Expression of cell-associated isoform of vascular endothelial growth factor 189 and its prognostic relevance in non-small cell lung cancer.

abstract：:Vascular endothelial growth factor (VEGF), a secreted endothelial-specific growth factor, and microvessel density was examined in 204 primary non-small cell lung carcinomas. The expression of VEGF was evaluated by immunohistochemical staining using an anti-VEGF antibody. Positive staining was obtained in 125 out of 20...

journal_title：International journal of oncology

authors： Mattern J,Koomagi R,Volm M

更新日期：1995-05-01 00:00:00

abstract：:Epithelial-mesenchymal transition (EMT) is associated with tumor malignancy. The hedgehog-EMT pathway is preferentially activated in diffuse-type gastric cancer (GC) compared with intestinal-type GC; however, histological typing is currently the only method for distinguishing these two major types of GC. We compared t...

journal_title：International journal of oncology

authors： Tanabe S,Aoyagi K,Yokozaki H,Sasaki H

更新日期：2014-06-01 00:00:00

abstract：:Genetically engineered stem cells (GESTECs) producing suicide enzymes and immunotherapeutic cytokines have therapeutic effects on tumors, and may possibly reduce the side effects of toxic drugs used for treatments. Suicide enzymes can convert non-toxic pro-drugs to toxic metabolites that can reduce tumor growth. Cytos...

journal_title：International journal of oncology

authors： Kim KY,Yi BR,Lee HR,Kang NH,Jeung EB,Kim SU,Choi KC

更新日期：2012-04-01 00:00:00

abstract：:The murine double minute-2 (MDM2) gene encodes a 90 kDa protein which binds and inactivates the protein product of the p53 tumor suppressor gene. To elucidate the potential role of MDM2 in benign and malignant hyperproliferative conditions in the pancreas, we studied MDM2 expression in cultured human pancreatic cancer...

journal_title：International journal of oncology

authors： Ebert M,Yokoyama M,Kobrin M,Friess H,Buchler M,Korc M

更新日期：1994-12-01 00:00:00

abstract：:Early gastric cancers (EGC) may be subdivided into 2 groups by means of the use of mitotic index, apoptotic index and cell density: EGCs with high cell turnover and low cell density, which show high cell dissociation and, more frequently, lymph node invasion; EGCs with low cell turnover and high cell density. The same...

journal_title：International journal of oncology

authors： Spina D,Miracco C,Vindigni C,Gallorini M,Presenti L,Marrelli D,Roviello F,Pinto E,Filipe MI,Tosi P

更新日期：1998-04-01 00:00:00

abstract：:Tumour cell surfaces possess a cell surface protease (GB), which can be recognised by a cytoplasmic inhibitor protein prepared from cultured tumour cells. This enzyme inhibitor complex has been shown to be reversibly dissociated by 10-(4)M sodium dodecyl sulphate. Sections of frozen tumour tissue were used to provide ...

journal_title：International journal of oncology

authors： Steven F,Griffin M,Blakey D

更新日期：1992-06-01 00:00:00

abstract：:Overexpression of p185erbB2/neu has been demonstrated in approximately 30% of prostatic carcinomas and has been shown to induce tumorigenesis and metastasis in a prostatic epithelial cell line, NbE. To metastasize successfully, cells must be able to proliferate, degrade and be motile on a variety of substrates; thus a...

journal_title：International journal of oncology

authors： Vafa A,Zhang Y,Sikes RA,Marengo SR

更新日期：1998-12-01 00:00:00

abstract：:Seventy-one patients with metastatic colorectal carcinoma(CRC) were treated with varying doses of the mouse monoclonal antibody (MAb) 17-1A. One patient achieved a partial remission (PR) (1%) with a survival duration of 114+ months. Further 10 patients showed a minor response (MR) or stable disease > 3 months (SD) (14...

journal_title：International journal of oncology

authors： Ragnhammar P,Frodin J,Hjelm A,Fagerberg J,Wersall P,Lindemalm C,Nilsson B,Fox K,Magnusson I,Ewerth S,Thor K,Secher E,Mellstedt H

更新日期：1995-11-01 00:00:00

abstract：:Neoadjuvant chemotherapy with docetaxel for advanced breast cancer can improve the radicality for a subset of patients, but some patients suffer from severe adverse drug reactions without any benefit. To establish a method for predicting responses to docetaxel, we analyzed gene expression profiles of biopsy materials ...

journal_title：International journal of oncology

authors： Zembutsu H,Suzuki Y,Sasaki A,Tsunoda T,Okazaki M,Yoshimoto M,Hasegawa T,Hirata K,Nakamura Y

更新日期：2009-02-01 00:00:00

abstract：:To examine the possibility that chemical inducers of cytochrome P450 may have effects on the expression of oncogenes and a tumor suppressor gene, human colon LS174T cells were treated with different cytochrome P450 inducers such as benzanthracene (Ba), pyrazole (Pyr) and phenobarbital-hydrocortisone (Pb-Hc). Three for...

