Increased hepatic ferritin-H messenger RNA levels correlate with those of c-myc in human hepatocellular carcinoma.

abstract：:Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is one of the most promising anti-cancer agents, but some tumor types develop resistance to TRAIL. Here, we report that chetomin, an inhibitor of hypoxia-inducible factors, is a potent enhancer of TRAIL-induced apoptosis. TRAIL or chetomin alone weakly in...

journal_title：International journal of oncology

authors： Yano K,Horinaka M,Yoshida T,Yasuda T,Taniguchi H,Goda AE,Wakada M,Yoshikawa S,Nakamura T,Kawauchi A,Miki T,Sakai T

更新日期：2011-02-01 00:00:00

abstract：:Cell lines established from the TH-MYCN transgenic murine model of neuroblastoma are a valuable preclinical, immunocompetent, syngeneic model of neuroblastoma, for which knowledge of their p53 pathway status is important. In this study, the Trp53 status and functional response to Nutlin-3 and ionising radiation (IR) w...

journal_title：International journal of oncology

authors： Chen L,Esfandiari A,Reaves W,Vu A,Hogarty MD,Lunec J,Tweddle DA

更新日期：2018-03-01 00:00:00

abstract：:Mismatch repair (MMR) genes play a fundamental role in the correction of replication errors, leading to cancer development when mutated. In order to test the hypothesis that the MMR system was compromised in the initiation and progression of breast cancer, we used an in vitro-in vivo model for analyzing the mRNA level...

journal_title：International journal of oncology

authors： Balogh GA,Russo IH,Russo J

更新日期：2003-08-01 00:00:00

abstract：:The aim of the present study was to evaluate the effects of programmed cell death 4 (PDCD4) on cell proliferation and apoptosis, and to elucidate the potential role of the Jun N-terminal kinase (JNK)/c-Jun pathway in human bladder cancer (BCa) cells. Mixed BCa cells were transfected with plasmids containing PDCD4 (PDC...

journal_title：International journal of oncology

authors： Liu J,Zhai R,Zhao J,Kong F,Wang J,Jiang W,Xin Q,Xue X,Luan Y

更新日期：2018-05-01 00:00:00

abstract：:A series of different human MDR (multidrug-resistant) cell lines including a HeLa-MDR1 transfectant which exhibit high overexpression of the MDR1/P-glycoprotein gene, but no enhanced expression of the MRP (multidrug resistance associated protein) gene, showed different ratios of relative resistances to the taxanes tax...

journal_title：International journal of oncology

authors： Ise W,Heuser M,Sanders K,Beck J,Gekeler V

更新日期：1996-05-01 00:00:00

abstract：:The prognostic value of immunohistochemical staining of P53, BCL-2, p27kip1, PSA, AR and MIB-1 was compared with that of established prognostic variables (Gleason score, surgical margins, tumour volume) following radical prostatectomy. Five groups were selected: negative margins with stable serum PSA (n=11), negative ...

journal_title：International journal of oncology

authors： Bai XZ,Masters JR,O'Donoghue N,Kirby R,Pan LX,Young M,Stafford M,Parkinson MC

更新日期：1999-04-01 00:00:00

abstract：:Lamins are the major components of the nuclear lamina and play important roles in many cellular processes. The role of lamins in cancer development and progression is still unclear but it is known that reduced expression of lamin B1 has been observed in colon cancer. Thus, the aim of the present study was to elucidate...

journal_title：International journal of oncology

authors： Izdebska M,Gagat M,Grzanka A

更新日期：2018-01-01 00:00:00

abstract：:The human immunodeficiency virus (HIV) protein negative factor (Nef) is important for AIDS pathogenesis. An anti-Nef single-domain antibody (sdAb19) derived from camelids has been previously generated and shown to effectively block the physiological functions of Nef in vitro and in vivo in nef-transgenic mice. However...

journal_title：International journal of oncology

authors： Fan X,Wei J,Xiong H,Liu X,Benichou S,Gao X,Liu L

更新日期：2015-10-01 00:00:00

abstract：:Acute lymphoblastic leukemia (ALL) with translocation t(4;11) is a high-risk leukemia found in 60-85% of infants with ALL and is often refractory to conventional chemotherapeutics after relapse. To evaluate the efficacy of dietary resveratrol in vivo, 5-week-old NOD.CB17-Prkdcscid/J mice were fed a control diet or a d...

journal_title：International journal of oncology

authors： Zunino SJ,Storms DH,Newman JW,Pedersen TL,Keen CL,Ducore JM

更新日期：2012-12-01 00:00:00

abstract：:Early detection and treatment are critical in the management of renal cell carcinoma (RCC). However, there is no standard serum biomarker to facilitate early diagnosis or prognostic stratification in patients with RCC. Recent reports suggest that circulating microRNAs (miRNAs) have great potential as biomarkers for di...

journal_title：International journal of oncology

authors： Iwamoto H,Kanda Y,Sejima T,Osaki M,Okada F,Takenaka A

更新日期：2014-01-01 00:00:00

abstract：:Fatigue is one of the most common complaints of people with cancer. It affects the majority of patients actively undergoing cancer related therapies, but also a meaningful number of those who successfully completed therapy and are disease-free and potentially cured at the end of the treatments. In cancer setting, fati...

