Ganoderma lucidum inhibits proliferation and induces apoptosis in human prostate cancer cells PC-3.

abstract：:Long noncoding RNA (lncRNA) MAF BZIP transcription factor G antisense RNA 1 (MAFG‑AS1) has been demonstrated to serve an important role in the progression of various types of cancer, whereas its role in breast cancer has not been fully elucidated. The present study aimed to explore the potential role and underlying me...

journal_title：International journal of oncology

authors： Jia H,Wu D,Zhang Z,Li S

更新日期：2020-11-20 00:00:00

abstract：:Several lines of direct evidence show that gliomas express high levels of vascular endothelial growth factor (VEGF). VEGF can promote the growth of gliomas through angiogenesis. It is believed that gliomas originate in the brain tumor stem cells (BTSCs). However, the direct effect of VEGF on the biological behavior of...

journal_title：International journal of oncology

authors： Li Q,Qiao G,Ma J,Li Y

更新日期：2014-05-01 00:00:00

abstract：:Sialic acid-containing glycosphingolipids, gangliosides, are expressed at high levels in the nerve tissues and various tumor cells. Although a number of studies on the roles of gangliosides in the regulation of cell proliferation have been performed, the mechanisms for the regulation are not well understood. We establ...

journal_title：International journal of oncology

authors： Nishio M,Tajima O,Furukawa K,Urano T,Furukawa K

更新日期：2005-01-01 00:00:00

abstract：:Cytokine production in squamous cell carcinoma (SCC) of the head and neck may directly influence the clinical behavior of this aggressive neoplasm since cytokines act as autocrine/paracrine growth factors, as well as immunomodulators. In the present study, the cytokine profiles of 16 SCCs of the head and neck and matc...

journal_title：International journal of oncology

authors： Sabourin C,Wang Q,Mallery S,Nicholson R,Gopalakrishnan R,Lang J,Schuller D,Stoner G

更新日期：1996-01-01 00:00:00

abstract：:Survivin is a member of the inhibitor of apoptosis protein (IAP) family and is frequently expressed in cancers, including meningiomas and gliomas. Survivin may be associated with tumor progression and poor prognosis of patients with brain tumors. Using ELISA and immunoblot analysis we asked whether survivin is capable...

journal_title：International journal of oncology

authors： Söling A,Plugge EM,Schmitz M,Weigle B,Jacob R,Illert J,Holzhausen HJ,Rainov NG

更新日期：2007-01-01 00:00:00

abstract：:The relationship between p53 point mutation and patient survival was examined in 328 colorectal cancer patients. Point mutation was detected in 51% (166/328) of cases and was associated with a poorer prognosis in univariate and multivariate analysis. However, subcohort analysis showed that this relationship was restri...

journal_title：International journal of oncology

authors： Goh HS,Elnatan J,Low CH,Smith DR

更新日期：1999-09-01 00:00:00

abstract：:We have demonstrated anti-proliferation and anti-metastasis effects of both interferon-alpha and a histone deacetylase inhibitor, sodium butyrate, on human liver cancer cell lines. In this study, invasive ability of human liver cancer cell lines through the matrix-coated membrane was examined and inhibitory effect of ...

journal_title：International journal of oncology

authors： Kaneko F,Saito H,Saito Y,Wakabayashi K,Nakamoto N,Tada S,Suzuki H,Tsunematsu S,Kumagai N,Ishii H

更新日期：2004-04-01 00:00:00

abstract：:Experimental evidence indicates that prostate apoptosis response-4 (Par-4, also known as PAWR) is a key regulator of cancer cell survival and may be a target for cancer-selective targeted therapeutics. Par-4 was first identified in prostate cancer cells undergoing apoptosis. Both intracellular and extracellular Par-4 ...

journal_title：International journal of oncology

authors： Pereira MC,de Bessa-Garcia SA,Burikhanov R,Pavanelli AC,Antunes L,Rangnekar VM,Nagai MA

更新日期：2013-08-01 00:00:00

abstract：:The efficacy of radioimmunotherapy with radiolabelled monoclonal antibody (Mab) depends on the amount of antibody taken up by the tumour and on its intratumoral distribution. Multicellular spheroids (MTS) of lung cell carcinoma was investigated to study cellular and subcellular distribution of a Mab Po66 labelled with...

journal_title：International journal of oncology

authors： Dazord L,Thomas D,Brichory F,Cavalier A,Meritte H,Desrues B,Cauletmaugendre S,Bourguet P

更新日期：1997-03-01 00:00:00

abstract：:Tumor cell invasion and metastasis requires precise coordination of adherence to the extracellular matrix (ECM) and controlled degradation of its components. lnvasive cells secrete proteolytic enzymes known as matrix metalloproteinases which degrade specific basement membrane molecules. Expression of these enzymes is ...

journal_title：International journal of oncology

authors： Vo HP,Lee MK,Crowe DL

更新日期：1998-12-01 00:00:00

abstract：:Dendritic cells (DCs) are powerful antigen-presenting cells (APCs), that have so far been applied for cancer specific immunotherapy. Recent results suggest that matured DCs derived from human monocytes have a significant impact on the outcome of vaccination. The conventional generation of mature DCs from human monocyt...