journal_title：International journal of oncology

authors： Vasquez H,Strobel H

更新日期：1996-09-01 00:00:00

abstract：:Previously we demonstrated that a mutated human prolactin (hPRL) with a single amino acid substitution at position 129 (hPRL-G129R) was able to inhibit human breast cancer cell proliferation via the induction of apoptosis. In this study, we report the in vivo anti-tumor effects of hPRL-G129R in nude mice bearing human...

journal_title：International journal of oncology

authors： Chen NY,Holle L,Li W,Peirce SK,Beck MT,Chen WY

更新日期：2002-04-01 00:00:00

abstract：:Angiogenesis plays a critical role in the development of solid tumors by supplying nutrients and oxygen to support continuous growth of tumor as well as providing an avenue for hematogenous metastasis. Tumor angiogenesis is highly regulated by multiple intracellular signaling transduction cascades such as Hedgehog, ST...

journal_title：International journal of oncology

authors： Lin J,Chen Y,Wei L,Hong Z,Sferra TJ,Peng J

更新日期：2013-11-01 00:00:00

abstract：:It is well documented that ultraviolet (UV) light-induced immune suppression and oxidative stress play an important role in the induction of skin cancers. Earlier, we have shown that topical treatment of silymarin, a plant flavonoid from milk thistle (Silybum marianum L. Gaertn.), to mouse skin prevents photocarcinoge...

journal_title：International journal of oncology

authors： Katiyar SK

更新日期：2002-12-01 00:00:00

abstract：:EMMPRIN (extracellular matrix metalloproteinase inducer)/CD147, a membrane-bound glycoprotein with two extracellular loop domains (termed loops I and II), progresses tumor invasion and metastasis by increasing the production of matrix metalloproteinase (MMP) in peritumoral stoma cel...

journal_title：International journal of oncology

authors： Sato T,Watanabe M,Hashimoto K,Ota T,Akimoto N,Imada K,Nomizu M,Ito A

更新日期：2012-01-01 00:00:00

abstract：:Evidence of circulating soluble DNA in blood-stream of cancer patients has emerged. Because the plasma DNA is largely derived from cancer cells, genetic analysis of plasma DNA is important to understand the molecular events occurred in cancer patient. Seven microsatellite markers in the soluble plasma DNA from patient...

journal_title：International journal of oncology

authors： Moriyama H,Matsubara N,Kanbara T,Mori M,Matsuoka J,Yoshino T,Takakura N,Shimizu K,Takaka N

更新日期：2002-11-01 00:00:00

abstract：:A new continuous cell line from a human malignant carcinoid of the small intestine (KRJ-I) was established. The cells showed morphological and immunocytochemical features of the tumor of origin and expressed estrogen receptors. The cells are growing as a suspension, forming multicellular aggregates and spheroids. Elec...

journal_title：International journal of oncology

authors： Pfragner R,Wirnsberger G,Niederle B,Behmel A,Rinner I,Mandl A,Wawrina F,Luo J,Adamiker D,Hoger H,Ingolic E,Schauenstein K

更新日期：1996-03-01 00:00:00

abstract：:CA IX is a tumor-associated transmembrane isoform of the carbonic anhydrase with a high enzyme activity and a functional involvement in the pH regulation and cell adhesion. Expression of CA9 gene in tumor cells is principally regulated by the high cell density and the hypoxia-related VHL-HIF pathway. In renal cell car...

journal_title：International journal of oncology

authors： Jakubicková L,Biesová Z,Pastoreková S,Kettmann R,Pastorek J

更新日期：2005-04-01 00:00:00

abstract：:Using two malignant rat glioma cell lines, we tested to what extent peripheral immunization could affect tumor growth in the brain of syngeneic rats. Peripheral subcutaneous (s.c.) immunization was performed with autologous Newcastle-disease-virus (NDV)-infected or non-infected live tumor cells. Thus immunized rats or...

journal_title：International journal of oncology

authors： Naujocks G,Schmitz A,Schramm J,Wiestler O,Schirrmacher V

更新日期：1995-04-01 00:00:00

abstract：:Galiximab is a primatized monoclonal antibody that targets CD80 expressed on malignant B cells and is being studied in the clinic as a potential treatment for follicular NHL. We have recently reported that galiximab signals B-NHL cells in vitro and inhibits cell growth and sensitizes resistant tumor cells to apoptosis...

journal_title：International journal of oncology

authors： Hariharan K,Chu P,Murphy T,Clanton D,Berquist L,Molina A,Ho SN,Vega MI,Bonavida B

更新日期：2013-08-01 00:00:00

abstract：:Cholangiocarcinoma (CCA) is a lethal malignancy which occurs with relatively high incidence in Thailand. This cancer is often difficult to diagnose and associated with high mortality. The secretome, containing the secreted proteins from cells, are potentially useful as biomarkers of cancers. Since three-dimensional (3...

journal_title：International journal of oncology

authors： Tit-Oon P,Chokchaichamnankit D,Khongmanee A,Sawangareetrakul P,Svasti J,Srisomsap C

