Expression of telomerase genes in thyroid carcinoma.

abstract：:The process of cell dissemination from the primary tumors to distant sites is the most harmful event during cancer progression, and the leading cause of cancer death. We have previously demonstrated that restoration of DLC1 tumor suppressor gene expression in the DLC1-negative Focus and 7703K human hepatocellular carc...

journal_title：International journal of oncology

authors： Zhou X,Zimonjic DB,Park SW,Yang XY,Durkin ME,Popescu NC

更新日期：2008-06-01 00:00:00

abstract：:Neuroblastoma (NB) is one of the most common extracranial solid tumors in children, which has complex molecular mechanisms. Increasing evidence has suggested that long noncoding RNAs (lncRNAs) account for NB pathogenesis. However, the function of small nucleolar RNA host gene 16 (SNHG16) in NB is currently unclear. In...

journal_title：International journal of oncology

authors： Yu Y,Chen F,Yang Y,Jin Y,Shi J,Han S,Chu P,Lu J,Tai J,Wang S,Yang W,Wang H,Guo Y,Ni X

更新日期：2019-07-01 00:00:00

abstract：:Patients with esophageal carcinoma (ESCA) have a poor prognosis and high mortality rate. Although standard therapies have had effect, there is an urgent requirement to develop novel options, as increasing drug tolerance has been identified in clinical practice. In the present study, differentially expressed genes (DEG...

journal_title：International journal of oncology

authors： Chen YT,Xie JY,Sun Q,Mo WJ

更新日期：2019-01-01 00:00:00

abstract：:Raf-1 protein kinase plays an important role in cell growth, proliferation and cell survival. We have previously described the use of liposome-entrapped antisense raf oligonucleotide (LErafAON) to inhibit Raf-1 expression resulting in tumor growth inhibition and radiosensitization. The present study was undertaken to ...

journal_title：International journal of oncology

authors： Mewani RR,Tang W,Rahman A,Dritschilo A,Ahmad I,Kasid UN,Gokhale PC

更新日期：2004-05-01 00:00:00

abstract：:Aurora kinase A (AURKA) regulates the cell cycle checkpoint and maintains genomic integrity. AURKA is overexpressed in various malignant tumors and its upregulation induces chromosomal instability, which leads to aneuploidy and cell transformation. To investigate the role of AURKA in endometrial cancer, we evaluated t...

journal_title：International journal of oncology

authors： Umene K,Yanokura M,Banno K,Irie H,Adachi M,Iida M,Nakamura K,Nogami Y,Masuda K,Kobayashi Y,Tominaga E,Aoki D

更新日期：2015-04-01 00:00:00

abstract：:To clarify the effect of L-histidinol on hyperthermic killing of cells, HeLa and mouse sarcoma-180 (S-180) cells were exposed to heat in vitro in the presence of L-histidinol and the clonogenic surviving fraction of the cells was examined. After pretreating the cells with L-histidinol for 4 h, exposure of the cells to...

journal_title：International journal of oncology

authors： Kohnoe S,Maehara Y,Takahashi I,Yoshida M,Emi Y,Baba H,Sugimachi K

更新日期：1993-11-01 00:00:00

abstract：:Gamma linolenic acid (GLA) is an anti-cancer agent recently reported to inhibit tumour cell-matrix attachment. This study examined the effects of GLA on the adhesion of two tumour cell lines, HT115 (human colon) and MDA MB 231 (human breast), to an extracellular matrix, Matrigel. The action of GLA on focal adhesion ki...

journal_title：International journal of oncology

authors： Jiang W,Hiscox S,Puntis M,Hallett M,Bryce R,Horrobin D,Mansel R

更新日期：1996-03-01 00:00:00

abstract：:Bioinformatics and computational modeling offer innovative approaches to investigate cancer metabolism and predict the secondary and tertiary cellular responses. Dysregulation of metabolism has also been implicated in the pathophysiology of cancer. A significant proportion of patients with glioblastoma and hematologic...

