Analysis of cytokine gene expression in squamous cell carcinoma of the head and neck.

abstract：:Several lines of direct evidence show that gliomas express high levels of vascular endothelial growth factor (VEGF). VEGF can promote the growth of gliomas through angiogenesis. It is believed that gliomas originate in the brain tumor stem cells (BTSCs). However, the direct effect of VEGF on the biological behavior of...

journal_title：International journal of oncology

authors： Li Q,Qiao G,Ma J,Li Y

更新日期：2014-05-01 00:00:00

abstract：:Hematopoietic disorders can be used as a suitable tool of additional information on the actual resolving power of comparative genomic hybridization (CGH). Therefore, CGH examination was performed of DNA extracted from 23 acute and 15 chronic myeloproliferative disorders which had just been analyzed using classical cyt...

journal_title：International journal of oncology

authors： Gebhart E,Verdorfer I,Saul W,Trautmann U,Brecevic L

更新日期：2000-06-01 00:00:00

abstract：:Sirtuins are critical players within multiple cellular pathways such as stress response, apoptosis and energy metabolism. They are associated with metabolic and degenerative diseases, the pathogenesis of cancer and are key elements in the regulation of cellular life span. From within the 7 known human sirtuins, SIRT3 ...

journal_title：International journal of oncology

authors： Dransfeld CL,Alborzinia H,Wölfl S,Mahlknecht U

更新日期：2010-04-01 00:00:00

abstract：:Lung cancer is a prevalent disease and is one of the leading causes of mortality worldwide. Despite the development of various anticancer drugs, the prognosis of lung cancer is relatively poor. Metastasis of lung cancer, as well as chemoresistance, is associated with a high mortality rate for patients with lung cancer...

journal_title：International journal of oncology

authors： Chiu YH,Hsu SH,Hsu HW,Huang KC,Liu W,Wu CY,Huang WP,Chen JY,Chen BH,Chiu CC

更新日期：2018-11-01 00:00:00

abstract：:CD44 is a marker of cancer stem cells in head and neck squamous cell carcinoma, and CD44 expression is related to prognosis in cancer patients. We examined whether herbal medicine components affect CD44 expression and induce cancer cell apoptosis. Baicalin enhanced apoptosis with no effect on CD44 levels, while baical...

journal_title：International journal of oncology

authors： Ohkoshi E,Umemura N

更新日期：2017-02-01 00:00:00

abstract：:Multidrug resistance (MDR) plays a pivotal role in human chronic myelogenous leukemia (CML) chemotherapy failure. MDR is mainly associated with the overexpression of drug efflux transporters of the ATP-binding cassette (ABC) proteins. Phosphoinositide 3-kinase (PI3K)/Akt signaling cascade is involved in the MDR phenot...

journal_title：International journal of oncology

authors： Wang H,Jia XH,Chen JR,Yi YJ,Wang JY,Li YJ,Xie SY

更新日期：2016-12-01 00:00:00

abstract：:We performed this study in order to evaluate the impact of the chemokine CXCL12 and its single-nucleotide polymorphism (SNP) rs1801157 on clinicopathological parameters and survival in patients undergoing surgery for esophagogastric cancer. The expression pattern of CXCL12 and its polymorphisms were analyzed by RT-PCR...

journal_title：International journal of oncology

authors： Schimanski CC,Jordan M,Schlaegel F,Schmidtmann I,Lang H,Galle PR,Moehler M,Gockel I

更新日期：2011-08-01 00:00:00

abstract：:The relation between the consumption of cruciferous vegetables and reduced prostate cancer occurrence has been documented, although the responsible phytochemicals are unknown. The effects of sulforaphane (SFN) which occurs as the precursor glucosinolate in broccoli and other cruciferous vegetables, and its metabolite ...

journal_title：International journal of oncology

authors： Chiao JW,Chung FL,Kancherla R,Ahmed T,Mittelman A,Conaway CC

更新日期：2002-03-01 00:00:00

abstract：:The negative signal provided by interactions of programmed death-1 (PD-1) and its ligands, B7-H1 and B7-DC, has been suggested to play an important role in tumor evasion from host immunity. Pancreas cancer patients with B7-H1 expression have a poor prognosis. B7-H1 blocking has been shown to inhibit the development of...

journal_title：International journal of oncology

authors： Okudaira K,Hokari R,Tsuzuki Y,Okada Y,Komoto S,Watanabe C,Kurihara C,Kawaguchi A,Nagao S,Azuma M,Yagita H,Miura S

更新日期：2009-10-01 00:00:00

abstract：:We examined the gene expression profiles of esophageal squamous cell carcinomas (ESCCs) with respect to degree of invasive depth and lymph node (LN) involvement in a large cohort. We used high-density oligonucleotide microarrays to examine the expression of 22,115 genes in 54 ESCCs and 11 non-cancerous esophageal tiss...

