Loss of telomeric DNA during aging may predispose cells to cancer (review).

abstract：:The ADAMs (A disintegrin and metalloproteinase) are a family of cell-surface membrane glycoproteins, whose multidomain structure enables diverse roles in a wide range of cellular processes. Accumulating evidence associates an increased expression of individual ADAM family members with various types of cancer, and we i...

journal_title：International journal of oncology

authors： Carl-McGrath S,Lendeckel U,Ebert M,Roessner A,Röcken C

更新日期：2005-01-01 00:00:00

abstract：:A serum-specific protein 'fingerprint' model was established which is capable of evaluating the effect of chemotherapy (gemcitabine) of pancreatic adenocarcinoma. We used SELDI-TOF-MS coupled with CM10 chips and bioinformatics tools to analyze a total of 45 mouse serum samples from three groups: the healthy control gr...

journal_title：International journal of oncology

authors： Cao L,Wang L,Wang G,Liu D,Yu J,Que R,Xie D

更新日期：2010-12-01 00:00:00

abstract：:The interactions between cells and the extracellular matrix (EM) have important effects on tumor invasion and metastasis. Osteosarcoma (OS) is a highly metastatic tumor, secondary lesions occurring early in the natural history of the disease. Despite the clinical relevance of disseminated disease in this neoplasia, th...

journal_title：International journal of oncology

authors： Scotlandi K,Serra M,Manara M,Nanni P,Nicoletti G,Landuzzi L,Maurici D,Baldini N

更新日期：1993-11-01 00:00:00

abstract：:Chronic exposure to nickel compounds is associated with increased incidence of certain types of human cancer, including lung and nasal cancers. Despite intensive investigation, the oncogenic processes remain poorly understood. Apoptosis resistance is a key feature for tumor cells to escape physiological surveillance a...

journal_title：International journal of oncology

authors： Yang YX,Li XL,Wang L,Han SY,Zhang YR,Pratheeshkumar P,Wang X,Lu J,Yin YQ,Sun LJ,Budhraja A,Hitron AJ,Ding SZ

更新日期：2013-09-01 00:00:00

abstract：:Temozolomide (TMZ) is an alkylating chemotherapeutic agent widely used in anti-glioma treatment. However, acquired TMZ resistance represents a major clinical challenge that leads to tumor relapse or progress. This study investigated the genomic profiles including long non-coding RNA (lncRNA) and mRNA expression associ...

journal_title：International journal of oncology

authors： Zeng H,Xu N,Liu Y,Liu B,Yang Z,Fu Z,Lian C,Guo H

更新日期：2017-08-01 00:00:00

abstract：:The non-invasive treatment of tumors with preserved fertility holds great promise. The application of pulsed electric field (PEF) is a new biomedical engineering technique for tumor therapy. Picosecond pulsed electric fields (psPEF) can be transferred to target deep tissue non-invas...

journal_title：International journal of oncology

authors： Chen WJ,Xiong ZA,Zhang M,Yao CG,Zhao ZY,Hua YY,Zhou W

更新日期：2013-03-01 00:00:00

abstract：:Continued emphasis on treating endometrial cancer primarily as a surgical disease has led to the institution, in 1988, of a new staging system based on operative findings. Since the system is new, limited experience has been published confirming its theoretical advantage in predicting clinical outcome. In a four year ...

journal_title：International journal of oncology

authors： Park T,Mann W,Meek A,Bethune W,Chalas E,Kim J

更新日期：1994-01-01 00:00:00

abstract：:The Warburg effect is a unique metabolic feature of the majority of tumor cells and is closely related to chemotherapeutic resistance. Pyruvate dehydrogenase kinase 1 (PDK1) is considered a 'switch' that controls the fate of pyruvate in glucose metabolism. However, to date, to the best of our knowledge, there are only...

journal_title：International journal of oncology

authors： Xu H,He Y,Ma J,Zhao Y,Liu Y,Sun L,Su J

更新日期：2020-09-01 00:00:00

abstract：:In the multistep progressive pathogenesis of human breast cancer, comedo ductal carcinoma in situ (DCIS) represents a preinvasive precursor lesion for therapy resistant invasive cancer. Human tissue derived cell culture models exhibiting molecular similarities to clinical DCIS facilitate an important preclinical mecha...

journal_title：International journal of oncology

authors： Katdare M,Osborne M,Telang NT

更新日期：2002-10-01 00:00:00

abstract：:Side population (SP) cells are isolated from various tissues and cell lines based on the exclusion of DNA-binding dye Hoechst 33,342 and exhibit potent stem cell characteristics. There have been few previous reports of SP cells in head and neck cancer cell lines. Thus, we isolated SP cells from oral squamous cell carc...

