当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF ONCOLOGY期刊下所有文献 > Inhibition of cell growth and telomerase activity of breast cancer cells in vitro by retinoic acids.

Inhibition of cell growth and telomerase activity of breast cancer cells in vitro by retinoic acids.

Abstract：

:The effects of retinoic acid (RA) and its analogs, all-trans RA, 9-cis RA and 13-cis RA, were investigated in human breast cancer MCF-7 cells and immortalized breast epithelial cell line MCF-10A. RA inhibited the telomerase activity of MCF-7 cells in a wide range of concentrations. RA at 10 microM also inhibited the growth of MCF-7 cells in a time-dependent manner. However, no significant growth inhibition was found between untreated control and RA-treated MCF-10A cells. Moreover, a marked inhibition of telomerase activity by RA was detected early in MCF-7 cells (after 24 h of RA treatment), which was preceded by a reduction of hTERT mRNA expression (after 12 h of RA treatment). However, MCF-10A cells showed a reduction of telomerase activity and down-regulation of hTERT after 4 days of RA treatment. Simultaneous changes in hTERT mRNA expression and telomerase activity were found for MCF-10A cells. The expressions of hTR and hTEP1 telomerase component genes were not changed after RA treatment. These results indicate that the anti-breast cancer activity of RA could be mediated by its ability to down-regulate the expression of hTERT telomerase gene.

journal_name

Int J Oncol

journal_title

International journal of oncology

authors

Choi SH,Kang HK,Im EO,Kim YJ,Bae YT,Choi YH,Lee KH,Chung HY,Chang HK,Kim ND

doi

10.3892/ijo.17.5.971

keywords:

subject

Has Abstract

pub_date

2000-11-01 00:00:00

pages

971-6

issue

5

eissn

1019-6439

issn

1791-2423

journal_volume

17

pub_type

杂志文章

相关文献

INTERNATIONAL JOURNAL OF ONCOLOGY文献大全
  • Resistance to cytotoxic chemotherapy-induced apoptosis in side population cells of human oral squamous cell carcinoma cell line Ho-1-N-1.

    abstract：:Side population (SP) cells are isolated from various tissues and cell lines based on the exclusion of DNA-binding dye Hoechst 33,342 and exhibit potent stem cell characteristics. There have been few previous reports of SP cells in head and neck cancer cell lines. Thus, we isolated SP cells from oral squamous cell carc...

    journal_title：International journal of oncology

    pub_type： 杂志文章

    doi：

    authors： Yajima T,Ochiai H,Uchiyama T,Takano N,Shibahara T,Azuma T

    更新日期：2009-08-01 00:00:00

  • Midkine expression is correlated with an adverse prognosis and is down-regulated by p53 in oral squamous cell carcinoma.

    abstract：:Midkine (MK) expression has been documented to be inversely correlated with the prognosis of patients with various tumors, but the mechanism of this relationship has not been well characterized. Recent studies have also correlated p53 expression with prognosis of patients with oral squamous cell carcinoma (OSCC). We e...

    journal_title：International journal of oncology

    pub_type： 杂志文章

    doi：10.3892/ijo_00000729

    authors： Ota K,Fujimori H,Ueda M,Jono H,Shinriki S,Ota T,Sueyoshi T,Taura M,Taguma A,Kai H,Shinohara M,Ando Y

    更新日期：2010-10-01 00:00:00

  • Metastatic lymph node ratio in advanced gastric carcinoma: a better prognostic factor than number of metastatic lymph nodes?

    abstract：:Gastric carcinoma is the most common cancer and the second most common cause of cancer-related death in Korea. Many studies have been reported regarding prognostic factors. Among the category I prognostic factors of gastric carcinoma, lymph node metastasis (nodal status) is considered to be the strongest prognostic fa...

    journal_title：International journal of oncology

    pub_type： 杂志文章

    doi：10.3892/ijo_00000632

    authors： Lee SY,Hwang I,Park YS,Gardner J,Ro JY

    更新日期：2010-06-01 00:00:00

  • Dexamethasone downregulates expression of carbonic anhydrase IX via HIF-1α and NF-κB-dependent mechanisms.

    abstract：:Dexamethasone is a synthetic glucocorticoid frequently used to suppress side-effects of anticancer chemotherapy. In the present study, we showed that dexamethasone treatment leads to concentration-dependent downregulation of cancer-associated marker, carbonic anhydrase IX (CA IX), at the level of promoter activity, mR...

    journal_title：International journal of oncology

    pub_type： 杂志文章

    doi：10.3892/ijo.2016.3621

    authors： Simko V,Takacova M,Debreova M,Laposova K,Ondriskova-Panisova E,Pastorekova S,Csaderova L,Pastorek J

