Myeloid cell leukemia-1 regulates the cell growth and predicts prognosis in gastric cancer.

abstract：:Midkine (MK) expression has been documented to be inversely correlated with the prognosis of patients with various tumors, but the mechanism of this relationship has not been well characterized. Recent studies have also correlated p53 expression with prognosis of patients with oral squamous cell carcinoma (OSCC). We e...

journal_title：International journal of oncology

authors： Ota K,Fujimori H,Ueda M,Jono H,Shinriki S,Ota T,Sueyoshi T,Taura M,Taguma A,Kai H,Shinohara M,Ando Y

更新日期：2010-10-01 00:00:00

abstract：:Proteasome activator 28γ (PA28γ) binds to and activates the proteasome in an ATP-independent manner to promote mainly ubiquitin-independent protein degradation in cells. Previously, four transcript variants of PA28γ have been identified, which have been closely correlated with the progression of cancers. In the presen...

journal_title：International journal of oncology

authors： Xu X,Liu D,Ji N,Li T,Li L,Jiang L,Li J,Zhang P,Zeng X,Chen Q

更新日期：2015-07-01 00:00:00

abstract：:In this study tumor-specific CTL effector and memory responses were analyzed in normal mice, in tumor bearing mice and in animals treated by active specific immunotherapy (ASI) with an autologous virus modified tumor vaccine. In the well defined DBA/2 mouse lymphoma model ESb, the tumor specific CTL response requires ...

journal_title：International journal of oncology

authors： Schirrmacher V

更新日期：1999-08-01 00:00:00

abstract：:Autocrine/paracrine stimulation of KIT has been observed in colorectal carcinoma (CRC) cell lines. We investigated the expression of KIT and stem cell factor (SCF) in CRC in comparison with premalignant colon lesions and normal colonic mucosa to assess the prognostic and therapeutic relevance of this receptor/ligand s...

journal_title：International journal of oncology

authors： Bellone G,Smirne C,Carbone A,Buffolino A,Scirelli T,Prati A,Solerio D,Pirisi M,Valente G,Nano M,Emanuelli G

更新日期：2006-10-01 00:00:00

abstract：:Frizzled (FZD) genes encode receptors for WNTs, which play key roles in carcinogenesis and embryogenesis. We have previously cloned the FZD10 gene, and demonstrated up-regulation of FZD10 mRNA in the cervical cancer cell line HeLa S3, gastric cancer cell lines TMK1 and MKN74, and 4 cases out of 10 cases of primary gas...

journal_title：International journal of oncology

authors： Saitoh T,Mine T,Katoh M

更新日期：2002-01-01 00:00:00

abstract：:Retroviral reverse transcriptase (RT) plays a definite role in retroviral life cycle and is essential for the process of retrotransposition. We investigated the RNA expression of endogenous reverse transcriptases (enRTs) in the NIH3T3 mouse genome using, as a probe, a mixture of RT-PCR generated reverse transcriptase ...

journal_title：International journal of oncology

authors： Tzavaras T,Eftaxia S,Tavoulari S,Hatzi P,Angelidis C

更新日期：2003-10-01 00:00:00

abstract：:From January 1992 to December 1995, 129 patients with previously untreated non-Hodgkin's lymphoma were randomised in a phase III multicenter trial to receive CEOP-B/VIMB or ProMACE-CytaBOM. Eligibility criteria included intermediate or high grade lymphoma (follicular large cell, diffuse small cleaved-cell, diffuse mix...

journal_title：International journal of oncology

authors： Lorusso V,Palmieri G,Bianco AR,Abate G,Catalano G,De Vita F,Dammacco F,Lauta VM,Lucarelli G,Polimeno G,Mantovani G,D'Aprile M,Marzullo F,De Lena M

更新日期：2000-01-01 00:00:00

abstract：:Overexpression of either of the multidrug resistance genes MDR1 and MRP is associated with resistance of tumors to multiple chemotherapeutic agents. Overexpression of MDR1 has been reported in some cell lines derived from human hepatocellular carcinomas (HCC) and hepatoblastomas (HB). The human gene for cMOAT (

journal_title：International journal of oncology

authors： Minemura M,Tanimura H,Tabor E

更新日期：1999-09-01 00:00:00

abstract：:Hepatocyte growth factor (HGF) is a key growth factor linked to promoting cancer progression and angiogenesis. The present study identifies repulsive guidance molecule b (RGMb), a bone morphogenetic protein (BMP) co-receptor, as a gene whose expression is regulated by HGF and explores the potential of RGMb to contribu...

journal_title：International journal of oncology

authors： Sanders AJ,Ye L,Li J,Mason MD,Jiang WG

更新日期：2014-09-01 00:00:00

abstract：:Primary intracerebral lymphoma is an uncommon presenting site for non-Hodgkin's lymphoma. The authors review 28 histopathologically confirmed, consecutive cases, presenting over a 15-year period. The cohort included 20 males and 8 females with a mean age at diagnosis of 54 years (range 27-75 years). Subtotal resection...

