The disintegrin-metalloproteinases ADAM9, ADAM12, and ADAM15 are upregulated in gastric cancer.

abstract：:Dissemination of single tumor cells to the bone marrow is a common event in cancer. The clinical significance of cytokeratin-positive cells detected in the bone marrow of cancer patients is still a matter of debate. In gastric cancer, overexpression of the receptor (uPAR or CD87) for the serine protease urokinase-type...

journal_title：International journal of oncology

authors： Noack F,Helmecke D,Rosenberg R,Thorban S,Nekarda H,Fink U,Lewald J,Stich M,Schutze K,Harbeck N,Magdolen V,Graeff H,Schmitt M

更新日期：1999-10-01 00:00:00

abstract：:Due to the central role in predicting response to herceptin and possibly also other anticancer drugs, accurate and reproducible detection of the HER2 status is important. Fluorescence in situ hybridization (FISH) and immunohistochemistry (IHC) are the most commonly used methods for HER2 analysis. It is a disadvantage ...

journal_title：International journal of oncology

authors： Tapia C,Schraml P,Simon R,Al-Kuraya KS,Maurer R,Mirlacher M,Novotny H,Spichtin H,Mihatsch MJ,Sauter G

更新日期：2004-12-01 00:00:00

abstract：:Cholecystokinin (CCK) and gastrin stimulate growth of pancreatic cancer. Although down-regulation of gastrin inhibits growth of pancreatic cancer, the contribution of endogenous CCK to tumor growth is unknown. The purpose of this study was to evaluate the role of endogenous CCK on autocrine growth of pancreatic cancer...

journal_title：International journal of oncology

authors： Matters GL,McGovern C,Harms JF,Markovic K,Anson K,Jayakumar C,Martenis M,Awad C,Smith JP

更新日期：2011-03-01 00:00:00

abstract：:Retroviral infection of hTERT, the catalytic component of telomerase, into BJ fibroblasts (population doubling 28) resulted in reconstitution of telomerase activity, telomere maintenance, and extension of in vitro lifespan. The hTERT-infected cells also exhibited increased growth rate and colony forming efficiency rel...

journal_title：International journal of oncology

authors： Forsythe HL,Elmore LW,Jensen KO,Landon MR,Holt SE

更新日期：2002-06-01 00:00:00

abstract：:Sirtuins are critical players within multiple cellular pathways such as stress response, apoptosis and energy metabolism. They are associated with metabolic and degenerative diseases, the pathogenesis of cancer and are key elements in the regulation of cellular life span. From within the 7 known human sirtuins, SIRT3 ...

journal_title：International journal of oncology

authors： Dransfeld CL,Alborzinia H,Wölfl S,Mahlknecht U

更新日期：2010-04-01 00:00:00

abstract：:Although histone deacetylase (HDAC) inhibitors are emerging as a promising new treatment strategy in malignancy, how they exert their effect on human non-small cell lung cancer cells is as yet unclear. This study was undertaken to investigate the underlying mechanism of an HDAC inhibitor, Trichostatin A (TSA), -induce...

journal_title：International journal of oncology

authors： Choi YH

更新日期：2005-08-01 00:00:00

abstract：:In the present study, we report the utility of transrectal ultrasonography guidance for laparoscopic radical prostatectomy (LRP), and the effect of a novel surgical approach of 'seven key elements of operative skill for the early recovery of urinary continence' ('7 key elements'). Among 170 patients who underwent lapa...

journal_title：International journal of oncology

authors： Azuma H,Ibuki N,Inamoto T,Koyama K,Utimoto S,Fujisue Y,Mizutani Y,Nomi H,Ubai T,Katsuoka Y

更新日期：2011-02-01 00:00:00

abstract：:High lactate production in cells during growth under oxygen-rich conditions (aerobic glycolysis) is a hallmark of tumor cells, indicating the role of mitochondrial function in tumorigenesis. In fact, enhanced mitochondrial biogenesis and impaired quality control are frequently observed in cancer cells. Mitochondrial D...

journal_title：International journal of oncology

authors： Jiménez-Morales S,Pérez-Amado CJ,Langley E,Hidalgo-Miranda A

更新日期：2018-09-01 00:00:00

abstract：:Primary liver cancer is globally the sixth most frequent cancer, and the second leading cause of cancer death and its incidence is increasing in many countries, thus, becoming serious threat to human health. Substantial research has focused on the treatment and prevention of liver cancer. However, the underlying molec...

journal_title：International journal of oncology

authors： Hu B,Sun M,Liu J,Hong G,Lin Q

更新日期：2016-04-01 00:00:00

abstract：:The developmentally regulated PLAG1 proto-oncogene has been implicated in the development of various human tumor types, such as pleomorphic salivary gland adenomas, lipoblastomas, hepatoblastomas and AML. In previous studies, we generated two independent PLAG1 transgenic founder strains, PTMS1 and PTMS2, in which PLAG...

