Genetic predisposition and specific chromosomal defects associated with Sinclair swine malignant melanomas.

abstract：:Human chondrosarcoma cells (HCS-TG) were transduced with the gene for a herpes simplex virus thymidine kinase (HSV-tk) or Escherichia coli beta-galactosidase (lacZ). We investigated the cytotoxicity of human chondrosarcoma bearing an HSV-tk gene after treatment with ganciclovir. Chondrosarcoma cells bearing an HSV-tk ...

journal_title：International journal of oncology

authors： Seto M,Wakabayashi H,Yamazaki T,Sonoda J,Shinto Y,Uchida A

更新日期：1999-06-01 00:00:00

abstract：:The hepatitis B virus (HBV) encodes a 16.5 kDa multifunctional protein termed pX or HBx, required for transcription of the viral genome and implicated in the development of hepatocellular carcinoma (HCC) in chronic HBV-infected patients. However, the mechanism of pX-mediated hepatocarcinogenesis remains unknown. pX is...

journal_title：International journal of oncology

authors： Andrisani OM,Barnabas S

更新日期：1999-08-01 00:00:00

abstract：:Mantle cell lymphoma (MCL) is typified by translocation t(11;14)(q13;q32) causing upregulation of cyclin D1 and deregulation of cell cycle. The cyclin D1 activation plays a critical role in MCL pathogenesis but additional oncogenic events, such as aberrations of the ARF/MDM2/p53 pathway are also necessary for progress...

journal_title：International journal of oncology

authors： Stefancikova L,Moulis M,Fabian P,Ravcukova B,Vasova I,Muzik J,Malcikova J,Falkova I,Slovackova J,Smardova J

更新日期：2010-03-01 00:00:00

abstract：:Glioblastomas are highly vascularized tumors and anti-angiogenic strategy is one of the most promising therapeutic approaches to treat brain tumors. Interferon alpha (IFN-alpha) as a single agent or combined with standard chemo-therapy has been shown to inhibit various tumors, but the effect of combination anti-angiog...

journal_title：International journal of oncology

authors： Son MJ,Song HS,Kim MH,Kim JT,Kang CM,Jeon JW,Park SY,Kim YJ,Groves MD,Park K,Kim JH,Nam DH

更新日期：2006-06-01 00:00:00

abstract：:To investigate the relationships of the gross appearance to cancer depth and microinvasion in gallbladder cancer, thirty-three cancers were macroscopically subgrouped: papillary (n=8), nodular (n=6), papillo-invasive (n=1), nodulo-invasive (n=11), and invasive (n=7) type, respectively. Papillary type cancers were limi...

journal_title：International journal of oncology

authors： Namieno T,Takahashi M,Koito K,Sato N,Uchino J

更新日期：1996-02-01 00:00:00

abstract：:Pancreatic cancer is characterized by a dense desmoplastic reaction in which extracellular matrix proteins accumulate and surround tumor cells. Integrins and their related signaling molecules are associated with progression of pancreatic cancer. In the present study, the association between the metastasis of pancreati...

journal_title：International journal of oncology

authors： Jiang P,Li Z,Tian F,Li X,Yang J

更新日期：2017-07-01 00:00:00

abstract：:Thirty-three adult patients with anaplastic astrocytoma or glioblastoma multiforme, verified between 1990 and 1997, received postoperative intra-arterial ACNU chemotherapy and irradiation. Since our previous strategies to malignant gliomas had included intra-venous ACNU, the purpose of the present study is to evaluate...

journal_title：International journal of oncology

authors： Hirano Y,Mineura K,Mizoi K,Tomura N

更新日期：1998-09-01 00:00:00

abstract：:Hepatocellular carcinoma is one of the most common cancers in the world. Previously, we found that the level of glucocorticoid receptor was significantly higher in hepatocellular carcinoma than in adjacent liver tissues. Moreover, in vitro and in vivo studies showed that glucocorticoid stimulated the growth of hepatom...

journal_title：International journal of oncology

authors： Uen YH,Ko PH,Yin PH,Liu TY,Chi CW,Lui WY

更新日期：2008-12-01 00:00:00

abstract：:Patients with esophageal carcinoma (ESCA) have a poor prognosis and high mortality rate. Although standard therapies have had effect, there is an urgent requirement to develop novel options, as increasing drug tolerance has been identified in clinical practice. In the present study, differentially expressed genes (DEG...

journal_title：International journal of oncology

authors： Chen YT,Xie JY,Sun Q,Mo WJ

更新日期：2019-01-01 00:00:00

abstract：:Chemotherapy is an established treatment modality for bone sarcomas such as osteosarcoma (OS). However, the use of chemotherapy in high-grade soft tissue sarcomas remains controversial, with the most active chemotherapeutic agent, doxorubicin (DOX), reported to have a response rate of, at best only 34% and most studie...

journal_title：International journal of oncology

authors： Bouralexis S,Clayer M,Atkins GJ,Labrinidis A,Hay S,Graves S,Findlay DM,Evdokiou A

