Histone deacetylase 7 inhibits plakoglobin expression to promote lung cancer cell growth and metastasis.

abstract：:Chemotherapy is an established treatment modality for bone sarcomas such as osteosarcoma (OS). However, the use of chemotherapy in high-grade soft tissue sarcomas remains controversial, with the most active chemotherapeutic agent, doxorubicin (DOX), reported to have a response rate of, at best only 34% and most studie...

journal_title：International journal of oncology

authors： Bouralexis S,Clayer M,Atkins GJ,Labrinidis A,Hay S,Graves S,Findlay DM,Evdokiou A

更新日期：2004-05-01 00:00:00

abstract：:Resveratrol and other polyphenols have anti-carcinogenic and anti-tumorigenic activities in various carcinomas. However, such studies are limited in endometrial cancer. We hypothesize that resveratrol suppresses cancer growth through modulation of cell cycle and cell growth regulatory genes. To test this hypothesis, w...

journal_title：International journal of oncology

authors： Kaneuchi M,Sasaki M,Tanaka Y,Yamamoto R,Sakuragi N,Dahiya R

更新日期：2003-10-01 00:00:00

abstract：:Endothelial cells (ECs), that comprise the tumor vasculature, are critical targets for anticancer radiotherapy. The aim of this work was to study the mechanism by which SU5416, a known anti-angiogenesis inhibitor, modifies the radiation responses of human vascular ECs. Two human endothelial cell lines (HUVEC and 2H11)...

journal_title：International journal of oncology

authors： Kim EH,Kim MS,Jeong YK,Cho I,You SH,Cho SH,Lee H,Jung WG,Kim HD,Kim J

更新日期：2015-10-01 00:00:00

abstract：:To elucidate the involvement of proteasome inhibition in apoptosis induced by anthracycline anticancer agents, we investigated the interaction between the proteasome and anthracycline anticancer agents, and the function of the proteasome in apoptosis. Exposure of L1210 mouse lymphocytic leukemia cells to adriamycin (A...

journal_title：International journal of oncology

authors： Kiyomiya K,Kurebe M,Nakagawa H,Matsuo S

更新日期：2002-06-01 00:00:00

abstract：:We have previously shown that growth of the oral squamous cell carcinoma cell line SAS, is resistant to cetuximab in monolayer culture conditions, even though epidermal growth factor receptor (EGFR) was phosphorylated, but the growth of SAS aggregates was sensitive to cetuximab. In the present study, we demonstrate di...

journal_title：International journal of oncology

authors： Ohnishi Y,Yasui H,Kakudo K,Nozaki M

更新日期：2015-12-01 00:00:00

abstract：:Uveal melanoma is the most common type of intraocular cancer with a low mean annual incidence of 5‑10 cases per million. Tumours are located in the choroid (90%), ciliary body (6%) or iris (4%) and of 85% are primary tumours. As in cutaneous melanoma, tumours arise in melanocytes; however, the characteristics of uveal...

journal_title：International journal of oncology

authors： Ortega MA,Fraile-Martínez O,García-Honduvilla N,Coca S,Álvarez-Mon M,Buján J,Teus MA

更新日期：2020-12-01 00:00:00

abstract：:We have examined antitumor effect of murine neuroblastoma cells (C1300) retrovirally transduced with interleukin-4 (IL-4) gene in syngeneic A/J and nude mice. Although in vitro proliferation of IL-4-secreting C1300 cells (C1300/IL-4) was not different from that of wild-type cells, the in vivo tumor growth of C1300/IL-...

journal_title：International journal of oncology

authors： Yoshida H,Enomoto H,Miyauchi M,Takenaga K,Tanabe M,Ohnuma N,Sakiyama S,Tagawa M

更新日期：1998-05-01 00:00:00

abstract：:Human pancreatic ductal adenocarcinomas overexpress the epidermal growth factor (EGF) receptor. Betacellulin is a mitogenic polypeptide that binds and activates this receptor. To determine whether betacellulin has a role in human pancreatic cancer, we studied its expression in cultured human pancreatic cancer cell lin...

