Promotion of cell differentiation, and suppression of cell growth and cyclooxygenase-2 expression by differentiation-inducing agents in human oral squamous carcinoma SCC25 cells.

abstract：:The suppressors of cytokine signaling (SOCS) family inhibits not only Janus kinase (JAK)/signal transducers and activators of transcription (STAT) but also focal adhesion kinase (FAK) signaling pathways, and has tumor suppressor activity. Aberrant methylation in the promoter region of the SOCS3 gene frequently occurs ...

journal_title：International journal of oncology

authors： Tokita T,Maesawa C,Kimura T,Kotani K,Takahashi K,Akasaka T,Masuda T

更新日期：2007-03-01 00:00:00

abstract：:Natural antisense transcripts (NATs) constitute a class of non-coding RNAs that have emerged as important regulators of gene expression. However, involvement of NATs in colorectal cancer (CRC) development has not been reported to date. In the present study, the up- and down-regulation of NATs were investigated in huma...

journal_title：International journal of oncology

authors： Kohno K,Chiba M,Murata S,Pak S,Nagai K,Yamamoto M,Yanagisawa K,Kobayashi A,Yasue H,Ohkohchi N

更新日期：2010-12-01 00:00:00

abstract：:Five retinoblastoma tumours from patients treated in the King Khaled Eye Specialist Hospital in Riyadh were analysed for mutations in the RB1 gene using single strand conformation polymorphism analysis and mutations were found in all of them. In one tumour the mutation in exon 11 was homozygous demonstrating the role ...

journal_title：International journal of oncology

authors： Su G,Senft S,Cowell J

更新日期：1995-03-01 00:00:00

abstract：:Loss of E-cadherin and catenin expression may be associated with distant and lymph node metastases in breast cancer. Heterogeneity of E-cadherin expression is associated with poor prognosis, suggesting that E-cadherin and catenins may serve as useful prognostic markers for invasive breast carcinoma. Reduction or loss ...

journal_title：International journal of oncology

authors： Yoshida R,Kimura N,Harada Y,Ohuchi N

更新日期：2001-03-01 00:00:00

abstract：:Accumulating evidence indicates that microRNAs (miRNAs) have a critical role in cell proliferation and metastasis in hepatocellular carcinoma (HCC). However, the effect of miR‑300 on the development and progression of HCC remains unclear. In the present study, it was observed that miRNA (miR)‑300 expression was signif...

journal_title：International journal of oncology

authors： Chen Y,Guo Y,Li Y,Yang J,Liu J,Wu Q,Wang R

更新日期：2019-04-01 00:00:00

abstract：:Tripartite motif 16 (TRIM16), a member of the RING B-box coiled-coil (RBCC)/tripartite totif (TRIM) protein family, has been demonstrated to have significant effects on tumor migration by previous studies, but its specific contribution to hepatocellular carcinoma (HCC) is currently unknown. The aim of this study was t...

journal_title：International journal of oncology

authors： Li L,Dong L,Qu X,Jin S,Lv X,Tan G

更新日期：2016-04-01 00:00:00

abstract：:Metastasis is the main challenge of osteosarcoma treatment. Herein, we first reveal the oncogenic role of FAT10 in metastasis of osteosarcoma. FAT10 was upregulated in osteosarcoma, especially in metastatic osteosarcoma. High level of FAT10 was associated with poorer prognosis of osteosarcoma patients. Moreover, Trans...

journal_title：International journal of oncology

authors： Ma C,Zhang Z,Cui Y,Yuan H,Wang F

更新日期：2016-08-01 00:00:00

abstract：:Uveal melanoma is the most common type of intraocular cancer with a low mean annual incidence of 5‑10 cases per million. Tumours are located in the choroid (90%), ciliary body (6%) or iris (4%) and of 85% are primary tumours. As in cutaneous melanoma, tumours arise in melanocytes; however, the characteristics of uveal...

journal_title：International journal of oncology

authors： Ortega MA,Fraile-Martínez O,García-Honduvilla N,Coca S,Álvarez-Mon M,Buján J,Teus MA

更新日期：2020-12-01 00:00:00

abstract：:Over the past few decades, there has been a tremendous increase in cancer biology data and treatment. Cancer research has opened exciting new areas of cellular and molecular biology. Month by month, new genes which regulate the carcinogenesis process are being discovered. The result is an incredible knowledge of cance...

journal_title：International journal of oncology

authors： Kanduc D,Bannasch P,Farber E

更新日期：1999-12-01 00:00:00

abstract：:Prostaglandin E2 (PGE2) can stimulate tumor progression by both direct and indirect mechanisms. However, its influence on cell proliferation is still unclear. The present study characterized expression of subtypes of PGE2 receptors in oral squamous cell carcinomas, while also investigating the effects of EP3 and EP4 s...

