Abstract:
:Ninety-four human non-small cell lung carcinomas (NSCLC) of previously untreated patients were analyzed for the presence of metallothionein (MT) expression by means of immunohistochemistry. Of the tumors investigated, expression of MT was detected in 63%. The expression of MT was correlated with the results of doxorubicin resistance of the tumors in vitro. A significant relationship between MT expression and doxorubicin resistance was found (p=0.01). Significant correlations also exist between MT and P-glycoprotein or glutathione-S-transferase-pi expression respectively (p<0.005).
journal_name
Int J Oncoljournal_title
International journal of oncologyauthors
Mattern J,Volm Mdoi
10.3892/ijo.1.6.687subject
Has Abstractpub_date
1992-11-01 00:00:00pages
687-9issue
6eissn
1019-6439issn
1791-2423journal_volume
1pub_type
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