EGCG inhibits recepteur d'origine nantais expression by suppressing Egr-1 in gastric cancer cells.

abstract：:Recent studies show an increased incidence of head and neck cancers worldwide. The present study evaluated the trend in the incidence of head and neck cancers in England during 2002-2011. Data were extracted from the database of Office for National Statistics. The study population was categorised according to age, res...

journal_title：International journal of oncology

authors： McCarthy CE,Field JK,Rajlawat BP,Field AE,Marcus MW

更新日期：2015-07-01 00:00:00

abstract：:The present in vitro study on three human renal cell carcinoma (RCC) cell lines (A-498, ACHN, SN12C) evaluated the efficacy of 2',2'-difluorodeoxycytidine (dFdC, gemcitabine), vinblastine (VBL), rhu-interferon-alpha (IFN-alpha) and rhu-interferon-gamma (IFN-gamma) alone or in combinations. The cytotoxicity was measure...

journal_title：International journal of oncology

authors： Rohde D,Hayn HK,Blatter J,Jakse G

更新日期：1998-06-01 00:00:00

abstract：:The gp160 human kidney differentiation antigen is identical to human aminopeptidase A (APA), a zinc-dependent cell-surface metallopeptidase which hydrolyzes peptides with N-terminal acidic residues. GP160/APA is constitutively expressed by proximal tubule cells, the normal cellular counterpart of most renal cancers (R...

journal_title：International journal of oncology

authors： Nanus DM,Bogenrieder T,Papandreou CN,Finstad CL,Lee A,Vlamis V,Motzer RJ,Bander NH,Albino AP,Reuter VE

更新日期：1998-08-01 00:00:00

abstract：:We examined the clinical significance of E-cadherin and vimentin expression in 83 patients with breast dancer. E-cadherin expression was correlated with axillary metastases, histologic grade, recurrence and disease-free survival, but not with overall survival. On the other hand, vimentin expression was correlated with...

journal_title：International journal of oncology

authors： Yagasaki R,Noguchi M,Minami M,Earashi M

更新日期：1996-10-01 00:00:00

abstract：:Chemotherapeutic resistance remains a critical clinical issue is responsible for treatment failure in patients with ovarian cancer. Evidence of the involvement of miRNAs in chemoresistance in ovarian cancer has been recently emerging. However, the underlying molecular links between chemoresistance and miRNAs remain la...

journal_title：International journal of oncology

authors： Xu M,Xiao J,Chen M,Yuan L,Li J,Shen H,Yao S

更新日期：2018-03-01 00:00:00

abstract：:Rearranged during transfection kinase (RET) is a validated molecular target in medullary thyroid cancer (MTC), as activating mutations in RET are often associated with the development of MTC. The present study reports the first preclinical characterization of salinomycin and selected analogs as potent RET transcriptio...

journal_title：International journal of oncology

authors： Alqahtani T,Kumarasamy VM,Huczyński A,Sun D

更新日期：2020-01-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is difficult to diagnose early, resulting in only 30% resection rate. HCC is a relatively chemo-resistant tumor, molecular targeted therapy can only benefit approximately 30% patients with liver cancer. Bufalin (Bu) is one of the topoisomerase II inhibitors, many studies have recently fo...

journal_title：International journal of oncology

authors： Sheng X,Sun X,Sun K,Sui H,Qin J,Li Q

更新日期：2016-10-01 00:00:00

abstract：:The lack of good molecular markers for diagnosis as well as treatment assessment has rendered the hepatocellular carcinoma (HCC) a major challenge in health care. In this study, woodchucks were used as an animal model for hepatitis virus-induced HCC, and gene expression studies were performed using a human oligonucleo...

journal_title：International journal of oncology

authors： Wang F,Anderson PW,Salem N,Kuang Y,Tennant BC,Lee Z

更新日期：2007-01-01 00:00:00

abstract：:Pleomorphic adenomas (PAs) of salivary glands are characterized by the mixed appearance of epithelial and mesenchymal-like components such as myxoid and chondroid tissues. Although various studies have examined PAs, thus far it is not clear how PAs make these multiple components. Thus, clarification of the histodiffer...

journal_title：International journal of oncology

authors： Kitagawa M,Ogawa I,Shima K,Hashimoto S,Kudo Y,Miyauchi M,Tahara H,Shimono M,Takata T

更新日期：2007-08-01 00:00:00

abstract：:Twenty-one patients with isolated colorectal liver metastases underwent hepatic artery infusion (HAI) port implantation for regional chemotherapy with bolus injections of 5-FU, LV and fast drip of cisplatin. Ten of the 21 patients had previously failed systemic chemotherapy before HAI. Toxicity was moderate and no nee...

journal_title：International journal of oncology

authors： Lyass S,Lyass O,Gabizon A,Peretz T,Eid A,Muggiasullam M,Durst A,Shiloni E

