Tetramethypyrazine inhibits renal cell carcinoma cells through inhibition of NKG2D signaling pathways.

abstract：:The aim of this study was to determine the prevalence of human papillomavirus (HPV) in patients with laryngeal benign lesions (LBLs) and laryngeal squamous cell carcinomas (LSCCs) using a sensitive E6/E7 type-specific PCR. Paraffin-embedded samples from LBL (n=39) and LSCC patients (n=67) were evaluated for the presen...

journal_title：International journal of oncology

authors： Duray A,Descamps G,Arafa M,Decaestecker C,Remmelink M,Sirtaine N,Ernoux-Neufcoeur P,Mutijima E,Somja J,Depuydt CE,Delvenne P,Saussez S

更新日期：2011-07-01 00:00:00

abstract：:Growth factors may play a role in autocrine or paracrine growth control of tumour cells. We have now examined the expression pattern in vivo by in situ hybridization (ISH) on a series of 13 ductal adenocarcinomas of the pancreas using the non-radioactive digoxigenin system to generate specific antisense orientated rib...

journal_title：International journal of oncology

authors： Leung H,Hughes C,Kloppel G,Williamson R,Lemoine N

更新日期：1994-06-01 00:00:00

abstract：:Previously we demonstrated that a mutated human prolactin (hPRL) with a single amino acid substitution at position 129 (hPRL-G129R) was able to inhibit human breast cancer cell proliferation via the induction of apoptosis. In this study, we report the in vivo anti-tumor effects of hPRL-G129R in nude mice bearing human...

journal_title：International journal of oncology

authors： Chen NY,Holle L,Li W,Peirce SK,Beck MT,Chen WY

更新日期：2002-04-01 00:00:00

abstract：:Pulmonary adenocarcinoma (PAC) is the leading type of lung cancer and is highly resistant to conventional cancer therapy. A better understanding of the regulatory mechanisms which control the growth of this deadly malignancy are urgently needed to develop more effective cancer intervention strategies. Recent studies h...

journal_title：International journal of oncology

authors： Schuller HM,Plummer HK 3rd,Bochsler PN,Dudric P,Bell JL,Harris RE

更新日期：2001-09-01 00:00:00

abstract：:Following the publication of this article, an interested reader drew to our attention that Fig. 1C contained an important flaw. The Figure shows a western blot for LCN2, DR4, DR5, and actin, and it was noted that the identical bands shown for actin were also featured in a paper by the same authors published in 2017 [L...

journal_title：International journal of oncology

authors： Kim SL,Min IS,Park YR,Lee ST,Kim SW

更新日期：2019-05-01 00:00:00

abstract：:The aim of the present review was to summarize the current knowledge of the involvement of nestin in breast cancer (BC) pathogenesis. Nestin is a member of the class VI family of intermediate filament proteins, originally identified as a marker of neural stem cells and subsequently demonstrated to be expressed in BC a...

journal_title：International journal of oncology

authors： Nowak A,Dziegiel P

更新日期：2018-08-01 00:00:00

abstract：:The development of targeted molecular therapies has greatly benefited patients with lung adenocarcinomas. In contrast, these treatments have had little benefit in the management of lung squamous cell carcinoma (lung SCC). Therefore, new treatment options based on current genomic approaches are needed for lung SCC. Abe...

journal_title：International journal of oncology

authors： Kumamoto T,Seki N,Mataki H,Mizuno K,Kamikawaji K,Samukawa T,Koshizuka K,Goto Y,Inoue H

更新日期：2016-11-01 00:00:00

abstract：:Conjugated linoleic acid (CLA) refers to a group of naturally occurring positional and geometrical conjugated dienoic isomers of linoleic acid (C18:2), of which the cis-9,trans-11 (c9,t11) and trans-10,cis-12 (t10,c12) isomers predominate. Accumulating evidence has demonstrated that CLA isomers are capable of inhibiti...

journal_title：International journal of oncology

authors： Lui OL,Mak NK,Leung KN

更新日期：2005-12-01 00:00:00

abstract：:MicroRNAs (miRNAs) are small non-coding, endogenous, single-stranded RNAs. MiRNAs have been implicated in different areas such as the immune response, neural development, DNA repair, apoptosis, oxidative stress response and cancer. However, while the majority of miRNAs are found int...

journal_title：International journal of oncology

authors： Allegra A,Alonci A,Campo S,Penna G,Petrungaro A,Gerace D,Musolino C

更新日期：2012-12-01 00:00:00

abstract：:p73 has been shown to transcriptionally activate genes positively responsive to wild-type p53. In order to undertake a comparative study of functions of p53 and p73 we have cloned the cDNA of p73 from MCF-7 cells. Adenovirus onco-protein E1A inhibits the transactivation by p73; a deletion mutant of E1A incapable of in...

