PRDX1 and PRDX6 are repressed in papillary thyroid carcinomas via BRAF V600E-dependent and -independent mechanisms.

abstract：:3F8 is an IgG3 murine monoclonal antibody directed against the ganglioside GD2. In a phase II study, 3F8 was administered i.v. to 16 patients (pts) who had stage 4 neuroblastoma. Response was seen in bony lesions (2 of 7 pts) and marrow (3 of 8 pts). Acute toxicities of pain, fever, urticaria, hypertension, hypotensio...

journal_title：International journal of oncology

authors： Cheung NK,Kushner BH,Yeh SD,Larson SM

更新日期：1998-06-01 00:00:00

abstract：:The modifying effects of dietary administration of capsaicin, which is the principal pungent capsicum fruit, and rotenone, which is a naturally occurring pesticide derived from Derris and Lonchorcarpus species, on azoxymethane (AOM)-induced colon tumorigenesis were investigated in male F344 rats. Gavage with capsaicin...

journal_title：International journal of oncology

authors： Yoshitani SI,Tanaka T,Kohno H,Takashima S

更新日期：2001-11-01 00:00:00

abstract：:Polo-like kinase 1 (PLK1), a serine/threonine kinase and an oncogene, is crucial in regulating cell cycle progression. PLK1 also has been demonstrated as a potential target of osteosarcoma (OS) by using short hairpin RNA libraries in lentiviral vectors for screening of protein kinase. In preclinical studies, GSK461364...

journal_title：International journal of oncology

authors： Chou YS,Yen CC,Chen WM,Lin YC,Wen YS,Ke WT,Wang JY,Liu CY,Yang MH,Chen TH,Liu CL

更新日期：2016-03-01 00:00:00

abstract：:The failure of androgen deprivation therapy in prostate cancer treatment mainly results from drug resistance to androgen receptor antagonists. Although an aberrant caveolin‑1 (Cav‑1) expression has been reported in multiple tumor cell lines, it is unknown whether it is responsible for the progression of castration‑res...

journal_title：International journal of oncology

authors： Gao Y,Li L,Li T,Ma L,Yuan M,Sun W,Cheng HL,Niu L,Du Z,Quan Z,Fan Y,Fan J,Luo C,Wu X

更新日期：2019-06-01 00:00:00

abstract：:We demonstrated previously that rat ascites hepatoma MM1 cells require both lysophosphatidic acid (LPA) and fibronectin (FN) for phagokinetic motility and transcellular migration and that these events are regulated through the RhoA-ROCK pathway and tyrosine phosphorylation of proteins including focal adhesion kinase (...

journal_title：International journal of oncology

authors： Mukai M,Iwasaki T,Tatsuta M,Togawa A,Nakamura H,Murakami-Murofushi K,Kobayashi S,Imamura F,Inoue M

更新日期：2003-06-01 00:00:00

abstract：:The hypoxia-inducible transcription factor, HIF-1, adapts cells to low oxygen tension. In addition to the activation of angiogenesis by induction of VEGF, HIF-1 may trigger hypoxia-induced growth arrest and apoptosis. The aim of this study was to analyze the overall effect of HIF-1 on tumor growth in a mouse model, em...

journal_title：International journal of oncology

authors： Savai R,Schermuly RT,Voswinckel R,Renigunta A,Reichmann B,Eul B,Grimminger F,Seeger W,Rose F,Hänze J

更新日期：2005-08-01 00:00:00

abstract：:Aberrant glycosylation is a universal feature of cancer cells, and certain glycan structures are well-known markers for tumor progression. Availability and composition of sugars in the microenvironment may affect cell glycosylation. Recent studies of human breast tumor cell lines indicate their ability to take up and ...

journal_title：International journal of oncology

authors： Monzavi-Karbassi B,Hine RJ,Stanley JS,Ramani VP,Carcel-Trullols J,Whitehead TL,Kelly T,Siegel ER,Artaud C,Shaaf S,Saha R,Jousheghany F,Henry-Tillman R,Kieber-Emmons T

