Low incidence of genetic alterations of the p16CDKN2a in clear cell chondrosarcoma.


:Mutational inactivation of the cyclin-dependent kinase inhibitors (CDKIs) (p16CDKN2a) tumor suppressor gene has been found in a variety of human tumor types. To investigate the involvement of CDKI abnormality in clear cell chondrosarcoma, alterations of CDKIs were examined in clear cell chondrosarcoma tissues using a quantitative DNA/PCR, PCR-SSCP. Two of 38 specimens (5.2%) we analyzed showed abnormally low levels of p16CDKN2a amplification, suggesting that the allelic deletion of the gene might be low frequent event in progression of this tumor. For detection of subtle sequence alterations such as point mutations, we performed SSCP analysis of the entire coding region of the p16CDKN2a gene. No altered SSCP patterns were found in 38 clear cell chondrosarcoma specimens. This study reflects the very low incidence of genetic alterations of the p16CDKN2a gene in clear cell chondrosarcoma. Therefore, we conclude that the alteration of the p16CDKN2a gene is not involved significantly in the development of clear cell chondrosarcoma.


Int J Oncol


Park YK,Cho CH,Chi SG,Han CS,Ushigome S,Unni KK





Has Abstract


2001-10-01 00:00:00












  • The mechanism of epithelial-mesenchymal transition induced by TGF-β1 in neuroblastoma cells.

    abstract::Neuroblastoma is the second most common extracranial malignant solid tumor that occurs in childhood, and metastasis is one of the major causes of death in neuroblastoma patients. The epithelial-mesenchymal transition (EMT) is an important mechanism for both the initiation of tumor invasion and subsequent metastasis. T...

    journal_title:International journal of oncology

    pub_type: 杂志文章


    authors: Shao JB,Gao ZM,Huang WY,Lu ZB

    更新日期:2017-05-01 00:00:00

  • Genomic characterization of five commonly used endometrial cancer cell lines.

    abstract::Recently, the compilation of massive amounts of genetic and genomic information on a wide variety of human cancer types, collectively known as The Cancer Genome Atlas (TCGA), has revealed a wealth of descriptive classification schemes both within and between different types and sources of cancer. In endometrial cancer...

    journal_title:International journal of oncology

    pub_type: 杂志文章


    authors: Devor EJ,Gonzalez-Bosquet J,Thiel KW,Leslie KK

    更新日期:2020-12-01 00:00:00

  • PNA-mediated modulation and redirection of Her-2 pre-mRNA splicing: specific skipping of erbB-2 exon 19 coding for the ATP catalytic domain.

    abstract::The Her-2 receptor coded for by the proto-oncogenic erbB-2 gene is a clinically validated target for treatment of a significant genetic subclass of breast cancers, and Her-2 is also overexpressed or mutated in a range of other cancers. In an approach to exploit antisense mediated splicing interference as a means of ma...

    journal_title:International journal of oncology

    pub_type: 杂志文章


    authors: Pankratova S,Nielsen BN,Shiraishi T,Nielsen PE

    更新日期:2010-01-01 00:00:00

  • Induction of differentiation accompanies inhibition of Cdk2 in a non-small cell lung cancer cell line.

    abstract::Induction of differentiation in a variety of model systems is accompanied by cell cycle exit and inhibition of Cdk2 kinase activity. We asked whether inhibition of Cdk2 activity is sufficient to allow differentiation to occur in a non-small cell lung cancer cell line. Treatment of NCI-H358 with flavopiridol, an inhibi...

    journal_title:International journal of oncology

    pub_type: 杂志文章


    authors: Lee HR,Chang TH,Tebalt MJ 3rd,Senderowicz AM,Szabo E

    更新日期:1999-07-01 00:00:00

  • Association between different levels of lipid metabolism‑related enzymes and fatty acid synthase in Wilms' tumor.

    abstract::Wilms' tumor is one of the most common malignant tumors of the abdomen in children. However, there is currently no recognized specific biomarker for the clinical diagnosis and prognosis of this tumor. Lipid metabolism is involved in membrane synthesis and oxidation in tumor cells. This process plays an important role ...

    journal_title:International journal of oncology

    pub_type: 杂志文章


    authors: Wang X,Du G,Wu Y,Zhang Y,Guo F,Liu W,Wu R

    更新日期:2020-02-01 00:00:00

  • Differential expression of platelet-derived endothelial cell growth factor (thymidine phosphorylase) in nonpolypoid and polypoid lesions of the colon.