    更新日期：2016-10-01 00:00:00

  • EGFR blockade by tyrosine kinase inhibitor or monoclonal antibody inhibits growth, directs terminal differentiation and induces apoptosis in the human squamous cell carcinoma HN5.

    abstract：:Human squamous cell carcinomas frequently overexpress the epidermal growth factor receptor (EGFR) and this is often associated with poor prognosis in patients with these cancers. The high level of expression of the EGFR provides an important target for therapy and we and others have shown that monoclonal antibodies (m...

    journal_title：International journal of oncology

    pub_type： 杂志文章

    doi：10.3892/ijo.13.2.335

    authors： Modjtahedi H,Affleck K,Stubberfield C,Dean C

    更新日期：1998-08-01 00:00:00

  • GSH loss per se does not affect neuroblastoma survival and is not genotoxic.

    abstract：:Depletion of glutathione (GSH) by buthionine sulfoximine (BSO) has been reported to be toxic against some cancer cells and to sensitize many tumours including neuroblastoma (NB) to anticancer drugs. The balance between the production rate of reactive oxygen species (ROS) and the function of GSH affects the intracellul...

    journal_title：International journal of oncology

    pub_type： 杂志文章

    doi：

    authors： Marengo B,Balbis E,Patriarca S,De Ciucis C,Furfaro A,Nitti M,Marinari UM,Pronzato MA,Traverso N,Domenicotti C

    更新日期：2008-01-01 00:00:00

  • Downmodulation of dimethyl transferase activity enhances tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in prostate cancer cells.

    abstract：:One of the major obstacles in curing prostate cancer is the development of drug resistance. It is not only imperative to discover the molecular basis of resistance but also to find therapeutic agents that can disrupt the resistant pathways. Tumor necrosis factor TNF-related apoptosis-inducing ligand TRAIL-like ligands...

    journal_title：International journal of oncology

    pub_type： 杂志文章

    doi：

    authors： Festuccia C,Gravina GL,D'Alessandro AM,Millimaggi D,Di Rocco C,Dolo V,Ricevuto E,Vicentini C,Bologna M

    更新日期：2008-08-01 00:00:00

  • Tumor-necrosis-factor and DNA topoisomerase-ii inhibitors in human ovarian-cancer - potential role in chemotherapy.

    abstract：:Seven ovarian and one cervical human cancer cell lines were examined far their sensitivity or resistance to tumor necrosis factor, to three topoisomerase II inhibitors and to cisplatin. Only one line exhibited the multidrug-resistance phenotype and another one an 'atypical'-MDR phenotype. The combination of TNF and to...

    journal_title：International journal of oncology

    pub_type： 杂志文章

    doi：

    authors： Aluigi M,Debernardis D,Cimoli G,Ottoboni C,Parodi S,Russo P

    更新日期：1995-09-01 00:00:00

  • Radiation-induced effects in unirradiated cells: a review and implications in cancer.

    abstract：:A long-held central dogma of radiation biology has been that the carcinogenic effects of ionizing radiation (IR) are induced by the direct and radiolytic actions of IR on nuclear DNA. Numerous investigations, however, have revealed that several cancer relevant effects of IR can occur in cells that have received only c...

    journal_title：International journal of oncology

    pub_type： 杂志文章,评审

    doi：

    authors： Goldberg Z,Lehnert BE

    更新日期：2002-08-01 00:00:00

  • Baicalein induces apoptosis via ROS-dependent activation of caspases in human bladder cancer 5637 cells.

    abstract：:Baicalein is a flavonoid derived originally from the root of Scutellaria baicalensis Georgi, which has been used in Oriental medicines for treating various diseases. Although this compound has been reported to have anticancer activities in several human cancer cell lines, the therapeutic effects of baicalein on human ...

    journal_title：International journal of oncology

    pub_type： 杂志文章

    doi：10.3892/ijo.2016.3606

    authors： Choi EO,Park C,Hwang HJ,Hong SH,Kim GY,Cho EJ,Kim WJ,Choi YH

    更新日期：2016-09-01 00:00:00

  • DNA binding protein A expression and methylation status in hepatocellular carcinoma and the adjacent tissue.

    abstract：:We investigated the expression and promoter methylation of dbpA in human hepatocellular carcinoma (HCC) and examined their correlation with clinicopathological features. In 96 paired samples of HCC and adjacent non-tumorous liver, and 10 normal liver specimens, dbpA mRNA was quantif...