journal_title：International journal of oncology

authors： Tanaka F,Yamaguchi H,Haraguchi N,Mashino K,Ohta M,Inoue H,Mori M

更新日期：2006-11-01 00:00:00

abstract：:Sonic hedgehog (SHH), Indian hedgehog (IHH) and Desert hedgehog (DHH) are Hedgehog family ligands, which play key roles in embryogenesis and carcinogenesis, especially in pancreatic cancer and gastric cancer. Drosophila Costal-2 (Cos2) is a Hedgehog signaling regulator, interacting with Smoothened (Smo), Cubitus inter...

journal_title：International journal of oncology

authors： Katoh Y,Katoh M

更新日期：2004-12-01 00:00:00

abstract：:Overexpression of either of the multidrug resistance genes MDR1 and MRP is associated with resistance of tumors to multiple chemotherapeutic agents. Overexpression of MDR1 has been reported in some cell lines derived from human hepatocellular carcinomas (HCC) and hepatoblastomas (HB). The human gene for cMOAT (

journal_title：International journal of oncology

authors： Minemura M,Tanimura H,Tabor E

更新日期：1999-09-01 00:00:00

abstract：:The expression of microRNA-375 (miR-375) is significantly reduced in cancer tissues of maxillary sinus squamous cell carcinoma (MSSCC). The aim of this study was to investigate the functional significance of miR-375 and a possible regulatory role in the MSSCC networks. Restoration o...

journal_title：International journal of oncology

authors： Kinoshita T,Nohata N,Yoshino H,Hanazawa T,Kikkawa N,Fujimura L,Chiyomaru T,Kawakami K,Enokida H,Nakagawa M,Okamoto Y,Seki N

更新日期：2012-01-01 00:00:00

abstract：:Patients who have inoperable lung cancer usually undergo chemotherapy and have problems such as a resistance against chemotherapeutic agents during the treatment. Glutathione S-transferase (GST) is one of the detoxication-related enzymes. We studied the relationship between immunohisto-chemical staining of GST-pi type...

journal_title：International journal of oncology

authors： Arai T,Yasuda Y,Takaya T,Yoshimi N,Ito H,Fujiwara H

更新日期：1997-07-01 00:00:00

abstract：:The gp160 human kidney differentiation antigen is identical to human aminopeptidase A (APA), a zinc-dependent cell-surface metallopeptidase which hydrolyzes peptides with N-terminal acidic residues. GP160/APA is constitutively expressed by proximal tubule cells, the normal cellular counterpart of most renal cancers (R...

journal_title：International journal of oncology

authors： Nanus DM,Bogenrieder T,Papandreou CN,Finstad CL,Lee A,Vlamis V,Motzer RJ,Bander NH,Albino AP,Reuter VE

更新日期：1998-08-01 00:00:00

abstract：:We investigated three clonally related human keratinocyte cell lines of different biological behaviour, HaCaT (non-tumorigenic), A5 (benign, tumorigenic) and II-4RT (malignant, tumorigenic), with regard to the cell-associated localization of the major MMPs -1, -2, -3, -9, -10 and -11. These observations were correlate...

journal_title：International journal of oncology

authors： Bachmeier BE,Nerlich AG

更新日期：2002-03-01 00:00:00

abstract：:A new continuous cell line from a human malignant carcinoid of the small intestine (KRJ-I) was established. The cells showed morphological and immunocytochemical features of the tumor of origin and expressed estrogen receptors. The cells are growing as a suspension, forming multicellular aggregates and spheroids. Elec...

journal_title：International journal of oncology

authors： Pfragner R,Wirnsberger G,Niederle B,Behmel A,Rinner I,Mandl A,Wawrina F,Luo J,Adamiker D,Hoger H,Ingolic E,Schauenstein K

更新日期：1996-03-01 00:00:00

abstract：:The p53 homologue p73 is overexpressed in many tumors, including lung cancer. We have evaluated the differential expression and subcellular localization of the functionally distinct apoptotic (TA) and anti-apoptotic (DeltaN) isoforms of p73 in non-small cell lung cancer (NSCLC), their possible association with p53 exp...

journal_title：International journal of oncology

authors： Di Vinci A,Sessa F,Casciano I,Banelli B,Franzi F,Brigati C,Allemanni G,Russo P,Dominioni L,Romani M

更新日期：2009-02-01 00:00:00

abstract：:Pancreatic cancer is one of the most aggressive solid malignancies with a dismal survival rate. Recent studies have shown that high expression levels of histone deacetylase 3 (HDAC3) correlate with malignant phenotype. However, the expression patterns and biological role of HDAC3 in pancreatic cancer remain unclear. I...