    abstract::To clarify the relationship between angiogenesis and the early development of colon cancer, expression of platelet-derived endothelial cell growth factor (PD-ECGF), a known angiogenic and endothelial cell chemotactic factor, was examined in 119 human colon premalignant adenomas and colon carcinomas. Localization of PD...

    journal_title:International journal of oncology

    pub_type: 杂志文章


    authors: Saeki T,Takashima S,Hosokawa S,Moriwaki S,Nagasako K,Masaki T,Salomon D,Ishitsuka H

    更新日期:1996-06-01 00:00:00

  • aP2-Cre-mediated expression activation of an oncogenic PLAG1 transgene results in cavernous angiomatosis in mice.

    abstract::The developmentally regulated PLAG1 proto-oncogene has been implicated in the development of various human tumor types, such as pleomorphic salivary gland adenomas, lipoblastomas, hepatoblastomas and AML. In previous studies, we generated two independent PLAG1 transgenic founder strains, PTMS1 and PTMS2, in which PLAG...

    journal_title:International journal of oncology

    pub_type: 杂志文章


    authors: Van Dyck F,Scroyen I,Declercq J,Sciot R,Kahn B,Lijnen R,Van de Ven WJ

    更新日期:2008-01-01 00:00:00

  • Anti-apoptotic proteins and catalase-dependent apoptosis resistance in nickel chloride-transformed human lung epithelial cells.

    abstract::Chronic exposure to nickel compounds is associated with increased incidence of certain types of human cancer, including lung and nasal cancers. Despite intensive investigation, the oncogenic processes remain poorly understood. Apoptosis resistance is a key feature for tumor cells to escape physiological surveillance a...

    journal_title:International journal of oncology

    pub_type: 杂志文章


    authors: Yang YX,Li XL,Wang L,Han SY,Zhang YR,Pratheeshkumar P,Wang X,Lu J,Yin YQ,Sun LJ,Budhraja A,Hitron AJ,Ding SZ

    更新日期:2013-09-01 00:00:00

  • Regulatory effect of the MAFG‑AS1/miR‑150‑5p/MYB axis on the proliferation and migration of breast cancer cells.

    abstract::Long noncoding RNA (lncRNA) MAF BZIP transcription factor G antisense RNA 1 (MAFG‑AS1) has been demonstrated to serve an important role in the progression of various types of cancer, whereas its role in breast cancer has not been fully elucidated. The present study aimed to explore the potential role and underlying me...

    journal_title:International journal of oncology

    pub_type: 杂志文章


    authors: Jia H,Wu D,Zhang Z,Li S

    更新日期:2020-11-20 00:00:00

  • Minichromosome maintenance protein 10 as a marker for proliferation and prognosis in lung cancer.

    abstract::DNA replication is a vital process in cell division where anomalies can lead to tumorigenesis. Minichromosome maintenance complex component 10 (MCM10) plays a crucial role in this process. However, the role of MCM10 in lung cancer pathogenesis remains to be elucidated. In current study, using the publicly available lu...

    journal_title:International journal of oncology

    pub_type: 杂志文章


    authors: Wang M,Xie S,Yuan W,Xie T,Jamal M,Huang J,Yin Q,Song H,Zhang Q

    更新日期:2019-12-01 00:00:00

  • Kinesin family members KIF11 and KIF23 as potential therapeutic targets in malignant pleural mesothelioma.

    abstract::Malignant pleural mesothelioma (MPM) is a rare and aggressive form of cancer commonly associated with asbestos exposure that stems from the thoracic mesothelium with high mortality rate. Currently, treatment options for MPM are limited, and new molecular targets for treatments are urgently needed. Using quantitative r...

    journal_title:International journal of oncology

    pub_type: 杂志文章


    authors: Kato T,Lee D,Wu L,Patel P,Young AJ,Wada H,Hu HP,Ujiie H,Kaji M,Kano S,Matsuge S,Domen H,Kaga K,Matsui Y,Kanno H,Hatanaka Y,Hatanaka KC,Matsuno Y,de Perrot M,Yasufuku K

    更新日期:2016-08-01 00:00:00

  • The Wnt regulator SFRP4 inhibits mesothelioma cell proliferation, migration, and antagonizes Wnt3a via its netrin-like domain.

    abstract::Secreted frizzled related proteins (SFRPs) are a family of Wnt regulators which are frequently downregulated in cancers. In malignant mesothelioma (MM), downregulation of SFRP4 has been reported as a mechanism which contributes to aberrant activation of oncogenic Wnt signaling. Here we investigated the biological cons...

