Dexamethasone downregulates expression of carbonic anhydrase IX via HIF-1α and NF-κB-dependent mechanisms.

abstract：:Our transcriptome analysis revealed in bladder cancer (BCa) tissues a significant induction of lysosomal-associated multispanning membrane protein 5 (LAPTM5), a lysosomal membrane protein preferentially expressing in immune cells and hematopoietic cells. Transportation of LAPTM5 from Golgi to lysosome could be inhibit...

journal_title：International journal of oncology

authors： Chen L,Wang G,Luo Y,Wang Y,Xie C,Jiang W,Xiao Y,Qian G,Wang X

更新日期：2017-01-01 00:00:00

abstract：:The objective of these studies was to examine the murine pharmacokinetics, pharmacodynamics and metabolism of (3-(1H-indol-2-yl)phenyl)(1H-indol-2-yl)methanone (Indole 15), a novel tubulin inhibitor for the treatment of cancer. We developed HPLC and LC/MS/MS assays to quantitate Indole 15 and characterize its metaboli...

journal_title：International journal of oncology

authors： Yang J,Ahn S,Wu Z,Hwang DJ,Miller DD,Dalton JT

更新日期：2012-07-01 00:00:00

abstract：:The CCND1-ORAOV1-FGF19-FGF4-FGF3-TMEM16A-FADD-PPFIA1-CTTN (EMS1) locus at human chromosome 11q13.3 is amplified in head and neck tumors, esophageal cancer, Kaposi's sarcoma, bladder tumors, breast cancer, and liver cancer. Fgf4 mRNA is expressed in embryonic stem (ES) cells depending on Sox2 and Pou5f1 (Oct3/Oct4) tra...

journal_title：International journal of oncology

authors： Katoh M,Katoh M

更新日期：2005-07-01 00:00:00

abstract：:Breast cancer remains the second most common disease worldwide. Radiotherapy, alone or in combination with chemotherapy, is widely used after surgery as a treatment for cancer with proven therapeutic efficacy manifested by reduced incidence of loco-regional and distant recurrences. However, clinical evidence indicates...

journal_title：International journal of oncology

authors： Calaf GM,Roy D

更新日期：2017-11-01 00:00:00

abstract：:Hypoxia regulates the expression of genes that promote tumor growth, angiogenesis and invasion. We previously studied hypoxic tumor cells in vitro and from hepatic metastases of colorectal cancer and determined several potential prognostic factors for hepatocellular carcinoma (HCC). In this study, we evaluated the pro...

journal_title：International journal of oncology

authors： Wada H,Yamamoto H,Kim C,Uemura M,Akita H,Tomimaru Y,Hama N,Kawamoto K,Kobayashi S,Eguchi H,Umeshita K,Doki Y,Mori M,Nagano H

更新日期：2014-09-01 00:00:00

abstract：:Dissemination of single tumor cells to the bone marrow is a common event in cancer. The clinical significance of cytokeratin-positive cells detected in the bone marrow of cancer patients is still a matter of debate. In gastric cancer, overexpression of the receptor (uPAR or CD87) for the serine protease urokinase-type...

journal_title：International journal of oncology

authors： Noack F,Helmecke D,Rosenberg R,Thorban S,Nekarda H,Fink U,Lewald J,Stich M,Schutze K,Harbeck N,Magdolen V,Graeff H,Schmitt M

更新日期：1999-10-01 00:00:00

abstract：:Cholangiocarcinoma (CCA) is a lethal malignancy which occurs with relatively high incidence in Thailand. This cancer is often difficult to diagnose and associated with high mortality. The secretome, containing the secreted proteins from cells, are potentially useful as biomarkers of cancers. Since three-dimensional (3...

journal_title：International journal of oncology

authors： Tit-Oon P,Chokchaichamnankit D,Khongmanee A,Sawangareetrakul P,Svasti J,Srisomsap C