journal_title：International journal of oncology

authors： Hoshikawa H,Goto R,Mori T,Mitani T,Mori N

更新日期：2009-03-01 00:00:00

abstract：:Prevention of chemotherapy induced nausea and vomiting in an outpatient population requires an antiemetic regimen which is reliable and safe and easy to administer. In this study the use of oral ondansetron was investigated in 45 patients receiving 143 courses of non-cisplatin containing chemotherapy regimens on an ou...

journal_title：International journal of oncology

authors： Casper J,Casper S,Kohnewompner C,Bokemeyer C,Hecker H,Schmoll H

更新日期：1994-06-01 00:00:00

abstract：:Following the publication of this article, the authors noted that there was an error in the affiliations. Specifically, the affiliation of the first author JUAN XU should be: Jinhua Municipal Central Hospital, Jinhua Hospital of Zhejiang University, Jinhua, Zhejiang 321000, P.R. China. [the original article was publis...

journal_title：International journal of oncology

authors： Xu J,Jiang N,Shi H,Zhao S,Yao S,Shen H

更新日期：2017-06-01 00:00:00

abstract：:EMMPRIN (extracellular matrix metalloproteinase inducer)/CD147, a membrane-bound glycoprotein with two extracellular loop domains (termed loops I and II), progresses tumor invasion and metastasis by increasing the production of matrix metalloproteinase (MMP) in peritumoral stoma cel...

journal_title：International journal of oncology

authors： Sato T,Watanabe M,Hashimoto K,Ota T,Akimoto N,Imada K,Nomizu M,Ito A

更新日期：2012-01-01 00:00:00

abstract：:The Tap1 and Tap2 genes encoding for a heterodimeric peptide transporter play a key role in antigen processing and presentation. The TAP complex mediates the transport of peptides generated by the IFN-gamma-inducible proteasome subunits LMP2, 7 and 10 from the cytosol into the endoplasmic reticulum (ER), where they bi...

journal_title：International journal of oncology

authors： Seliger B,Bock M,Ritz U,Huber C

更新日期：2002-02-01 00:00:00

abstract：:One hundred five patients with clinical stage T2-T4 transitional cell bladder carcinoma who completed either low-dose (20-26 Gy) or high dose (40-50 Gy) preoperative radiotherapy (RT) followed by cystectomy were reviewed. Five-year actuarial survival was 42%, 52%, and 17% for stages T2, T3, and T4, respectively. Five-...

journal_title：International journal of oncology

authors： Cox J,Greven K,Anscher M,Morgan T

更新日期：1992-10-01 00:00:00

abstract：:Previously, we found that the injection of zoledronic acid (ZOL) into mice bearing tumor induced changes of the vascular structure in the tumor. In this study, we examined whether ZOL treatment could decrease interstitial fluid pressure (IFP) via change of tumor vasculature, and enhance the antitumor efficacy of lipos...

journal_title：International journal of oncology

authors： Hattori Y,Shibuya K,Kojima K,Miatmoko A,Kawano K,Ozaki K,Yonemochi E

更新日期：2015-07-01 00:00:00

abstract：:Previously we have demonstrated that the tumor infiltrating lymphocytes found in SJL/J mice with reticulum cell sarcomas (RCS) are CD4+ T cells which express T cell receptor (TCR) beta chain molecules comprised principally of Vbeta17a encoded variable gene segments. Herein we report both the cellular and molecular cha...

journal_title：International journal of oncology

authors： Katz J,Bonavida B

更新日期：1994-04-01 00:00:00

abstract：:A total of forty-one tumor infiltrating T cell lines (TIL) were cloned, in the presence of interleukin-2, from nine breast tumor and five melanoma specimens with limiting dilution in a microculture system. Nineteen (46%) of the lines/clones reacted to autologous tumor targets. The T cell receptor (TcR) V beta gene usa...

journal_title：International journal of oncology

authors： Chin Y,Janssens J,Bleus J,Vandevijver C,Zhang J,Raus J

更新日期：1995-07-01 00:00:00

abstract：:Cervical cancer is a potentially preventable disease; however, it is the third most commonly diagnosed cancer and the fourth leading cause of cancer deaths in women worldwide. Cervical cancer is thought to develop through a multistep process involving virus, tumor suppressor genes, proto-oncogenes and immunological fa...

journal_title：International journal of oncology

authors： Xiao S,Zhou Y,Yi W,Luo G,Jiang B,Tian Q,Li Y,Xue M

更新日期：2015-04-01 00:00:00

abstract：:It has previously been suggested that some tumours may elaborate substances which can suppress the functional activity of lymphokine activated killer (LAK) cells. We have investigated the effects of secreted products from the colorectal cancer cell line LoVo on the pattern of expression of T lymphocyte subsets and nat...

