Abstract:
:Overexpression of p185erbB2/neu has been demonstrated in approximately 30% of prostatic carcinomas and has been shown to induce tumorigenesis and metastasis in a prostatic epithelial cell line, NbE. To metastasize successfully, cells must be able to proliferate, degrade and be motile on a variety of substrates; thus attachment and spreading on a variety of substrates are key features of the metastatic phenotype. Using in vitro assays, we demonstrate that NbE-neuT-9/10 clones attached significantly better to specific substrates and spread significantly better on both specific and non-specific substrates as compared to the control clones. Additionally, the expression of integrin alpha6beta1, a key receptor enabling attachment and spreading on laminin, is upregulated on the metastatic clones NbE-neuT-9 and 10.
journal_name
Int J Oncoljournal_title
International journal of oncologyauthors
Vafa A,Zhang Y,Sikes RA,Marengo SRsubject
Has Abstractpub_date
1998-12-01 00:00:00pages
1191-7issue
6eissn
1019-6439issn
1791-2423journal_volume
13pub_type
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