HOXB4 knockdown reverses multidrug resistance of human myelogenous leukemia K562/ADM cells by downregulating P-gp, MRP1 and BCRP expression via PI3K/Akt signaling pathway.

abstract：:Hematopoietic disorders can be used as a suitable tool of additional information on the actual resolving power of comparative genomic hybridization (CGH). Therefore, CGH examination was performed of DNA extracted from 23 acute and 15 chronic myeloproliferative disorders which had just been analyzed using classical cyt...

journal_title：International journal of oncology

authors： Gebhart E,Verdorfer I,Saul W,Trautmann U,Brecevic L

更新日期：2000-06-01 00:00:00

abstract：:The modifying effects of dietary administration of capsaicin, which is the principal pungent capsicum fruit, and rotenone, which is a naturally occurring pesticide derived from Derris and Lonchorcarpus species, on azoxymethane (AOM)-induced colon tumorigenesis were investigated in male F344 rats. Gavage with capsaicin...

journal_title：International journal of oncology

authors： Yoshitani SI,Tanaka T,Kohno H,Takashima S

更新日期：2001-11-01 00:00:00

abstract：:Accumulation of epigenetic alterations causes inactivation of tumor suppressors and contributes to the initiation and progression of hepatocellular carcinoma (HCC). Identification of methylated genes is necessary to improve our understanding of the pathogenesis of HCC and develop novel biomarkers and therapeutic targe...

journal_title：International journal of oncology

authors： Tanaka Y,Kanda M,Sugimoto H,Shimizu D,Sueoka S,Takami H,Ezaka K,Hashimoto R,Okamura Y,Iwata N,Tanaka C,Yamada S,Fujii T,Nakayama G,Koike M,Nomoto S,Fujiwara M,Kodera Y

更新日期：2015-01-01 00:00:00

abstract：:The p53-induced wig-1 gene encodes an unusual nuclear zinc finger protein with high sequence similarity between human, rat and mouse. Wig-1 belongs to a group of proteins with widely spaced zinc fingers that bind double stranded (ds) RNA. We show here that wig-1 is present in Gallus gallus (chicken), Silurana tropical...

journal_title：International journal of oncology

authors： Hellborg F,Wiman KG

更新日期：2004-06-01 00:00:00

abstract：:Recent studies demonstrated an epigenetic inactivation of the runt-related transcription factor 3 (RUNX3) gene in human colon cancer. However, it remains unclear whether RUNX3 is tumor suppressive in colon cancer and, if so, the underlying molecular mechanisms of this activity are still unknown. In the present study, ...

journal_title：International journal of oncology

authors： Peng Z,Tang H,Wang X,Zhou C,Fan J,Wang L,Jia Z,Li Q,Le X,Wei D,Xie K

更新日期：2008-11-01 00:00:00

abstract：:Using two malignant rat glioma cell lines, we tested to what extent peripheral immunization could affect tumor growth in the brain of syngeneic rats. Peripheral subcutaneous (s.c.) immunization was performed with autologous Newcastle-disease-virus (NDV)-infected or non-infected live tumor cells. Thus immunized rats or...

journal_title：International journal of oncology

authors： Naujocks G,Schmitz A,Schramm J,Wiestler O,Schirrmacher V

更新日期：1995-04-01 00:00:00

abstract：:The tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has emerged as a promising anticancer agent with high tumor-selective cytotoxicity. The congenital and acquired resistance of some cancer types including malignant melanoma and osteosarcoma impede the current TRAIL therapy of these cancers. Since fine...

journal_title：International journal of oncology

authors： Ohshima Y,Takata N,Suzuki-Karasaki M,Yoshida Y,Tokuhashi Y,Suzuki-Karasaki Y

更新日期：2017-10-01 00:00:00

abstract：:Growth factors may play a role in autocrine or paracrine growth control of tumour cells. We have now examined the expression pattern in vivo by in situ hybridization (ISH) on a series of 13 ductal adenocarcinomas of the pancreas using the non-radioactive digoxigenin system to generate specific antisense orientated rib...

journal_title：International journal of oncology

authors： Leung H,Hughes C,Kloppel G,Williamson R,Lemoine N

更新日期：1994-06-01 00:00:00

abstract：:It is well established that the tumor microenvironment plays a major role in the aggressive behavior of malignant solid tumors. Among cell types associated with tumor microenvironment, tumor-associated macrophages (TAMs) are the most influential for tumor progression. Breast cancer is characterized by having a large p...

journal_title：International journal of oncology

authors： Obeid E,Nanda R,Fu YX,Olopade OI

更新日期：2013-07-01 00:00:00

abstract：:After the publication of the article, the authors have realized that the affiliation presented for the joint co‑author listed on the paper (Jian‑Ren Tu) was incorrect. The correct author list (and affiliations) should therefore have been published as follows: Yu‑Hua Xu1*, Jian‑Ren Tu2*, Tian‑Tian Zhao3, Shi‑Guang Xie3...