journal_title：International journal of oncology

authors： Yokoyama M,Funatomi H,Kobrin M,Ebert M,Friess H,Buchler M,Korc M

更新日期：1995-10-01 00:00:00

abstract：:We investigated the clinical significance of the expression levels of matrix metalloproteinase 9 (MMP-9) in renal cell carcinoma (RCC). In addition, we validated the efficacy of pyrrole imidazole polyamide (PIP) targeting MMP-9 on inhibiting proliferation and invasion of RCC. We evaluated the expression levels of MMP-...

journal_title：International journal of oncology

authors： Sato A,Nagase H,Obinata D,Fujiwara K,Fukuda N,Soma M,Yamaguchi K,Kawata N,Takahashi S

更新日期：2013-11-01 00:00:00

abstract：:Diosmetin, a plant flavonoid, has been shown to exert promising effects on prostate cancer cells as an anti‑proliferative and anticancer agent. In this study, using western blot analysis for protein expression and flow cytometry for cell cycle analysis, we determined that the treatment of the LNCaP and PC‑3 prostate c...

journal_title：International journal of oncology

authors： Oak C,Khalifa AO,Isali I,Bhaskaran N,Walker E,Shukla S

更新日期：2018-08-01 00:00:00

abstract：:Rhabdomyosarcoma (RMS) is a malignant tumour of skeletal muscle origin which includes two major histological subtypes: alveolar rhabdomyosarcoma (ARMS), the more aggressive, and embryonal rhabdomyosarcoma (ERMS). In order to establish whether the higher metastatic potential of ARMS cells may depend on differential exp...

journal_title：International journal of oncology

authors： Onisto M,Slongo ML,Gregnanin L,Gastaldi T,Carli M,Rosolen A

更新日期：2005-09-01 00:00:00

abstract：:Modulation of gene expression through histone deacetylase (HDAC) inhibition is considered a possible therapeutic strategy in acute myeloid leukaemia (AML). In vitro effects and basal gene expression of structurally different HDAC inhibitors were examined. Primary human AML cells were derived from 59 consecutive patien...

journal_title：International journal of oncology

authors： Stapnes C,Ryningen A,Hatfield K,Øyan AM,Eide GE,Corbascio M,Kalland KH,Gjertsen BT,Bruserud Ø

更新日期：2007-12-01 00:00:00

abstract：:DNA replication is a vital process in cell division where anomalies can lead to tumorigenesis. Minichromosome maintenance complex component 10 (MCM10) plays a crucial role in this process. However, the role of MCM10 in lung cancer pathogenesis remains to be elucidated. In current study, using the publicly available lu...

journal_title：International journal of oncology

authors： Wang M,Xie S,Yuan W,Xie T,Jamal M,Huang J,Yin Q,Song H,Zhang Q

更新日期：2019-12-01 00:00:00

abstract：:Breast cancer is the most common type of cancer and is also the second leading cause of cancer‑associated death in women worldwide. Thus, there is an urgent requirement for the development of effective treatments for this disease. Bridelia ovata and Croton oblongifolius are herbs used in Thai traditional medicine that...

journal_title：International journal of oncology

authors： Poofery J,Sripanidkulchai B,Banjerdpongchai R

更新日期：2020-04-01 00:00:00

abstract：:The naturally occurring photosensitizer, hypericin, with its high quantum yield of singlet oxygen photogeneration was studied for its ability to differentiate between glioblastoma cells and fetal rat neurons using fluorescence microscopy. Eight human glioma cell lines and twelve primary human glioma cell cultures were...