journal_title：International journal of oncology

authors： Johnston D,Allen P,Newland A,Williams N

更新日期：1993-10-01 00:00:00

abstract：:Neuroblastoma is the second most common extracranial malignant solid tumor that occurs in childhood, and metastasis is one of the major causes of death in neuroblastoma patients. The epithelial-mesenchymal transition (EMT) is an important mechanism for both the initiation of tumor invasion and subsequent metastasis. T...

journal_title：International journal of oncology

authors： Shao JB,Gao ZM,Huang WY,Lu ZB

更新日期：2017-05-01 00:00:00

abstract：:This study examined whether the soluble tumor-associated-antigens (TAA), of 66 kDa and 51 kDa, could promote suppression by anticancer drugs of chemically-induced mammary tumorigenesis. Dimethylbenzanthracene (DMBA, 10 mg/rat, twice) was used to induce mammary tumors. Then, for nine more weeks, the preparation of TAA ...

journal_title：International journal of oncology

authors： Ben-Hur H,Kossoy G,Zusman I

更新日期：2001-08-01 00:00:00

abstract：:In a recent study, we evaluated the efficacy and toxicity of 5-fluorouracil (5-FU), cisplatin (CDDP), and 5-FU plus CDDP (FP treatment) in gastric cancer cell lines and examined the relationship between the response to FP treatment and apoptosis. Our study indicated that there may be prognostic value in measuring p53 ...

journal_title：International journal of oncology

authors： Matsuhashi N,Saio M,Matsuo A,Sugiyama Y,Saji S

更新日期：2005-06-01 00:00:00

abstract：:We found that a mouse p53 cDNA clone (pP53-5; Jenkins et al, Nature 312: 651-654, 1984), which previously was characterized as encoding mutant p53 protein, in fact represents wild-type mouse p53 cDNA, as we were able to demonstrate that the mutations described represented sequencing artefacts (compressions). Such sequ...

journal_title：International journal of oncology

authors： Kolzau T,Deppert W

更新日期：1993-07-01 00:00:00

abstract：:Extrahepatic cholangiocarcinoma (CC) is an aggressive malignancy with dismal prognosis and characterized by early invasion, metastasis and postoperative recurrence. Therefore, understanding the main molecular mechanisms of this malignancy is the key for the development of novel and effective therapeutic strategies for...

journal_title：International journal of oncology

authors： Qiang Y,Wang F,Yan S,Zhang H,Zhu L,Chen Z,Tu F,Wang D,Wang G,Wang W,Chen Z

更新日期：2015-01-01 00:00:00

abstract：:Three separate experiments, designed to minimize the DNA repair process following exposures to mutagens, were performed to determine whether DNA repair capability is the sole factor responsible for differential mutagen sensitivity. These experiments included (i) very short bleomycin pulse treatments (2, 5 and 10 min),...

journal_title：International journal of oncology

authors： Wang R,Hsu T,Brock W,Liang J

更新日期：1995-01-01 00:00:00

abstract：:MUC16 (CA125) is a transmembrane mucin that contributes to the progression of epithelial ovarian cancer (EOC). Expression of MUC16 is not detectable in the epithelial surface of normal ovaries. MUC16 expression is, however, common in serous EOC as well as in metastatic and recurrent tumors. Despite these observations,...

journal_title：International journal of oncology

authors： Giannakouros P,Matte I,Rancourt C,Piché A

更新日期：2015-01-01 00:00:00

abstract：:Thymidylate synthase (TS) is an essential enzyme for DNA biosynthesis that is an important target of fluoropyrimidine anti-cancer drugs such as 5-fluorouracil (5-FU), which is frequently used against human colon adenocarcinomas. Because levels of TS in such tumors may be predictive of chemotherapeutic response to 5-FU...

journal_title：International journal of oncology

authors： Weitz S,Wildrick D,Boman B

更新日期：1993-02-01 00:00:00

abstract：:Arsenic trioxide (As2O3) can induce clinical remission in patients with acute promyelocytic leukemia (APL) through induction of apoptosis. To investigate the potential therapeutic usage of As2O3 in cervical cancer and its possible mechanisms, human cervical cancer cell line HeLa was employed. The cells underwent apopt...

journal_title：International journal of oncology

authors： Woo SH,Park IC,Park MJ,Lee HC,Lee SJ,Chun YJ,Lee SH,Hong SI,Rhee CH

更新日期：2002-07-01 00:00:00

abstract：:Osteosarcoma is the most common primary malignancy of the bone. There have been some advances in surgical and chemotherapeutic strategies, but it is still a tumor with a high mortality rate in children and young adults. Mitogen-activated protein kinase/extracellular signal regulated...

journal_title：International journal of oncology

authors： Si H,Peng C,Li J,Wang X,Zhai L,Li X,Li J

更新日期：2012-04-01 00:00:00