Upregulation of IGF-2 and IGF-1 receptor expression in oral cancer cell lines.

abstract：:The p16INK4a tumor suppressor gene is frequently inactivated in nasopharyngeal carcinoma (NPC) and hence it may play an important role in the suppression of this tumor. In order to study the effect of p16INK4a restoration in NPC cells, full-length human p16INK4a gene was transfected into a NPC cell line, CNE1. Four in...

journal_title：International journal of oncology

authors： Chow LS,Wang X,Kwong DL,Sham JS,Tsao SW,Nicholls JM

更新日期：2000-07-01 00:00:00

abstract：:Following the publication of this article, the authors noted that there was an error in Fig. 4. The lines representing the two groups were indicated incorrectly in all graphs in Fig. 4. A corrected version of Fig. 4 is presented below. Furthermore, we regret any inconvenience this error may have caused. [the original ...

journal_title：International journal of oncology

authors： Nogimori K,Hori T,Kawaguchi K,Fukui T,Mii S,Nakada H,Matsumoto Y,Yamauchi Y,Takahashi M,Furukawa K,Tetsuya O,Yokoi K,Hasegawa Y,Furukawa K

更新日期：2017-02-01 00:00:00

abstract：:We have previously investigated the possibility of using hypericin as a diagnostic tool for the fluorescence detection of flat bladder carcinoma. In these clinical studies, it was shown that following intravesical application in humans, hypericin becomes selectively localized in transitional papillary carcinoma and ca...

journal_title：International journal of oncology

authors： Kamuhabwa AA,Roskams T,Baert L,De Witte PA

更新日期：2003-04-01 00:00:00

abstract：:The Warburg effect is a unique metabolic feature of the majority of tumor cells and is closely related to chemotherapeutic resistance. Pyruvate dehydrogenase kinase 1 (PDK1) is considered a 'switch' that controls the fate of pyruvate in glucose metabolism. However, to date, to the best of our knowledge, there are only...

journal_title：International journal of oncology

authors： Xu H,He Y,Ma J,Zhao Y,Liu Y,Sun L,Su J

更新日期：2020-09-01 00:00:00

abstract：:Nasopharyngeal carcinoma (NPC) is a major cause of cancer deaths. Concurrent administration of radiation and chemotherapy is the treatment of choice for advanced NPC. Previously, we showed that apogossypolone (ApoG2) induced apoptosis by blocking the binding of Bcl-2 to Bax, arresting the cell cycle in the S phase, in...

journal_title：International journal of oncology

authors： He JH,Liao XL,Wang W,Li DD,Chen WD,Deng R,Yang D,Han ZP,Jiang JW,Zhu XF

更新日期：2014-09-01 00:00:00

abstract：:Accumulating evidence suggests that colorectal cancer (CRC) should be viewed as a heterogeneous disease, with proximal and distal CRCs showing multiple biological and clinical differences. The aim of this study was to develop a clinicopathological, molecular and protein profile for CRCs based on their region and thus ...

journal_title：International journal of oncology

authors： Minoo P,Zlobec I,Peterson M,Terracciano L,Lugli A

更新日期：2010-09-01 00:00:00

abstract：:The cell-adhesion properties of cancer cells can be targeted to block cancer metastasis. Although cytosolic lysyl-tRNA synthetase (KRS) functions in protein synthesis, KRS on the plasma membrane is involved in cancer metastasis. We hypothesized that KRS is involved in cell adhesion-related signal transduction for cell...

journal_title：International journal of oncology

authors： Nam SH,Kang M,Ryu J,Kim HJ,Kim D,Kim DG,Kwon NH,Kim S,Lee JW

更新日期：2016-04-01 00:00:00

abstract：:Induction of differentiation represents a promising concept for chemotherapy of malignant gliomas, which are often refractory even to the combined treatment with surgery, irradiation and chemotherapy. Since anti-neoplastic alkylphosphocholines can induce differentiation of leukemic cell lines, the effects of the intra...

journal_title：International journal of oncology

authors： Jendrossek V,Kugler W,Erdlenbruch B,Eibl H,Lakomek M

更新日期：2001-10-01 00:00:00

abstract：:An overview of the current mechanisms identified as associated with the expression of multidrug resistance is provided. The clinical relevance of multidrug resistance associated with the overexpression of the three major drug resistance-associated proteins namely, P-glycoprotein, MRP and/or LRP, is discussed. Alternat...

journal_title：International journal of oncology

authors： Hill B

更新日期：1996-08-01 00:00:00

abstract：:Activation of the Wingless (Wnt)/ß-catenin signaling pathway contributes to prostate tumorigenesis and metastasis. Depending of the stage of prostate cancer development, current drug therapies are of limited efficiency, so that prevention with natural compounds appears as an attractive strategy especially due to the s...

journal_title：International journal of oncology

authors： Teiten MH,Gaascht F,Cronauer M,Henry E,Dicato M,Diederich M

更新日期：2011-03-01 00:00:00

abstract：:Lack of life-prolonging therapies has provided much of the impetus for seeking complementary and alternative management/treatment options by prostate cancer (CaP) patients. Among these, the use of dietary supplements and botanical products has been showing a sustained increase in recent years, owing in part to some en...