journal_title：International journal of oncology

authors： Sato T,Iizuka N,Hamamoto Y,Yoshino S,Abe T,Takeda S,Uchimura S,Miyamoto T,Sei F,Hamada K,Yamada-Okabe H,Oka M

更新日期：2006-05-01 00:00:00

abstract：:Glycodelin [gene name, progesterone associated endometrial protein (PAEP)] was initially described as an immune system modulator in reproduction. Today, it is also known to be expressed in several types of cancer, including non‑small cell lung cancer (NSCLC). In this cancer type, the feasibility of its usage as a foll...

journal_title：International journal of oncology

authors： Weber R,Meister M,Muley T,Thomas M,Sültmann H,Warth A,Winter H,Herth FJF,Schneider MA

更新日期：2019-02-01 00:00:00

abstract：:'Rare sugars' are defined as monosaccharides that exist in nature but are only present in limited quantities. The development of mass production method of rare sugars revealed some interesting physiological effects of these on animal cells, but the mechanisms have not been well studied. We examined the effect of D-all...

journal_title：International journal of oncology

authors： Yamaguchi F,Takata M,Kamitori K,Nonaka M,Dong Y,Sui L,Tokuda M

更新日期：2008-02-01 00:00:00

abstract：:The ability of lonidamine (LND), an energolytic derivative of indazol-carboxylic acid, to modulate the cytotoxic activity of idarubicin (IDA) and doxorubicin (DX) was investigated in two human lymphoma cell lines (H9 and U937). A different pattern of interaction between the drugs was observed as a function of treatmen...

journal_title：International journal of oncology

authors： Zaffaroni N,Villa R,Gornati D,Folini M,Silvestrini R

更新日期：1997-10-01 00:00:00

abstract：:The epidermal growth factor (EGFR) pathway is frequently activated in glioblastoma but the clinical efficacy of EGFR inhibitors in malignant glioma has been disappointing. The reasons for the failure of the mechanisms of resistance of these inhibitors are unclear, but may involve factors of the tumor microenvironment ...

journal_title：International journal of oncology

authors： Hartel I,Ronellenfitsch M,Wanka C,Wolking S,Steinbach JP,Rieger J

更新日期：2016-07-01 00:00:00

abstract：:Benzyl isothiocyanate (BITC) is known for its pharmacological properties against malignant neoplasm, including bladder cancer (BC). The current study investigated microRNAs (miRNA or miR) expression profiles with an emphasis on the role of miR‑99a‑5p in BITC‑treated BC cells. A quantitative polymerase chain reaction (...

journal_title：International journal of oncology

authors： Lin JF,Tsai TF,Lin YC,Chen HE,Chou KY,Hwang TI

更新日期：2019-06-01 00:00:00

abstract：:Tamoxifen (Tam), a selective estrogen receptor modulator, is in wide clinical use for the treatment and prevention of breast cancer. However, extended TAM administration for breast cancer induces increased VEGF levels in patients, promoting new blood vessel formation and thereby limiting its efficacy and highlighting ...

journal_title：International journal of oncology

authors： Du Y,Shi A,Han B,Li S,Wu D,Jia H,Zheng C,Ren L,Fan Z

更新日期：2014-04-01 00:00:00

abstract：:Overexpression of TMPRSS4, a cell surface-associated transmembrane serine protease, has been reported in pancreatic, colorectal and thyroid cancers, and has been implicated in tumor cell migration and metastasis. Few reports have investigated both TMPRSS4 gene expression levels and ...

journal_title：International journal of oncology

authors： Nguyen TH,Weber W,Havari E,Connors T,Bagley RG,McLaren R,Nambiar PR,Madden SL,Teicher BA,Roberts B,Kaplan J,Shankara S

更新日期：2012-09-01 00:00:00

abstract：:We have previously investigated the possibility of using hypericin as a diagnostic tool for the fluorescence detection of flat bladder carcinoma. In these clinical studies, it was shown that following intravesical application in humans, hypericin becomes selectively localized in transitional papillary carcinoma and ca...

journal_title：International journal of oncology

authors： Kamuhabwa AA,Roskams T,Baert L,De Witte PA

更新日期：2003-04-01 00:00:00

abstract：:Metastasis is an important prognosis factor in lung cancer, therefore, it is imperative to identify target molecules and elucidate molecular mechanism of metastasis for developing new therapeutics and diagnosis methods. We searched for metastasis-related proteins by utilizing a novel antibody proteome technology devel...

journal_title：International journal of oncology

authors： Nagano K,Imai S,Zhao X,Yamashita T,Yoshioka Y,Abe Y,Mukai Y,Kamada H,Nakagawa S,Tsutsumi Y,Tsunoda S

更新日期：2015-07-01 00:00:00

abstract：:Lamins are the major components of the nuclear lamina and play important roles in many cellular processes. The role of lamins in cancer development and progression is still unclear but it is known that reduced expression of lamin B1 has been observed in colon cancer. Thus, the aim of the present study was to elucidate...

