Salinomycin and its derivatives as potent RET transcriptional inhibitors for the treatment of medullary thyroid carcinoma.

abstract：:Most malignant tumors have a defect in the Rb pathway that allows them to proliferate autonomously, unrestricted by the availability of mitogens and growth factors. This defect preconditions tumor cells to be less sensitive to inhibitors of growth factor receptors and/or signal transduction pathways that arrest normal...

journal_title：International journal of oncology

authors： Du L,Smolewski P,Bedner E,Traganos F,Darzynkiewicz Z

更新日期：2001-10-01 00:00:00

abstract：:Selenium is considered to be one of the most promising micronutrients for cancer prevention and therapy, based on evidence from epidemiological studies, laboratory-based research and clinical trial intervention. There are ample reports of selenium methionine and sodium selenite's ability to induce apoptosis in various...

journal_title：International journal of oncology

authors： Rooprai HK,Kyriazis I,Nuttall RK,Edwards DR,Zicha D,Aubyn D,Davies D,Gullan R,Pilkington GJ

更新日期：2007-05-01 00:00:00

abstract：:Elevated levels of p21WAF1/CIP1, an important mediator of DNA repair, have been observed in various aggressive tumors as well as linked to chemoresistance. We examined whether heregulin (HRG), a member of the EGF-like growth factor family closely related to breast cancer tumorigenesis and metastasis, modulates p21WAF1...

journal_title：International journal of oncology

authors： Menendez JA,Mehmi I,Lupu R

更新日期：2005-03-01 00:00:00

abstract：:Although it has been shown that the cross-talk between osteoblasts and tumor cells stimulates proliferation and invasion of prostate carcinoma (PCa) cells, the molecular mechanisms underlying this event are largely unknown. In this study, we demonstrated that the PCa cells, PC3, derived from bone metastasis, undergo c...

journal_title：International journal of oncology

authors： Millimaggi D,Festuccia C,Angelucci A,D'Ascenzo S,Rucci N,Flati S,Bologna M,Teti A,Pavan A,Dolo V

更新日期：2006-04-01 00:00:00

abstract：:Using two malignant rat glioma cell lines, we tested to what extent peripheral immunization could affect tumor growth in the brain of syngeneic rats. Peripheral subcutaneous (s.c.) immunization was performed with autologous Newcastle-disease-virus (NDV)-infected or non-infected live tumor cells. Thus immunized rats or...

journal_title：International journal of oncology

authors： Naujocks G,Schmitz A,Schramm J,Wiestler O,Schirrmacher V

更新日期：1995-04-01 00:00:00

abstract：:Hepatocellular carcinoma is one of the most common cancers in the world. Previously, we found that the level of glucocorticoid receptor was significantly higher in hepatocellular carcinoma than in adjacent liver tissues. Moreover, in vitro and in vivo studies showed that glucocorticoid stimulated the growth of hepatom...

journal_title：International journal of oncology

authors： Uen YH,Ko PH,Yin PH,Liu TY,Chi CW,Lui WY

更新日期：2008-12-01 00:00:00

abstract：:In recent years major progress has been made in understanding the molecular steps of death receptor and mitochondrial pathway of apoptosis. Mechanisms of NF-kappaB-mediated survival (anti-apoptotic) signal have been delineated. A novel anti-apoptotic mechanism of FLIP in the recruitment of RIP and TRAF-1 and TRAF-2 to...

journal_title：International journal of oncology

authors： Gupta S

更新日期：2003-01-01 00:00:00

abstract：:Observational, clinical and experimental studies have suggested that dietary supplementation with selenium can inhibit the development of colon cancer. Since toxicity and chemopreventive efficacy of selenium compounds depend to a large extent, on the form of selenium the development of efficacious organoselenium compo...

journal_title：International journal of oncology

authors： Kawamori T,El-Bayoumy K,Ji BY,Rodriguez JG,Rao CV,Reddy BS

更新日期：1998-07-01 00:00:00

abstract：:The regions upstream from the human N-myc gene were examined for both transcription and replication. The plasmids containing several N-myc regions linked to the bacterial chloramphenicol acetyltransferase (CAT) gene were transfected to human neuroblastoma IMR32 cells. The results indicated that the region spanning fro...

journal_title：International journal of oncology

authors： Nakagawa T,Imamura Y,Iguchiariga S,Ariga H

更新日期：1994-09-01 00:00:00

abstract：:Peptide hormone relaxin produced in normal and cancer prostate cells can stimulate prostate cancer progression. Suppression of relaxin or relaxin receptor RXFP1 expression inhibited prostate cancer both in vitro and in vivo. RXFP1 is a G protein-coupled receptor with the extracellular low density lipoprotein A (LDL-A)...

