Increased malignant behavior in neuroblastoma cells with acquired multi-drug resistance does not depend on P-gp expression.

abstract：:Retroviral reverse transcriptase (RT) plays a definite role in retroviral life cycle and is essential for the process of retrotransposition. We investigated the RNA expression of endogenous reverse transcriptases (enRTs) in the NIH3T3 mouse genome using, as a probe, a mixture of RT-PCR generated reverse transcriptase ...

journal_title：International journal of oncology

authors： Tzavaras T,Eftaxia S,Tavoulari S,Hatzi P,Angelidis C

更新日期：2003-10-01 00:00:00

abstract：:Glutathione S-transferase (GST) enzymes catalyse the detoxification of by-products of reactive oxygen species and are thus important in cellular defence mechanisms. The GSTs are polymorphic with allelic variants encoding isoforms with functional differences. GST polymorphism has been associated with susceptibility and...

journal_title：International journal of oncology

authors： Holley SL,Rajagopal R,Hoban PR,Deakin M,Fawole AS,Elder JB,Elder J,Smith V,Strange RC,Fryer AA

更新日期：2006-01-01 00:00:00

abstract：:The DNA topoisomerase I inhibitor beta-lapachone, the product of a tree from South America, is known to exhibit various biological properties, the mechanisms of which are poorly understood. We investigated the effects of beta-lapachone on the growth of human prostate epithelial cells. Upon treatment with beta-lapachon...

journal_title：International journal of oncology

authors： Choi YH,Kim MJ,Lee SY,Lee YN,Chi GY,Eom HS,Kim ND,Choi BT

更新日期：2002-12-01 00:00:00

abstract：:The Raf/MEK/ERK signaling cascade has been extensively studied for its roles in growth and differentiation of a variety of cell types. Confliciting evidence exists regarding the function of classical MAPK signaling with regards to the development of chemotherapeutic drug resistance; some reports describe an pro-surviv...

journal_title：International journal of oncology

authors： Lee JT Jr,Steelman LS,McCubrey JA

更新日期：2005-06-01 00:00:00

abstract：:Abstract. The gestational trophoblastic diseases (GTD) are uncommon complications of pregnancy. The UK GTD registration scheme offers specialist facilities for screening and treatment. In Sheffield about 5% of all patients monitored require chemotherapy. The successful treatment - almost 100% cure - of these patients ...

journal_title：International journal of oncology

authors： Sheridan E,Hancock B,Smith S,Dorreen M,Neal F,Pennington G,Millar D

更新日期：1993-08-01 00:00:00

abstract：:The active metabolite of vitamin D, 1alpha,25-dihydroxyvitamin D3, can induce differentiation in breast cancer cells; however, it is hypercalcemic in vivo. Therefore, development of non-calcemic analogs of vitamin D has received considerable attention. Recently, we synthesized an analog of vitamin D [1alpha(OH)D5] tha...

journal_title：International journal of oncology

authors： Mehta RR,Bratescu L,Graves JM,Green A,Mehta RG

更新日期：2000-01-01 00:00:00

abstract：:5-Fluorouracil (5-FU), often used in combination with levofolene (LF), can induce, as an important side effect, the hand-foot syndrome (HFS) due to toxicity on keratinocytes. This can also damage workers involved in its handling. In the present study, we investigated the mechanisms of the toxicity induced by 5-FU alon...

journal_title：International journal of oncology

authors： Lamberti M,Porto S,Zappavigna S,Stiuso P,Tirino V,Desiderio V,Mele L,Caraglia M

更新日期：2015-05-01 00:00:00

abstract：:Voltage-gated potassium (Kv) channels play important roles in differentiation and growth of non-excitable cells. Inhibition of these channels is also known to suppress proliferation of various cancer cells. Here we examine expression of K+ channel subunit genes in various uterine cancer cells and their roles in cell p...

journal_title：International journal of oncology

authors： Suzuki T,Takimoto K

更新日期：2004-07-01 00:00:00

abstract：:There is an urgent requirement for a new therapeutic target for activated B-cell-like lymphoma (ABC-DLBCL), which is known to have dismal outcome and constitutive activation of NF-κB. Heme oxygenase-1 (HO-1) can inhibit apoptosis and promote proliferation in many cancers. To our knowledge, no studies have been perform...

journal_title：International journal of oncology

authors： Huang J,Guo P,Ma D,Lin X,Fang Q,Wang J

更新日期：2016-07-01 00:00:00

abstract：:Multidrug-resistance (MDR) is largely caused by the efflux of therapeutics from the tumor cell by means of P-glycoprotein (P-gp), resulting in reduced efficacy of the chemotherapy. In order to overcome MDR, substances, such as verapamil and cyclosporin A (CsA), were employed. As these P-gp modulating agents did not se...

journal_title：International journal of oncology

authors： Meschini S,Marra M,Calcabrini A,Federici E,Galeffi C,Arancia G

更新日期：2003-12-01 00:00:00

abstract：:MicroRNA (miR) can exert various biological functions by targeting oncogenes or tumor suppressor genes in numerous human malignancies. Recent evidence has shown that miR-148a increases the drug sensitivity of various cancer cells. Herein, we show that ectopic expression of miR-148a induces apoptosis, reduces clonogeni...