更新日期：2014-11-01 00:00:00

abstract：:Targeting protein kinases as a therapeutic approach to treat various diseases, especially cancer is currently a fast growing business. Although many inhibitors are available, exhibiting remarkable potency, the major challenge is their selectivity. Here we show that the protein kinase CK2 inhibitors DMAT, TBB and resor...

journal_title：International journal of oncology

authors： Fritz G,Issinger OG,Olsen BB

更新日期：2009-11-01 00:00:00

abstract：:A precise diagnosis of peritoneal dissemination is necessary to determine the appropriate treatment strategy for colorectal cancer. However, small peritoneal dissemination is difficult to diagnose. 5-aminolevulinic acid (5-ALA) is an intermediate substrate of heme metabolism. The administration of 5-ALA to cancer pati...

journal_title：International journal of oncology

authors： Kondo Y,Murayama Y,Konishi H,Morimura R,Komatsu S,Shiozaki A,Kuriu Y,Ikoma H,Kubota T,Nakanishi M,Ichikawa D,Fujiwara H,Okamoto K,Sakakura C,Takahashi K,Inoue K,Nakajima M,Otsuji E

更新日期：2014-07-01 00:00:00

abstract：:ATP-dependent transport of doxorubicin (DOX) by recombinant human RLIP76 has been demonstrated previously in reconstituted proteoliposomes. In the preceding communication, we demonstrated that the ATPase activity of RLIP76 was 2-fold higher in NSCLC as compared with SCLC, and it correlated with their inherent DOX resi...

journal_title：International journal of oncology

authors： Awasthi S,Singhal SS,Singhal J,Cheng J,Zimniak P,Awasthi YC

更新日期：2003-04-01 00:00:00

abstract：:Retroviral infection of hTERT, the catalytic component of telomerase, into BJ fibroblasts (population doubling 28) resulted in reconstitution of telomerase activity, telomere maintenance, and extension of in vitro lifespan. The hTERT-infected cells also exhibited increased growth rate and colony forming efficiency rel...

journal_title：International journal of oncology

authors： Forsythe HL,Elmore LW,Jensen KO,Landon MR,Holt SE

更新日期：2002-06-01 00:00:00

abstract：:Fluoroquinolone antibiotics induce cytotoxicity in various cancer cell lines and may therefore represent a potentially important source of novel anticancer agents. The aim of the present study was to examine the effect of ciprofloxacin on the viability, redox balance, apoptosis, expression of p53, Bax and Bcl-2, cell ...

journal_title：International journal of oncology

authors： Beberok A,Wrześniok D,Rok J,Rzepka Z,Respondek M,Buszman E

更新日期：2018-05-01 00:00:00

abstract：:Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is one of the most promising anti-cancer agents, but some tumor types develop resistance to TRAIL. Here, we report that chetomin, an inhibitor of hypoxia-inducible factors, is a potent enhancer of TRAIL-induced apoptosis. TRAIL or chetomin alone weakly in...

journal_title：International journal of oncology

authors： Yano K,Horinaka M,Yoshida T,Yasuda T,Taniguchi H,Goda AE,Wakada M,Yoshikawa S,Nakamura T,Kawauchi A,Miki T,Sakai T

更新日期：2011-02-01 00:00:00

abstract：:The representative halophyte Calystegia soldanella (L) Roem. et Schult is a perennial vine herb that grows in coastal dunes throughout South Korea as well as in other regions around the world. This plant has long been used as an edible and medicinal herb to cure rheumatic arthritis, sore throat, dropsy, and scurvy. So...

journal_title：International journal of oncology

authors： Lee JI,Kim IH,Nam TJ

更新日期：2017-02-01 00:00:00

abstract：:Metastasis is an important prognosis factor in lung cancer, therefore, it is imperative to identify target molecules and elucidate molecular mechanism of metastasis for developing new therapeutics and diagnosis methods. We searched for metastasis-related proteins by utilizing a novel antibody proteome technology devel...