journal_title：International journal of oncology

authors： Feng S,Agoulnik AI

更新日期：2011-12-01 00:00:00

abstract：:Breast cancer (BC) continues to affect the lives of millions of women worldwide. Several members of the carcinoembryonic antigen-related cell adhesion molecule (CEACAM) subfamily are involved in tumor progression. Notably, the CEACAM subfamily harbors the already established cancer biomarker CEA, as well as other pote...

journal_title：International journal of oncology

authors： Michaelidou K,Tzovaras A,Missitzis I,Ardavanis A,Scorilas A

更新日期：2013-05-01 00:00:00

abstract：:Liposarcoma (LPS) is one of the most frequently reported type of soft‑tissue sarcoma (STS). Well‑differentiated (WD) LPS and dedifferentiated (DD) LPS are the two most common subtypes. Chemotherapy has been considered to be ineffective in LPS, and novel treatment agents are thus necessary. In this study, we reanalyzed...

journal_title：International journal of oncology

authors： Yen CC,Chen SC,Hung GY,Wu PK,Chua WY,Lin YC,Yen CH,Chen YC,Wang JY,Yang MH,Chao Y,Chang MC,Chen WM

更新日期：2019-10-01 00:00:00

abstract：:Hematopoietic disorders can be used as a suitable tool of additional information on the actual resolving power of comparative genomic hybridization (CGH). Therefore, CGH examination was performed of DNA extracted from 23 acute and 15 chronic myeloproliferative disorders which had just been analyzed using classical cyt...

journal_title：International journal of oncology

authors： Gebhart E,Verdorfer I,Saul W,Trautmann U,Brecevic L

更新日期：2000-06-01 00:00:00

abstract：:Establishment of tumor cell lines as model systems for studying tumor biology or as a part of immunotherapeutic anti-cancer strategies is of high importance, whereby the highest possible preservation of the original tumor cell phenotype is a prerequisite for these aims. Since overexpression of the catalytic subunit of...

journal_title：International journal of oncology

authors： Voglauer R,Grillari J,Fortschegger K,Wieser M,Sterovsky T,Gunsberg P,Katinger H,Pfragner R

更新日期：2005-04-01 00:00:00

abstract：:Shc protein is known to be related to cell proliferation and carcinogenesis. However, the involvement of Shc in hepatocellular carcinoma (HCC) remains unknown. In the present study, we report that p46 Shc is probably expressed in the nuclei of hepatocytes and/or cancer cells during the development of HCC in Long-Evans...

journal_title：International journal of oncology

authors： Yoshida S,Masaki T,Feng H,Yuji J,Miyauchi Y,Funaki T,Yoshiji H,Matsumoto K,Uchida N,Watanabe S,Kurokohchi K,Kuriyama S

更新日期：2004-10-01 00:00:00

abstract：:alpha-tocopheryl phosphate (TocP) has been elucidated for diverse effectiveness through unequivocal mechanisms independent of its conversion to alpha-tocopherol (Toc). The present study showed that TocP, in a dose-dependent manner, repressed invasion of human fibrosarcoma HT-1080 cells through the basement membrane, m...

journal_title：International journal of oncology

authors： Saitoh Y,Yumoto A,Miwa N

更新日期：2009-12-01 00:00:00

abstract：:Following the publication of this article, an interested reader drew to our attention that Fig. 1C contained an important flaw. The Figure shows a western blot for LCN2, DR4, DR5, and actin, and it was noted that the identical bands shown for actin were also featured in a paper by the same authors published in 2017 [L...

journal_title：International journal of oncology

authors： Kim SL,Min IS,Park YR,Lee ST,Kim SW

更新日期：2019-05-01 00:00:00

abstract：:Cervical cancer is a potentially preventable disease; however, it is the third most commonly diagnosed cancer and the fourth leading cause of cancer deaths in women worldwide. Cervical cancer is thought to develop through a multistep process involving virus, tumor suppressor genes, proto-oncogenes and immunological fa...

journal_title：International journal of oncology

authors： Xiao S,Zhou Y,Yi W,Luo G,Jiang B,Tian Q,Li Y,Xue M

更新日期：2015-04-01 00:00:00

abstract：:Gamma linolenic acid (GLA) is an anti-cancer agent recently reported to inhibit tumour cell-matrix attachment. This study examined the effects of GLA on the adhesion of two tumour cell lines, HT115 (human colon) and MDA MB 231 (human breast), to an extracellular matrix, Matrigel. The action of GLA on focal adhesion ki...

journal_title：International journal of oncology

authors： Jiang W,Hiscox S,Puntis M,Hallett M,Bryce R,Horrobin D,Mansel R

更新日期：1996-03-01 00:00:00

abstract：:Although epidemiological studies have suggested a positive correlation between environmental radon exposure and prostate cancer, the mechanism involved is not clear. In the present study, we examined the oncogenic transforming potency of alpha-particles using non-tumorigenic, telomerase-immortalized human benign prost...