journal_title：International journal of oncology

authors： Hough RE,Smith CM,Nakielny RA,Robinson MH,Jacubowski J,Lorigan PC,Hancock BW

更新日期：1999-04-01 00:00:00

abstract：:TGF-β-induced epithelial-mesenchymal transition (EMT) plays an important role in tumor progression. We assessed whether the TGF-β-induced EMT contributed to vasculogenic mimicry (VM) formation in glioma, we established an SHG44 cell line stably transfected with TGF-β cDNA loaded lentivirus. SB203580 was employed to in...

journal_title：International journal of oncology

authors： Ling G,Ji Q,Ye W,Ma D,Wang Y

更新日期：2016-12-01 00:00:00

abstract：:Experimental evidence indicates that prostate apoptosis response-4 (Par-4, also known as PAWR) is a key regulator of cancer cell survival and may be a target for cancer-selective targeted therapeutics. Par-4 was first identified in prostate cancer cells undergoing apoptosis. Both intracellular and extracellular Par-4 ...

journal_title：International journal of oncology

authors： Pereira MC,de Bessa-Garcia SA,Burikhanov R,Pavanelli AC,Antunes L,Rangnekar VM,Nagai MA

更新日期：2013-08-01 00:00:00

abstract：:Human telomerase is a ribonucleoprotein DNA polymerase which maintains the telomeric region of human chromosomes and has been detected in all types of human cancer tested. We used the telomeric repeat amplification protocol (TRAP) assay to examine 71 non-small cell lung carcinomas (NSCLC) and their adjacent normal tis...

journal_title：International journal of oncology

authors： Xinarianos G,Scott FM,Liloglou T,Prime W,Callaghan J,Gosney JR,Field JK

更新日期：1999-11-01 00:00:00

abstract：:Smac/DIABLO promotes apoptosis by antagonizing inhibitor of apoptosis proteins. The expression of Smac/DIABLO in tissues has been reported in various cancers; however, little is known about circulating levels of Smac/DIABLO. The present study was designed to first determine if Smac/...

journal_title：International journal of oncology

authors： Mizutani Y,Katsuoka Y,Bonavida B

更新日期：2012-04-01 00:00:00

abstract：:Acquirement of multi-drug resistance by tumor cells represents a major obstacle in the management of prostate cancer. Such resistance was demonstrated in the androgen-independent DU-145 cells in response to paclitaxel and the mechanisms by which these cell develops resistance was not understood. The objective of this ...

journal_title：International journal of oncology

authors： Flynn V Jr,Ramanitharan A,Moparty K,Davis R,Sikka S,Agrawal KC,Abdel-Mageed AB

更新日期：2003-08-01 00:00:00

abstract：:Cowden's disease (CD) is an autosomal dominant disorder which confers a high susceptibility to diverse benign and malignant tumors. The PTEN (phosphatase and tensin homologue deleted in chromosome ten) gene has been identified as a tumor suppressor gene responsible for cancers of the endometrium, ovary, prostate, and ...

journal_title：International journal of oncology

authors： Kato N,Kimura K,Sugawara H,Aoyagi S,Ikeda T,Horii A

更新日期：2001-05-01 00:00:00

abstract：:We demonstrated previously that rat ascites hepatoma MM1 cells require both lysophosphatidic acid (LPA) and fibronectin (FN) for phagokinetic motility and transcellular migration and that these events are regulated through the RhoA-ROCK pathway and tyrosine phosphorylation of proteins including focal adhesion kinase (...

journal_title：International journal of oncology

authors： Mukai M,Iwasaki T,Tatsuta M,Togawa A,Nakamura H,Murakami-Murofushi K,Kobayashi S,Imamura F,Inoue M

更新日期：2003-06-01 00:00:00

abstract：:Secondary metabolites from actinomycetes especially the genus Streptomyces may be one of the most important sources for novel anticancer agents. A purified fraction from a novel actinomycete strain, Streptomyces sp. H7372, was elucidated in breast cancer cells. We have isolated three purified fractions from a novel st...

journal_title：International journal of oncology

authors： Yip WK,Cheenpracha S,Chang LC,Ho CC,Seow HF

更新日期：2010-11-01 00:00:00

abstract：:Conventional diagnosis of prostate cancer does not appear to be sensitive enough to differentiate pre-operatively between organ-confined and extracapsular disease. New technologies, arising from the field of molecular biology, have been introduced to improve diagnosis and their implementation into the clinical practic...

journal_title：International journal of oncology

authors： Schamhart DH,Maiazza R,Kurth KH

更新日期：2005-03-01 00:00:00

abstract：:SK-N-SH human neuroblastoma cell line was employed to test whether direct introduction of the RII beta subunit of PKA could induce growth inhibition and reverse-transformation of cancer cells. We infected SK-N-SH cells with an RII beta expression construct and the clonal line with the highest expression level was sele...

journal_title：International journal of oncology

authors： Kim S,Lee G,Chochung Y,Park S,Hong S

更新日期：1996-04-01 00:00:00

abstract：:Hepatocellular carcinoma is the most frequent liver cancer and hepatitis B virus is included among the risk factors for the development of this type of neoplasia. Direct detection of this virus is difficult due to the lack of a simple tissue culture system for growing the virus. Amplification of HBV nucleic acid seque...