journal_title：International journal of oncology

authors： Tavio M,Milan I,Tirelli U

更新日期：2002-11-01 00:00:00

abstract：:Previously, we found that the injection of zoledronic acid (ZOL) into mice bearing tumor induced changes of the vascular structure in the tumor. In this study, we examined whether ZOL treatment could decrease interstitial fluid pressure (IFP) via change of tumor vasculature, and enhance the antitumor efficacy of lipos...

journal_title：International journal of oncology

authors： Hattori Y,Shibuya K,Kojima K,Miatmoko A,Kawano K,Ozaki K,Yonemochi E

更新日期：2015-07-01 00:00:00

abstract：:To evaluate the significance of microsatellite instability (MI) and loss of heterozygosity (LOH) in the development of different histological subgroups of liposarcomas, we examined 28 tissue-samples from 21 patients and the corresponding non-neoplastic reference tissues. We investigated nine microsatellite loci and de...

journal_title：International journal of oncology

authors： Schneider-Stock R,Szibor R,Walter H,Plate I,Roessner A

更新日期：1999-04-01 00:00:00

abstract：:Pristimerin (PM), a quinonemethide triterpenoid, is a promising anticancer agent with potent antiproliferative and apoptosis-inducing activities against cancer cell lines. However, the anticancer activity and mechanisms of PM in prostate cancer cells have not been adequately investigated. Here we report that the degra...

journal_title：International journal of oncology

authors： Liu YB,Gao X,Deeb D,Brigolin C,Zhang Y,Shaw J,Pindolia K,Gautam SC

更新日期：2014-10-01 00:00:00

abstract：:In this study we investigated the relationship between the development of either HSILs (high-grade squamous intraepithelial lesions) or invasive cancers of the uterine cervix and the p53 codon 72 polymorphisms consisting of arginine (Arg)- or proline (Pro)-encoded allele in Japanese populations. Furthermore, we determ...

journal_title：International journal of oncology

authors： Kawamata Y,Mitsuhashi A,Unno Y,Kado S,Shino Y,Uesugi K,Eguchi O,Ishii J,Seki K,Sekiya S,Shirasawa H

更新日期：2002-09-01 00:00:00

abstract：:Although several therapeutic options are available for hepatocellular carcinoma (HCC), the outcome is still very poor. One reason is the complexity of signal transduction in the pathogenesis of HCC. The aim of this study was to identify new HCC-related genes and to investigate the functions of these genes in the patho...

journal_title：International journal of oncology

authors： Tameda M,Sugimoto K,Shiraki K,Yamamoto N,Okamoto R,Usui M,Ito M,Takei Y,Nobori T,Kojima T,Suzuki H,Uchida M,Uchida K

更新日期：2014-08-01 00:00:00

abstract：:Seaweeds are commonly used as functional foods and drugs. A glycoprotein (GP) from the green alga Capsosiphon fulvescens (Cf) has been reported to have antitumor activity toward various cancer cells. We previously observed that Cf-GP induced different pathways of apoptosis in AGS human gastric cancer cells. Transformi...

journal_title：International journal of oncology

authors： Kim YM,Kim IH,Nam TJ

更新日期：2013-10-01 00:00:00

abstract：:The efficacy of resveratrol as a preventive agent against the growth of t(4;11) acute lymphoblastic leukemia (ALL) was evaluated in NOD.CB17-Prkdcscid/J mice engrafted with the human t(4;11) ALL SEM cell line. SEM cells were injected into the tail vein and engraftment was monitored ...

journal_title：International journal of oncology

authors： Zunino SJ,Storms DH,Newman JW,Pedersen TL,Keen CL,Ducore JM

更新日期：2012-04-01 00:00:00

abstract：:Fatty acid synthase (FASN) is a key enzyme that plays a critical role in numerous metabolic functions by catalyzing the synthesis for long-chain fatty acids. FASN is highly expressed in various human cancers. This preferential expression makes FASN an attractive target for anticance...

journal_title：International journal of oncology

authors： Jeong NY,Yoo YH

更新日期：2012-06-01 00:00:00

abstract：:The FHIT gene, at 3p14.2, has been suggested to form a molecular target to damage induced by human lung carcinogens. We examined aberrant expression of the Fhit protein and allele loss at the FHIT gene in a series of lung cancer cases, mainly of non-small cell carcinoma (NSCLC) histology. We had detailed data on tobac...

journal_title：International journal of oncology

authors： Pylkkanen L,Wolff H,Stjernvall T,Tuominen P,Sioris T,Karjalainen A,Anttila S,Husgafvel-Pursiainen K

更新日期：2002-02-01 00:00:00

abstract：:Breast cancer cells can switch from estrogen receptor α (ER)- to human epidermal growth factor receptor (HER)-driven cell growth upon acquiring antiestrogen resistance. HER ligands are cleaved by metalloproteinases leading to release of active HER ligands, activation of HER receptors and consequently increased cell gr...