journal_title：International journal of oncology

authors： Li H,Gu Y,Miki J,Hukku B,McLeod DG,Hei TK,Rhim JS

更新日期：2007-09-01 00:00:00

abstract：:Aurora kinase A (AURKA) regulates the cell cycle checkpoint and maintains genomic integrity. AURKA is overexpressed in various malignant tumors and its upregulation induces chromosomal instability, which leads to aneuploidy and cell transformation. To investigate the role of AURKA in endometrial cancer, we evaluated t...

journal_title：International journal of oncology

authors： Umene K,Yanokura M,Banno K,Irie H,Adachi M,Iida M,Nakamura K,Nogami Y,Masuda K,Kobayashi Y,Tominaga E,Aoki D

更新日期：2015-04-01 00:00:00

abstract：:Upregulation of nuclear factor-κB (NF-κB) in colorectal carcinoma (CRC) accelerates tumor growth, whereas, irinotecan (CPT-11)-induced NF-κB activation reduces chemosensitivity and weakens the anti-colorectal cancer function itself, while proteasome inhibitors can inhibit NF-κB and improve the effect of chemotherapy. ...

journal_title：International journal of oncology

authors： Tang W,Su G,Li J,Liao J,Chen S,Huang C,Liu F,Chen Q,Ye Y

更新日期：2014-09-01 00:00:00

abstract：:Cadherins play a crucial role in epithelial morphogenesis and mediate intercellular adhesion. These receptors bind catenins and are involved in signal transduction pathways that regulate cell growth and apoptosis, and are frequently down-regulated in invasive and metastatic carcinomas. In order to assess the role of E...

journal_title：International journal of oncology

authors： Vizirianakis IS,Chen YQ,Kantak SS,Tsiftsoglou AS,Kramer RH

更新日期：2002-07-01 00:00:00

abstract：:In the multistep progressive pathogenesis of human breast cancer, comedo ductal carcinoma in situ (DCIS) represents a preinvasive precursor lesion for therapy resistant invasive cancer. Human tissue derived cell culture models exhibiting molecular similarities to clinical DCIS facilitate an important preclinical mecha...

journal_title：International journal of oncology

authors： Katdare M,Osborne M,Telang NT

更新日期：2002-10-01 00:00:00

abstract：:Advanced metastatic melanoma is a malignant tumor for which there is currently no effective treatment due to resistance development. Ginsenoside Rg3, a saponin component extracted from ginseng roots, has been shown to reduce melanoma cell proliferation by decreasing histone deacetylase 3 and increasing p53 acetylation...

journal_title：International journal of oncology

authors： Meng L,Ji R,Dong X,Xu X,Xin Y,Jiang X

更新日期：2019-06-01 00:00:00

abstract：:Identification of aberrant expression patterns of genes in prostate cancer (PCa) is a key step towards the development of effective therapies. Prostate-specific antigen (PSA) levels are commonly measured for the early detection of PCa, but which itself is still not an ideal biomarker. We analysed the expression patter...

journal_title：International journal of oncology

authors： Lenka G,Weng WH,Chuang CK,Ng KF,Pang ST

更新日期：2013-12-01 00:00:00

abstract：:Reduced expression of a cyclin-dependent kinase inhibitor, p27, has been reported to be associated with poor prognosis in several human cancers. The aim of this study was to investigate the potential role of p27 in ovarian cancer development and progression. Immunohistochemical expression of p27 was determined using 1...

journal_title：International journal of oncology

authors： Shigemasa K,Shiroyama Y,Sawasaki T,Fujii T,Nagai N,Parmley TH,O'Brien TJ,Ohama K

更新日期：2001-05-01 00:00:00

abstract：:Early-onset breast cancer is one of the most common malignancies and causes of death among young women, and its incidence is increasing. In the present study, we aimed to investigate the epigenetic modifications of the breast cancer type 1 susceptibility gene (BRCA1) in breast tissues and blood cells derived from wome...

journal_title：International journal of oncology

authors： Al-Moghrabi N,Al-Qasem AJ,Aboussekhra A

更新日期：2011-07-01 00:00:00

abstract：:Double-stranded RNA-dependent protein kinase (PKR) is one of the players in the cellular antiviral responses and is involved in transcriptional stimulation through activation of NF-κB. Treatment of the human osteosarcoma cell line MG63 with the protein phosphatase inhibitor okadaic acid stimulated the expression and p...

journal_title：International journal of oncology

authors： Haneji T,Hirashima K,Teramachi J,Morimoto H

更新日期：2013-06-01 00:00:00

abstract：:Diosmetin, a plant flavonoid, has been shown to exert promising effects on prostate cancer cells as an anti‑proliferative and anticancer agent. In this study, using western blot analysis for protein expression and flow cytometry for cell cycle analysis, we determined that the treatment of the LNCaP and PC‑3 prostate c...

journal_title：International journal of oncology

authors： Oak C,Khalifa AO,Isali I,Bhaskaran N,Walker E,Shukla S

更新日期：2018-08-01 00:00:00