journal_title：International journal of oncology

authors： Ritz R,Müller M,Weller M,Dietz K,Kuci S,Roser F,Tatagiba M

更新日期：2005-12-01 00:00:00

abstract：:Glycodelin [gene name, progesterone associated endometrial protein (PAEP)] was initially described as an immune system modulator in reproduction. Today, it is also known to be expressed in several types of cancer, including non‑small cell lung cancer (NSCLC). In this cancer type, the feasibility of its usage as a foll...

journal_title：International journal of oncology

authors： Weber R,Meister M,Muley T,Thomas M,Sültmann H,Warth A,Winter H,Herth FJF,Schneider MA

更新日期：2019-02-01 00:00:00

abstract：:Epidemiologic studies on the protective role of omega-3 fatty acids (n:3) on breast cancer prevention remain inconclusive but studies in preclinical models provide more positive outcome. However, the mechanisms accounting for the protective effect of n:3 are not defined. In the present study, conducted in the N-methyl...

journal_title：International journal of oncology

authors： Manni A,Richie JP Jr,Xu H,Washington S,Aliaga C,Cooper TK,Bruggeman R,Das A,Prokopczyk B,Calcagnotto A,Trushin N,Dickinson R,Liao J,Verderame MF,El-Bayoumy K

更新日期：2011-11-01 00:00:00

abstract：:Chronic exposure to nickel compounds is associated with increased incidence of certain types of human cancer, including lung and nasal cancers. Despite intensive investigation, the oncogenic processes remain poorly understood. Apoptosis resistance is a key feature for tumor cells to escape physiological surveillance a...

journal_title：International journal of oncology

authors： Yang YX,Li XL,Wang L,Han SY,Zhang YR,Pratheeshkumar P,Wang X,Lu J,Yin YQ,Sun LJ,Budhraja A,Hitron AJ,Ding SZ

更新日期：2013-09-01 00:00:00

abstract：:Autocrine fibroblast growth factor (FGF) signaling was genetically manipulated in human gliomas by an adenovirus-mediated strategy. Antisense inhibition of endogenous basic FGF (bFGF) expression showed inhibition of the proliferation of human glioma cells (U251MG, NMC-G1) without promoting apoptosis. The reduction in ...

journal_title：International journal of oncology

authors： Aoki T,Kato S,Fox JC,Okamoto K,Sakata K,Morimatsu M,Shigemori M

更新日期：2002-09-01 00:00:00

abstract：:The purpose of the study was to assess response rate, clinical outcome, organ/function preservation and toxicity in head and neck cancer patients treated with induction chemotherapy followed by concomitant chemoradiotherapy and, when necessary, limited surgery. The study design was a phase II non-randomized trial in h...

journal_title：International journal of oncology

authors： Mantovani G,Maccio A,Massa E,Mulas C,Mudu MC,Massidda S,Massa D,Murgia V,Ferreli L,Succu G,Astara G,Proto E,Tore G,Mura M,Maxia G

更新日期：2000-06-01 00:00:00

abstract：:An ETS family member, ETS Related Gene (ERG) is involved in the Ewing family of tumors as well as leukemias. Rearrangement of the ERG gene with the TMPRSS2 gene has been identified in the majority of prostate cancer patients. Additionally, overexpression of ERG is associated with unfavorable prognosis in prostate canc...

journal_title：International journal of oncology

authors： Fortson WS,Kayarthodi S,Fujimura Y,Xu H,Matthews R,Grizzle WE,Rao VN,Bhat GK,Reddy ES

更新日期：2011-07-01 00:00:00

abstract：:Autocrine/paracrine stimulation of KIT has been observed in colorectal carcinoma (CRC) cell lines. We investigated the expression of KIT and stem cell factor (SCF) in CRC in comparison with premalignant colon lesions and normal colonic mucosa to assess the prognostic and therapeutic relevance of this receptor/ligand s...

journal_title：International journal of oncology

authors： Bellone G,Smirne C,Carbone A,Buffolino A,Scirelli T,Prati A,Solerio D,Pirisi M,Valente G,Nano M,Emanuelli G