journal_title：International journal of oncology

authors： Koseki J,Colvin H,Fukusumi T,Nishida N,Konno M,Kawamoto K,Tsunekuni K,Matsui H,Doki Y,Mori M,Ishii H

更新日期：2015-03-01 00:00:00

abstract：:The hypoxia-inducible transcription factor, HIF-1, adapts cells to low oxygen tension. In addition to the activation of angiogenesis by induction of VEGF, HIF-1 may trigger hypoxia-induced growth arrest and apoptosis. The aim of this study was to analyze the overall effect of HIF-1 on tumor growth in a mouse model, em...

journal_title：International journal of oncology

authors： Savai R,Schermuly RT,Voswinckel R,Renigunta A,Reichmann B,Eul B,Grimminger F,Seeger W,Rose F,Hänze J

更新日期：2005-08-01 00:00:00

abstract：:The p53 homologue p73 is overexpressed in many tumors, including lung cancer. We have evaluated the differential expression and subcellular localization of the functionally distinct apoptotic (TA) and anti-apoptotic (DeltaN) isoforms of p73 in non-small cell lung cancer (NSCLC), their possible association with p53 exp...

journal_title：International journal of oncology

authors： Di Vinci A,Sessa F,Casciano I,Banelli B,Franzi F,Brigati C,Allemanni G,Russo P,Dominioni L,Romani M

更新日期：2009-02-01 00:00:00

abstract：:We demonstrated previously that rat ascites hepatoma MM1 cells require both lysophosphatidic acid (LPA) and fibronectin (FN) for phagokinetic motility and transcellular migration and that these events are regulated through the RhoA-ROCK pathway and tyrosine phosphorylation of proteins including focal adhesion kinase (...

journal_title：International journal of oncology

authors： Mukai M,Iwasaki T,Tatsuta M,Togawa A,Nakamura H,Murakami-Murofushi K,Kobayashi S,Imamura F,Inoue M

更新日期：2003-06-01 00:00:00

abstract：:Although it has been shown that the cross-talk between osteoblasts and tumor cells stimulates proliferation and invasion of prostate carcinoma (PCa) cells, the molecular mechanisms underlying this event are largely unknown. In this study, we demonstrated that the PCa cells, PC3, derived from bone metastasis, undergo c...

journal_title：International journal of oncology

authors： Millimaggi D,Festuccia C,Angelucci A,D'Ascenzo S,Rucci N,Flati S,Bologna M,Teti A,Pavan A,Dolo V

更新日期：2006-04-01 00:00:00

abstract：:WNT signaling pathway plays a key role in carcinogenesis and embryogenesis. We have cloned and characterized the human WNT5B. Overlapping WNT5B cDNAs, containing 1080-bp ORF, were isolated. WNT5B encoded a 359-amino-acid polypeptide with the N-terminal signal peptide, four N-linked glycosylation sites, and consensus a...

journal_title：International journal of oncology

authors： Saitoh T,Katoh M

更新日期：2001-08-01 00:00:00

abstract：:'Rare sugars' are defined as monosaccharides that exist in nature but are only present in limited quantities. The development of mass production method of rare sugars revealed some interesting physiological effects of these on animal cells, but the mechanisms have not been well studied. We examined the effect of D-all...

journal_title：International journal of oncology

authors： Yamaguchi F,Takata M,Kamitori K,Nonaka M,Dong Y,Sui L,Tokuda M

更新日期：2008-02-01 00:00:00

abstract：:Aberrant glycosylation is a universal feature of cancer cells, and certain glycan structures are well-known markers for tumor progression. Availability and composition of sugars in the microenvironment may affect cell glycosylation. Recent studies of human breast tumor cell lines indicate their ability to take up and ...

