Abstract:
:The positron-emitting radiohalogens 18F, 75Br, 76Br, and 124I are reviewed regarding their relevance for positron emission tomography (PET) in oncology. Relevant production routes of these cyclotron-generated isotopes are given, followed by publications that deal with applications of these radiohalogens. This article tries to cover the whole literature for the non-conventional isotopes 75Br, 76Br, and 124I. From the literature on 18F, only articles since 2000 are considered. Here, the emphasis is also given to alternative biomarkers beyond [18]2-fluoro-2-deoxyglucose ([18F]FDG).
journal_name
Int J Oncoljournal_title
International journal of oncologyauthors
Glaser M,Luthra SK,Brady Fkeywords:
subject
Has Abstractpub_date
2003-02-01 00:00:00pages
253-67issue
2eissn
1019-6439issn
1791-2423journal_volume
22pub_type
杂志文章,评审abstract::In solid tumours, necrosis is commonly found in the core region in response to metabolic stress that results from oxygen and glucose depletion (OGD) due to insufficient vascularization and has been implicated in tumour progression. We have previously shown that metabolic stress due to glucose depletion (GD) induces ne...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:
更新日期:2010-01-01 00:00:00
abstract::Colorectal cancer (CRC) is the third most common type of cancer; however, the molecular mechanisms underlying colorectal tumor metastasis and growth remain elusive. Recently, accumulating evidence has indicated that long non‑coding RNAs (lncRNAs) play a critical role in CRC progression and metastasis; however, the bio...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2018.4451
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abstract::The presence of arachidonate 12-lipoxygenase (12-LOX) potentiates prostate cancer (PCa) progression and therefore may be a good therapeutic target and/or a potential diagnostic predictor for PCa. In this study, we examined the expression of 12-LOX in PCa stem cells (PCa SCs) to test if it can serve as a unique marker ...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2011.901
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abstract::Von Hippel-Lindau (VHL) disease is a rare autosomal dominant syndrome that is the main cause of inherited clear-cell renal cell carcinoma (ccRCC), which generally occurs in the form of multiple recurrent synchronized tumors. Affected patients are carriers of a germline mutation in the VHL tumor suppressor gene. Somati...
journal_title:International journal of oncology
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doi:10.3892/ijo.2018.4490
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abstract::Collagen type I is an abundant component of the extracellular matrix and due to its longevity, constitutes a prominent target of non-enzymatic post-translational in vivo modifications such as carbamylation and glycation. These protein modifications involved in aging, renal diseases and diabetes, are linked to elevated...
journal_title:International journal of oncology
pub_type: 杂志文章
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abstract::Cancer-associated fibroblasts (CAFs) are key determinants in the malignant progression of cancer, supporting tumorigenesis and metastasis. CAFs also mediate epithelial to mesenchymal transition (EMT) in tumor cells and their achievement of stem cell traits. Curcumin has recently been found to possess anticancer activi...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2015.3202
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abstract::Hematopoietic disorders can be used as a suitable tool of additional information on the actual resolving power of comparative genomic hybridization (CGH). Therefore, CGH examination was performed of DNA extracted from 23 acute and 15 chronic myeloproliferative disorders which had just been analyzed using classical cyt...
journal_title:International journal of oncology
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doi:10.3892/ijo.16.6.1099
更新日期:2000-06-01 00:00:00
abstract::Although a correlation between anaplasia and mutations of the p53 tumor suppressor gene has been found in Wilms' tumor (WT) a prognostic significance of p53 in WT remains largely unresolved. The goal of this study was to obtain a better understanding of the role of p53 expression in WT. Immunohistochemical analysis wa...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:
更新日期:2001-01-01 00:00:00
abstract::Lymph node metastasis of tumors is a crucial early step in the metastatic process. Tumor lymphangiogenesis plays an important role in promoting tumor metastasis to regional lymph nodes. Norcantharidin (NCTD) has been reported to possess potent anti-angiogenesis and antitumor propert...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2012.1603
更新日期:2012-11-01 00:00:00
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journal_title:International journal of oncology
pub_type: 杂志文章
doi:
更新日期:2005-01-01 00:00:00
abstract::Epithelial-mesenchymal transition (EMT) is associated with tumor malignancy. The hedgehog-EMT pathway is preferentially activated in diffuse-type gastric cancer (GC) compared with intestinal-type GC; however, histological typing is currently the only method for distinguishing these two major types of GC. We compared t...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2014.2387
更新日期:2014-06-01 00:00:00
abstract::Dexamethasone is a synthetic glucocorticoid frequently used to suppress side-effects of anticancer chemotherapy. In the present study, we showed that dexamethasone treatment leads to concentration-dependent downregulation of cancer-associated marker, carbonic anhydrase IX (CA IX), at the level of promoter activity, mR...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2016.3621
更新日期:2016-10-01 00:00:00
abstract::Metallothionein 3 (MT-3) has the ability to regulate the growth of nerve cells, but the significance of MT-3 expression outside the central nervous system and its participation in carcinogenesis have not yet been clarified. The aim of our study was to investigate the expression of MT-3 in ductal breast cancer and to d...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2016.3759
更新日期:2016-12-01 00:00:00
abstract::Nonsteroidal anti-inflammatory drugs (NSAIDs) are known to induce apoptosis in a variety of cancer cells, including colon, prostate, breast and leukemia. Among them, aspirin, a classical NSAID, shows promise in cancer therapy in certain types of cancers. We hypothesized that aspirin...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2011.1304
更新日期:2012-04-01 00:00:00
abstract::Human breast epithelial MCF10AT cells injected with Matrigel into the subcutis of nude/beige mice form simple ducts which, with time, resemble human proliferative breast disease and sporadically progress to carcinoma. Basement membrane was visualized with a silver stain and myoepithelial cells detected by their reacti...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.9.2.263
更新日期:1996-08-01 00:00:00
abstract::Oral squamous cell carcinoma (OSCC) is the sixth most common cancer and frequently metastasizes to the cervical lymph nodes, leading to poor survival of patients with OSCC. However, the mechanism of lymph node metastasis is not fully understood. To clarify the molecular mechanism un...