journal_title：International journal of oncology

authors： Xu YH,Tu JR,Zhao TT,Xie SG,Tang SB

更新日期：2019-07-01 00:00:00

abstract：:There is an urgent requirement for a new therapeutic target for activated B-cell-like lymphoma (ABC-DLBCL), which is known to have dismal outcome and constitutive activation of NF-κB. Heme oxygenase-1 (HO-1) can inhibit apoptosis and promote proliferation in many cancers. To our knowledge, no studies have been perform...

journal_title：International journal of oncology

authors： Huang J,Guo P,Ma D,Lin X,Fang Q,Wang J

更新日期：2016-07-01 00:00:00

abstract：:The DNA topoisomerase I inhibitor beta-lapachone, the product of a tree from South America, is known to exhibit various biological properties, the mechanisms of which are poorly understood. We investigated the effects of beta-lapachone on the growth of human prostate epithelial cells. Upon treatment with beta-lapachon...

journal_title：International journal of oncology

authors： Choi YH,Kim MJ,Lee SY,Lee YN,Chi GY,Eom HS,Kim ND,Choi BT

更新日期：2002-12-01 00:00:00

abstract：:Thymic epithelial tumors comprise thymoma, thymic carcinoma and neuroendocrine tumors of the thymus. Recent studies have revealed that the incidence of somatic non‑synonymous mutations is significantly higher in thymic carcinoma than in thymoma. However, limited information is currently available on epigenetic alterat...

journal_title：International journal of oncology

authors： Kishibuchi R,Kondo K,Soejima S,Tsuboi M,Kajiura K,Kawakami Y,Kawakita N,Sawada T,Toba H,Yoshida M,Takizawa H,Tangoku A

更新日期：2020-01-01 00:00:00

abstract：:We evaluated the effect of intravenous thermosensitive liposomal doxorubicin (TL-DOX) together with local hyperthermia on primary tumors in highly metastatic hamster osteosarcoma. This combination resulted in higher DOX concentrations in plasma, primary tumors and lungs than standard DOX under the same conditions. Tum...

journal_title：International journal of oncology

authors： Shimose S,Sugita T,Nitta Y,Kubo T,Ikuta Y,Murakami T

更新日期：2001-09-01 00:00:00

abstract：:We examined the optimal duration of whole body hyperthermia (WBH, 41.5 degrees C) when administered simultaneously with cis-diamminedichloroplatinum(II) (CDDP) using F344 rat fibrosarcoma model. The antitumor efficacy was measured by tumor growth delay (TGD) and nephrotoxicity was evaluated by the day 5 blood urea nit...

journal_title：International journal of oncology

authors： Makino M,Ohno S,Sakaguchi Y,Kaneko T,Strebel F,Jenkins G,Bull J

更新日期：1997-02-01 00:00:00

abstract：:Patients with long-standing ulcerative colitis (UC) have higher risk of developing colorectal cancer. Albeit the causes remain to be understood, epigenetic alterations have been suggested to play a role in the long-term cancer risk of these patients. In this work, we developed a novel microarray platform based on meth...

journal_title：International journal of oncology

authors： Koizumi K,Alonso S,Miyaki Y,Okada S,Ogura H,Shiiya N,Konishi F,Taya T,Perucho M,Suzuki K

更新日期：2012-04-01 00:00:00

abstract：:The effects of different substrate stiffness were investigated on epithelial-mesenchymal transition (EMT) of cervical cancer cell lines and the role of miR-106b and its target protein DAB2 therein. Cervical cancer cell lines HeLa and SiHa were cultured on artificial substrates with different stiffness prepared using d...

journal_title：International journal of oncology

authors： Piao J,You K,Guo Y,Zhang Y,Li Z,Geng L

更新日期：2017-06-01 00:00:00

abstract：:Our study reviews the central role of androgens for the development of androgen-insensitive growth in prostatic carcinoma using an individual dynamic model which emulates aspects of proliferation control. Our aim is the identification of individually proliferating cells from prostate carcinoma. Short-term cultured cel...

journal_title：International journal of oncology

authors： Zwergel T,Burk U,Herter S,Lindenmeir T,Wullich B,Unteregger G

更新日期：1995-12-01 00:00:00

abstract：:Seventy French high-risk families were screened for germ-line BRCA-1 mutations. The BRCA-1 coding region and the exon-intron boundaries were sequenced, except when pre-screening by PTT revealed a truncated protein in exon 11. Germ-line BRCA-1 mutations were detected in 24% of families. The number of breast and ovarian...

journal_title：International journal of oncology

authors： Laplace-Marieze V,Presneau N,Sylvain V,Kwiatkowski F,Lortholary A,Hardouin A,Bignon YJ

更新日期：1999-05-01 00:00:00

abstract：:Primary liver cancer is globally the sixth most frequent cancer, and the second leading cause of cancer death and its incidence is increasing in many countries, thus, becoming serious threat to human health. Substantial research has focused on the treatment and prevention of liver cancer. However, the underlying molec...

journal_title：International journal of oncology

authors： Hu B,Sun M,Liu J,Hong G,Lin Q

更新日期：2016-04-01 00:00:00

abstract：:Primary cilia are microtubule-based organelles that regulate smoothened-dependent activation of the GLI transcription factors in canonical hedgehog signaling. In many cancers, primary cilia are markedly decreased or absent. The lack of primary cilia may inhibit or alter canonical hedgehog signaling and, thereby, inter...