    journal_title:International journal of oncology

    pub_type: 杂志文章


    authors: Perumal V,Dharmarajan AM,Fox SA

    更新日期:2017-07-01 00:00:00

  • Thrombomodulin, a receptor for the serine protease thrombin, is decreased in primary tumors and metastases but increased in ascitic fluids of patients with advanced ovarian cancer FIGO IIIc.

    abstract::The human ovarian cancer cell line OV-MZ-19, established from a patient with cystadenocarcinoma of the ovary, expressing thrombomodulin (TM), a cell surface receptor for the serine protease thrombin, interacts with monoclonal and polyclonal antibodies having different specificity for TM. These antibodies detect TM ant...

    journal_title:International journal of oncology

    pub_type: 杂志文章


    authors: Wilhelm S,Schmitt M,Parkinson J,Kuhn W,Graeff H,Wilhelm OG

    更新日期:1998-10-01 00:00:00

  • The role of WWOX tumor suppressor gene in the regulation of EMT process via regulation of CDH1-ZEB1-VIM expression in endometrial cancer.

    abstract::This study defines the role of WWOX in the regulation of epithelial to mesenchymal transition. A group of 164 endometrial adenocarcinoma patients was studied as well as an ECC1 well-differentiated steroid-responsive endometrial cell line, which was transducted with WWOX cDNA by a retroviral system. The relationship be...

    journal_title:International journal of oncology

    pub_type: 杂志文章


    authors: Płuciennik E,Nowakowska M,Pospiech K,Stępień A,Wołkowicz M,Gałdyszyńska M,Popęda M,Wójcik-Krowiranda K,Bieńkiewicz A,Bednarek AK

    更新日期:2015-01-01 00:00:00

  • Effects of fish oil and Tamoxifen on preneoplastic lesion development and biomarkers of oxidative stress in the early stages of N-methyl-N-nitrosourea-induced rat mammary carcinogenesis.

    abstract::Epidemiologic studies on the protective role of omega-3 fatty acids (n:3) on breast cancer prevention remain inconclusive but studies in preclinical models provide more positive outcome. However, the mechanisms accounting for the protective effect of n:3 are not defined. In the present study, conducted in the N-methyl...

    journal_title:International journal of oncology

    pub_type: 杂志文章


    authors: Manni A,Richie JP Jr,Xu H,Washington S,Aliaga C,Cooper TK,Bruggeman R,Das A,Prokopczyk B,Calcagnotto A,Trushin N,Dickinson R,Liao J,Verderame MF,El-Bayoumy K

    更新日期:2011-11-01 00:00:00

  • Expression and function of interleukin-8 in human hepatocellular carcinoma.

    abstract::Expression and functions of interleukin (IL)-8, a pro-inflammatory cytokine with angiogenesis action, was examined in 23 surgically resected hepatocellular carcinoma (HCC) specimens and 7 HCC cell lines. In all HCC tissues, IL-8 expression was confirmed with reverse-transcription polymerase chain reaction method and e...

    journal_title:International journal of oncology

    pub_type: 杂志文章


    authors: Akiba J,Yano H,Ogasawara S,Higaki K,Kojiro M

    更新日期:2001-02-01 00:00:00

  • Production and characterization of a monoclonal antibody (MSN-3) for uterine endometrial and endocervical adenocarcinoma.

    abstract::A monoclonal antibody (MSN-3) was raised using HEC-108 cells derived from poorly differentiated endometrial carcinoma as the immunogen. The immunoglobulin subclass of MSN-3 was IgGr1. The target antigen of MSN-3 was a protein with a molecular weight of 77 kDa, and it was shown to be localized in the cytoplasm. MSN-3 o...

    journal_title:International journal of oncology

    pub_type: 杂志文章


    authors: Hasegawa K,Tsukazaki K,Kubushiro K,Kobayashi Y,Kobiki K,Udagawa Y,Nozawa S

    更新日期:1997-10-01 00:00:00

  • SIRT3 SNPs validation in 640 individuals, functional analyses and new insights into SIRT3 stability.

    abstract::Sirtuins are critical players within multiple cellular pathways such as stress response, apoptosis and energy metabolism. They are associated with metabolic and degenerative diseases, the pathogenesis of cancer and are key elements in the regulation of cellular life span. From within the 7 known human sirtuins, SIRT3 ...