journal_title：International journal of oncology

authors： Izdebska M,Gagat M,Grzanka A

更新日期：2018-01-01 00:00:00

abstract：:Acquisition of P-gp-mediated multidrug-resistance does not always correlate with observed malignant behavior of NB. To characterize alterations accompanying development of multidrug-resistance in NB we established two neuroblastoma cell sublines resistant to vincristine (UKF-NB-3rVCR10) and doxorubicin (UKF-NB-3rDOX20...

journal_title：International journal of oncology

authors： Kotchetkov R,Driever PH,Cinatl J,Michaelis M,Karaskova J,Blaheta R,Squire JA,Von Deimling A,Moog J,Cinatl J Jr

更新日期：2005-10-01 00:00:00

abstract：:Prostate cancer, the third most common cancer in men worldwide, varies substantially according to geographic region and race/ethnicity. Obesity and associated endocrine variation are foremost among the risk factors that may underlie these regional and ethnic differences. The association between obesity and prostate ca...

journal_title：International journal of oncology

authors： Baillargeon J,Rose DP

更新日期：2006-03-01 00:00:00

abstract：:Photodynamic therapy (PDT) is a tool against neoplastic and non-neoplastic diseases. PDT is capable to induce different cell death mechanisms in vitro, triggered in a dose-dependent manner. Relationships between PDT and apoptosis or necrosis induction are well-known, but other cell death mechanisms triggered after PDT...

journal_title：International journal of oncology

authors： Rello-Varona S,Stockert JC,Cañete M,Acedo P,Villanueva A

更新日期：2008-06-01 00:00:00

abstract：:Chemokine-mediated activation of G protein-coupled receptors CXCR1/2 promotes tumor growth, invasion, inflammation and metastasis. Repertaxin, a CXCR1/2 small-molecule inhibitor, has been shown to attenuate many of these tumor-associated processes. The present study aimed to investigate the effects of repertaxin alone...

journal_title：International journal of oncology

authors： Wang J,Hu W,Wang K,Yu J,Luo B,Luo G,Wang W,Wang H,Li J,Wen J

更新日期：2016-04-01 00:00:00

abstract：:Although strong evidence is available suggesting that microenvironmental parameters play a role in lymphogenic or hematogenic metastasis, the underlying mechanisms are still unclear and further investigations of this topic are needed. For such a study however, an appropriate model of metastasis for in vivo analysis of...

journal_title：International journal of oncology

authors： Thews O,Lambert C,Kelleher DK,Biesalski HK,Vaupel P,Frank J

更新日期：2005-09-01 00:00:00

abstract：:The effects of pretreatment with the multidrug resistance (MDR) modulators verapamil (VPM), tamoxifen (TMX), cyclosporin A (CsA), and SDZ PSC833 (PSC) on drug sensitivity of the P-glycoprotein (Pgp) expressing human ileocecal carcinoma cell line HCT-8 is described. Following pretreatment of 2, 16 and 48 h with the ind...

journal_title：International journal of oncology

authors： Haberl I,Swatonek H,Schaufler K,Ulsperger E,Wenzl E,Theyer G,Hamilton G,Thalhammer T

更新日期：1998-05-01 00:00:00

abstract：:Targeting protein kinases as a therapeutic approach to treat various diseases, especially cancer is currently a fast growing business. Although many inhibitors are available, exhibiting remarkable potency, the major challenge is their selectivity. Here we show that the protein kinase CK2 inhibitors DMAT, TBB and resor...

journal_title：International journal of oncology

authors： Fritz G,Issinger OG,Olsen BB

更新日期：2009-11-01 00:00:00

abstract：:Most solid tumors display extracellular acidosis, which only partially overlaps with hypoxia and induces distinct adaptive changes leading to aggressive phenotype. Although acidosis is mainly attributable to excessive production of lactic acid, it also involves carbonic anhydrase (CA) IX-mediated conversion of CO(2) t...

journal_title：International journal of oncology

authors： Ihnatko R,Kubes M,Takacova M,Sedlakova O,Sedlak J,Pastorek J,Kopacek J,Pastorekova S

更新日期：2006-10-01 00:00:00

abstract：:The Tap1 and Tap2 genes encoding for a heterodimeric peptide transporter play a key role in antigen processing and presentation. The TAP complex mediates the transport of peptides generated by the IFN-gamma-inducible proteasome subunits LMP2, 7 and 10 from the cytosol into the endoplasmic reticulum (ER), where they bi...

journal_title：International journal of oncology

authors： Seliger B,Bock M,Ritz U,Huber C

更新日期：2002-02-01 00:00:00

abstract：:Developing simple and effective approaches to detect tumor markers will be critical for early diagnosis or prognostic evaluation of prostate cancer treatment. Prostate‑specific membrane antigen (PSMA) has been validated as an important tumor marker for prostate cancer progression including angiogenesis and metastasis....

journal_title：International journal of oncology

authors： Liu T,Mendes DE,Berkman CE

更新日期：2014-03-01 00:00:00