journal_title：International journal of oncology

authors： Monzavi-Karbassi B,Hine RJ,Stanley JS,Ramani VP,Carcel-Trullols J,Whitehead TL,Kelly T,Siegel ER,Artaud C,Shaaf S,Saha R,Jousheghany F,Henry-Tillman R,Kieber-Emmons T

更新日期：2010-09-01 00:00:00

abstract：:Glycodelin [gene name, progesterone associated endometrial protein (PAEP)] was initially described as an immune system modulator in reproduction. Today, it is also known to be expressed in several types of cancer, including non‑small cell lung cancer (NSCLC). In this cancer type, the feasibility of its usage as a foll...

journal_title：International journal of oncology

authors： Weber R,Meister M,Muley T,Thomas M,Sültmann H,Warth A,Winter H,Herth FJF,Schneider MA

更新日期：2019-02-01 00:00:00

abstract：:Phosphorylation of histone H2AX (gammaH2AX) is a sensitive marker of DNA damage, particularly induction of DNA double-strand breaks. Using multiparameter cytometry we explored the effects of doxorubicin (DOX), cisplatin (CDDP) and 5-fluorouracil (5-FU) on four types of endometrioid adenocarcinoma cell lines (HEC-1A, H...

journal_title：International journal of oncology

authors： Ikeda M,Kurose A,Takatori E,Sugiyama T,Traganos F,Darzynkiewicz Z,Sawai T

更新日期：2010-05-01 00:00:00

abstract：:The two-kringle domain of tissue-type plasminogen activator (TK1-2) has been identified as a novel angiogenesis inhibitor. In the previous study, purified Pichia-derived TK1-2 has been shown to suppress in vivo growth of human lung and colon cancer cells. Here, we demonstrate that E. coli-derived non-glycosylated TK1-...

journal_title：International journal of oncology

authors： Kang BH,Shim BS,Lee SY,Lee SK,Hong YK,Joe YA

更新日期：2006-02-01 00:00:00

abstract：:The effect of immune cells on the growth and development of human prostatic cancer cells was investigated. Cell proliferation of androgen-independent human prostatic cancer cells JCA-1 was reduced 30-40% with the supplementation of a growth modulating activity present in lymphocyte conditioned medium. The slower growi...

journal_title：International journal of oncology

authors： Hsieh T,Xu W,Tang S,Chiao J

更新日期：1994-10-01 00:00:00

abstract：:Mucosa-associated lymphoid tissue (MALT) lymphomas usually involve extranodal sites, especially the stomach, lung and salivary glands. The Bcl10 gene was recently isolated from the breakpoint region of t(1;14) (p22;q32) in MALT lymphomas, and considered to be an apoptosis-associated gene, and involves a caspase recrui...

journal_title：International journal of oncology

authors： Ohshima K,Muta H,Kawasaki C,Muta K,Deyev V,Kanda M,Kumano Y,Podack ER,Kikuchi M

更新日期：2001-08-01 00:00:00

abstract：:Although mesenchymal stem cells (MSCs) are considered to be the cells of origin for most sarcomas, the role of MSCs as a source of tumor stroma is not fully understood in this tumor type. The current study investigated whether MSCs affect the tumor growth and metastatic ability in r...

journal_title：International journal of oncology

authors： Tsukamoto S,Honoki K,Fujii H,Tohma Y,Kido A,Mori T,Tsujiuchi T,Tanaka Y

更新日期：2012-01-01 00:00:00

abstract：:The lack of good molecular markers for diagnosis as well as treatment assessment has rendered the hepatocellular carcinoma (HCC) a major challenge in health care. In this study, woodchucks were used as an animal model for hepatitis virus-induced HCC, and gene expression studies were performed using a human oligonucleo...

journal_title：International journal of oncology

authors： Wang F,Anderson PW,Salem N,Kuang Y,Tennant BC,Lee Z

更新日期：2007-01-01 00:00:00

abstract：:This study examined whether the soluble tumor-associated-antigens (TAA), of 66 kDa and 51 kDa, could promote suppression by anticancer drugs of chemically-induced mammary tumorigenesis. Dimethylbenzanthracene (DMBA, 10 mg/rat, twice) was used to induce mammary tumors. Then, for nine more weeks, the preparation of TAA ...