journal_title：International journal of oncology

authors： Spann AL,Yuan K,Goliwas KF,Steg AD,Kaushik DD,Kwon YJ,Frost AR

更新日期：2015-07-01 00:00:00

abstract：:The case of a patient presenting with a myeloproliferative disorder (MPD) characterized by a t(8;22) (p12;q11) translocation was investigated. The rearrangement resulted in the production of BCR-FGFR1 and FGFR1-BCR chimeric transcripts after in-frame fusions of BCR exon 4 with FGFR1 exon 9 and FGFR1 exon 8 with BCR ex...

journal_title：International journal of oncology

authors： Murati A,Arnoulet C,Lafage-Pochitaloff M,Adélaide J,Derré M,Slama B,Delaval B,Popovici C,Vey N,Xerri L,Mozziconacci MJ,Boulat O,Sainty D,Birnbaum D,Chaffanet M

更新日期：2005-06-01 00:00:00

abstract：:Reports of the metabolomic characteristics of esophageal cancer are limited. In the present study, we thus conducted metabolome analysis of paired tumor tissues (Ts) and non-tumor esophageal tissues (NTs) using capillary electrophoresis time-of-flight mass spectrometry (CE-TOFMS). The Ts and surrounding NTs were surgi...

journal_title：International journal of oncology

authors： Tokunaga M,Kami K,Ozawa S,Oguma J,Kazuno A,Miyachi H,Ohashi Y,Kusuhara M,Terashima M

更新日期：2018-06-01 00:00:00

abstract：:Intrinsic resistance of glioma cells to radiation and chemotherapy is currently hypothesized to be partially attributed to the existence of cancer stem cells. Emerging studies suggest that mesenchymal stem cells may serve as a potential carrier for delivery of therapeutic genes to disseminated glioma cells. However, t...

journal_title：International journal of oncology

authors： Liu Z,Jiang Z,Huang J,Huang S,Li Y,Sheng F,Yu S,Yu S,Liu X

更新日期：2014-04-01 00:00:00

abstract：:Abnormal accumulation and activation of the recepteur d'origine nantais (RON) has been implicated in epithelial tumor carcinogenesis. In the present study, we examined the effect of epigallocatechin-3-gallate (EGCG), the major green tea catechin, on the induction of RON and tumor growth in human gastric cancer. EGCG i...

journal_title：International journal of oncology

authors： Park JS,Khoi PN,Joo YE,Lee YH,Lang SA,Stoeltzing O,Jung YD

更新日期：2013-03-01 00:00:00

abstract：:A normal human lymphocyte-derived 54 kDa polypeptide, capable of regulating cell growth has been identified as an isoform variant (abbreviated as NP54) of protein neuroleukin-phosphoglucose isomerase (PGI). Since distinct PGI variants undetectable in normal tissues had been identified in breast cancer tissues, the eff...

journal_title：International journal of oncology

authors： Chiao JW,Xu W,Yang YM,Kancherla R,Seiter K,Ahmed T,Mittelman A

更新日期：1999-10-01 00:00:00

abstract：:Regulation of cytoplasmic p21CIP/WAF1 (p21) is of great clinical significance in molecular oncology due to its identification as an antiapoptotic factor, a poor survival predictor as well as a drug-resistance inducer. A retrospective study of the immunohistochemical (IHC) profiles of 128 human primary breast cancers s...

journal_title：International journal of oncology

authors： Ping B,He X,Xia W,Lee DF,Wei Y,Yu D,Mills G,Shi D,Hung MC

更新日期：2006-11-01 00:00:00

abstract：:Diagnostic features of 102 consecutive cases of cancer reoccurrence in the conserved breast are reported. The sensitivity of palpation, mammography, cytology or ultrasonography was 75.5%, 58.7%, 77.4% and 77.8%, respectively. Mammography failures were not due to natural breast density and could probably be explained b...

journal_title：International journal of oncology

authors： Ciatto S,Cataliotti L,Pacini P,Distante V,Bianchi S,Simoncini R,Cardona G,Rontini M,Falli F,Elbetti C

更新日期：1993-08-01 00:00:00

abstract：:Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is promising for cancer treatment owing to its selective cytotoxicity against malignant cells. However, some cancer cell types, including malignant melanoma cells, are resistant to TRAIL-induced apoptosis. Therefore, dr...

journal_title：International journal of oncology

authors： Suzuki Y,Inoue T,Murai M,Suzuki-Karasaki M,Ochiai T,Ra C

更新日期：2012-08-01 00:00:00

abstract：:Chemotherapy is an established treatment modality for bone sarcomas such as osteosarcoma (OS). However, the use of chemotherapy in high-grade soft tissue sarcomas remains controversial, with the most active chemotherapeutic agent, doxorubicin (DOX), reported to have a response rate of, at best only 34% and most studie...

journal_title：International journal of oncology

authors： Bouralexis S,Clayer M,Atkins GJ,Labrinidis A,Hay S,Graves S,Findlay DM,Evdokiou A

更新日期：2004-05-01 00:00:00