journal_title：International journal of oncology

authors： Kim EA,Kim TG,Sung EG,Song IH,Kim JY,Doh KO,Lee TJ

更新日期：2017-03-01 00:00:00

abstract：:UNC5A is an axon-guidance molecule, and plays a critical role in neuronal development and differentiation as a netrin-1 receptor. Emerging evidence suggests that axon guidance molecules including UNC5A regulate apoptosis in non-neuronal cells. Here, we report that UNC5A regulates apoptosis as a downstream target of p5...

journal_title：International journal of oncology

authors： Miyamoto Y,Futamura M,Kitamura N,Nakamura Y,Baba H,Arakawa H

更新日期：2010-05-01 00:00:00

abstract：:Mesenchymal stem cells (MSCs) can be used as a delivery vehicle for gene therapy against brain tumors, because these cells have a migratory capacity toward glioma cells. Soluble factors including chemokines or growth factors expressed and released by glioma cells mediate the tropism of MSCs for gliomas. Among them, st...

journal_title：International journal of oncology

authors： Park SA,Ryu CH,Kim SM,Lim JY,Park SI,Jeong CH,Jun JA,Oh JH,Park SH,Oh W,Jeun SS

更新日期：2011-01-01 00:00:00

abstract：:CXC chemokines have a major influence on the angiogenesis, growth and metastatic potential of pancreatic ductal adenocarcinoma. CXCL16 is a unique transmembrane CXC chemokine, which is shed by members of the disintegrins and metalloproteases (ADAMs), in particular by ADAM10 and ADAM17. In our study, we evaluated expre...

journal_title：International journal of oncology

authors： Wente MN,Gaida MM,Mayer C,Michalski CW,Haag N,Giese T,Felix K,Bergmann F,Giese NA,Friess H

更新日期：2008-08-01 00:00:00

abstract：:Employing the transgenic BALB-neuT mouse tumor model, we explored the in vivo biologic relevance of immunocompetent epitopes shared among the four ErbB receptors. The outcome of neu-mediated tumorigenesis was compared following vaccination with isogeneic normal rat ErbB2/Neu (LTR-Neu) or xenogeneic human ErbB receptor...

journal_title：International journal of oncology

authors： Masuelli L,Focaccetti C,Cereda V,Lista F,Vitolo D,Trono P,Gallo P,Amici A,Monaci P,Mattei M,Modesti M,Forni G,Kraus MH,Muraro R,Modesti A,Bei R

更新日期：2007-02-01 00:00:00

abstract：:Although a correlation between anaplasia and mutations of the p53 tumor suppressor gene has been found in Wilms' tumor (WT) a prognostic significance of p53 in WT remains largely unresolved. The goal of this study was to obtain a better understanding of the role of p53 expression in WT. Immunohistochemical analysis wa...

journal_title：International journal of oncology

authors： Beniers AJ,Efferth T,Füzesi L,Granzen B,Mertens R,Jakse G

更新日期：2001-01-01 00:00:00

abstract：:Chemotherapy is an established treatment modality for bone sarcomas such as osteosarcoma (OS). However, the use of chemotherapy in high-grade soft tissue sarcomas remains controversial, with the most active chemotherapeutic agent, doxorubicin (DOX), reported to have a response rate of, at best only 34% and most studie...

journal_title：International journal of oncology

authors： Bouralexis S,Clayer M,Atkins GJ,Labrinidis A,Hay S,Graves S,Findlay DM,Evdokiou A

更新日期：2004-05-01 00:00:00

abstract：:Growth and differentiation of MCF-7 breast adenocarcinoma cells were studied in mixed cultures of MCF-7 cells and PA 16/23 myoepithelial cells and in isolated cultures of MCF-7 cells grown in the absence and presence of conditioned medium of PA 16/23 cells. In the cocultures, the MCF-7 cells grew in smaller aggregates...

journal_title：International journal of oncology

authors： Bani D,Magnelli L,Gallo O

更新日期：1996-07-01 00:00:00

abstract：:The molecular mechanism playing a role in the development of benign prostate hypertrophy (BPH) and prostate cancer (PC) is not well defined. We performed microarray analysis to assess the gene expression change in BPH and PC, and performed network analysis. Normal prostate, BPH and PC tissues were obtained from patien...

journal_title：International journal of oncology

authors： Endo T,Uzawa K,Suzuki H,Tanzawa H,Ichikawa T

更新日期：2009-09-01 00:00:00

abstract：:Dual oxidase 2 (Duox2), one of the seven members of the NADPH oxidase gene family, plays a critical role in generating H2O2 for thyroid hormone biosynthesis and as an integral part of the host defense system of the respiratory epithelium and the gastrointestinal tract. Recent evidence suggests that the regulation of D...