    journal_title:International journal of oncology

    pub_type: 杂志文章


    authors: Dransfeld CL,Alborzinia H,Wölfl S,Mahlknecht U

    更新日期:2010-04-01 00:00:00

  • Ras and p53 expression in non-small-cell lung-cancer patients - p53 over-expression correlates with a poor prognosis.

    abstract::Expression of the tumor suppressor gene p53 and the ras oncogene were examined in 46 tumor and nodal specimens of non-small cell lung cancer (NSCLC) using the antibodies p53 pAb 240 and ras Y13-259 respectively. p53 expression was elevated in 46% and ras p21 was over-expressed in 85% of the tumor specimens analyzed. F...

    journal_title:International journal of oncology

    pub_type: 杂志文章


    authors: Papadakis E,Malliri A,Linardopoulos S,Karaiossifidi H,Field J,Spandidos D

    更新日期:1992-09-01 00:00:00

  • A cisplatin‑incorporated liposome that targets the epidermal growth factor receptor enhances radiotherapeutic efficacy without nephrotoxicity.

    abstract::Radiotherapy (RT) is one of the major modalities for non‑small cell lung cancer (NSCLC), but its efficacy is often compromised by cellular resistance caused by various mechanisms including the overexpression of epidermal growth factor receptor (EGFR). Although cis‑diamminedichloroplatinum(Ⅱ) (cisplatin, CDDP) has been...

    journal_title:International journal of oncology

    pub_type: 杂志文章


    authors: Jung J,Jeong SY,Park SS,Shin SH,Ju EJ,Choi J,Park J,Lee JH,Kim I,Suh YA,Hwang JJ,Kuroda S,Lee JS,Song SY,Choi EK

    更新日期:2015-03-01 00:00:00

  • Effect of the anti-diabetic drug metformin in hepatocellular carcinoma in vitro and in vivo.

    abstract::Metformin is a commonly used oral anti-hyperglycemic agent of the biguanide family. Recent studies suggest that metformin may reduce cancer risk and improve prognosis. However, the antitumor mechanism of metformin in several types of cancers, including hepatocellular carcinoma (HCC), has not been elucidated. The goal ...

    journal_title:International journal of oncology

    pub_type: 杂志文章


    authors: Miyoshi H,Kato K,Iwama H,Maeda E,Sakamoto T,Fujita K,Toyota Y,Tani J,Nomura T,Mimura S,Kobayashi M,Morishita A,Kobara H,Mori H,Yoneyama H,Deguchi A,Himoto T,Kurokohchi K,Okano K,Suzuki Y,Murao K,Masaki T

    更新日期:2014-07-01 00:00:00

  • CXCR4-transfected human umbilical cord blood-derived mesenchymal stem cells exhibit enhanced migratory capacity toward gliomas.

    abstract::Mesenchymal stem cells (MSCs) can be used as a delivery vehicle for gene therapy against brain tumors, because these cells have a migratory capacity toward glioma cells. Soluble factors including chemokines or growth factors expressed and released by glioma cells mediate the tropism of MSCs for gliomas. Among them, st...

    journal_title:International journal of oncology

    pub_type: 杂志文章


    authors: Park SA,Ryu CH,Kim SM,Lim JY,Park SI,Jeong CH,Jun JA,Oh JH,Park SH,Oh W,Jeun SS

    更新日期:2011-01-01 00:00:00

  • Metaanalysis of 4 Swedish case-control studies on exposure to pesticides as risk-factor for soft-tissue sarcoma including the relation to tumor-localization and histopathological type.

    abstract::In four previous case-control studies we have shown an association between exposure to phenoxyacetic acids or chlorophenols and soft-tissue sarcoma (STS). These chemicals are contaminated by dioxins and dibenzofurans, some of which are known carcinogens in experimental animals. In a meta-analysis of our four studies w...

    journal_title:International journal of oncology

    pub_type: 杂志文章


    authors: Hardell L,Eriksson M,Degerman A

    更新日期:1995-04-01 00:00:00

  • Mechanisms for SU5416 as a radiosensitizer of endothelial cells.

    abstract::Endothelial cells (ECs), that comprise the tumor vasculature, are critical targets for anticancer radiotherapy. The aim of this work was to study the mechanism by which SU5416, a known anti-angiogenesis inhibitor, modifies the radiation responses of human vascular ECs. Two human endothelial cell lines (HUVEC and 2H11)...