journal_title：International journal of oncology

authors： Haliassos A,Arvanitis D,Parliaras J,Spandidos D

更新日期：1992-07-01 00:00:00

abstract：:Alternative polyadenylation and microRNA regulation are both mechanisms of post-transcriptional regulation of gene expression. Alternative polyadenylation often results in mRNA isoforms with the same coding sequence but different lengths of 3' UTRs, while microRNAs regulate gene expression by binding to specific mRNA ...

journal_title：International journal of oncology

authors： An J,Zhu X,Wang H,Jin X

更新日期：2013-10-01 00:00:00

abstract：:We examined the effects of suppressing multidrug resistance-associated protein (MRP) and multidrug resistance 1 (MDR1) gene expression in HCT-8DDP human colon cancer cell lines, which showed both cisplatin and multidrug resistance. Hammerhead ribozymes, designed to cleave MRP mRNA (anti-MRP Rz) and MDR1 mRNA (anti-MDR...

journal_title：International journal of oncology

authors： Nagata J,Kijima H,Hatanaka H,Asai S,Miyachi H,Abe Y,Yamazaki H,Nakamura M,Watanabe N,Mine T,Kondo T,Scanlon KJ,Ueyama Y

更新日期：2002-11-01 00:00:00

abstract：:Matrix metalloproteinases (MMPs) play a key role in events related to tumor cell invasion and growth. Therefore, we examined tumor tissue samples from 12 individuals with invasive breast cancer for the expression and localization of MMP-1, -2, -3 and -9. These were detected by immunohistochemistry. Simultaneously in t...

journal_title：International journal of oncology

authors： Bachmeier BE,Rohrbach H,De Waal J,Jochum M,Nerlich AG

更新日期：2005-05-01 00:00:00

abstract：:Extrahepatic cholangiocarcinoma (CC) is an aggressive malignancy with dismal prognosis and characterized by early invasion, metastasis and postoperative recurrence. Therefore, understanding the main molecular mechanisms of this malignancy is the key for the development of novel and effective therapeutic strategies for...

journal_title：International journal of oncology

authors： Qiang Y,Wang F,Yan S,Zhang H,Zhu L,Chen Z,Tu F,Wang D,Wang G,Wang W,Chen Z

更新日期：2015-01-01 00:00:00

abstract：:Endosialin emerged recently as a potential therapeutic target for sarcoma. Since some sarcoma subtypes, such as Ewing's sarcoma, show characteristics of neuroendocrine differentiation, we wondered whether cancers with neuro-endocrine properties and/or neuroectodermal origin, such as neuroblastoma, small cell lung canc...

journal_title：International journal of oncology

authors： Rouleau C,Smale R,Sancho J,Fu YS,Kurtzberg L,Weber W,Kruger A,Jones C,Roth S,Bormann C,Dunham S,Krumbholz R,Curiel M,Wallar G,Mascarello J,Campos-Rivera J,Horten B,Schmid S,Miller G,Teicher BA

更新日期：2011-10-01 00:00:00

abstract：:Using a transdisciplinary methodological approach we have conducted a multifactorial analysis in Martinique and Guadeloupe in order to elucidate the aetiology of prostate cancer. In 2002, world age standardized rates of prostate cancer were 152 new cases per 100,000 person-years in the two islands; one of the highest ...

journal_title：International journal of oncology

authors： Belpomme D,Irigaray P,Ossondo M,Vacque D,Martin M

更新日期：2009-04-01 00:00:00

abstract：:To overcome the poor tumor transduction efficiency of adenovirus serotype 5 (Ad5) observed in several types of cancer, the fiber region of Ad5, apart from its tail, was replaced by adenovirus serotype 35 (Ad35). The chimeric Ad5/F35 adenoviral vector did not exhibit any significant enhancement of transduction efficien...

journal_title：International journal of oncology

authors： Kim SY,Kang S,Song JJ,Kim JH

更新日期：2013-04-01 00:00:00

abstract：:The Liverpool Lung Project (LLP) is being conducted within a defined geographic area of Merseyside, based on contiguous districts with a high incidence of lung cancer. As well as increasing the scientific understanding of the interactions between the different risk factors for lung cancer, the LLP aims to develop a mo...

journal_title：International journal of oncology

authors： Field JK,Smith DL,Duffy S,Cassidy A

更新日期：2005-12-01 00:00:00

abstract：:The protease-activated receptor-2 (PAR-2) is a G protein-coupled receptor that is cleaved and activated by trypsin and tryptase. The purpose of this study was to clarify the role of PAR-2 in proliferation of human pancreatic cancer cells. PAR-2 mRNA and protein expression were detected by RT-PCR and Western blotting i...

journal_title：International journal of oncology

authors： Shimamoto R,Sawada T,Uchima Y,Inoue M,Kimura K,Yamashita Y,Yamada N,Nishihara T,Ohira M,Hirakawa K

更新日期：2004-06-01 00:00:00