    journal_title：International journal of oncology

    pub_type： 杂志文章

    doi：10.3892/ijo.2011.1282

    authors： Yasen M,Obulhasim G,Kajino K,Mogushi K,Mizushima H,Tanaka S,Tanaka H,Hino O,Arii S

    更新日期：2012-03-01 00:00:00

  • Telomerase activity in non-small cell lung carcinomas correlates with smoking status.

    abstract：:Human telomerase is a ribonucleoprotein DNA polymerase which maintains the telomeric region of human chromosomes and has been detected in all types of human cancer tested. We used the telomeric repeat amplification protocol (TRAP) assay to examine 71 non-small cell lung carcinomas (NSCLC) and their adjacent normal tis...

    journal_title：International journal of oncology

    pub_type： 杂志文章

    doi：10.3892/ijo.15.5.961

    authors： Xinarianos G,Scott FM,Liloglou T,Prime W,Callaghan J,Gosney JR,Field JK

    更新日期：1999-11-01 00:00:00

  • Fibrous tumors in children - a morphologic and interphase cytogenetic analysis of problematic cases.

    abstract：:We describe and discuss the findings by fluorescent in situ hybridization (FISH) for detection of non-random chromosomal gains, in a group of unusual fibrous lesions in children. Nuclear disaggregation was used to prepare slides from eight cases which were hybridized using alpha-satellite enumeration probes for chromo...

    journal_title：International journal of oncology

    pub_type： 杂志文章

    doi：10.3892/ijo.17.3.433

    authors： Flores-Stadler EM,Chou PM,Barquin N,Thangavelu M,Gonzalez-Crussi F

    更新日期：2000-09-01 00:00:00

  • Expression of Müllerian inhibiting substance type II receptor and antiproliferative effects of MIS on human cervical cancer.

    abstract：:This study aimed to analyze expression of Müllerian inhibiting substance type II receptor (MISRII) protein and mRNA in cervical neoplasia, to demonstrate the growth inhibition of cervical cancer cells by administration of highly purified recombinant human Müllerian inhibiting substa...

    journal_title：International journal of oncology

    pub_type： 杂志文章

    doi：10.3892/ijo.2012.1370

    authors： Song JY,Jo HH,Kim MR,Lew YO,Ryu KS,Cha JH,Kang CS,Donahoe PK,MacLaughlin DT,Kim JH

    更新日期：2012-06-01 00:00:00

  • HIF1-positive and HIF1-negative glioblastoma cells compete in vitro but cooperate in tumor growth in vivo.

    abstract：:Glioblastoma multiforme (GBM) is characterized by extensive angiogenesis that is mostly orchestrated by the hypoxia inducible factor HIF-1. Deregulation of HIF-1 is believed to contribute to cancer initiation and progression. However, instances have been described in which loss of HIF-1 leads to more aggressive tumors...

    journal_title：International journal of oncology

    pub_type： 杂志文章

    doi：10.3892/ijo_00000554

    authors： Fiorenzo P,Mongiardi MP,Dimitri D,Cozzolino M,Ferri A,Montano N,Trevisi G,Maira G,Battistini L,Falchetti ML,Levi A,Pallini R

    更新日期：2010-04-01 00:00:00

  • Oncogenic mutation of the p53 gene derived from head and neck cancer prevents cells from undergoing apoptosis after DNA damage.

    abstract：:A p53 functional analysis system, which can identify the types of abnormality of p53, such as loss of function, dominant negative function, or gain of oncogenic function, is now required. In this study, we examined the functional diversity of several mutations of p53 derived from human head and neck cancer cells. The ...

    journal_title：International journal of oncology

    pub_type： 杂志文章

    doi：

    authors： Kawamata H,Omotehara F,Nakashiro K,Uchida D,Shinagawa Y,Tachibana M,Imai Y,Fujimori T

    更新日期：2007-05-01 00:00:00

  • Mutational state of p16/cdkn2 and vhl genes in squamous-cell carcinoma of the oral cavity.

    abstract：:Two new tumor-suppressor genes, the cyclin dependent kinase 4 inhibitor gene (p16/CDKN2) and the von Hippel-Lindau disease gene (VHL), have been cloned and mapped on chromosomes 9p and 3p respectively, where putative tumor-suppressor genes of the oral squamous-cell carcinoma (SCC) may be present. In order to elucidate...

    journal_title：International journal of oncology

    pub_type： 杂志文章

    doi：10.3892/ijo.7.4.895

    authors： Uzawa K,Suzuki H,Yokoe H,Tanzawa H,Sato K

    更新日期：1995-10-01 00:00:00

  • Percutaneous ethanol injection therapy for hepatocellular-carcinoma (review).