更新日期：2004-05-01 00:00:00

abstract：:Myofibroblasts in the stroma of pancreatic cancers promote tumor proliferation, invasion and metastasis by increasing extracellular matrix and secretion of several growth factors. In contrast, the role of myofibroblasts at peritoneally disseminated sites of pancreatic cancer has not yet been determined. This study was...

journal_title：International journal of oncology

authors： Akagawa S,Ohuchida K,Torata N,Hattori M,Eguchi D,Fujiwara K,Kozono S,Cui L,Ikenaga N,Ohtsuka T,Aishima S,Mizumoto K,Oda Y,Tanaka M

更新日期：2014-07-01 00:00:00

abstract：:Structural maintenance of chromosome 1 alpha (SMC1A) gene has been reported to be related to tumor development in some types of human cancers. However, the misregulation of SMC1A and its functions in castration-resistant prostate cancer (CRPC) have not been well understood. In the present study, we found that SMC1A wa...

journal_title：International journal of oncology

authors： Pan XW,Gan SS,Ye JQ,Fan YH,Hong Υ,Chu CM,Gao Y,Li L,Liu X,Chen L,Huang Y,Xu H,Ren JZ,Yin L,Qu FJ,Huang H,Cui XG,Xu DF

更新日期：2016-11-01 00:00:00

abstract：:In recent years major progress has been made in understanding the molecular steps of death receptor and mitochondrial pathway of apoptosis. Mechanisms of NF-kappaB-mediated survival (anti-apoptotic) signal have been delineated. A novel anti-apoptotic mechanism of FLIP in the recruitment of RIP and TRAF-1 and TRAF-2 to...

journal_title：International journal of oncology

authors： Gupta S

更新日期：2003-01-01 00:00:00

abstract：:Toxicity of polyphenols against rat 3Y1 fibroblasts and the cells transformed by human adenovirus (Ad12-3Y1), its EIA gene (EIA-3Y1), or simian virus 40 (SV-3Y1) was examined. Among the diphenol compounds examined, pyrocatechol (o-diphenol) and hydroquinone (p-diphenol) showed selective toxicity against Ad12-3Y1 and E...

journal_title：International journal of oncology

authors： Yamada K,Mitsui T,Okuda A,Kimura G,Sugano M

更新日期：1993-01-01 00:00:00

abstract：:Breast cancer is the most common type of cancer and is also the second leading cause of cancer‑associated death in women worldwide. Thus, there is an urgent requirement for the development of effective treatments for this disease. Bridelia ovata and Croton oblongifolius are herbs used in Thai traditional medicine that...

journal_title：International journal of oncology

authors： Poofery J,Sripanidkulchai B,Banjerdpongchai R

更新日期：2020-04-01 00:00:00

abstract：:Recently, ultrasound-guided percutaneous ethanol injection therapy (PEIT) has been widely performed in the treatment of hepatocellular carcinoma. Histopathologic examinations after the therapy have revealed that PEIT can destroy the tumor completely in most cases. Findings in imaging modalities and serum tumor marker ...

journal_title：International journal of oncology

authors： Shiina S,Niwa Y,Shiratori Y,Terano A,Omata M

更新日期：1993-04-01 00:00:00

abstract：:After the publication of the article, the authors noted that they had made the following errors. In Fig. 5B, total PDK1 is incorrect in the published paper. The corrected version of Fig. 5B is shown below. Also in Fig. 6B, the DMSO-treated group and the brassinin (400 µM)-treated group are incorrect, and the corrected...

journal_title：International journal of oncology

authors： Izutani Y,Yogosawa S,Sowa Y,Sakai T

更新日期：2016-03-01 00:00:00

abstract：:In order to realise the full potential of gene therapy as a rational approach to the treatment of cancer, it will be necessary to achieve delivery of the therapeutic gene selectively to target tumour cells. Such cancer cell-specific gene delivery is mandated in the context of locoregional or compartmentalised carcinom...

journal_title：International journal of oncology

authors： Douglas J,Curiel D

更新日期：1997-08-01 00:00:00

abstract：:Developing simple and effective approaches to detect tumor markers will be critical for early diagnosis or prognostic evaluation of prostate cancer treatment. Prostate‑specific membrane antigen (PSMA) has been validated as an important tumor marker for prostate cancer progression including angiogenesis and metastasis....

journal_title：International journal of oncology

authors： Liu T,Mendes DE,Berkman CE

更新日期：2014-03-01 00:00:00

abstract：:In four previous case-control studies we have shown an association between exposure to phenoxyacetic acids or chlorophenols and soft-tissue sarcoma (STS). These chemicals are contaminated by dioxins and dibenzofurans, some of which are known carcinogens in experimental animals. In a meta-analysis of our four studies w...