journal_title：International journal of oncology

authors： Yajima T,Ochiai H,Uchiyama T,Takano N,Shibahara T,Azuma T

更新日期：2009-08-01 00:00:00

abstract：:New aromatase inhibitors are an exciting treatment option for postmenopausal women with hormone sensitive breast cancer. They have been shown to reduce tumors in a significant number of patients, and exhibit definite antitumor activity at a relatively low daily dose, and are highly potent, highly selective, and well-t...

journal_title：International journal of oncology

authors： Crucitta E,Lorusso V,Attolico M,Sambiasi D,Mazzei A,De Lena M

更新日期：2000-11-01 00:00:00

abstract：:Regulatory T cells (CD4+CD25+FoxP3+, Treg) have been shown to play a major role in suppression of the immune response to malignant gliomas. In this study, we investigated the kinetics of Treg infiltration in metastatic brain tumor models, including melanoma, breast and colon cancers. Our data indicate that both CD4+ a...

journal_title：International journal of oncology

authors： Sugihara AQ,Rolle CE,Lesniak MS

更新日期：2009-06-01 00:00:00

abstract：:Reduced expression of a cyclin-dependent kinase inhibitor, p27, has been reported to be associated with poor prognosis in several human cancers. The aim of this study was to investigate the potential role of p27 in ovarian cancer development and progression. Immunohistochemical expression of p27 was determined using 1...

journal_title：International journal of oncology

authors： Shigemasa K,Shiroyama Y,Sawasaki T,Fujii T,Nagai N,Parmley TH,O'Brien TJ,Ohama K

更新日期：2001-05-01 00:00:00

abstract：:Autocrine/paracrine stimulation of KIT has been observed in colorectal carcinoma (CRC) cell lines. We investigated the expression of KIT and stem cell factor (SCF) in CRC in comparison with premalignant colon lesions and normal colonic mucosa to assess the prognostic and therapeutic relevance of this receptor/ligand s...

journal_title：International journal of oncology

authors： Bellone G,Smirne C,Carbone A,Buffolino A,Scirelli T,Prati A,Solerio D,Pirisi M,Valente G,Nano M,Emanuelli G

更新日期：2006-10-01 00:00:00

abstract：:Previous studies from this laboratory have shown that bioflavonoids including luteolin and quercetin possess antiestrogenic activity in the female reproductive tract and appear to elicit this activity by interaction with type II [H-3]estradiol binding sites in the cell nucleus. Studies by a number of laboratories incl...

journal_title：International journal of oncology

authors： Markaverich B,Alejandro M

更新日期：1997-12-01 00:00:00

abstract：:Early detection and treatment are critical in the management of renal cell carcinoma (RCC). However, there is no standard serum biomarker to facilitate early diagnosis or prognostic stratification in patients with RCC. Recent reports suggest that circulating microRNAs (miRNAs) have great potential as biomarkers for di...

journal_title：International journal of oncology

authors： Iwamoto H,Kanda Y,Sejima T,Osaki M,Okada F,Takenaka A

更新日期：2014-01-01 00:00:00

abstract：:Autoimmune diseases are the consequence of the immune system attack on the self. Autoimmunity, sometimes, is reflected through the production of autoantibodies to various self antigens leading to cellular malfunction or destruction. In the current study we employ such autoantibodies for the treatment of cancer origina...

journal_title：International journal of oncology

authors： Fishman P,Merimsky O,Shoenfeld Y

更新日期：1997-05-01 00:00:00

abstract：:Raman spectroscopy is a vibrational spectroscopic technique that can be used to probe molecular changes associated with tissue malignancy. In this report, the effect of formalin fixation on human bronchial tissues was studied by near-infrared (NIR) Raman spectroscopy to determine if the variations of Raman spectra cau...

journal_title：International journal of oncology

authors： Huang Z,McWilliams A,Lam S,English J,McLean DI,Lui H,Zeng H

更新日期：2003-09-01 00:00:00

abstract：:To test the effects of combined transduction of a suicide gene and genes coding for various immunostimulatory factors on the oncogenicity and immunogenicity of TC-1 cells (HPV-16 transformed C57BL/6 mouse cells), several bicistronic recombinant adeno-associated viruses (rAAV) were constructed. Each of these constructs...

journal_title：International journal of oncology

authors： Janousková O,Síma P,Kunke D

更新日期：2003-03-01 00:00:00

abstract：:Chemokine-mediated activation of G protein-coupled receptors CXCR1/2 promotes tumor growth, invasion, inflammation and metastasis. Repertaxin, a CXCR1/2 small-molecule inhibitor, has been shown to attenuate many of these tumor-associated processes. The present study aimed to investigate the effects of repertaxin alone...

journal_title：International journal of oncology

authors： Wang J,Hu W,Wang K,Yu J,Luo B,Luo G,Wang W,Wang H,Li J,Wen J

更新日期：2016-04-01 00:00:00

abstract：:Bone morphogenetic protein 7 (BMP-7) is an important regulator of cell development and differentiation of various organs. Tumorigenesis and tumor progression are also strongly associated with changes of the fate of cells which are highly differentiated in healthy tissues. Therefore, we studied the role of BMP-7 in bre...