journal_title：International journal of oncology

authors： Nagano K,Imai S,Zhao X,Yamashita T,Yoshioka Y,Abe Y,Mukai Y,Kamada H,Nakagawa S,Tsutsumi Y,Tsunoda S

更新日期：2015-07-01 00:00:00

abstract：:Resistance to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a major limitation for its clinical use. The mechanisms of TRAIL resistance have been mostly studied in the context of cell lines that are intrinsically resistant to TRAIL. However, little is known about the molecular alterations that con...

journal_title：International journal of oncology

authors： Ouyang W,Yang C,Zhang S,Liu Y,Yang B,Zhang J,Zhou F,Zhou Y,Xie C

更新日期：2013-02-01 00:00:00

abstract：:Selenium is a trace nutrient element that protects cells against oxidative damage. In this study, the potential of selenium to improve stem cell potency through active proliferation and migration of 3T3-L1 preadipocytes was investigated, together with the underlying molecular mechanisms. The results indicated that sel...

journal_title：International journal of oncology

authors： Park SH,Kim JH,Nam SW,Kim BW,Kim GY,Kim WJ,Choi YH

更新日期：2014-01-01 00:00:00

abstract：:Induction of differentiation in a variety of model systems is accompanied by cell cycle exit and inhibition of Cdk2 kinase activity. We asked whether inhibition of Cdk2 activity is sufficient to allow differentiation to occur in a non-small cell lung cancer cell line. Treatment of NCI-H358 with flavopiridol, an inhibi...

journal_title：International journal of oncology

authors： Lee HR,Chang TH,Tebalt MJ 3rd,Senderowicz AM,Szabo E

更新日期：1999-07-01 00:00:00

abstract：:Myofibroblasts in the stroma of pancreatic cancers promote tumor proliferation, invasion and metastasis by increasing extracellular matrix and secretion of several growth factors. In contrast, the role of myofibroblasts at peritoneally disseminated sites of pancreatic cancer has not yet been determined. This study was...

journal_title：International journal of oncology

authors： Akagawa S,Ohuchida K,Torata N,Hattori M,Eguchi D,Fujiwara K,Kozono S,Cui L,Ikenaga N,Ohtsuka T,Aishima S,Mizumoto K,Oda Y,Tanaka M

更新日期：2014-07-01 00:00:00

abstract：:Malignant gliomas are diffuse infiltrative growing tumors with a poor prognosis despite treatment with a combination of surgery, radiotherapy and chemotherapy. It has been shown recently that complete tumor resection improves the survival time significantly. Hypericin, a component of St. Johns Wort, is one of the most...

journal_title：International journal of oncology

authors： Noell S,Mayer D,Strauss WS,Tatagiba MS,Ritz R

更新日期：2011-05-01 00:00:00

abstract：:Multidrug-resistance (MDR) is largely caused by the efflux of therapeutics from the tumor cell by means of P-glycoprotein (P-gp), resulting in reduced efficacy of the chemotherapy. In order to overcome MDR, substances, such as verapamil and cyclosporin A (CsA), were employed. As these P-gp modulating agents did not se...

journal_title：International journal of oncology

authors： Meschini S,Marra M,Calcabrini A,Federici E,Galeffi C,Arancia G

更新日期：2003-12-01 00:00:00

abstract：:Increased expression levels of the long non-coding RNA metastasis-associated lung adenocarcinoma transcript 1 (Malat1) have been associated with enhanced proliferation and metastasis of several cancer cell types. Hypoxia, a hallmark characteristic of solid tumors, has been linked to an increase in the activity of the ...

journal_title：International journal of oncology

authors： Sallé-Lefort S,Miard S,Nolin MA,Boivin L,Paré MÈ,Debigaré R,Picard F

更新日期：2016-10-01 00:00:00

abstract：:Bile duct carcinoma patients generally have a poor prognosis. Understanding this cancer at the biological, genetic, molecular, and cellular level in ways relevant to clinical management is essential for developing effective preventive and therapeutic regimens. However, the currently established bile duct cancer cell l...

