Ursolic acid promotes colorectal cancer cell apoptosis and inhibits cell proliferation via modulation of multiple signaling pathways.

abstract：:The identification of cell surface markers expressed selectively by tumor vasculature is challenging. To get as close to the human disease as possible, investigators have isolated endothelial cells from fresh human tumor specimens and subjected them to RNA-based gene expression analysis. The data indicate that there a...

journal_title：International journal of oncology

authors： Teicher BA

更新日期：2007-02-01 00:00:00

abstract：:Thymidylate synthase (TS) is an essential enzyme for DNA biosynthesis that is an important target of fluoropyrimidine anti-cancer drugs such as 5-fluorouracil (5-FU), which is frequently used against human colon adenocarcinomas. Because levels of TS in such tumors may be predictive of chemotherapeutic response to 5-FU...

journal_title：International journal of oncology

authors： Weitz S,Wildrick D,Boman B

更新日期：1993-02-01 00:00:00

abstract：:Squamous cell carcinoma antigen (SCCA) is overexpressed in many squamous cell cancers and SCCA‑derived peptide-specific CD8(+) cytotoxic T lymphocytes can display cytotoxicity against tumor cells. In the present study, we screened the SCCA amino acid sequence for potential HLA-A*0201-binding CD8(+) T‑cell epitopes usi...

journal_title：International journal of oncology

authors： Duan ZL,Wang ZB,Guo JL,Liu WQ,Hu J,Li J,Wang SN,Li Q,Wen JS

更新日期：2013-04-01 00:00:00

abstract：:The relation between the consumption of cruciferous vegetables and reduced prostate cancer occurrence has been documented, although the responsible phytochemicals are unknown. The effects of sulforaphane (SFN) which occurs as the precursor glucosinolate in broccoli and other cruciferous vegetables, and its metabolite ...

journal_title：International journal of oncology

authors： Chiao JW,Chung FL,Kancherla R,Ahmed T,Mittelman A,Conaway CC

更新日期：2002-03-01 00:00:00

abstract：:The purpose of the study was to assess response rate, clinical outcome, organ/function preservation and toxicity in head and neck cancer patients treated with induction chemotherapy followed by concomitant chemoradiotherapy and, when necessary, limited surgery. The study design was a phase II non-randomized trial in h...

journal_title：International journal of oncology

authors： Mantovani G,Maccio A,Massa E,Mulas C,Mudu MC,Massidda S,Massa D,Murgia V,Ferreli L,Succu G,Astara G,Proto E,Tore G,Mura M,Maxia G

更新日期：2000-06-01 00:00:00

abstract：:The MyD118/Gadd45/CR6 gene family (also termed Gadd45beta/alpha/gamma) has been identified as genes which are rapidly induced by genotoxic agents, during terminal differentiation, as well as by apoptotic cytokines. In recent years, evidence has emerged that the proteins encoded by these genes play pivotal roles in neg...

journal_title：International journal of oncology

authors： Zhang W,Hoffman B,Liebermann DA

更新日期：2001-04-01 00:00:00

abstract：:The aim of the present study was to evaluate the effects of programmed cell death 4 (PDCD4) on cell proliferation and apoptosis, and to elucidate the potential role of the Jun N-terminal kinase (JNK)/c-Jun pathway in human bladder cancer (BCa) cells. Mixed BCa cells were transfected with plasmids containing PDCD4 (PDC...

journal_title：International journal of oncology

authors： Liu J,Zhai R,Zhao J,Kong F,Wang J,Jiang W,Xin Q,Xue X,Luan Y

更新日期：2018-05-01 00:00:00

abstract：:Recent studies have reported that chemically synthesized small activating RNA (saRNA) targeting the promoter regions of a gene can activate its expression in different cell lines. This technique can be a powerful therapeutic method for diseases caused by complete inactivation or reduced expression of specific genes. E...

journal_title：International journal of oncology

authors： Wu Z,Li Y,Li Z,Liu Z,Qin Z,Li X,Ye Y,Bu L,Lin B,Wang Z,Jia G,Chen G

更新日期：2016-10-01 00:00:00

abstract：:Hypoxia is an important factor of tumor microenvironment that significantly influences behaviour of tumor cells via activation of genes whose products are involved in adaptation to hypoxic stress, such as vascular endothelial growth factor (VEGF) and glucose transporter (GLUT-1). Carbonic anhydrase IX (CA IX) is one o...

journal_title：International journal of oncology

authors： Rafajová M,Zatovicová M,Kettmann R,Pastorek J,Pastoreková S

更新日期：2004-04-01 00:00:00

abstract：:The aminoacyl-tRNA synthetase interacting multi-functional protein 1 (AIMP1) participates in a variety of cellular processes, including translation, cell proliferation, inflammation and wound healing. Previously, we showed that the N-terminal peptide of AIMP1 (6-46 aa) induced ERK phosphorylation. Liver fibrosis is ch...