更新日期：2006-10-01 00:00:00

abstract：:CD26 is a surface glycoprotein with intrinsic dipeptidyl peptidase IV (DPPIV) enzyme activity with multiple biological roles, including being intricately involved in immunoregulation as a T-cell activation molecule and as a regulator of chemokine function. T-cell lymphoid malignancies represent a heterogeneous group o...

journal_title：International journal of oncology

authors： Sato K,Dang NH

更新日期：2003-03-01 00:00:00

abstract：:It has been demonstrated that triptolide inhibits the growth of several types of cancer cells in vitro and prevents tumor growth in vivo by inducing apoptosis and autophagy. Here we showed that Tripchlorolide (T4) significantly suppressed the proliferation of A549 cells in a dose- a...

journal_title：International journal of oncology

authors： Chen L,Liu Q,Huang Z,Wu F,Li Z,Chen X,Lin T

更新日期：2012-04-01 00:00:00

abstract：:The expression of myeloid cell leukemia-1 (Mcl‑1), a member of the anti-apoptotic Bcl-2 protein family, has been associated with tumor progression and adverse patient outcome. The aims of current study were to evaluate whether Mcl-1 affects the survival or death of gastric cancer cells, and to investigate the prognost...

journal_title：International journal of oncology

authors： Lee WS,Park YL,Kim N,Oh HH,Son DJ,Kim MY,Oak CY,Chung CY,Park HC,Kim JS,Myung DS,Cho SB,Joo YE

更新日期：2015-05-01 00:00:00

abstract：:MicroRNAs (miRNAs) represent a class of small non-coding RNAs regulating gene expression by inducing RNA degradation or interfering with translation. Aberrant miRNA expression has been described for several human malignancies. Herein, we show that miR-145 is down-regulated in human cancer cell line MCF-7 when compared...

journal_title：International journal of oncology

authors： Wang S,Bian C,Yang Z,Bo Y,Li J,Zeng L,Zhou H,Zhao RC

更新日期：2009-05-01 00:00:00

abstract：:Alternative polyadenylation and microRNA regulation are both mechanisms of post-transcriptional regulation of gene expression. Alternative polyadenylation often results in mRNA isoforms with the same coding sequence but different lengths of 3' UTRs, while microRNAs regulate gene expression by binding to specific mRNA ...

journal_title：International journal of oncology

authors： An J,Zhu X,Wang H,Jin X

更新日期：2013-10-01 00:00:00

abstract：:The objective of these studies was to examine the murine pharmacokinetics, pharmacodynamics and metabolism of (3-(1H-indol-2-yl)phenyl)(1H-indol-2-yl)methanone (Indole 15), a novel tubulin inhibitor for the treatment of cancer. We developed HPLC and LC/MS/MS assays to quantitate Indole 15 and characterize its metaboli...

journal_title：International journal of oncology

authors： Yang J,Ahn S,Wu Z,Hwang DJ,Miller DD,Dalton JT

更新日期：2012-07-01 00:00:00

abstract：:Tumor cell invasion and metastasis requires precise coordination of adherence to the extracellular matrix (ECM) and controlled degradation of its components. lnvasive cells secrete proteolytic enzymes known as matrix metalloproteinases which degrade specific basement membrane molecules. Expression of these enzymes is ...

journal_title：International journal of oncology

authors： Vo HP,Lee MK,Crowe DL

更新日期：1998-12-01 00:00:00

abstract：:We have assessed the prognostic significance of mutations in the p53 tumor suppressor gene in patients with small non-cleaved cell lymphomas. In this retrospective pilot study we have, been able to evaluate the response to therapy of 21 previously untreated patients. Seven of these patients (33%) had tumors which cont...

journal_title：International journal of oncology

authors： Gutierrez M,Bhatia K,Diez B,Muriel F,Epelman S,Deandreas M,Huppi K,Magrath I

更新日期：1994-03-01 00:00:00