journal_title：International journal of oncology

authors： Lu X,Hsieh TC,Wu JM

更新日期：2004-12-01 00:00:00

abstract：:We hypothesize that dysregulated expression levels of the developmental regulatory genes in the adult body result in tumor development and malignant progression. PAX genes discovered as human orthologous genes of Drosophila 'paired' encode transcription factors, which control the expression of target genes to go on al...

journal_title：International journal of oncology

authors： Hata S,Hamada J,Maeda K,Murai T,Tada M,Furukawa H,Tsutsumida A,Saito A,Yamamoto Y,Moriuchi T

更新日期：2008-11-01 00:00:00

abstract：:The non-invasive treatment of tumors with preserved fertility holds great promise. The application of pulsed electric field (PEF) is a new biomedical engineering technique for tumor therapy. Picosecond pulsed electric fields (psPEF) can be transferred to target deep tissue non-invas...

journal_title：International journal of oncology

authors： Chen WJ,Xiong ZA,Zhang M,Yao CG,Zhao ZY,Hua YY,Zhou W

更新日期：2013-03-01 00:00:00

abstract：:The Pleomorphic adenoma gene 1 (PLAG1) is involved in various human neoplasias, including pleomorphic adenomas of the salivary glands. Moreover, the oncogenic role of PLAG1 was clearly demonstrated in two independent PLAG1 transgenic mouse founders, in which PLAG1 expression could be targeted to different tissues usin...

journal_title：International journal of oncology

authors： Declercq J,Van Dyck F,Van Damme B,Van de Ven WJ

更新日期：2008-05-01 00:00:00

abstract：:Intracellular antigens are presented to CD8+ T cells through major histocompatibility complex (MHC) class I molecule. For stable MHC class I expression, several molecules as well as the MHC molecule itself have to express simultaneously and function well. To determine a gene associated with MHC class I surface express...

journal_title：International journal of oncology

authors： Kang JK,Yoon SJ,Kim NK,Heo DS

更新日期：2000-06-01 00:00:00

abstract：:Rat C6 glioma is a chemo-resistant experimental brain tumor that is difficult to treat with various drug combinations. Previous studies suggested that imatinib mesylate (Gleevec) is effective in pre-clinical trials for glioblastoma. Also, chlorimipramine (Anafranil) is an anti-depressant drug in use in the clinic and ...

journal_title：International journal of oncology

authors： Bilir A,Erguven M,Oktem G,Ozdemir A,Uslu A,Aktas E,Bonavida B

更新日期：2008-04-01 00:00:00

abstract：:The negative signal provided by interactions of programmed death-1 (PD-1) and its ligands, B7-H1 and B7-DC, has been suggested to play an important role in tumor evasion from host immunity. Pancreas cancer patients with B7-H1 expression have a poor prognosis. B7-H1 blocking has been shown to inhibit the development of...

journal_title：International journal of oncology

authors： Okudaira K,Hokari R,Tsuzuki Y,Okada Y,Komoto S,Watanabe C,Kurihara C,Kawaguchi A,Nagao S,Azuma M,Yagita H,Miura S

更新日期：2009-10-01 00:00:00

abstract：:The last decade has brought increased awareness to prostate cancer as a significant health problem. Prostate cancer is very heterogeneous in its etiology and progression, but androgen signaling appears to be a common key element in its development and progression. Blocking of androgen signaling results in a decrease i...

journal_title：International journal of oncology

authors： Cronauer MV,Schulz WA,Burchardt T,Anastasiadis AG,de la Taille A,Ackermann R,Burchardt M

更新日期：2003-10-01 00:00:00

abstract：:We report here that lysocellin, a polyether antibiotic from a streptomycete, induces G1 phase arrest in human osteosarcoma MG63 cells. Lysocellin up-regulates p21WAF1/Cip1 and down-regulates cyclin D1 at the mRNA level. In addition, cyclin D1 is down-regulated by the proteasome-dependent signal pathway in MG63 cells. ...

journal_title：International journal of oncology

authors： Takahara Y,Yogosawa S,Maruyama S,Watanabe N,Yokoyama H,Fukasawa K,Sukenaga Y,Kamiyama J,Izumi M,Wakada M,Zhang H,Yoshizawa K,Kawa S,Nikaido T,Sakai T

更新日期：2006-04-01 00:00:00

abstract：:Multidrug-resistance (MDR) is largely caused by the efflux of therapeutics from the tumor cell by means of P-glycoprotein (P-gp), resulting in reduced efficacy of the chemotherapy. In order to overcome MDR, substances, such as verapamil and cyclosporin A (CsA), were employed. As these P-gp modulating agents did not se...

journal_title：International journal of oncology

authors： Meschini S,Marra M,Calcabrini A,Federici E,Galeffi C,Arancia G

更新日期：2003-12-01 00:00:00

abstract：:Approximately 90% of all pancreatic cancers are pancreatic ductal adenocarcinomas (PDAC). PDAC is a highly aggressive malignancy and is one of the deadliest. This poor clinical outcome is due to the prominent resistance of pancreatic cancer to drug and radiation therapies. Regucalcin plays a pivotal role as a suppress...

