhibitors are emerging as a promising new treatment strategy in malignancy, how they exert their effect on human non-small cell lung cancer cells is as yet unclear. This study was undertaken to investigate the underlying mechanism of an HDAC inhibitor, Trichostatin A (TSA), -induce...

journal_title：International journal of oncology

authors： Choi YH

更新日期：2005-08-01 00:00:00

abstract：:Interleukin-2 (IL-2) which has no cross-resistance with chemotherapy, has given responses in tumors resistant to chemotherapy, and shown to be more effective when tumor burden is low. 13-cis retinoic acid (RA) has immunomodulatory properties, potentially synergistic with IL-2. The objective of this pilot phase II stud...

journal_title：International journal of oncology

authors： Recchia F,De Filippis S,Rosselli M,Saggio G,Fumagalli L,Rea S

更新日期：2002-06-01 00:00:00

abstract：:This retrospective study looks at the differences between adolescents (15-19 years) and young adults (20-25 years), diagnosed with Hodgkin lymphoma and treated at the same adult institution. Outcome according to risk category was evaluated, and although there were no significant differences in the whole cohort, or low...

journal_title：International journal of oncology

authors： Herbertson RA,Evans LS,Hutchinson J,Horsman J,Hancock BW

更新日期：2008-07-01 00:00:00

abstract：:To examine the possibility that chemical inducers of cytochrome P450 may have effects on the expression of oncogenes and a tumor suppressor gene, human colon LS174T cells were treated with different cytochrome P450 inducers such as benzanthracene (Ba), pyrazole (Pyr) and phenobarbital-hydrocortisone (Pb-Hc). Three for...

journal_title：International journal of oncology

authors： Vasquez H,Strobel H

更新日期：1996-09-01 00:00:00

abstract：:We have previously shown that growth of the oral squamous cell carcinoma cell line SAS, is resistant to cetuximab in monolayer culture conditions, even though epidermal growth factor receptor (EGFR) was phosphorylated, but the growth of SAS aggregates was sensitive to cetuximab. In the present study, we demonstrate di...

journal_title：International journal of oncology

authors： Ohnishi Y,Yasui H,Kakudo K,Nozaki M

更新日期：2015-12-01 00:00:00

abstract：:Breast cancer remains the second most common disease worldwide. Radiotherapy, alone or in combination with chemotherapy, is widely used after surgery as a treatment for cancer with proven therapeutic efficacy manifested by reduced incidence of loco-regional and distant recurrences. However, clinical evidence indicates...

journal_title：International journal of oncology

authors： Calaf GM,Roy D

更新日期：2017-11-01 00:00:00

abstract：:Sialyl Le(a) antigen (CA19-9), a member of a family of high molecular weight glycoproteins, was originally described as a gastrointestinal- and pancreatic-specific tumor marker. Recent studies have demonstrated that sialyl Le(a) is a ligand for E-selectin and may play an important role in tumor metastasis. However, ex...

journal_title：International journal of oncology

authors： Oshiba G,Kijima H,Tanaka H,Kenmochi T,Himeno S,Kise Y,Nishi T,Chino O,Shimada H,Abe Y,Yamazaki H,Nakamura M,Ueyama Y,Tanaka M,Makuuchi H

更新日期：2000-10-01 00:00:00

abstract：:Multidrug resistance (MDR) is one of the major reasons for the failure of chemotherapy-based gastric carcinoma (GC) treatments, hence, biologically based therapies are urgently needed. Gastrin (GAS), a key gastrointestinal (GI) hormone, was found to be involved in tumor formation, progression, and metastasis. In this ...

journal_title：International journal of oncology

authors： Zhuang K,Zhang L,Zhang X,Tang H,Zhang J,Yan Y,Han K,Guo H

更新日期：2017-06-01 00:00:00