更新日期：2010-09-01 00:00:00

abstract：:Induction of differentiation in a variety of model systems is accompanied by cell cycle exit and inhibition of Cdk2 kinase activity. We asked whether inhibition of Cdk2 activity is sufficient to allow differentiation to occur in a non-small cell lung cancer cell line. Treatment of NCI-H358 with flavopiridol, an inhibi...

journal_title：International journal of oncology

authors： Lee HR,Chang TH,Tebalt MJ 3rd,Senderowicz AM,Szabo E

更新日期：1999-07-01 00:00:00

abstract：:Currently, some evidence suggests that human multipotential mesenchymal stems cells (hMSCs) aid tumor growth and metastasis. Nutrient deprivation and oxygen deficiency are representative characteristics of solid tumor microenvironment during the cancer development. Because the effects of hMSCs on tumors under stressfu...

journal_title：International journal of oncology

authors： Zhang MH,Hu YD,Xu Y,Xiao Y,Luo Y,Song ZC,Zhou J

更新日期：2013-04-01 00:00:00

abstract：:Resistance may be classified as active (or competitive) (due to excess amount of a factor) vs passive (or non-competitive) (due to a deficiency of a factor). Passive resistance may be important in human solid tumors. In passive resistance, the dose-response curve may be shallow, or may flatten at a relatively low dose...

journal_title：International journal of oncology

authors： Stewart DJ,Goel R,Gertler SZ,Huan S,Tomiak EM,Yau J,Cripps C,Evans WK

更新日期：1999-10-01 00:00:00

abstract：:Hypoxia is an important factor of tumor microenvironment that significantly influences behaviour of tumor cells via activation of genes whose products are involved in adaptation to hypoxic stress, such as vascular endothelial growth factor (VEGF) and glucose transporter (GLUT-1). Carbonic anhydrase IX (CA IX) is one o...

journal_title：International journal of oncology

authors： Rafajová M,Zatovicová M,Kettmann R,Pastorek J,Pastoreková S

更新日期：2004-04-01 00:00:00

abstract：:Docetaxel is one of the most commonly used chemotherapeutic agents in breast cancer. To avert from significant toxicities with no clinical benefit, identification of predictive markers for response is one of the most important unsolved clinical needs. Therefore, the potential associ...

journal_title：International journal of oncology

authors： Gil EY,Jo UH,Jeong H,Whang YM,Woo OH,Cho KR,Seo JH,Kim A,Lee ES,Koh I,Kim YH,Park KH

更新日期：2012-08-01 00:00:00

abstract：:Peroxisome proliferator-activated receptor gamma (PPARγ) agonists have been demonstrated to exert an inhibitory effect on cell growth in several tumor models, including clear cell renal cell carcinoma (CCRCC). PPARγ has therefore been proposed to be a potential therapeutic target. Thus, the PPARγ gene must be expresse...

journal_title：International journal of oncology

authors： Collet N,Théoleyre S,Rageul J,Mottier S,Jouan F,Rioux-Leclercq N,Fergelot P,Patard JJ,Masson D,Denis MG

更新日期：2011-03-01 00:00:00

abstract：:Ovarian cancer is a lethal malignancy, rarely diagnosed early, and there is currently little, if any, preventive strategies which can be followed. This study attempts to identify lifestyle profiles which might be associated with ovarian cancer, and could then be subject to subsequent modification in an effort to preve...

journal_title：International journal of oncology

authors： Loesch M,Fischer M,Shurpin K,Mann W

更新日期：1994-03-01 00:00:00

abstract：:A herbal preparation denoted PC SPES(R) is available in 'natural food' or 'health food' stores in the United States. This mixture (patent pending, US Serial number 08/697,920) consists of extracts from 8 different herbs, 7 originating from China and one from America, and is sold as a dietary supplement. Although sever...