journal_title：International journal of oncology

authors： Ahn J,Son MK,Jung KH,Kim K,Kim GJ,Lee SH,Hong SS,Park SG

更新日期：2016-02-01 00:00:00

abstract：:Microsatellite instability (MSI) is an indicator of DNA instability and is caused by abnormalities in DNA mismatch repair (MMR) genes such as hMLH1, hMSH2 and hMSH6. MSI occurs frequently in endometrial cancer (in approximately 30% of cases), and accumulation of gene mutations due to MSI may therefore have a major rol...

journal_title：International journal of oncology

authors： Kawaguchi M,Banno K,Yanokura M,Kobayashi Y,Kishimi A,Ogawa S,Kisu I,Nomura H,Hirasawa A,Susumu N,Aoki D

更新日期：2009-11-01 00:00:00

abstract：:Periostin (POSTN) is a protein involved in multiple processes important for cancer development, both at the stage of cancer initiation and progression, as well as metastasis. The aim of this study was to determine the expression of POSTN in the cells of non-invasive ductal breast carcinoma in situ (DCIS) and invasive ...

journal_title：International journal of oncology

authors： Ratajczak-Wielgomas K,Grzegrzolka J,Piotrowska A,Matkowski R,Wojnar A,Rys J,Ugorski M,Dziegiel P

更新日期：2017-10-01 00:00:00

abstract：:The α6 integrin subunit (α6) has been implicated in cancer cell migration and in the progression of several malignancies, but its role in tumor angiogenesis is unclear. In mice, anti-α6 blocking antibodies reduce tumor angiogenesis, whereas Tie1-dependent α6 gene deletion enhances neovessel formation in melanoma and l...

journal_title：International journal of oncology

authors： Bouvard C,Segaoula Z,De Arcangelis A,Galy-Fauroux I,Mauge L,Fischer AM,Georges-Labouesse E,Helley D

更新日期：2014-11-01 00:00:00

abstract：:Although histone deacetylase (HDAC) inhibitors are emerging as a promising new treatment strategy in malignancy, how they exert their effect on human non-small cell lung cancer cells is as yet unclear. This study was undertaken to investigate the underlying mechanism of an HDAC inhibitor, Trichostatin A (TSA), -induce...

journal_title：International journal of oncology

authors： Choi YH

更新日期：2005-08-01 00:00:00

abstract：:5-Fluorouracil (5-FU), a fluoropyrimidine analogue, is one of the most commonly used anticancer drugs for the treatment of gastrointestinal malignancies. Some studies reported that the cytotoxicity of fluoropyrimidines is mediated, in large part, by inhibition of the thymidylate synthase (TS), an essential DNA synthet...

journal_title：International journal of oncology

authors： Matsuoka K,Tsukuda K,Suda M,Kobayashi K,Ota T,Okita A,Watanabe K,Suzuki E,Murakami M,Doihara H,Shimizu N

更新日期：2004-01-01 00:00:00

abstract：:A long-held central dogma of radiation biology has been that the carcinogenic effects of ionizing radiation (IR) are induced by the direct and radiolytic actions of IR on nuclear DNA. Numerous investigations, however, have revealed that several cancer relevant effects of IR can occur in cells that have received only c...

journal_title：International journal of oncology

authors： Goldberg Z,Lehnert BE

更新日期：2002-08-01 00:00:00

abstract：:We compared the responses of c-Jun/AP-1 transcriptional complexes with those of NF-kappa B, an established hypoxia-inducible transcriptional complex, in hypoxic SiHa human squamous carcinoma cells. We observed that NF-kappa B was activated rapidly, while AP-1 activation was detectable only after prolonged hypoxia. How...

journal_title：International journal of oncology

authors： Laderoute K,Calaoagan J,Mendonca H,Ausserer W,Chen E,Giaccia A,Sutherland R

更新日期：1996-05-01 00:00:00

abstract：:Most tissue microarray studies have used a single 0.6-mm tissue core per donor tissue. It has been suggested that multiple cores per donor can increase the representativity of tissue microarray studies. To estimate the potential benefit of multiple cores, we analyzed Ki67 and p53 in...

journal_title：International journal of oncology

authors： Tennstedt P,Köster P,Brüchmann A,Mirlacher M,Haese A,Steuber T,Sauter G,Huland H,Graefen M,Schlomm T,Minner S,Simon R

更新日期：2012-01-01 00:00:00

abstract：:Fucoidan, a sulfated polysaccharide, has significant cytotoxic activity against tumor cells; however, the mechanism(s) of this action remains poorly understood. The present study was designed to determine the in vitro and in vivo effects of fucoidan and their molecular mechanisms. F...

journal_title：International journal of oncology

authors： Takeda K,Tomimori K,Kimura R,Ishikawa C,Nowling TK,Mori N

更新日期：2012-01-01 00:00:00

abstract：:IL-10 has been shown to play a crucial role in immunosuppression in cancer patients. We explored the regulation of IL-10 production by TNF-alpha, IL-1 beta, IL-6, IL-8, and IFN-gamma in human colon carcinoma COLO205 cells. Northern analysis revealed a marked expression of IL-10 mRNA after stimulation by IL-6, and a ma...