journal_title：International journal of oncology

authors： Deb D,Lanyi A,Scian M,Keiger J,Brown DR,Le Roith D,Deb SP,Deb S

更新日期：2001-02-01 00:00:00

abstract：:Primary hyperparathyroidism is a common endocrine disease with a multifaceted genetic background, the elucidation of which has only begun. Among others, loss of the short arm of chromosome 1 and somatic inactivation of the multiple endocrine neoplasia type 1 gene (MEN1) in 11q13 represent significant alterations in th...

journal_title：International journal of oncology

authors： Välimäki S,Forsberg L,Farnebo LO,Larsson C

更新日期：2002-10-01 00:00:00

abstract：:Voltage-gated potassium (Kv) channels play important roles in differentiation and growth of non-excitable cells. Inhibition of these channels is also known to suppress proliferation of various cancer cells. Here we examine expression of K+ channel subunit genes in various uterine cancer cells and their roles in cell p...

journal_title：International journal of oncology

authors： Suzuki T,Takimoto K

更新日期：2004-07-01 00:00:00

abstract：:Chromosomal aneuploidy is associated with invasive bladder cancer and one of the genes implicated in these changes is Aurora-A/STK15/BTAK, that is localized on chromosome 20q13 and encodes a centrosome-associated serine/threonine kinase. To better understand the association between Aurora-A/STK15 expression, tumor ane...

journal_title：International journal of oncology

authors： Fraizer GC,Diaz MF,Lee IL,Grossman HB,Sen S

更新日期：2004-12-01 00:00:00

abstract：:The molecular basis of host-tumor interaction in HLA-A31+ cancer patients has not been well understood. This lack of clarification is hampering the development of specific immunotherapies for these patients. This study aimed to identify a set of CTL-epitope peptides applicable for the specific immunotherapy of cancer ...

journal_title：International journal of oncology

authors： Takedatsu H,Shichijo S,Azuma K,Takedatsu H,Sata M,Itoh K

更新日期：2004-02-01 00:00:00

abstract：:The objective of these studies was to examine the murine pharmacokinetics, pharmacodynamics and metabolism of (3-(1H-indol-2-yl)phenyl)(1H-indol-2-yl)methanone (Indole 15), a novel tubulin inhibitor for the treatment of cancer. We developed HPLC and LC/MS/MS assays to quantitate Indole 15 and characterize its metaboli...

journal_title：International journal of oncology

authors： Yang J,Ahn S,Wu Z,Hwang DJ,Miller DD,Dalton JT

更新日期：2012-07-01 00:00:00

abstract：:Five retinoblastoma tumours from patients treated in the King Khaled Eye Specialist Hospital in Riyadh were analysed for mutations in the RB1 gene using single strand conformation polymorphism analysis and mutations were found in all of them. In one tumour the mutation in exon 11 was homozygous demonstrating the role ...

journal_title：International journal of oncology

authors： Su G,Senft S,Cowell J

更新日期：1995-03-01 00:00:00

abstract：:Mutational inactivation of the cyclin-dependent kinase inhibitors (CDKIs) (p16CDKN2a) tumor suppressor gene has been found in a variety of human tumor types. To investigate the involvement of CDKI abnormality in clear cell chondrosarcoma, alterations of CDKIs were examined in clear cell chondrosarcoma tissues using a ...

journal_title：International journal of oncology

authors： Park YK,Cho CH,Chi SG,Han CS,Ushigome S,Unni KK

更新日期：2001-10-01 00:00:00

abstract：:On the basis of the gene expression profiles of 120 lung cancer cases using a cDNA microarray containing 27,648 genes or expressed sequence tags (ESTs), we identified LRRC42 (Leucine-rich repeat containing 42) to be significantly upregulated in the majority of lung cancers. Northern blot analysis demonstrated that LRR...

journal_title：International journal of oncology

authors： Fujitomo T,Daigo Y,Matsuda K,Ueda K,Nakamura Y

更新日期：2014-07-01 00:00:00

abstract：:The non-invasive treatment of tumors with preserved fertility holds great promise. The application of pulsed electric field (PEF) is a new biomedical engineering technique for tumor therapy. Picosecond pulsed electric fields (psPEF) can be transferred to target deep tissue non-invas...

journal_title：International journal of oncology

authors： Chen WJ,Xiong ZA,Zhang M,Yao CG,Zhao ZY,Hua YY,Zhou W

更新日期：2013-03-01 00:00:00

abstract：:A group of 133 primary oral squamous cell carcinomas were studied concerning a relationship between exposure factors and tumour biological parameters with a focus on the TP53 gene and p53 protein status. Tumours were evaluated using immunohistochemistry (IHC) for expression of p53, PCNA, Ki-67 and bcl-2 proteins. The ...