journal_title：International journal of oncology

authors： Halicka H,Ardelt B,Juan G,Mittelman A,Chen S,Traganos F,Darzynkiewicz Z

更新日期：1997-09-01 00:00:00

abstract：:Mos is a germ cell-specific serine/threonine protein kinase that plays an important role during meiotic divisions of oocytes. Upon expression in somatic cells, Mos causes cell cycle perturbations leading to neoplastic transformation. Mos activates the MAP kinase pathway in both oocytes and transformed somatic cells. T...

journal_title：International journal of oncology

authors： Yang Y,Pham CD,Arlinghaus RB,Khillan JS,Singh B

更新日期：1998-05-01 00:00:00

abstract：:Resistance to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a major limitation for its clinical use. The mechanisms of TRAIL resistance have been mostly studied in the context of cell lines that are intrinsically resistant to TRAIL. However, little is known about the molecular alterations that con...

journal_title：International journal of oncology

authors： Ouyang W,Yang C,Zhang S,Liu Y,Yang B,Zhang J,Zhou F,Zhou Y,Xie C

更新日期：2013-02-01 00:00:00

abstract：:The CCND1-ORAOV1-FGF19-FGF4-FGF3-TMEM16A-FADD-PPFIA1-CTTN (EMS1) locus at human chromosome 11q13.3 is amplified in head and neck tumors, esophageal cancer, Kaposi's sarcoma, bladder tumors, breast cancer, and liver cancer. Fgf4 mRNA is expressed in embryonic stem (ES) cells depending on Sox2 and Pou5f1 (Oct3/Oct4) tra...

journal_title：International journal of oncology

authors： Katoh M,Katoh M

更新日期：2005-07-01 00:00:00

abstract：:Transforming growth factor beta1 (TGF-beta1) has been shown to exhibit anti-proliferative activity for mammary gland epithelial cells and for human breast cancer cells. Insulin-like growth factor I (IGF-I), in contrast, is a well-characterized mitogenic and anti-apoptotic factor involved in mammary gland physiology. I...

journal_title：International journal of oncology

authors： Huynh H,Beamer W,Pollak M,Chan TW

更新日期：2000-02-01 00:00:00

abstract：:Acute lymphoblastic leukemia (ALL) with translocation t(4;11) is a high-risk leukemia found in 60-85% of infants with ALL and is often refractory to conventional chemotherapeutics after relapse. To evaluate the efficacy of dietary resveratrol in vivo, 5-week-old NOD.CB17-Prkdcscid/J mice were fed a control diet or a d...

journal_title：International journal of oncology

authors： Zunino SJ,Storms DH,Newman JW,Pedersen TL,Keen CL,Ducore JM

更新日期：2012-12-01 00:00:00

abstract：:alpha-tocopheryl phosphate (TocP) has been elucidated for diverse effectiveness through unequivocal mechanisms independent of its conversion to alpha-tocopherol (Toc). The present study showed that TocP, in a dose-dependent manner, repressed invasion of human fibrosarcoma HT-1080 cells through the basement membrane, m...

journal_title：International journal of oncology

authors： Saitoh Y,Yumoto A,Miwa N

更新日期：2009-12-01 00:00:00

abstract：:p21WAF1/CIP1 protein is a cyclin-dependent kinase inhibitor, able to prevent the CDK2/cyclin E induced retinoblastoma protein (pRB) phosphorylation, thus inhibiting cell cycle progression at G1 phase. p21WAF1/CIP1 protein levels were examined in a series of 102 ovarian tissue samples including normal ovary, primary ov...

journal_title：International journal of oncology

authors： Ferrandina G,Stoler A,Fagotti A,Fanfani F,Sacco R,De Pasqua A,Mancuso S,Scambia G

更新日期：2000-12-01 00:00:00

abstract：:Although radiation therapy is a powerful anticancer modality, radiation- induced stress response and gene expression with adaptive resistance may severely compromise the effectiveness of radiation. The function of rotundic acid (RA) on inducing apoptosis in the human breast cancer cell line MCF-7 has been investigated...