journal_title：International journal of oncology

authors： Kirkegaard T,Yde CW,Kveiborg M,Lykkesfeldt AE

更新日期：2014-07-01 00:00:00

abstract：:The role and expression of ROCKI and ROCKII in human breast cancer was investigated and the effect on clinical outcome assessed. ROCK knockdown cells (MDA-MB-231DeltaROCKI and MDA-MB-231DeltaROCKII were tested for their in vitro invasiveness, motility and in vivo tumour growth. Samples of fresh frozen breast tumour ti...

journal_title：International journal of oncology

authors： Lane J,Martin TA,Watkins G,Mansel RE,Jiang WG

更新日期：2008-09-01 00:00:00

abstract：:The impacts of post‑operative abdominal infectious complications increase hematogenous distant metastasis and result in poor long‑term survival after curative resection. Even if curative resection can be performed, the presence of circulating tumor cells is affected. The liver, the most common site of metastases, is a...

journal_title：International journal of oncology

authors： Okazaki M,Yamaguchi T,Tajima H,Fushida S,Ohta T

更新日期：2020-10-01 00:00:00

abstract：:Recent studies have demonstrated that natural antisense transcripts, which are complementary sequences to messenger RNA, have important cellular functions such as the stabilization and silencing of mRNA. However, the possible contribution of antisense transcripts in hepatocellular c...

journal_title：International journal of oncology

authors： Nagai K,Kohno K,Chiba M,Pak S,Murata S,Fukunaga K,Kobayashi A,Yasue H,Ohkohchi N

更新日期：2012-06-01 00:00:00

abstract：:Bcl-xL is an apoptosis inhibitor that is upregulated in bladder cancer (BCa) and provides an attractive target for molecular therapies. Treatment with specific antisense oligodeoxynucleotides (AS‑ODNs) or small interfering RNAs (siRNAs) were able to sensitize BCa cells to conventional chemotherapeutics. Ten new Bcl‑xL...

journal_title：International journal of oncology

authors： Rieger C,Huebner D,Temme A,Wirth MP,Fuessel S

更新日期：2015-09-01 00:00:00

abstract：:Hypoxia regulates the expression of genes that promote tumor growth, angiogenesis and invasion. We previously studied hypoxic tumor cells in vitro and from hepatic metastases of colorectal cancer and determined several potential prognostic factors for hepatocellular carcinoma (HCC). In this study, we evaluated the pro...

journal_title：International journal of oncology

authors： Wada H,Yamamoto H,Kim C,Uemura M,Akita H,Tomimaru Y,Hama N,Kawamoto K,Kobayashi S,Eguchi H,Umeshita K,Doki Y,Mori M,Nagano H

更新日期：2014-09-01 00:00:00

abstract：:Sentinel node (SN) mapping and biopsy is a procedure that accurately stages the regional lymph node (LN) basin. Defined patterns of lymphatic drainage allow intraoperative determination of the first (sentinel) lymph node in the regional basin, and the absence of metastatic disease in the SN accurately reflects the abs...

journal_title：International journal of oncology

authors： Gennari R,Stoldt HS,Bartolomei M,Zurrida S,Testori A,Mazzarol G,Paganelli G,Veronesi U

更新日期：1999-07-01 00:00:00

abstract：:Oxidative stress due to intratumoral hypoxia in solid cancer has been shown to be associated with increased mortality. Phosphoglycerate kinase 1 (PGK1) is an enzyme of the glycolytic pathway, which is regulated by hypoxia-inducible factor-1α (HIF-1α) and has been described for its role in tumor progression and metasta...

journal_title：International journal of oncology

authors： Ahmad SS,Glatzle J,Bajaeifer K,Bühler S,Lehmann T,Königsrainer I,Vollmer JP,Sipos B,Ahmad SS,Northoff H,Königsrainer A,Zieker D

更新日期：2013-08-01 00:00:00

abstract：:Human papillomavirus 16 (HPV-16) is strongly associated with the development of 50% of cervical cancers. The E6 and E7 proteins encoded by high-risk HPV types are associated with the immune evasion of cervical cancer cells, but the mechanism is poorly understood. The purpose of this study was to investigate whether ce...

journal_title：International journal of oncology

authors： Gao LJ,Gu PQ,Fan WM,Liu Z,Qiu F,Peng YZ,Guo XR

更新日期：2011-11-01 00:00:00

abstract：:From January 1992 to December 1995, 129 patients with previously untreated non-Hodgkin's lymphoma were randomised in a phase III multicenter trial to receive CEOP-B/VIMB or ProMACE-CytaBOM. Eligibility criteria included intermediate or high grade lymphoma (follicular large cell, diffuse small cleaved-cell, diffuse mix...

journal_title：International journal of oncology

authors： Lorusso V,Palmieri G,Bianco AR,Abate G,Catalano G,De Vita F,Dammacco F,Lauta VM,Lucarelli G,Polimeno G,Mantovani G,D'Aprile M,Marzullo F,De Lena M

更新日期：2000-01-01 00:00:00