Abstract:
:A major limitation of cancer chemotherapy is development of resistance. In this study, we analyzed KB-3-1 cells and adriamycin-selected multidrug resistant sublines KB-A1 and KB-A10 cells for mechanisms of resistance. KB-A10 cells are 10-fold more resistant than KB-A1 cells but have lower P-glycoprotein. Of the known mechanisms of multidrug resistance, topoisomerase II and lung-resistance-related protein were altered between the resistant cell lines. Glutathione-S-transferase activity and multidrug-resistance-related protein levels were higher in the resistant cell lines compared to the sensitive cells but were similar in KB-A1 and KB-A10 cells. Results indicate differential regulation of mechanisms of resistance with stepwise selection.
journal_name
Int J Oncoljournal_title
International journal of oncologyauthors
Villagra L,Darling A,Yassa D,Scheper R,Tritton T,Bhushan Adoi
10.3892/ijo.11.5.1025subject
Has Abstractpub_date
1997-11-01 00:00:00pages
1025-33issue
5eissn
1019-6439issn
1791-2423journal_volume
11pub_type
杂志文章abstract::Nonsteroidal anti-inflammatory drugs (NSAIDs) are known to induce apoptosis in a variety of cancer cells, including colon, prostate, breast and leukemia. Among them, aspirin, a classical NSAID, shows promise in cancer therapy in certain types of cancers. We hypothesized that aspirin...
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