    abstract：:Recently, ultrasound-guided percutaneous ethanol injection therapy (PEIT) has been widely performed in the treatment of hepatocellular carcinoma. Histopathologic examinations after the therapy have revealed that PEIT can destroy the tumor completely in most cases. Findings in imaging modalities and serum tumor marker ...

    journal_title：International journal of oncology

    pub_type： 杂志文章

    doi：10.3892/ijo.2.4.669

    authors： Shiina S,Niwa Y,Shiratori Y,Terano A,Omata M

    更新日期：1993-04-01 00:00:00

  • Retinoids induce differentiation and downregulate telomerase activity and N-Myc to increase sensitivity to flavonoids for apoptosis in human malignant neuroblastoma SH-SY5Y cells.

    abstract：:Human malignant neuroblastoma is characterized by poor differentiation and uncontrolled proliferation of immature neuroblasts. Retinoids such as all-trans-retinoic acid (ATRA), 13-cis-retinoic acid (13-CRA), and N-(4-hydroxyphenyl) retinamide (4-HPR) at low doses are capable of inducing differentiation, while flavonoi...

    journal_title：International journal of oncology

    pub_type： 杂志文章

    doi：10.3892/ijo_00000201

    authors： Das A,Banik NL,Ray SK

    更新日期：2009-03-01 00:00:00

  • Protein profiling of osteosarcoma tissue and soft callus unveils activation of the unfolded protein response pathway.

    abstract：:Oncogenic drivers of osteosarcoma remain controversial due to the complexity of the genomic background of the disease. There are limited novel therapeutic options, and the survival rate of patients with osteosarcoma has not improved in decades. Genomic instability leads to complexity in various pathways, which is pote...

    journal_title：International journal of oncology

    pub_type： 杂志文章

    doi：10.3892/ijo.2019.4737

    authors： Chaiyawat P,Sungngam P,Teeyakasem P,Sirikaew N,Klangjorhor J,Settakorn J,Diskul-Na-Ayudthaya P,Chokchaichamnankit D,Srisomsap C,Svasti J,Pruksakorn D

    更新日期：2019-05-01 00:00:00

  • Alphavirus vectors for cancer gene therapy (review).

    abstract：:Alphaviruses have several characteristics that make them attractive as gene therapy vectors such as transient and high-level expression of a heterologous gene. Alphavirus vectors, Semliki Forest virus (SFV), Sindbis virus (SIN) and Venezuelan equine encephalitis virus (VEE) have been developed as gene expression vecto...

    journal_title：International journal of oncology

    pub_type： 杂志文章,评审

    doi：

    authors： Yamanaka R

    更新日期：2004-04-01 00:00:00

  • Soy isoflavones suppress invasiveness of breast cancer cells by the inhibition of NF-kappaB/AP-1-dependent and -independent pathways.

    abstract：:High consumption of soy products in some Asian countries has been linked to the low incidence of breast cancer in women. The chemopreventive effect of the soy isoflavone, genistein, has been observed through the suppression of cell proliferation, inhibition of angiogenesis and stimulation of apoptosis in breast carcin...

    journal_title：International journal of oncology

    pub_type： 杂志文章

    doi：

    authors： Valachovicova T,Slivova V,Bergman H,Shuherk J,Sliva D

    更新日期：2004-11-01 00:00:00

  • Apoptosis induction of human prostate carcinoma cells by cordycepin through reactive oxygen species‑mediated mitochondrial death pathway.

    abstract：:Cordycepin is the main functional component of Cordyceps militaris, which has been widely used in oriental traditional medicine. This compound has been shown to possess many pharmacological properties, such as enhancing the body's immune function, and anti-inflammatory, anti-aging and anticancer effects. In the presen...

    journal_title：International journal of oncology

    pub_type： 杂志文章

    doi：10.3892/ijo.2013.1762

    authors： Lee HH,Park C,Jeong JW,Kim MJ,Seo MJ,Kang BW,Park JU,Kim GY,Choi BT,Choi YH,Jeong YK

    更新日期：2013-03-01 00:00:00

  • DCLK1 is correlated with MET and ERK5 expression, and associated with prognosis in malignant pleural mesothelioma.

    abstract：:Malignant pleural mesothelioma (MPM) is an aggressive cancer for which more effective treatments are needed. In this study, strong to moderate staining of MET and ERK5 was detected in 67.1 and 48% of the analyzed 73 human mesothelioma tumors, and significant correlation of MET and ERK5 expression was identified (P<0.0...