journal_title：International journal of oncology

authors： Suzuki S,Mita S,Kamohara H,Sakamoto K,Ishiko T,Ogawa M

更新日期：2001-03-01 00:00:00

abstract：:This study examined whether the soluble tumor-associated-antigens (TAA), of 66 kDa and 51 kDa, could promote suppression by anticancer drugs of chemically-induced mammary tumorigenesis. Dimethylbenzanthracene (DMBA, 10 mg/rat, twice) was used to induce mammary tumors. Then, for nine more weeks, the preparation of TAA ...

journal_title：International journal of oncology

authors： Ben-Hur H,Kossoy G,Zusman I

更新日期：2001-08-01 00:00:00

abstract：:An ETS family member, ETS Related Gene (ERG) is involved in the Ewing family of tumors as well as leukemias. Rearrangement of the ERG gene with the TMPRSS2 gene has been identified in the majority of prostate cancer patients. Additionally, overexpression of ERG is associated with unfavorable prognosis in prostate canc...

journal_title：International journal of oncology

authors： Fortson WS,Kayarthodi S,Fujimura Y,Xu H,Matthews R,Grizzle WE,Rao VN,Bhat GK,Reddy ES

更新日期：2011-07-01 00:00:00

abstract：:The biological factors responsible for the increased aggressiveness in atypical meningiomas are not well known. The aim of this study is to evaluate the discriminatory value of a number of biological markers (S100 proteins and galectin-3 and its ligand profile) with respect to benign and atypical meningiomas. Using 63...

journal_title：International journal of oncology

authors： Hancq S,Salmon I,Brotchi J,Gabius HJ,Heizmann CW,Kiss R,Decaestecker C

更新日期：2004-11-01 00:00:00

abstract：:The Tap1 and Tap2 genes encoding for a heterodimeric peptide transporter play a key role in antigen processing and presentation. The TAP complex mediates the transport of peptides generated by the IFN-gamma-inducible proteasome subunits LMP2, 7 and 10 from the cytosol into the endoplasmic reticulum (ER), where they bi...

journal_title：International journal of oncology

authors： Seliger B,Bock M,Ritz U,Huber C

更新日期：2002-02-01 00:00:00

abstract：:Tumour cell surfaces possess a cell surface protease (GB), which can be recognised by a cytoplasmic inhibitor protein prepared from cultured tumour cells. This enzyme inhibitor complex has been shown to be reversibly dissociated by 10-(4)M sodium dodecyl sulphate. Sections of frozen tumour tissue were used to provide ...

journal_title：International journal of oncology

authors： Steven F,Griffin M,Blakey D

更新日期：1992-06-01 00:00:00

abstract：:There is emerging evidence for the prognostic role of various microRNA (miRNA) molecules in colon cancer. The aim of this study was therefore to compare the miRNA profiles in the primary tumor of patients with recurrent and non-recurrent colon cancer. The study population included 110 patients, 51 (46%) with stage I a...

journal_title：International journal of oncology

authors： Weissmann-Brenner A,Kushnir M,Lithwick Yanai G,Aharonov R,Gibori H,Purim O,Kundel Y,Morgenstern S,Halperin M,Niv Y,Brenner B

更新日期：2012-06-01 00:00:00

abstract：:The tumor suppressor protein p53 is one of the most important manipulators of the cell cycle. By interaction with targets such as WAF1/CIP1, mdm2 or GADD45 p53 functions as a negative or positive regulator of the cell cycle. After DNA damage p53 is implicated in growth arrest of cells in the G(1) phase of the cell cyc...

journal_title：International journal of oncology

authors： Gotz C,Montenarh M

更新日期：1995-05-01 00:00:00

abstract：:Following the publication of this article, an interested reader drew to our attention that Fig. 1C contained an important flaw. The Figure shows a western blot for LCN2, DR4, DR5, and actin, and it was noted that the identical bands shown for actin were also featured in a paper by the same authors published in 2017 [L...

journal_title：International journal of oncology

authors： Kim SL,Min IS,Park YR,Lee ST,Kim SW

更新日期：2019-05-01 00:00:00

abstract：:In the present study, we report the utility of transrectal ultrasonography guidance for laparoscopic radical prostatectomy (LRP), and the effect of a novel surgical approach of 'seven key elements of operative skill for the early recovery of urinary continence' ('7 key elements'). Among 170 patients who underwent lapa...

journal_title：International journal of oncology

authors： Azuma H,Ibuki N,Inamoto T,Koyama K,Utimoto S,Fujisue Y,Mizutani Y,Nomi H,Ubai T,Katsuoka Y

更新日期：2011-02-01 00:00:00

abstract：:We investigated the effect of stabilized Fab oligomerization by disuccinimidyl suberate on tumor uptake in a pancreatic carcinoma xenograft model in nude mice. Recombinant mouse/human chimeric Fab of the anti-carcinoembryonic antigen (CEA) monoclonal antibody A10, which was previously shown to react specifically with ...

journal_title：International journal of oncology

authors： Kamigaki T,Ajiki T,Yamamoto M,Kuroda Y

更新日期：1999-01-01 00:00:00