journal_title：International journal of oncology

authors： Jiao F,Hu H,Yuan C,Jin Z,Guo Z,Wang L,Wang L

更新日期：2014-10-01 00:00:00

abstract：:Following the publication of the above paper, an interested reader drew to the authors' attention that, in Fig. 2D, the si‑ITGB3/E‑cadherin image appeared to show an overlap with the Scr/MDA231+CCL18/N‑cadherin image from Fig. 4E in a paper published in 2013 that shared some of the same authors [Zhang B, Yin C, Li H, ...

journal_title：International journal of oncology

authors： Li W,Liu C,Zhao C,Zhai L,Lv S

更新日期：2021-01-11 00:00:00

abstract：:The prognosis of patients carrying glottic squamous cell carcinomas (GSCCs) involving the anterior commissure is often unpredictable. In order to assess the possible prognostic role of new and reliable parameters, p53 and cyclin D1 protein expression was immunohistochemically analysed in pathological samples from 27 p...

journal_title：International journal of oncology

authors： Pignataro L,Capaccio P,Pruneri G,Carboni N,Fracchiolla N,Richelda R,Scaramellini G,Neri A,Buffa R

更新日期：1996-09-01 00:00:00

abstract：:Most cancer cells trigger thrombin generation (TG) to various extent. In the present study, we dissected the mechanisms responsible for the procoagulant activity of pancreatic adenocarcinoma cells (BXPC3), a highly thrombogenic cancer type, and breast cancer cells (MCF7), a less thombogenic tumor type. TG of normal pl...

journal_title：International journal of oncology

authors： Rousseau A,Larsen AK,Van Dreden P,Sabbah M,Elalamy I,Gerotziafas GT

更新日期：2017-12-01 00:00:00

abstract：:Adrenomedullin (AM) is a multifunctional 52-amino acid peptide. AM has several effects and acts as a growth factor in several types of cancer cells. Our previous study revealed that an AM antagonist (AMA) suppressed the growth of pancreatic tumors in mice, although its mechanism was not elucidated. In this study, we c...

journal_title：International journal of oncology

authors： Tsuchiya K,Hida K,Hida Y,Muraki C,Ohga N,Akino T,Kondo T,Miseki T,Nakagawa K,Shindoh M,Harabayashi T,Shinohara N,Nonomura K,Kobayashi M

更新日期：2010-06-01 00:00:00

abstract：:Conventional diagnosis of prostate cancer does not appear to be sensitive enough to differentiate pre-operatively between organ-confined and extracapsular disease. New technologies, arising from the field of molecular biology, have been introduced to improve diagnosis and their implementation into the clinical practic...

journal_title：International journal of oncology

authors： Schamhart DH,Maiazza R,Kurth KH

更新日期：2005-03-01 00:00:00

abstract：:The aim of this study was to demonstrate the potential of electrogene therapy with the bacterial purine nucleoside phosphorylase gene (ePNP), on pancreatic carcinoma (PC) large tumors. The in vivo electroporation (EP) conditions and efficacy were investigated on both subcutaneous xenografts of human PC cells in immuno...

journal_title：International journal of oncology

authors： Deharvengt S,Rejiba S,Wack S,Aprahamian M,Hajri A

更新日期：2007-06-01 00:00:00

abstract：:CXC chemokines have a major influence on the angiogenesis, growth and metastatic potential of pancreatic ductal adenocarcinoma. CXCL16 is a unique transmembrane CXC chemokine, which is shed by members of the disintegrins and metalloproteases (ADAMs), in particular by ADAM10 and ADAM17. In our study, we evaluated expre...

journal_title：International journal of oncology

authors： Wente MN,Gaida MM,Mayer C,Michalski CW,Haag N,Giese T,Felix K,Bergmann F,Giese NA,Friess H

更新日期：2008-08-01 00:00:00

abstract：:Prostaglandin E2 (PGE2) can stimulate tumor progression by both direct and indirect mechanisms. However, its influence on cell proliferation is still unclear. The present study characterized expression of subtypes of PGE2 receptors in oral squamous cell carcinomas, while also investigating the effects of EP3 and EP4 s...

journal_title：International journal of oncology

authors： Hoshikawa H,Goto R,Mori T,Mitani T,Mori N

更新日期：2009-03-01 00:00:00

abstract：:Hematopoietic disorders can be used as a suitable tool of additional information on the actual resolving power of comparative genomic hybridization (CGH). Therefore, CGH examination was performed of DNA extracted from 23 acute and 15 chronic myeloproliferative disorders which had just been analyzed using classical cyt...

journal_title：International journal of oncology

authors： Gebhart E,Verdorfer I,Saul W,Trautmann U,Brecevic L

更新日期：2000-06-01 00:00:00

abstract：:Retroviral infection of hTERT, the catalytic component of telomerase, into BJ fibroblasts (population doubling 28) resulted in reconstitution of telomerase activity, telomere maintenance, and extension of in vitro lifespan. The hTERT-infected cells also exhibited increased growth rate and colony forming efficiency rel...

journal_title：International journal of oncology

authors： Forsythe HL,Elmore LW,Jensen KO,Landon MR,Holt SE

更新日期：2002-06-01 00:00:00