更新日期：1996-12-01 00:00:00

abstract：:Multiple drug resistance is reported to be a major obstacle in treatment of osteosarcoma (OS). Research has demonstrated that small subsets of cells called cancer stem cells (CSCs) are responsible for multiple drug resistance. CSCs are potential targets for reversing chemoresistance. In the present study, we compared ...

journal_title：International journal of oncology

authors： Shang D,Wu J,Guo L,Xu Y,Liu L,Lu J

更新日期：2017-05-01 00:00:00

abstract：:Conventional cancer treatments are not adequate for the majority of most patients stricken with squamous cell carcinomas of the head and neck (SCCHN). Conditionally replicating adenoviruses (CRAds) represent a promising new modality for treating of neoplastic diseases, including SCCHN. Specifically, CRAd agents infect...

journal_title：International journal of oncology

authors： Zhu ZB,Mathis JM,Makhija SK,Lu B,Wang M,Ji S,Rivera AA,Rosenthal EL,Siegal GP,Curiel DT

更新日期：2007-11-01 00:00:00

abstract：:The effects of a thymic peptide preparation (TP) on the immunocytotoxicity and cytokine secretion of peripheral blood lymphocytes and monocytes from patients with colorectal tumors, breast tumors and melanoma were studied in vitro. On average, breast tumor and melanoma patients showed significantly lower natural kille...

journal_title：International journal of oncology

authors： Eckert K,Mayer G,Stange R,Kalden M,Krasagakis K,Maurer H

更新日期：1997-03-01 00:00:00

abstract：:Retroviral infection of hTERT, the catalytic component of telomerase, into BJ fibroblasts (population doubling 28) resulted in reconstitution of telomerase activity, telomere maintenance, and extension of in vitro lifespan. The hTERT-infected cells also exhibited increased growth rate and colony forming efficiency rel...

journal_title：International journal of oncology

authors： Forsythe HL,Elmore LW,Jensen KO,Landon MR,Holt SE

更新日期：2002-06-01 00:00:00

abstract：:Delivery of electric pulses to an established solid tumor augments the permeability of cell membrane and increases the susceptibility of tumors to an anti-cancer agent that is administered in the vicinity of tumors. Forced expression of the wild-type p53 gene in tumor cells that have non-functional p53 gene(s) can als...

journal_title：International journal of oncology

authors： Matsubara H,Maeda T,Gunji Y,Koide Y,Asano T,Ochiai T,Sakiyama S,Tagawa M

更新日期：2001-04-01 00:00:00

abstract：:We investigated Fas expression and Fas-mediated apoptosis on 25 surgically resected renal cell carcinoma (RCC) tissues and 8 RCC cell lines. Immunohistochemistry demonstrated that cancer cells in the 25 tissues expressed Fas (100%). Fas expression was confirmed in all cell lines at protein and mRNA levels, but the 7 c...

journal_title：International journal of oncology

authors： Inoue M,Yano H,Kojiro M

更新日期：1996-07-01 00:00:00

abstract：:After the publication of the article, the authors have realized that the affiliation presented for the joint co‑author listed on the paper (Jian‑Ren Tu) was incorrect. The correct author list (and affiliations) should therefore have been published as follows: Yu‑Hua Xu1*, Jian‑Ren Tu2*, Tian‑Tian Zhao3, Shi‑Guang Xie3...

journal_title：International journal of oncology

authors： Xu YH,Tu JR,Zhao TT,Xie SG,Tang SB

更新日期：2019-07-01 00:00:00

abstract：:Gallbladder cancer (GBC) is one of the most unfavorable prognostic tumor, and immediate growth and distant metastasis are important factors associated with the poor prognosis of patients with this disease. Standard and variant isoforms of CD44 are associated with tumor growth, metastasis, and epithelial-mesenchymal tr...

journal_title：International journal of oncology

authors： Miwa T,Nagata T,Kojima H,Sekine S,Okumura T

更新日期：2017-09-01 00:00:00

abstract：:A multi stage extraction procedure which gives the possibility to analyze both water soluble and lipid components stemming from the same specimen has been developed in our laboratory. Metabolites from brain cancer biopsies have been compared to metabolites in normal human brain, developing mouse brain and primary mous...

journal_title：International journal of oncology

authors： Sonnewald U,Westergaard N,Isern E,Muller T,Schousboe A,Petersen S,Unsgard G

更新日期：1993-04-01 00:00:00

abstract：:The human immunodeficiency virus (HIV) protein negative factor (Nef) is important for AIDS pathogenesis. An anti-Nef single-domain antibody (sdAb19) derived from camelids has been previously generated and shown to effectively block the physiological functions of Nef in vitro and in vivo in nef-transgenic mice. However...

journal_title：International journal of oncology

authors： Fan X,Wei J,Xiong H,Liu X,Benichou S,Gao X,Liu L

更新日期：2015-10-01 00:00:00

abstract：:The epidermal growth factor (EGFR) pathway is frequently activated in glioblastoma but the clinical efficacy of EGFR inhibitors in malignant glioma has been disappointing. The reasons for the failure of the mechanisms of resistance of these inhibitors are unclear, but may involve factors of the tumor microenvironment ...