journal_title：International journal of oncology

authors： Ghosh M,Koike N,Tsunoda S,Hirano T,Kaul S,Kashiwagi H,Kawamoto T,Ohkohchi N,Saijo K,Ohno T,Miwa M,Todoroki T

更新日期：2005-02-01 00:00:00

abstract：:Endometrial cancer (EC) is one of the most common malignancies of the female reproductive system, and metastasis is a major cause of mortality. In this study, we aimed to explore the role of CP‑31398 in the migration, invasion and apoptosis of EC cells by its regulation of the expression of the murine double minute 2 ...

journal_title：International journal of oncology

authors： Liu L,Yang L,Chang H,Chen YN,Zhang F,Feng S,Peng J,Ren CC,Zhang XA

更新日期：2019-03-01 00:00:00

abstract：:Pancreatic cancer is characterized by a dense desmoplastic reaction in which extracellular matrix proteins accumulate and surround tumor cells. Integrins and their related signaling molecules are associated with progression of pancreatic cancer. In the present study, the association between the metastasis of pancreati...

journal_title：International journal of oncology

authors： Jiang P,Li Z,Tian F,Li X,Yang J

更新日期：2017-07-01 00:00:00

abstract：:The mutation of isocitrate dehydrogenase (IDH)1 (R132H) and IDH2 (R172K) and the induction of hypoxia in various solid tumors results in alterations in metabolic profiles, including the production of the d‑ or l‑forms of 2‑hydroxyglutarate (2HG) from α‑ketoglutarate in aerobic metabolism in the tricarboxylic acid (TCA...

journal_title：International journal of oncology

authors： Seok J,Yoon SH,Lee SH,Jung JH,Lee YM

更新日期：2019-02-01 00:00:00

abstract：:Establishment of tumor cell lines as model systems for studying tumor biology or as a part of immunotherapeutic anti-cancer strategies is of high importance, whereby the highest possible preservation of the original tumor cell phenotype is a prerequisite for these aims. Since overexpression of the catalytic subunit of...

journal_title：International journal of oncology

authors： Voglauer R,Grillari J,Fortschegger K,Wieser M,Sterovsky T,Gunsberg P,Katinger H,Pfragner R

更新日期：2005-04-01 00:00:00

abstract：:SOX2, a SRY-related HMG box protein, is thought to be an important transcription factor during organogenesis, including the stomach although the expression and function are unclear. We investigated SOX2 protein expression to clarify its roles in differentiation and carcinogenesis of the stomach. Using polyclonal SOX2 ...

journal_title：International journal of oncology

authors： Li XL,Eishi Y,Bai YQ,Sakai H,Akiyama Y,Tani M,Takizawa T,Koike M,Yuasa Y

更新日期：2004-02-01 00:00:00

abstract：:High consumption of soy products in some Asian countries has been linked to the low incidence of breast cancer in women. The chemopreventive effect of the soy isoflavone, genistein, has been observed through the suppression of cell proliferation, inhibition of angiogenesis and stimulation of apoptosis in breast carcin...

journal_title：International journal of oncology

authors： Valachovicova T,Slivova V,Bergman H,Shuherk J,Sliva D

更新日期：2004-11-01 00:00:00

abstract：:Increasing evidence has confirmed that dysregulation of microRNAs (miRNAs) can contribute to the progression and metastasis of human tumors. Previous studied have shown dysregulation of miR-24 in a variety of tumors. However, the roles of miR-24 in human bladder cancer have not been well clarified. Therefore, we inves...

journal_title：International journal of oncology

authors： Zhang S,Zhang C,Liu W,Zheng W,Zhang Y,Wang S,Huang D,Liu X,Bai Z

更新日期：2015-10-01 00:00:00