journal_title：International journal of oncology

authors： Wang ZF,Sun WY,Yu DH,Zhao Y,Xu HM,He YF,Li HJ

更新日期：2018-11-01 00:00:00

abstract：:Multi-drug resistance (MDR) limits the effectiveness of chemotherapy. P-glycoprotein encoded by the MDR1 gene, is known to be implicated in MDR phenotype, but other factors could be determinant in MDR. The aim of this study was to investigate new molecular factors potentially associated with the MDR phenotype using a ...

journal_title：International journal of oncology

authors： Visentin M,Simula MP,Sartor F,Petrucco A,De Re V,Toffoli G

更新日期：2009-05-01 00:00:00

abstract：:The effects of a thymic peptide preparation (TP) on the immunocytotoxicity and cytokine secretion of peripheral blood lymphocytes and monocytes from patients with colorectal tumors, breast tumors and melanoma were studied in vitro. On average, breast tumor and melanoma patients showed significantly lower natural kille...

journal_title：International journal of oncology

authors： Eckert K,Mayer G,Stange R,Kalden M,Krasagakis K,Maurer H

更新日期：1997-03-01 00:00:00

abstract：:We report a retrospective study of all patients with localised non-Hodgkin's lymphoma referred to the Sheffield Lymphoma Group (1970-1995). A total of 1,979 patients with non-Hodgkin's lymphoma were seen: 553 (28%) presented with stage I or II disease, 411 (21%) extranodal, 142 (7%) nodal. The commonest extranodal sit...

journal_title：International journal of oncology

authors： Dobson LS,Hancock H,Bright N,Robinson MH,Hancock BW

更新日期：1998-12-01 00:00:00

abstract：:Optimal conditions have been defined to grow primary cultures of malignant melanoma suitable for in vitro pharmacological studies. A feasibility of primary cultures was observed in 60% of 62 clinical melanoma lymph node metastases. The neoplastic nature of the cells grown in culture, as assessed by the highly specific...

journal_title：International journal of oncology

authors： Villa R,Zaffaroni N,Orlandi L,Costa A,Veronese S,Vaglini M,Silvestrini R

更新日期：1992-11-01 00:00:00

abstract：:Thirty-one patients with metastatic breast cancer not responding or progressing after initial response to adriamycin + cyclophosphamide (AC) treatment entered a phase 11 study with oral lonidamine in association to AC. Objective clinical responses were observed in 10 patients (32%) and consisted of 1 complete + 9 part...

journal_title：International journal of oncology

authors： Tomirotti M,Bernardo G,Epifani C,Biasioli R,Franchi R,Mensi F,Carnaghi P,Schieppati G,Scanni A

更新日期：1993-08-01 00:00:00

abstract：:Resistance to first-line chemotherapeutic drugs such as gemcitabine contributes to the poor prognosis of patients with pancreatic cancer. MicroRNAs (miRNA) regulate chemoresistance in pancreatic cancer. By analyzing the miRNA sequencing dataset of pancreatic cancer from The Cancer Genome Atlas, it was demonstrated tha...

journal_title：International journal of oncology

authors： Sun D,Wang X,Sui G,Chen S,Yu M,Zhang P

更新日期：2018-05-01 00:00:00

abstract：:Chronic exposure to nickel compounds is associated with increased incidence of certain types of human cancer, including lung and nasal cancers. Despite intensive investigation, the oncogenic processes remain poorly understood. Apoptosis resistance is a key feature for tumor cells to escape physiological surveillance a...

journal_title：International journal of oncology

authors： Yang YX,Li XL,Wang L,Han SY,Zhang YR,Pratheeshkumar P,Wang X,Lu J,Yin YQ,Sun LJ,Budhraja A,Hitron AJ,Ding SZ

更新日期：2013-09-01 00:00:00