journal_title：International journal of oncology

authors： Yamaguchi M,Osuka S,Weitzmann MN,El-Rayes BF,Shoji M,Murata T

更新日期：2016-05-01 00:00:00

abstract：:Seventy-one patients with metastatic colorectal carcinoma(CRC) were treated with varying doses of the mouse monoclonal antibody (MAb) 17-1A. One patient achieved a partial remission (PR) (1%) with a survival duration of 114+ months. Further 10 patients showed a minor response (MR) or stable disease > 3 months (SD) (14...

journal_title：International journal of oncology

authors： Ragnhammar P,Frodin J,Hjelm A,Fagerberg J,Wersall P,Lindemalm C,Nilsson B,Fox K,Magnusson I,Ewerth S,Thor K,Secher E,Mellstedt H

更新日期：1995-11-01 00:00:00

abstract：:Medulloblastoma is the most common malignant brain tumor in childhood. The most prevalent chromosomal abnormalities are isochromosome 17q and loss of 17p, the location of the tumor suppressor gene p53. Mutations in the p53 gene in medulloblastoma are relatively infrequent but have recently been correlated to poor prog...

journal_title：International journal of oncology

authors： Philipova T,Baryawno N,Hartmann W,Pietsch T,Druid H,Johnsen JI,Ekström TJ

更新日期：2011-03-01 00:00:00

abstract：:Endoscopic examination with iodine staining has led to the easy detection of multiple superficial esophageal carcinoma (MSEC). The purpose of this study was to better understand the characteristics of MSEC. Of 49 patients with multiple esophageal carcinomas, 19 had superficial carcinoma. Multiple esophageal carcinomas...

journal_title：International journal of oncology

authors： Fujii T,Yamana H,Fujita H,Sueyoshi S,Nakashima A,Hayashi I,Nishi M,Kato S,Shirouzu K,Morimatsu M

更新日期：1998-02-01 00:00:00

abstract：:Evidence from the literature widely supports the efficacy of screening for colorectal cancer (CRC) in reducing mortality. A blood-based assay, potentially, represents a more accessible early detection tool for the identification of circulating tumour cells originating from a primary tumour site in the body. The presen...

journal_title：International journal of oncology

authors： Lauriola M,Ugolini G,Rosati G,Zanotti S,Montroni I,Manaresi A,Zattoni D,Rivetti S,Mattei G,Coppola D,Strippoli P,Taffurelli M,Solmi R

更新日期：2010-08-01 00:00:00

abstract：:Triple negative breast cancer (TNBC) patients cannot be treated with endocrine therapy or targeted therapies due to lack of related receptors. These patients overexpress the epidermal growth factor receptor (EGFR), but are resistant to tyrosine kinase inhibitors (TKIs) and anti-EGFR therapies. Mechanisms suggested for...

journal_title：International journal of oncology

authors： Bellizzi A,Greco MR,Rubino R,Paradiso A,Forciniti S,Zeeberg K,Cardone RA,Reshkin SJ

更新日期：2015-03-01 00:00:00

abstract：:Uveal malignant melanoma (UMM), the most common primary adult intraocular tumor with a marked metastatic potential, is genetically unique and has unfortunately had few treatment breakthroughs. In this study, we subjected a UMM cell line to high‑throughput library screening with 1,018 FDA‑approved compounds to identify...

journal_title：International journal of oncology

authors： Shaughnessy M,Lamuraglia G,Klebanov N,Ji Z,Rajadurai A,Kumar R,Flaherty K,Tsao H

更新日期：2019-11-01 00:00:00

abstract：:Glutathione S-transferase (GST) enzymes catalyse the detoxification of by-products of reactive oxygen species and are thus important in cellular defence mechanisms. The GSTs are polymorphic with allelic variants encoding isoforms with functional differences. GST polymorphism has been associated with susceptibility and...

journal_title：International journal of oncology

authors： Holley SL,Rajagopal R,Hoban PR,Deakin M,Fawole AS,Elder JB,Elder J,Smith V,Strange RC,Fryer AA

更新日期：2006-01-01 00:00:00

abstract：:Three separate experiments, designed to minimize the DNA repair process following exposures to mutagens, were performed to determine whether DNA repair capability is the sole factor responsible for differential mutagen sensitivity. These experiments included (i) very short bleomycin pulse treatments (2, 5 and 10 min),...

journal_title：International journal of oncology

authors： Wang R,Hsu T,Brock W,Liang J

更新日期：1995-01-01 00:00:00

abstract：:Growth and inflammatory factors are associated with poor prognosis in gastric adenocarcinoma (GA); however, the additive effects of growth and inflammatory factors in GA remain unclear. In this study, we investigated the ability of epidermal growth factor (EGF) and interleukin (IL-1β) to activate extracellular signal-...

journal_title：International journal of oncology

authors： Han J,Xie Y,Lan F,Yu Y,Liu W,Chen J,Zheng F,Ouyang X,Lin X,Lin Y,Huang Q,Wang L,Tan J

更新日期：2014-07-01 00:00:00