journal_title：International journal of oncology

authors： Van Dyck F,Scroyen I,Declercq J,Sciot R,Kahn B,Lijnen R,Van de Ven WJ

更新日期：2008-01-01 00:00:00

abstract：:Primary cilia are microtubule-based organelles that regulate smoothened-dependent activation of the GLI transcription factors in canonical hedgehog signaling. In many cancers, primary cilia are markedly decreased or absent. The lack of primary cilia may inhibit or alter canonical hedgehog signaling and, thereby, inter...

journal_title：International journal of oncology

authors： Spann AL,Yuan K,Goliwas KF,Steg AD,Kaushik DD,Kwon YJ,Frost AR

更新日期：2015-07-01 00:00:00

abstract：:BALB/c 3T3 cells transformed by 1,1,2,2-tetrachloroethane, the most toxic chloroethane, acquired a fully malignant phenotype. They were capable of growing in soft agar, were tumorigenic when injected in athymic mice and produced pulmonary nodules after i.v. injection. Untreated BALB/c 3T3 cells were weakly tumorigenic...

journal_title：International journal of oncology

authors： Colacci A,Albini A,Melchiori A,Nanni P,Nicoletti G,Noonan D,Parodi S,Grilli S

更新日期：1993-06-01 00:00:00

abstract：:The prognosis of patients carrying glottic squamous cell carcinomas (GSCCs) involving the anterior commissure is often unpredictable. In order to assess the possible prognostic role of new and reliable parameters, p53 and cyclin D1 protein expression was immunohistochemically analysed in pathological samples from 27 p...

journal_title：International journal of oncology

authors： Pignataro L,Capaccio P,Pruneri G,Carboni N,Fracchiolla N,Richelda R,Scaramellini G,Neri A,Buffa R

更新日期：1996-09-01 00:00:00

abstract：:Side population (SP) cells may play a crucial role in tumorigenesis and the recurrence of cancer. Many types of cell lines and tissues have demonstrated the presence of SP cells, including colon cancer cell lines. This study aimed to identify cancer stem cells (CSCs) in the SP of the colon cancer cell line SW480. SP c...

journal_title：International journal of oncology

authors： Xiong B,Ma L,Hu X,Zhang C,Cheng Y

更新日期：2014-09-01 00:00:00

abstract：:The murine double minute-2 (MDM2) gene encodes a 90 kDa protein which binds and inactivates the protein product of the p53 tumor suppressor gene. To elucidate the potential role of MDM2 in benign and malignant hyperproliferative conditions in the pancreas, we studied MDM2 expression in cultured human pancreatic cancer...

journal_title：International journal of oncology

authors： Ebert M,Yokoyama M,Kobrin M,Friess H,Buchler M,Korc M

更新日期：1994-12-01 00:00:00

abstract：:The expression of RNA for interleukin (IL) -9, -10 and -12, interferon gamma (IFN-gamma), transforming growth factor beta one (TGF-beta1), macrophage inflammatory protein one alpha (MIP-1alpha) and granulocyte-macrophage colony-stimulating factor (GM-CSF) in a panel of human T leukemia cell lines at various stages of ...

journal_title：International journal of oncology

authors： Micallef M,Ariyasu T,Dao T,Matsuo Y,Minowada J

更新日期：1994-03-01 00:00:00

abstract：:Acquisition of P-gp-mediated multidrug-resistance does not always correlate with observed malignant behavior of NB. To characterize alterations accompanying development of multidrug-resistance in NB we established two neuroblastoma cell sublines resistant to vincristine (UKF-NB-3rVCR10) and doxorubicin (UKF-NB-3rDOX20...

journal_title：International journal of oncology

authors： Kotchetkov R,Driever PH,Cinatl J,Michaelis M,Karaskova J,Blaheta R,Squire JA,Von Deimling A,Moog J,Cinatl J Jr

更新日期：2005-10-01 00:00:00

abstract：:Dual oxidase 2 (Duox2), one of the seven members of the NADPH oxidase gene family, plays a critical role in generating H2O2 for thyroid hormone biosynthesis and as an integral part of the host defense system of the respiratory epithelium and the gastrointestinal tract. Recent evidence suggests that the regulation of D...

journal_title：International journal of oncology

authors： Wu Y,Antony S,Hewitt SM,Jiang G,Yang SX,Meitzler JL,Juhasz A,Lu J,Liu H,Doroshow JH,Roy K

更新日期：2013-04-01 00:00:00

abstract：:Simultaneous resistance of cancer cells to multiple cytotoxic drugs, multidrug resistance (MDR), is the major limitation to the successful chemotherapeutic treatment of disseminated neoplasms. The 'classical' MDR phenotype is conferred by MDR1/P-glycoprotein (MDR1/P-gp) that is expressed in almost 50% of human cancers...

journal_title：International journal of oncology

authors： Kaszubiak A,Holm PS,Lage H

更新日期：2007-08-01 00:00:00

abstract：:The hematogenous metastasis of cancer consists of a multistep process. It is surmised that a number of interactions between cancer and endothelial cells occur, with cell adhesion molecules playing certain roles in this process. The authors conducted an investigation on the interaction between human cancer cells and cu...