更新日期：2014-11-01 00:00:00

abstract：:A camptothecin (CPT) formulation that can be easily administered, is less toxic, and has greater antitumor effect is needed. In this study, a water-soluble CPT derivative was obtained by direct coupling of CPT to poly(L-glutamic acid) (PG) through the C20(S)-hydroxyl group. CPT was released from the resulting conjugat...

journal_title：International journal of oncology

authors： Zou Y,Wu QP,Tansey W,Chow D,Hung MC,Charnsangavej C,Wallace S,Li C

更新日期：2001-02-01 00:00:00

abstract：:Structural maintenance of chromosome 1 alpha (SMC1A) gene has been reported to be related to tumor development in some types of human cancers. However, the misregulation of SMC1A and its functions in castration-resistant prostate cancer (CRPC) have not been well understood. In the present study, we found that SMC1A wa...

journal_title：International journal of oncology

authors： Pan XW,Gan SS,Ye JQ,Fan YH,Hong Υ,Chu CM,Gao Y,Li L,Liu X,Chen L,Huang Y,Xu H,Ren JZ,Yin L,Qu FJ,Huang H,Cui XG,Xu DF

更新日期：2016-11-01 00:00:00

abstract：:Bone morphogenetic protein 7 (BMP-7) is an important regulator of cell development and differentiation of various organs. Tumorigenesis and tumor progression are also strongly associated with changes of the fate of cells which are highly differentiated in healthy tissues. Therefore, we studied the role of BMP-7 in bre...

journal_title：International journal of oncology

authors： Schwalbe M,Sänger J,Eggers R,Naumann A,Schmidt A,Höffken K,Clement JH

更新日期：2003-07-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is difficult to diagnose early, resulting in only 30% resection rate. HCC is a relatively chemo-resistant tumor, molecular targeted therapy can only benefit approximately 30% patients with liver cancer. Bufalin (Bu) is one of the topoisomerase II inhibitors, many studies have recently fo...

journal_title：International journal of oncology

authors： Sheng X,Sun X,Sun K,Sui H,Qin J,Li Q

更新日期：2016-10-01 00:00:00

abstract：:Nestin is an intermediate filament protein and a stem cell marker expressed in several tumours. There is growing evidence of an association between the expression level of nestin and the pathogenesis of triple-negative breast cancer (TNBC). Nestin is also expressed in newly forming tumour vessels and is a valuable mar...

journal_title：International journal of oncology

authors： Nowak A,Grzegrzółka J,Kmiecik A,Piotrowska A,Matkowski R,Dzięgiel P

更新日期：2018-02-01 00:00:00

abstract：:The intensity of post-treatment melanoma patient follow-up varies widely among physicians. We investigated whether physician age accounts for the observed variation in surveillance intensity among plastic surgeons. A custom-designed questionnaire was mailed to USA and non-USA surgeons, all of whom were members of the ...

journal_title：International journal of oncology

authors： Margenthaler JA,Virgo KS,Johnson DY,Sugarbaker EM,Handler BS,Johnson FE

更新日期：2001-07-01 00:00:00

abstract：:IGF-2 mRNA binding protein 3 (IGF2BP3, IMP-3) is a well-known post-transcriptional regulatory factor of gene expression, mainly involved in embryonic development and oncogenesis. We have previously demonstrated that a subset of IMP-3 targets, such as the mRNAs of cyclins D1, D3 and G1, are positively regulated by IMP-...

journal_title：International journal of oncology

authors： Deforzh E,Vargas TR,Kropp J,Vandamme M,Pinna G,Polesskaya A

更新日期：2016-12-01 00:00:00

abstract：:Curcumin (diferulolylmethane), an active ingredient derived from the rhizome of the plant Curcuma longa, has anticancer activity in vitro and in vivo. Although curcumin possesses chemopreventive properties against several types of cancer, the molecular mechanisms by which it inhibits cell growth and induces apoptosis ...

journal_title：International journal of oncology

authors： Shankar S,Srivastava RK

更新日期：2007-04-01 00:00:00

abstract：:The mechanisms of invasion and metastasis are poorly understood. Our previous studies demonstrated that cancer cell invasion may result from reorganization of membrane molecules, thereby initiating signaling pathways. To increase our understanding on how cancer cells govern metastases we studied the established LNCaP ...

journal_title：International journal of oncology

authors： Van Slambrouck S,Jenkins AR,Romero AE,Steelant WF

更新日期：2009-06-01 00:00:00

abstract：:Malignant pleural mesothelioma (MPM) is an aggressive cancer for which more effective treatments are needed. In this study, strong to moderate staining of MET and ERK5 was detected in 67.1 and 48% of the analyzed 73 human mesothelioma tumors, and significant correlation of MET and ERK5 expression was identified (P<0.0...

journal_title：International journal of oncology

authors： Wang H,Dai YY,Zhang WQ,Hsu PC,Yang YL,Wang YC,Chan G,Au A,Xu ZD,Jiang SJ,Wang W,Jablons DM,You L

更新日期：2017-07-01 00:00:00