KIT/stem cell factor expression in premalignant and malignant lesions of the colon mucosa in relationship to disease progression and outcomes.

abstract：:Patients with long-standing ulcerative colitis (UC) have higher risk of developing colorectal cancer. Albeit the causes remain to be understood, epigenetic alterations have been suggested to play a role in the long-term cancer risk of these patients. In this work, we developed a novel microarray platform based on meth...

journal_title：International journal of oncology

authors： Koizumi K,Alonso S,Miyaki Y,Okada S,Ogura H,Shiiya N,Konishi F,Taya T,Perucho M,Suzuki K

更新日期：2012-04-01 00:00:00

abstract：:A number of glycosyltransferases have been identified and biologically characterized in cancer cells, yet their exact pathophysiological functions are largely unknown. Here, we report the critical role of β1,3-N-acetylgalactosaminyltransferase II (B3GALNT2), which transfers N-acetylgalactosamine (GalNAc) in a β1,3 lin...

journal_title：International journal of oncology

authors： Matsuo T,Komatsu M,Yoshimaru T,Kiyotani K,Miyoshi Y,Sasa M,Katagiri T

更新日期：2014-02-01 00:00:00

abstract：:Tumor-bearing mice with two different locally growing malignant tumors (epithelial like, MCG 101; malignant melanoma, K1735-M2) were used to evaluate the putative role of prostaglandins for survival and local tumor growth in experimental cancer. Daily systemic injections of indomethacin (1 mu g/g bw) were used to bloc...

journal_title：International journal of oncology

authors： Lonnroth C,Svaninger G,Gelin J,Cahlin C,Iresjo B,Cvetkovska E,Edstrom S,Andersson M,Svanberg E,Lundholm K

更新日期：1995-12-01 00:00:00

abstract：:Although only less than 10% of women with primary breast cancer have clinicopathologic signs of overt metastases, metastatic relapse occurs in about half of the cases with apparently localized tumors within five years after surgery. In 23% of the patients, bone marrow metastases are detectable at first relapse and thi...

journal_title：International journal of oncology

authors： Kasimir-Bauer S,Oberhoff C,Schindler AE,Seeber S

更新日期：2002-05-01 00:00:00

abstract：:We performed this study in order to evaluate the impact of the chemokine CXCL12 and its single-nucleotide polymorphism (SNP) rs1801157 on clinicopathological parameters and survival in patients undergoing surgery for esophagogastric cancer. The expression pattern of CXCL12 and its polymorphisms were analyzed by RT-PCR...

journal_title：International journal of oncology

authors： Schimanski CC,Jordan M,Schlaegel F,Schmidtmann I,Lang H,Galle PR,Moehler M,Gockel I

更新日期：2011-08-01 00:00:00

abstract：:Cadherins play a crucial role in epithelial morphogenesis and mediate intercellular adhesion. These receptors bind catenins and are involved in signal transduction pathways that regulate cell growth and apoptosis, and are frequently down-regulated in invasive and metastatic carcinomas. In order to assess the role of E...

journal_title：International journal of oncology

authors： Vizirianakis IS,Chen YQ,Kantak SS,Tsiftsoglou AS,Kramer RH

更新日期：2002-07-01 00:00:00

abstract：:In the present study, the precise mechanism of the enhancing action of histone deacetylase (HDAC) inhibitors on cisplatin (CDDP)-induced apoptosis was investigated using suberoylanilide hydroxamic acid (SAHA) in human oral squamous cell carcinoma cells (HSC-3). HDAC inhibitors are promising novel compounds for the tre...

journal_title：International journal of oncology

authors： Rikiishi H,Shinohara F,Sato T,Sato Y,Suzuki M,Echigo S

更新日期：2007-05-01 00:00:00

abstract：:We have initiated studies to enhance targeted delivery of an anticancer agent, curcumin, for prostate cancer treatment by incorporating this agent into the liposomes (nanodelivery vehicles primarily composed of phospholipids) coated with prostate membrane specific antigen specific antibodies. We prepared curcumin-load...

journal_title：International journal of oncology

authors： Thangapazham RL,Puri A,Tele S,Blumenthal R,Maheshwari RK

更新日期：2008-05-01 00:00:00

abstract：:Cholangiocarcinoma is the most common biliary duct malignancy and the second most common primary liver cancer, accounting for 10‑20% of hepatic malignancies. With high mortality and poor prognosis, the 5‑year survival rate of cholangiocarcinoma is only 10%. A previous study demonstrated a significant association betwe...

journal_title：International journal of oncology

authors： Shi T,Gong J,Fujita K,Nishiyama N,Iwama H,Liu S,Nakahara M,Yoneyama H,Morishita A,Nonura T,Kobara H,Okano K,Suzuki Y,Masaki T

更新日期：2020-12-30 00:00:00

abstract：:The neuroepithelioma cell line CHP100 expresses low but detectable amounts of N-myc protein together with large amounts of c-myc protein. We have recently demonstrated that antisense inhibition of N-myc expression in CHP100 cells leads to decreased in vitro growth and alterations in cellular morphology without affecti...