journal_title：International journal of oncology

authors： Hartel I,Ronellenfitsch M,Wanka C,Wolking S,Steinbach JP,Rieger J

更新日期：2016-07-01 00:00:00

abstract：:This study defines the role of WWOX in the regulation of epithelial to mesenchymal transition. A group of 164 endometrial adenocarcinoma patients was studied as well as an ECC1 well-differentiated steroid-responsive endometrial cell line, which was transducted with WWOX cDNA by a retroviral system. The relationship be...

journal_title：International journal of oncology

authors： Płuciennik E,Nowakowska M,Pospiech K,Stępień A,Wołkowicz M,Gałdyszyńska M,Popęda M,Wójcik-Krowiranda K,Bieńkiewicz A,Bednarek AK

更新日期：2015-01-01 00:00:00

abstract：:Bioinformatics and computational modeling offer innovative approaches to investigate cancer metabolism and predict the secondary and tertiary cellular responses. Dysregulation of metabolism has also been implicated in the pathophysiology of cancer. A significant proportion of patients with glioblastoma and hematologic...

journal_title：International journal of oncology

authors： Koseki J,Colvin H,Fukusumi T,Nishida N,Konno M,Kawamoto K,Tsunekuni K,Matsui H,Doki Y,Mori M,Ishii H

更新日期：2015-03-01 00:00:00

abstract：:The objective of the present study was to establish the individual and combined chemopreventive potential of a widely used non-steroidal anti-inflammatory drug, ibuprofen (IBU), encapsulated in solid lipid nanoparticles (SLNs) for the chemoprevention of pancreatic cancer. The IBU SLNs were optimized using various lipi...

journal_title：International journal of oncology

authors： Thakkar A,Chenreddy S,Wang J,Prabhu S

更新日期：2015-04-01 00:00:00

abstract：:Advanced castration-resistant prostate cancer has high mortality rates and limited treatment options. Novel therapies are needed to better contend with this disease. Polysaccharide-K® (PSK), an extract of the mushroom Trametes versicolor, has immunomodulatory and tumor suppressive a...

journal_title：International journal of oncology

authors： Wenner CA,Martzen MR,Lu H,Verneris MR,Wang H,Slaton JW

更新日期：2012-04-01 00:00:00

abstract：:Although epidemiological studies have suggested a positive correlation between environmental radon exposure and prostate cancer, the mechanism involved is not clear. In the present study, we examined the oncogenic transforming potency of alpha-particles using non-tumorigenic, telomerase-immortalized human benign prost...

journal_title：International journal of oncology

authors： Li H,Gu Y,Miki J,Hukku B,McLeod DG,Hei TK,Rhim JS

更新日期：2007-09-01 00:00:00

abstract：:Targeted cancer therapies are used to inhibit the growth, progression, and metastasis of the tumor by interfering with specific molecular targets and are currently the focus of anticancer drug development. Protein kinase B, also known as Akt, plays a central role in many types of cancer and has been validated as a the...

journal_title：International journal of oncology

authors： Nitulescu GM,Margina D,Juzenas P,Peng Q,Olaru OT,Saloustros E,Fenga C,Spandidos DΑ,Libra M,Tsatsakis AM

更新日期：2016-03-01 00:00:00

abstract：:The inhibitory effects of macrolide antibiotics including clarithromycin (CAM) on autophagy flux have been reported. Although a macrolide antibiotic exhibits no cytotoxicity, its combination with bortezomib (BZ), a proteasome inhibitor, for the simultaneous blocking of the ubiquitin (Ub)‑proteasome and autophagy‑lysos...

journal_title：International journal of oncology

authors： Moriya S,Komatsu S,Yamasaki K,Kawai Y,Kokuba H,Hirota A,Che XF,Inazu M,Gotoh A,Hiramoto M,Miyazawa K

更新日期：2015-02-01 00:00:00

abstract：:The mitogen-activated protein kinase (MAPK) cascade is a critical component in the regulation of cell survival and proliferation decisions. In breast carcinoma cells, activation of the p38-MAPK member of this family occurs in response to pro-inflammatory cytokines and cellular stress. The involvement of p38-MAPK in th...

journal_title：International journal of oncology

authors： Weldon CB,Parker AP,Patten D,Elliott S,Tang Y,Frigo DE,Dugan CM,Coakley EL,Butler NN,Clayton JL,Alam J,Curiel TJ,Beckman BS,Jaffe BM,Burow ME

更新日期：2004-06-01 00:00:00

abstract：:Gastric carcinoma is the most common cancer and the second most common cause of cancer-related death in Korea. Many studies have been reported regarding prognostic factors. Among the category I prognostic factors of gastric carcinoma, lymph node metastasis (nodal status) is considered to be the strongest prognostic fa...

journal_title：International journal of oncology

authors： Lee SY,Hwang I,Park YS,Gardner J,Ro JY

更新日期：2010-06-01 00:00:00