journal_title：International journal of oncology

authors： Schwalbe M,Sänger J,Eggers R,Naumann A,Schmidt A,Höffken K,Clement JH

更新日期：2003-07-01 00:00:00

abstract：:Long non-coding RNAs (lncRNAs) are involved in cancer progression. In the present study, we analyzed the lncRNA profiles in adriamycin-resistant and -sensitive breast cancer cells and found a group of dysregulated lncRNAs in the adriamycin-resistant cells. Expression of the dysregulated lncRNAs was correlated with dys...

journal_title：International journal of oncology

authors： He DX,Zhang GY,Gu XT,Mao AQ,Lu CX,Jin J,Liu DQ,Ma X

更新日期：2016-10-01 00:00:00

abstract：:The Equiguard is a dietary supplement comprised of standardized extracts from nine herbs, respectively, Herba epimedium brevicornum Maxim (stem and leaves), Radix morindae officinalis (root), Fructus rosa laevigatae michx (fruit), Rubus chingii Hu (fruit), Schisandra chinensis (Turz.) Baill (fruit), Ligustrum lucidum ...

journal_title：International journal of oncology

authors： Hsieh TC,Lu X,Guo J,Xiong W,Kunicki J,Darzynkiewicz Z,Wu JM

更新日期：2002-04-01 00:00:00

abstract：:Specific chromosomal abnormalities, such as del(7q), t(12;14), 12 trisomy, or the rearrangement of 6p, are seen in approximately 30% of uterine leiomyomas despite their benign status. We investigated the association between the shrinkage of uterine leiomyomas treated with a GnRH agonist and the interstitial deletion o...

journal_title：International journal of oncology

authors： Takahashi K,Kawamura N,Tsujimura A,Ichimura T,Ito F,Ishiko O,Ogita S

更新日期：2001-06-01 00:00:00

abstract：:Recently, the inflammatory cytokine IL-6 has been reported as a potent inducer of epithelial-mesenchymal transition (EMT) in breast cancer cells with an epithelial phenotype. Furthermore, EMT induces stem cell features in normal and transformed mammary cells. We explored whether IL-...

journal_title：International journal of oncology

authors： Xie G,Yao Q,Liu Y,Du S,Liu A,Guo Z,Sun A,Ruan J,Chen L,Ye C,Yuan Y

更新日期：2012-04-01 00:00:00

abstract：:A series of different human MDR (multidrug-resistant) cell lines including a HeLa-MDR1 transfectant which exhibit high overexpression of the MDR1/P-glycoprotein gene, but no enhanced expression of the MRP (multidrug resistance associated protein) gene, showed different ratios of relative resistances to the taxanes tax...

journal_title：International journal of oncology

authors： Ise W,Heuser M,Sanders K,Beck J,Gekeler V

更新日期：1996-05-01 00:00:00

abstract：:It has been reported that XAF1 expression in gastric cancer is negatively correlated with p53. Our purpose was to clarify the regulatory mechanism of p53 on XAF1 expression. The effects of overexpressed wild-type and mutant p53 on XAF1 expression were evaluated. Binding capacity of core XAF1 promoter sequence to the r...

journal_title：International journal of oncology

authors： Zhang W,Guo Z,Jiang B,Niu L,Xia G,Wang X,Cheng T,Zhang Y,Wang J

更新日期：2010-04-01 00:00:00

abstract：:Anisi stellati fructus (ASF), commonly known as star anise, has long been used as a traditional Chinese medicine to treat inflammation, nervousness, insomnia and pain. In recent studies, it has been demonstrated that ASF possesses anti-bacterial, anti-fungal and anti-oxidant activities, as well as exhibits inhibitory ...

journal_title：International journal of oncology

authors： Kim A,Im M,Ma JY

更新日期：2014-11-01 00:00:00

abstract：:A camptothecin (CPT) formulation that can be easily administered, is less toxic, and has greater antitumor effect is needed. In this study, a water-soluble CPT derivative was obtained by direct coupling of CPT to poly(L-glutamic acid) (PG) through the C20(S)-hydroxyl group. CPT was released from the resulting conjugat...

journal_title：International journal of oncology

authors： Zou Y,Wu QP,Tansey W,Chow D,Hung MC,Charnsangavej C,Wallace S,Li C

更新日期：2001-02-01 00:00:00

abstract：:Highly aggressive murine B16 melanoma was engineered to secrete IFN-alpha constitutively. Cells expressing IFN-alpha were injected into syngeneic C57BL/6 mice and the mice were monitored for tumor development. Secretion of IFN-alpha by B16 melanoma cells completely abrogated their tumorigenicity in syngeneic mice. LFN...

journal_title：International journal of oncology

authors： Sarkar S,Flores I,Ron Y,Derosa C,Ozzello L,Pestka S

更新日期：1995-07-01 00:00:00