journal_title：International journal of oncology

authors： Rosolen A,Frascella E,Toretsky J,Neckers L

更新日期：1995-01-01 00:00:00

abstract：:Endometrial cancer (EC) is one of the most common malignancies of the female reproductive system, and metastasis is a major cause of mortality. In this study, we aimed to explore the role of CP‑31398 in the migration, invasion and apoptosis of EC cells by its regulation of the expression of the murine double minute 2 ...

journal_title：International journal of oncology

authors： Liu L,Yang L,Chang H,Chen YN,Zhang F,Feng S,Peng J,Ren CC,Zhang XA

更新日期：2019-03-01 00:00:00

abstract：:Side population (SP) cells may play a crucial role in tumorigenesis and the recurrence of cancer. Many types of cell lines and tissues have demonstrated the presence of SP cells, including colon cancer cell lines. This study aimed to identify cancer stem cells (CSCs) in the SP of the colon cancer cell line SW480. SP c...

journal_title：International journal of oncology

authors： Xiong B,Ma L,Hu X,Zhang C,Cheng Y

更新日期：2014-09-01 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) has four isoforms (VEGF121, VEGF165, VEGF189, VEGF206). We examined the expression patterns of VEGF isoforms in non-small cell lung cancer (NSCLC) by RT-PCR. The cell-associated isoform VEGF189 was more frequently expressed in NSCLC (90.5%) than in extraneoplastic lung tissue ...

journal_title：International journal of oncology

authors： Oshika Y,Nakamura M,Tokunaga T,Ozeki Y,Fukushima Y,Hatanaka H,Abe Y,Yamazaki H,Kijima H,Tamaoki N,Ueyama Y

更新日期：1998-03-01 00:00:00

abstract：:We investigated the expression and promoter methylation of dbpA in human hepatocellular carcinoma (HCC) and examined their correlation with clinicopathological features. In 96 paired samples of HCC and adjacent non-tumorous liver, and 10 normal liver specimens, dbpA mRNA was quantif...

journal_title：International journal of oncology

authors： Yasen M,Obulhasim G,Kajino K,Mogushi K,Mizushima H,Tanaka S,Tanaka H,Hino O,Arii S

更新日期：2012-03-01 00:00:00

abstract：:Telomerase activation in differentiated cells is associated with cell immortalization. Detection of telomerase expression in cancer provides a potential biomarker to be evaluated in the diagnosis and prognosis of cancer patients. Analysis of telomerase activity in biopsy specimens may serve as a useful marker for the ...

journal_title：International journal of oncology

authors： Pearson AS,Chiao P,Zhang L,Zhang W,Larry L,Katz RL,Evans DB,Abbruzzese JL

更新日期：2000-08-01 00:00:00

abstract：:MicroRNAs (miRNAs) are small non-coding, endogenous, single-stranded RNAs. MiRNAs have been implicated in different areas such as the immune response, neural development, DNA repair, apoptosis, oxidative stress response and cancer. However, while the majority of miRNAs are found int...

journal_title：International journal of oncology

authors： Allegra A,Alonci A,Campo S,Penna G,Petrungaro A,Gerace D,Musolino C

更新日期：2012-12-01 00:00:00

abstract：:Antisense oligonucleotides that selectively inhibit gene expression are a genetic approach for disease treatment and prevention. However, their use as therapeutic agents is complicated by their low rate of transport across cellular membranes and their sequestration within endocytic-like vesicles. We report that the ad...

journal_title：International journal of oncology

authors： Smith CC,Kulka M,Aurelian L

更新日期：2000-10-01 00:00:00

abstract：:The failure of androgen deprivation therapy in prostate cancer treatment mainly results from drug resistance to androgen receptor antagonists. Although an aberrant caveolin‑1 (Cav‑1) expression has been reported in multiple tumor cell lines, it is unknown whether it is responsible for the progression of castration‑res...

journal_title：International journal of oncology

authors： Gao Y,Li L,Li T,Ma L,Yuan M,Sun W,Cheng HL,Niu L,Du Z,Quan Z,Fan Y,Fan J,Luo C,Wu X

更新日期：2019-06-01 00:00:00

abstract：:Gamma linolenic acid (GLA) is an anti-cancer agent recently reported to inhibit tumour cell-matrix attachment. This study examined the effects of GLA on the adhesion of two tumour cell lines, HT115 (human colon) and MDA MB 231 (human breast), to an extracellular matrix, Matrigel. The action of GLA on focal adhesion ki...

journal_title：International journal of oncology

authors： Jiang W,Hiscox S,Puntis M,Hallett M,Bryce R,Horrobin D,Mansel R

更新日期：1996-03-01 00:00:00

abstract：:Establishment of tumor cell lines as model systems for studying tumor biology or as a part of immunotherapeutic anti-cancer strategies is of high importance, whereby the highest possible preservation of the original tumor cell phenotype is a prerequisite for these aims. Since overexpression of the catalytic subunit of...