journal_title：International journal of oncology

authors： Hardell L,Eriksson M,Degerman A

更新日期：1995-04-01 00:00:00

abstract：:Gicerin, an immunoglobulin superfamily protein, is expressed abundantly in the embryonic tissues and plays an important role in development through its cell adhesive activity. Interestingly, re-expression of gicerin is found in a variety of tumors. In the present study, the possible role of gicerin in the progression ...

journal_title：International journal of oncology

authors： Tsukamoto Y,Sakaiuchi T,Hiroi S,Furuya M,Tsuchiya S,Sasaki F,Miki N,Taira E

更新日期：2003-12-01 00:00:00

abstract：:Chemokine (C-C motif) ligand 21 (CCL21) and SPARC-like protein 1 (SPARCL1/MAST9/hevin/SC-1) are associated with various biological behavior in the development of cancers. Although the expression of CCL21 and SPARCL1 is downregulated in many solid tumors, their roles in ovarian cancer and their associations with drug r...

journal_title：International journal of oncology

authors： Yin F,Liu X,Li D,Wang Q,Zhang W,Li L

更新日期：2013-04-01 00:00:00

abstract：:Overexpression of either of the multidrug resistance genes MDR1 and MRP is associated with resistance of tumors to multiple chemotherapeutic agents. Overexpression of MDR1 has been reported in some cell lines derived from human hepatocellular carcinomas (HCC) and hepatoblastomas (HB). The human gene for cMOAT (

journal_title：International journal of oncology

authors： Minemura M,Tanimura H,Tabor E

更新日期：1999-09-01 00:00:00

abstract：:DNA double-strand breaks (DSBs) are potentially mutagenic/carcinogenic lesions. Induction of DSBs triggers phosphorylation of histone H2AX on Ser-139. Phosphorylated H2AX (gammaH2AX) can be detected immunocytochemically, and the intensity of gammaH2AX immunofluorescence (IF), reflecting the number of gammaH2AX-IF foci...

journal_title：International journal of oncology

authors： Albino AP,Huang X,Jorgensen ED,Gietl D,Traganos F,Darzynkiewicz Z

更新日期：2006-06-01 00:00:00

abstract：:The development of colorectal cancer (CRC) is strongly correlated with the aberrant activation of multiple intracellular signaling transduction cascades including STAT3, ERK, JNK and p38 pathways which usually function redundantly. In addition, crosstalk between these pathways forms a complicated signaling network tha...

journal_title：International journal of oncology

authors： Lin J,Chen Y,Wei L,Shen A,Sferra TJ,Hong Z,Peng J

更新日期：2013-10-01 00:00:00

abstract：:MicroRNA (miRNA or miR)-506 is a novel miRNA related to the survival of breast cancer patients. However, the mechanism underlying miRNA-506 involvement in breast carcinogenesis remains unclear. In the present study, we found that miR-506 was downregulated in human breast malignant tissues and breast cancer cell lines ...

journal_title：International journal of oncology

authors： Sun G,Liu Y,Wang K,Xu Z

更新日期：2015-11-01 00:00:00

abstract：:Midkine (MK) expression has been documented to be inversely correlated with the prognosis of patients with various tumors, but the mechanism of this relationship has not been well characterized. Recent studies have also correlated p53 expression with prognosis of patients with oral squamous cell carcinoma (OSCC). We e...

journal_title：International journal of oncology

authors： Ota K,Fujimori H,Ueda M,Jono H,Shinriki S,Ota T,Sueyoshi T,Taura M,Taguma A,Kai H,Shinohara M,Ando Y

更新日期：2010-10-01 00:00:00

abstract：:A disintegrin and metalloproteinase-17 (ADAM17) can cut and release a wide variety of epidermal growth factor receptor (EGFR) ligands to promote survival, invasion and proliferation of cancer cell, and therefore, is considered to be a potential therapeutic target for cancer. The main goal of the present study was to o...

journal_title：International journal of oncology

authors： Meng X,Hu B,Hossain MM,Chen G,Sun Y,Zhang X

更新日期：2016-08-01 00:00:00

abstract：:The effects of prostaglandin E2 and indomethacin on carcinogenesis were studied in male Wistar rats. Of the rats, those treated with MNNG (MNNG group) were given 1 ml of 0.1% solution of MNNG in distilled water by intrarectal instillation every day for 14 days. The diet for the rats treated with Indomethacin and MNNG ...

journal_title：International journal of oncology

authors： Yamaguchi A,Goi T,Nakagawara G,Ishida T,Miyazaki I

更新日期：1993-08-01 00:00:00

abstract：:Dendritic cells (DCs) are powerful antigen-presenting cells (APCs), that have so far been applied for cancer specific immunotherapy. Recent results suggest that matured DCs derived from human monocytes have a significant impact on the outcome of vaccination. The conventional generation of mature DCs from human monocyt...

journal_title：International journal of oncology

authors： Tanaka F,Yamaguchi H,Haraguchi N,Mashino K,Ohta M,Inoue H,Mori M

更新日期：2006-11-01 00:00:00