    journal_title：International journal of oncology

    pub_type： 杂志文章

    doi：10.3892/ijo.2017.4021

    authors： Wang H,Dai YY,Zhang WQ,Hsu PC,Yang YL,Wang YC,Chan G,Au A,Xu ZD,Jiang SJ,Wang W,Jablons DM,You L

    更新日期：2017-07-01 00:00:00

  • Effects of fish oil and Tamoxifen on preneoplastic lesion development and biomarkers of oxidative stress in the early stages of N-methyl-N-nitrosourea-induced rat mammary carcinogenesis.

    abstract：:Epidemiologic studies on the protective role of omega-3 fatty acids (n:3) on breast cancer prevention remain inconclusive but studies in preclinical models provide more positive outcome. However, the mechanisms accounting for the protective effect of n:3 are not defined. In the present study, conducted in the N-methyl...

    journal_title：International journal of oncology

    pub_type： 杂志文章

    doi：10.3892/ijo.2011.1133

    authors： Manni A,Richie JP Jr,Xu H,Washington S,Aliaga C,Cooper TK,Bruggeman R,Das A,Prokopczyk B,Calcagnotto A,Trushin N,Dickinson R,Liao J,Verderame MF,El-Bayoumy K

    更新日期：2011-11-01 00:00:00

  • A multicentre, double-blind, randomised trial comparing ondansetron versus ondansetron plus dexamethasone in the prophylaxis of cisplatin-induced delayed emesis.

    abstract：:The aim was to compare the efficacy of ondansetron and a combination of ondansetron plus dexamethasone in the prophylaxis of cisplatin-induced delayed emesis over three consecutive courses of chemotherapy. Cancer patients scheduled to receive for the first time cisplatin (>50 mg/m(2)) in combination with other cytotox...

    journal_title：International journal of oncology

    pub_type： 杂志文章

    doi：10.3892/ijo.10.2.395

    authors： Gridelli C,Ianniello G,Ambrosini G,Mustacchi G,Pedicini T,Farris A,Iacobelli S,Rossi G,Moretti G,Angelini F,Delena M,Dicarlo A,Bonsignori M,Sabbatini R,Catalano G,Rossi A,Olivieri A,Fina P,Bianco A

    更新日期：1997-02-01 00:00:00

  • Diosmetin suppresses human prostate cancer cell proliferation through the induction of apoptosis and cell cycle arrest.

    abstract：:Diosmetin, a plant flavonoid, has been shown to exert promising effects on prostate cancer cells as an anti‑proliferative and anticancer agent. In this study, using western blot analysis for protein expression and flow cytometry for cell cycle analysis, we determined that the treatment of the LNCaP and PC‑3 prostate c...

    journal_title：International journal of oncology

    pub_type： 杂志文章

    doi：10.3892/ijo.2018.4407

    authors： Oak C,Khalifa AO,Isali I,Bhaskaran N,Walker E,Shukla S

    更新日期：2018-08-01 00:00:00

  • Involvement of Bcl-2 family members, phosphatidylinositol 3'-kinase/AKT and mitochondrial p53 in curcumin (diferulolylmethane)-induced apoptosis in prostate cancer.

    abstract：:Curcumin (diferulolylmethane), an active ingredient derived from the rhizome of the plant Curcuma longa, has anticancer activity in vitro and in vivo. Although curcumin possesses chemopreventive properties against several types of cancer, the molecular mechanisms by which it inhibits cell growth and induces apoptosis ...

    journal_title：International journal of oncology

    pub_type： 杂志文章

    doi：

    authors： Shankar S,Srivastava RK

    更新日期：2007-04-01 00:00:00

  • In vitro reversion of transformed phenotype in mouse C3H/10T1/2 cells.

    abstract：:Spontaneous tumor regression is still one of the most puzzling events in human cancer. A cell culture model of malignant transformation designed to permit the study of this phenomenon in vitro was applied to examine reversion and re-expression of the transformed phenotype in two X-ray transformed mouse 10T1/2 cell clo...

    journal_title：International journal of oncology

    pub_type： 杂志文章

    doi：10.3892/ijo.8.4.727

    authors： Paquette B,Wagner R,Little J

    更新日期：1996-04-01 00:00:00

  • Autoimmunity and cancer - Beneficial relationships.

    abstract：:Autoimmune diseases are the consequence of the immune system attack on the self. Autoimmunity, sometimes, is reflected through the production of autoantibodies to various self antigens leading to cellular malfunction or destruction. In the current study we employ such autoantibodies for the treatment of cancer origina...

    journal_title：International journal of oncology

    pub_type： 杂志文章

    doi：10.3892/ijo.10.5.901

    authors： Fishman P,Merimsky O,Shoenfeld Y

    更新日期：1997-05-01 00:00:00