journal_title：International journal of oncology

authors： Ben-Hur H,Kossoy G,Zusman I

更新日期：2001-08-01 00:00:00

abstract：:Many clinical studies highlight the dichotomous role of PRDXs in human cancers, where they can exhibit strong tumor-suppressive or tumor-promoting functions. Recent evidence suggests that lower expression of PRDXs correlates with cancer progression in colorectal cancer (CRC) or in esophageal squamous carcinoma. In the...

journal_title：International journal of oncology

authors： Nicolussi A,D'Inzeo S,Mincione G,Buffone A,Di Marcantonio MC,Cotellese R,Cichella A,Capalbo C,Di Gioia C,Nardi F,Giannini G,Coppa A

更新日期：2014-02-01 00:00:00

abstract：:Tissue samples from a malignant melanoma of the anal canal and its local metastasis were short-term cultured and analyzed cytogenetically. Complex chromosome aberrations were found in the primary tumor, yielding the karyotype 49-50,X,-Y,der(1)t(1;13)(q44;q12),+der(2)t(2;8) (q31;q12),der(6)t(5;6)(q13;q21),+del(6)(q12q2...

journal_title：International journal of oncology

authors： Bardi G,Fenger C,Pandis N,Mitelman F,Heim S

更新日期：1995-03-01 00:00:00

abstract：:Lymph node metastasis of tumors is a crucial early step in the metastatic process. Tumor lymphangiogenesis plays an important role in promoting tumor metastasis to regional lymph nodes. Norcantharidin (NCTD) has been reported to possess potent anti-angiogenesis and antitumor propert...

journal_title：International journal of oncology

authors： Liu ZY,Qiu HO,Yuan XJ,Ni YY,Sun JJ,Jing W,Fan YZ

更新日期：2012-11-01 00:00:00

abstract：:Increasing evidence has confirmed that dysregulation of microRNAs (miRNAs) can contribute to the progression and metastasis of human tumors. Previous studied have shown dysregulation of miR-24 in a variety of tumors. However, the roles of miR-24 in human bladder cancer have not been well clarified. Therefore, we inves...

journal_title：International journal of oncology

authors： Zhang S,Zhang C,Liu W,Zheng W,Zhang Y,Wang S,Huang D,Liu X,Bai Z

更新日期：2015-10-01 00:00:00

abstract：:Cadherins play a crucial role in epithelial morphogenesis and mediate intercellular adhesion. These receptors bind catenins and are involved in signal transduction pathways that regulate cell growth and apoptosis, and are frequently down-regulated in invasive and metastatic carcinomas. In order to assess the role of E...

journal_title：International journal of oncology

authors： Vizirianakis IS,Chen YQ,Kantak SS,Tsiftsoglou AS,Kramer RH

更新日期：2002-07-01 00:00:00

abstract：:Serum ferritin is elevated in many cancers. Using the subtraction-enhanced display technique, we isolated several cDNA clones including ferritin-H which is overexpressed in rat hepatocellular carcinoma (HCC) induced by diethylnitrosamine. We investigated hepatic messenger RNA (mRNA) levels of ferritin-H in patients wi...

journal_title：International journal of oncology

authors： Wu C,Habib N,Mitry R,Reitsma P,Vandeventer S,Chamuleau R

更新日期：1997-07-01 00:00:00

abstract：:The impacts of post‑operative abdominal infectious complications increase hematogenous distant metastasis and result in poor long‑term survival after curative resection. Even if curative resection can be performed, the presence of circulating tumor cells is affected. The liver, the most common site of metastases, is a...

journal_title：International journal of oncology

authors： Okazaki M,Yamaguchi T,Tajima H,Fushida S,Ohta T

更新日期：2020-10-01 00:00:00