journal_title：International journal of oncology

authors： Voglauer R,Grillari J,Fortschegger K,Wieser M,Sterovsky T,Gunsberg P,Katinger H,Pfragner R

更新日期：2005-04-01 00:00:00

abstract：:Although several therapeutic options are available for hepatocellular carcinoma (HCC), the outcome is still very poor. One reason is the complexity of signal transduction in the pathogenesis of HCC. The aim of this study was to identify new HCC-related genes and to investigate the functions of these genes in the patho...

journal_title：International journal of oncology

authors： Tameda M,Sugimoto K,Shiraki K,Yamamoto N,Okamoto R,Usui M,Ito M,Takei Y,Nobori T,Kojima T,Suzuki H,Uchida M,Uchida K

更新日期：2014-08-01 00:00:00

abstract：:Anisi stellati fructus (ASF), commonly known as star anise, has long been used as a traditional Chinese medicine to treat inflammation, nervousness, insomnia and pain. In recent studies, it has been demonstrated that ASF possesses anti-bacterial, anti-fungal and anti-oxidant activities, as well as exhibits inhibitory ...

journal_title：International journal of oncology

authors： Kim A,Im M,Ma JY

更新日期：2014-11-01 00:00:00

abstract：:Total body irradiation (TBI), given in low to moderate doses as a single modality, can enhance leukocyte populations and immune modifiers, resulting in slowed tumor progression. The aim of this study was to evaluate natural killer (NK) cell involvement in mediating the antitumor effect of TBI by depleting NK populatio...

journal_title：International journal of oncology

authors： Miller GM,Andres ML,Gridley DS

更新日期：2003-12-01 00:00:00

abstract：:It has been demonstrated that triptolide inhibits the growth of several types of cancer cells in vitro and prevents tumor growth in vivo by inducing apoptosis and autophagy. Here we showed that Tripchlorolide (T4) significantly suppressed the proliferation of A549 cells in a dose- a...

journal_title：International journal of oncology

authors： Chen L,Liu Q,Huang Z,Wu F,Li Z,Chen X,Lin T

更新日期：2012-04-01 00:00:00

abstract：:Thymidylate synthase (TS) is an essential enzyme for DNA biosynthesis that is an important target of fluoropyrimidine anti-cancer drugs such as 5-fluorouracil (5-FU), which is frequently used against human colon adenocarcinomas. Because levels of TS in such tumors may be predictive of chemotherapeutic response to 5-FU...

journal_title：International journal of oncology

authors： Weitz S,Wildrick D,Boman B

更新日期：1993-02-01 00:00:00

abstract：:In the present study, we analyzed the proliferation and cytotoxic activities of LAK cells and initial phase TILs by stimulation with IL-4. IL-4 obviously inhibited the DNA synthesis of LAK cells and initial phase TILs at the concentration of 250 pg/ml and 25 pg/ml, respectively. Furthermore, IL-4 (25 ng/ml for LAK cel...

journal_title：International journal of oncology

authors： Tsunoda T,Tanimura H,Yamaue H,Iwahashi M,Tani M,Tamai M,Noguchi K,Mizobata S,Arii K

更新日期：1995-11-01 00:00:00

abstract：:Tissue samples from a malignant melanoma of the anal canal and its local metastasis were short-term cultured and analyzed cytogenetically. Complex chromosome aberrations were found in the primary tumor, yielding the karyotype 49-50,X,-Y,der(1)t(1;13)(q44;q12),+der(2)t(2;8) (q31;q12),der(6)t(5;6)(q13;q21),+del(6)(q12q2...

journal_title：International journal of oncology

authors： Bardi G,Fenger C,Pandis N,Mitelman F,Heim S

更新日期：1995-03-01 00:00:00

abstract：:Cytogenetic abnormalities are the hallmarks of most cancers and cutaneous melanomas are no exception. The purpose of this study was to determine whether nonrandom chromosomal abnormalities are associated with development and spontaneous regression of congenital cutaneous melanoma in Sinclair miniature swine. Careful a...

journal_title：International journal of oncology

authors： Pathak S,Amoss M

更新日期：1997-07-01 00:00:00

abstract：:The mitogen-activated protein kinase (MAPK) cascade, which includes MAPK, MAP kinase kinase (MAPKK) and Raf-l, is involved in the signal transduction of growth factor receptors. We found that the MAPK and Raf-l proteins are increased in human breast cancer. Activated MAPKK was also observed. We then investigated wheth...

journal_title：International journal of oncology

authors： Koibuchi Y,Iino Y,Uchida T,Nagasawa M,Morishita Y

更新日期：1997-09-01 00:00:00

abstract：:The objective of the present study was to establish the individual and combined chemopreventive potential of a widely used non-steroidal anti-inflammatory drug, ibuprofen (IBU), encapsulated in solid lipid nanoparticles (SLNs) for the chemoprevention of pancreatic cancer. The IBU SLNs were optimized using various lipi...

journal_title：International journal of oncology

authors： Thakkar A,Chenreddy S,Wang J,Prabhu S

更新日期：2015-04-01 00:00:00