journal_title：International journal of oncology

authors： Wu Y,Antony S,Hewitt SM,Jiang G,Yang SX,Meitzler JL,Juhasz A,Lu J,Liu H,Doroshow JH,Roy K

更新日期：2013-04-01 00:00:00

abstract：:We examined the clinical significance of E-cadherin and vimentin expression in 83 patients with breast dancer. E-cadherin expression was correlated with axillary metastases, histologic grade, recurrence and disease-free survival, but not with overall survival. On the other hand, vimentin expression was correlated with...

journal_title：International journal of oncology

authors： Yagasaki R,Noguchi M,Minami M,Earashi M

更新日期：1996-10-01 00:00:00

abstract：:The mitogen-activated protein kinase (MAPK) cascade, which includes MAPK, MAP kinase kinase (MAPKK) and Raf-l, is involved in the signal transduction of growth factor receptors. We found that the MAPK and Raf-l proteins are increased in human breast cancer. Activated MAPKK was also observed. We then investigated wheth...

journal_title：International journal of oncology

authors： Koibuchi Y,Iino Y,Uchida T,Nagasawa M,Morishita Y

更新日期：1997-09-01 00:00:00

abstract：:Integrins are adhesion receptors involved in bidirectional signaling and are crucial for various cellular responses during normal homeostasis and pathological conditions, such as cancer progression and metastasis. In the present study, we demonstrated that blockage of β3 integrin-mediated cell- extracellular matrix in...

journal_title：International journal of oncology

authors： Li W,Liu C,Zhao C,Zhai L,Lv S

更新日期：2016-03-01 00:00:00

abstract：:Choriocarcinoma is a highly malignant trophoblastic tumor related to pregnancy that often occurs with a complete hydatidiform mole. It grows quickly and can also widely metastasize to other organs or tissues through both the venous and lymphatic systems. The transforming growth factor-β1 (TGF-β1) belongs to a growth f...

journal_title：International journal of oncology

authors： Xu Q,Tan Y,Zhang K,Li Y

更新日期：2013-10-01 00:00:00

abstract：:Uveal melanoma is the most common type of intraocular cancer with a low mean annual incidence of 5‑10 cases per million. Tumours are located in the choroid (90%), ciliary body (6%) or iris (4%) and of 85% are primary tumours. As in cutaneous melanoma, tumours arise in melanocytes; however, the characteristics of uveal...

journal_title：International journal of oncology

authors： Ortega MA,Fraile-Martínez O,García-Honduvilla N,Coca S,Álvarez-Mon M,Buján J,Teus MA

更新日期：2020-12-01 00:00:00

abstract：:p73 has been shown to transcriptionally activate genes positively responsive to wild-type p53. In order to undertake a comparative study of functions of p53 and p73 we have cloned the cDNA of p73 from MCF-7 cells. Adenovirus onco-protein E1A inhibits the transactivation by p73; a deletion mutant of E1A incapable of in...

journal_title：International journal of oncology

authors： Deb D,Lanyi A,Scian M,Keiger J,Brown DR,Le Roith D,Deb SP,Deb S

更新日期：2001-02-01 00:00:00

abstract：:Tumor-bearing mice with two different locally growing malignant tumors (epithelial like, MCG 101; malignant melanoma, K1735-M2) were used to evaluate the putative role of prostaglandins for survival and local tumor growth in experimental cancer. Daily systemic injections of indomethacin (1 mu g/g bw) were used to bloc...

journal_title：International journal of oncology

authors： Lonnroth C,Svaninger G,Gelin J,Cahlin C,Iresjo B,Cvetkovska E,Edstrom S,Andersson M,Svanberg E,Lundholm K

更新日期：1995-12-01 00:00:00

abstract：:Acquirement of multi-drug resistance by tumor cells represents a major obstacle in the management of prostate cancer. Such resistance was demonstrated in the androgen-independent DU-145 cells in response to paclitaxel and the mechanisms by which these cell develops resistance was not understood. The objective of this ...

journal_title：International journal of oncology

authors： Flynn V Jr,Ramanitharan A,Moparty K,Davis R,Sikka S,Agrawal KC,Abdel-Mageed AB

更新日期：2003-08-01 00:00:00

abstract：:Bile acids serve a critical role in the induction of gastric intestinal metaplasia (IM) and gastric carcinogenesis. The present study investigated the effects of bile acids on the induction of gastric IM formation. The results demonstrated that the expression levels of caudal‑related homeobox transcription factor 2 (C...

journal_title：International journal of oncology

authors： Yu JH,Zheng JB,Qi J,Yang K,Wu YH,Wang K,Wang CB,Sun XJ

更新日期：2019-03-01 00:00:00

abstract：:In order to realise the full potential of gene therapy as a rational approach to the treatment of cancer, it will be necessary to achieve delivery of the therapeutic gene selectively to target tumour cells. Such cancer cell-specific gene delivery is mandated in the context of locoregional or compartmentalised carcinom...

journal_title：International journal of oncology

authors： Douglas J,Curiel D

更新日期：1997-08-01 00:00:00