journal_title：International journal of oncology

authors： Sato M,Narita T,Kimura N,Nakashio T,Hashimoto T,Manabe T,Kannagi R

更新日期：1997-06-01 00:00:00

abstract：:Intrinsic resistance of glioma cells to radiation and chemotherapy is currently hypothesized to be partially attributed to the existence of cancer stem cells. Emerging studies suggest that mesenchymal stem cells may serve as a potential carrier for delivery of therapeutic genes to disseminated glioma cells. However, t...

journal_title：International journal of oncology

authors： Liu Z,Jiang Z,Huang J,Huang S,Li Y,Sheng F,Yu S,Yu S,Liu X

更新日期：2014-04-01 00:00:00

abstract：:Telomerase activity and its subunits (hTERC, hTERT mRNA) were evaluated in ovarian tumours in relation to the expression of p53, c-Myc and estrogen receptor (ER). Furthermore, relations between telomerase activity, hTERC and hTERT with known clinicopathologic prognostic factors and survival in patients with malignant ...

journal_title：International journal of oncology

authors： Wisman GB,Hollema H,Helder MN,Knol AJ,Van der Meer GT,Krans M,De Jong S,De Vries EG,Van der Zee AG

更新日期：2003-11-01 00:00:00

abstract：:Lamins are the major components of the nuclear lamina and play important roles in many cellular processes. The role of lamins in cancer development and progression is still unclear but it is known that reduced expression of lamin B1 has been observed in colon cancer. Thus, the aim of the present study was to elucidate...

journal_title：International journal of oncology

authors： Izdebska M,Gagat M,Grzanka A

更新日期：2018-01-01 00:00:00

abstract：:EGFR is frequently overexpressed in head and neck squamous cell cancer (HNSCC). Cetuximab is a monoclonal antibody designed to interact with EGFR, block its activation, reduce the downstream signaling pathways and induce EGFR internalization. This study aims to investigate the role of the EGFR signaling pathway and EG...

journal_title：International journal of oncology

authors： Rebucci M,Peixoto P,Dewitte A,Wattez N,De Nuncques MA,Rezvoy N,Vautravers-Dewas C,Buisine MP,Guerin E,Peyrat JP,Lartigau E,Lansiaux A

更新日期：2011-01-01 00:00:00

abstract：:Tumor cell (TC) metastasis is initiated by selective adhesion of TCs to target structures such as basement membrane and endotheliaI cells (ECs), followed by transvascular migration of TCs. Variants of murine B16 melanoma having different metastatic potentials (in the order BL6 greater than or equal to F10>F1>WA4) have...

journal_title：International journal of oncology

authors： Otsuji E,Park Y,Tashiro K,Kojima N,Toyokuni T,Hakomori S

更新日期：1995-02-01 00:00:00

abstract：:Whether elderly patients with metastatic esophageal, gastroesophageal, and gastric cancer do as well with chemotherapy as their younger counterparts was investigated in this pooled analysis. In total, 367 patients from 8 consecutive, first-line trials were included: i) etoposide + cisplatin; ii) 5-fluorourucil + leuco...

journal_title：International journal of oncology

authors： Jatoi A,Foster NR,Egner JR,Burch PA,Stella PJ,Rubin J,Dakhil SR,Sargent DJ,Murphy BR,Alberts SR

更新日期：2010-03-01 00:00:00

abstract：:Multi-drug resistance (MDR) limits the effectiveness of chemotherapy. P-glycoprotein encoded by the MDR1 gene, is known to be implicated in MDR phenotype, but other factors could be determinant in MDR. The aim of this study was to investigate new molecular factors potentially associated with the MDR phenotype using a ...

journal_title：International journal of oncology

authors： Visentin M,Simula MP,Sartor F,Petrucco A,De Re V,Toffoli G

更新日期：2009-05-01 00:00:00

abstract：:Narrow band imaging (NBI) has been used in the gastrointestinal endoscopy field as a novel endoscopic imaging technique and has contributed to improved qualitative diagnosis and detection of lesions. However, there are only a few studies of use of NBI in the gynecology field. We applied NBI in flexible hysteroscopy at...

journal_title：International journal of oncology

authors： Kisu I,Banno K,Kobayashi Y,Ono A,Masuda K,Ueki A,Nomura H,Hirasawa A,Abe T,Kouyama K,Susumu N,Aoki D

更新日期：2011-11-01 00:00:00

abstract：:We have previously demonstrated the multipotent nature of human umbilical cord blood stem cells (hUCB). In this study, we have attempted to show the use of hUCB in glioma therapy. We used hUCB enriched in CD44 and CD133 cells for our studies and observed that glioma cells co-cultured with hUCB undergo apoptosis. To pr...

journal_title：International journal of oncology

authors： Gondi CS,Gogineni VR,Chetty C,Dasari VR,Gorantla B,Gujrati M,Dinh DH,Rao JS

更新日期：2010-05-01 00:00:00

abstract：:Hereditary nonpolyposis colorectal cancer (HNPCC) is a syndrome involving a predisposition to cancers of the colon, endometrium and several other extra-colonic sites, accounting for approximately 1-5% of all colorectal cancer cases. It is not easily recognized because of a lack of distinctive clinical markers, making ...

journal_title：International journal of oncology

authors： Park JG,Yuan Y

更新日期：1998-04-01 00:00:00