    journal_title:International journal of oncology

    pub_type: 杂志文章


    authors: Kim EH,Kim MS,Jeong YK,Cho I,You SH,Cho SH,Lee H,Jung WG,Kim HD,Kim J

    更新日期:2015-10-01 00:00:00

  • AKT serine/threonine protein kinase modulates baicalin-triggered autophagy in human bladder cancer T24 cells.

    abstract::Baicalin is one of the major compounds in the traditional Chinese medicinal herb from Scutellaria baicalensis Georgi. We investigated the molecular mechanisms of cell autophagy induced by baicalin in human bladder cancer T24 cells. Baicalin inhibited cell survival as shown by MTT assay and increased cell death by tryp...

    journal_title:International journal of oncology

    pub_type: 杂志文章


    authors: Lin C,Tsai SC,Tseng MT,Peng SF,Kuo SC,Lin MW,Hsu YM,Lee MR,Amagaya S,Huang WW,Wu TS,Yang JS

    更新日期:2013-03-01 00:00:00

  • Selective cytostatic activity of hexadecylphosphocholine against tumor-cells invitro leads to the establishment of an invivo screening system for phospholipid analogs.

    abstract::Hexadecylphosphocholine (HPC, D-18506, INN: Miltefosine) was characterized in a clonogenic micro assay in vitro with respect to its cytotoxicity against a panel of human and murine tumor cell lines and murine bone marrow cultures (GM-CFC). The KB human epithelial carcinoma line was found to be more sensitive by at lea...

    journal_title:International journal of oncology

    pub_type: 杂志文章


    authors: Voegeli R,Echarti C,Maurer H,Stekar J,Hilgard P,Unger C

    更新日期:1993-02-01 00:00:00

  • Histone deacetylase inhibitors, valproic acid and trichostatin-A induce apoptosis and affect acetylation status of p53 in ERG-positive prostate cancer cells.

    abstract::An ETS family member, ETS Related Gene (ERG) is involved in the Ewing family of tumors as well as leukemias. Rearrangement of the ERG gene with the TMPRSS2 gene has been identified in the majority of prostate cancer patients. Additionally, overexpression of ERG is associated with unfavorable prognosis in prostate canc...

    journal_title:International journal of oncology

    pub_type: 杂志文章


    authors: Fortson WS,Kayarthodi S,Fujimura Y,Xu H,Matthews R,Grizzle WE,Rao VN,Bhat GK,Reddy ES

    更新日期:2011-07-01 00:00:00

  • 12-O-tetradecanoyl phorbol 13-acetate induces the expression of B7-DC, -H1, -H2, and -H3 in K562 cells.

    abstract::Induction of the B7 family molecules by 12-O-tetradecanoyl phorbol 13-acetate (TPA) has been reported, however, the mechanism by which TPA up-regulates these molecules remains poorly understood. In this study, the expression of B7-DC, -H1, -H2, and -H3 in response to TPA was markedly induced in K562 cells. TPA also in...

    journal_title:International journal of oncology

    pub_type: 杂志文章


    authors: Jang BC,Park YK,Choi IH,Kim SP,Hwang JB,Baek WK,Suh MH,Mun KC,Suh SI

    更新日期:2007-12-01 00:00:00

  • Resistance to cisplatin-induced apoptosis via PI3K-dependent survivin expression in a rat hepatoma cell line.

    abstract::Hepatocellular carcinoma (HCC) is known to be resistant to chemotherapy. Survivin, a member of the inhibitor of apoptosis proteins, is overexpressed in most cancers but is absent in most normal adult tissue. The aim of this study was to investigate whether expression of survivin contributes to resistance to cisplatin-...

    journal_title:International journal of oncology

    pub_type: 杂志文章


    authors: Asechi H,Hatano E,Nitta T,Tada M,Iwaisako K,Tamaki N,Nagata H,Narita M,Yanagida A,Ikai I,Uemoto S

    更新日期:2010-07-01 00:00:00

  • SNP rs1801157 significantly correlates with distant metastasis in CXCL12 expressing esophagogastric cancer.

    abstract::We performed this study in order to evaluate the impact of the chemokine CXCL12 and its single-nucleotide polymorphism (SNP) rs1801157 on clinicopathological parameters and survival in patients undergoing surgery for esophagogastric cancer. The expression pattern of CXCL12 and its polymorphisms were analyzed by RT-PCR...

    journal_title:International journal of oncology

    pub_type: 杂志文章


    authors: Schimanski CC,Jordan M,Schlaegel F,Schmidtmann I,Lang H,Galle PR,Moehler M,Gockel I

    更新日期:2011-08-01 00:00:00