journal_title：International journal of oncology

authors： Schildt EB,Nylander K,Eriksson M,Hardell L,Magnusson A,Roos G

更新日期：2003-04-01 00:00:00

abstract：:CD44 is a marker of cancer stem cells in head and neck squamous cell carcinoma, and CD44 expression is related to prognosis in cancer patients. We examined whether herbal medicine components affect CD44 expression and induce cancer cell apoptosis. Baicalin enhanced apoptosis with no effect on CD44 levels, while baical...

journal_title：International journal of oncology

authors： Ohkoshi E,Umemura N

更新日期：2017-02-01 00:00:00

abstract：:Dendritic cells (DCs) are powerful antigen-presenting cells (APCs), that have so far been applied for cancer specific immunotherapy. Recent results suggest that matured DCs derived from human monocytes have a significant impact on the outcome of vaccination. The conventional generation of mature DCs from human monocyt...

journal_title：International journal of oncology

authors： Tanaka F,Yamaguchi H,Haraguchi N,Mashino K,Ohta M,Inoue H,Mori M

更新日期：2006-11-01 00:00:00

abstract：:Polymerase chain reaction (PCR) has been reported as one of the most efficient techniques to detect hepatitis C virus (HCV) RNA. The determination of the specificity of PCR products is usually based on 'nested' PCR, Southern blotting and hybridization of the amplified DNA to radioactive oligonucleotide probes recogniz...

journal_title：International journal of oncology

authors： Bianchi N,Mischiati C,Feriotto G,Gambari R

更新日期：1994-04-01 00:00:00

abstract：:Lipomas are the most common soft tissue tumors in adults. They often carry chromosome aberrations involving 12q13~15 leading to rearrangements of the HMGA2 gene in 12q14.3, with breakpoints occurring within or outside of the gene. Here, we present eleven lipomas and one osteochondrolipoma with a novel recurrent chromo...

journal_title：International journal of oncology

authors： Panagopoulos I,Gorunova L,Bjerkehagen B,Lobmaier I,Heim S

更新日期：2015-09-01 00:00:00

abstract：:The biological processes of cancer cells such as tumorigenesis, proliferation, angiogenesis, apoptosis and invasion are greatly influenced by the surrounding microenvironment. The ability of solid malignant tumors to alter the microenvironment represents an important characteristic through which tumor cells are able t...

journal_title：International journal of oncology

authors： Zhang X,Huang S,Guo J,Zhou L,You L,Zhang T,Zhao Y

更新日期：2016-05-01 00:00:00

abstract：:The hypoxia-inducible transcription factor, HIF-1, adapts cells to low oxygen tension. In addition to the activation of angiogenesis by induction of VEGF, HIF-1 may trigger hypoxia-induced growth arrest and apoptosis. The aim of this study was to analyze the overall effect of HIF-1 on tumor growth in a mouse model, em...

journal_title：International journal of oncology

authors： Savai R,Schermuly RT,Voswinckel R,Renigunta A,Reichmann B,Eul B,Grimminger F,Seeger W,Rose F,Hänze J

更新日期：2005-08-01 00:00:00

abstract：:Both chemical and physical carcinogens are potent inducers of asynchronous replication of various DNA tumor viruses. Employing H3 cells that carry an integrated copy of polyoma virus we have evaluated potential effects of known chemopreventive agents on carcinogen-induced polyoma DNA replication. The ability of well e...

journal_title：International journal of oncology

authors： Foiles P,Miglietta L,Dolan L,Elbayoumy K,Ronai Z

更新日期：1993-03-01 00:00:00

abstract：:We studied the mechanism by which the para and meta positional isomers of nitric oxide-donating aspirin (NO-ASA) inhibit human colon cancer cell growth. These compounds are promising chemopreventive agents and represent a broader class of novel drugs. The two isomers differ drastically in their 24-h IC50s for cell gro...

journal_title：International journal of oncology

authors： Hua A,Mackenzie GG,Rigas B

更新日期：2009-10-01 00:00:00

abstract：:Temozolomide (TMZ) is an alkylating chemotherapeutic agent widely used in anti-glioma treatment. However, acquired TMZ resistance represents a major clinical challenge that leads to tumor relapse or progress. This study investigated the genomic profiles including long non-coding RNA (lncRNA) and mRNA expression associ...

journal_title：International journal of oncology

authors： Zeng H,Xu N,Liu Y,Liu B,Yang Z,Fu Z,Lian C,Guo H

更新日期：2017-08-01 00:00:00

abstract：:Investigators have shown that green tea may decrease the risk of cancer. It is widely accepted that the main active component of green tea is EGCG (epigallocatechin-3-gallate). In our previous study, we examined the effect of green tea on breast cancer growth and endothelial cells both in in vitro assays and in animal...

journal_title：International journal of oncology

authors： Sartippour MR,Heber D,Zhang L,Beatty P,Elashoff D,Elashoff R,Go VL,Brooks MN

更新日期：2002-09-01 00:00:00