journal_title:International journal of oncology
pub_type: 杂志文章
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更新日期:2012-09-01 00:00:00
abstract::Thermal ablation of solid tumors using conductive interstitial thermal therapy (CITT) produces coagulative necrosis in the center of ablation. Local changes in homeostasis for surviving tumor and systemic changes in circulation and distant organs must be understood and monitored in order to prevent tumor re-growth and...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2013.2185
更新日期:2014-02-01 00:00:00
abstract::Delivery of electric pulses to an established solid tumor augments the permeability of cell membrane and increases the susceptibility of tumors to an anti-cancer agent that is administered in the vicinity of tumors. Forced expression of the wild-type p53 gene in tumor cells that have non-functional p53 gene(s) can als...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.18.4.825
更新日期:2001-04-01 00:00:00
abstract::Early detection and treatment are critical in the management of renal cell carcinoma (RCC). However, there is no standard serum biomarker to facilitate early diagnosis or prognostic stratification in patients with RCC. Recent reports suggest that circulating microRNAs (miRNAs) have great potential as biomarkers for di...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2013.2169
更新日期:2014-01-01 00:00:00
abstract::Tamoxifen (Tam), a selective estrogen receptor modulator, is in wide clinical use for the treatment and prevention of breast cancer. However, extended TAM administration for breast cancer induces increased VEGF levels in patients, promoting new blood vessel formation and thereby limiting its efficacy and highlighting ...
journal_title:International journal of oncology
pub_type: 杂志文章
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更新日期:2014-04-01 00:00:00
abstract::Chemo- and radiotherapy induce apoptosis in tumours and surrounding tissues. In a search for robust and reliable apoptosis markers, we have evaluated immunostaining patterns of gammaH2AX and cleaved PARP-1 in paraffin-embedded cellular spheroids. Breast cancer BT474 cells were grown as cell spheroids to diameters of 7...
journal_title:International journal of oncology
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journal_title:International journal of oncology
pub_type: 杂志文章,评审
doi:
更新日期:2011-01-01 00:00:00
abstract::Patients with non-small cell lung cancer (NSCLC) with echinoderm microtubule-associated protein-like 4 (EML4)-anaplastic lymphoma kinase (ALK) rearrangements generally respond to ALK inhibitors such as crizotinib. However, some patients with EML4-ALK rearrangements respond poorly to crizotinib. Hypoxia is involved in ...
journal_title:International journal of oncology
pub_type: 杂志文章
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abstract::The in situ formation of cytotoxic metabolites by an enzyme-catalyzed reaction is a recent approach in cancer therapy. The present results show that multidrug-resistant human colon adenocarcinoma cells (LoVo) are significantly more sensitive than corresponding wild-type cells to hydrogen peroxide and aldehydes, the pr...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:
更新日期:2006-10-01 00:00:00
abstract::Whilst the role of microRNA‑143 (miR‑143) in myelodysplastic syndrome (MDS) remains unclear, abnormally expressed microRNA‑143 has been detected in many types of cancer tissues. In this study, we describe a cohort study for the verification of miR‑143 expression, as well as the investigation of the molecular mechanism...
journal_title:International journal of oncology
pub_type: 杂志文章
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更新日期:2018-11-01 00:00:00
abstract::Tetramethypyrazine (TMP), one of the active compounds extracted from the traditional Chinese medicinal herb (Chuanxiong), has been verified as an anticancer compound against several types of cancer. However, understanding of the molecular mechanisms have not been fully elucidated. In the present study, the anticancer ...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2016.3670
更新日期:2016-10-01 00:00:00
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journal_title:International journal of oncology
pub_type: 杂志文章
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abstract::The murine double minute-2 (MDM2) gene encodes a 90 kDa protein which binds and inactivates the protein product of the p53 tumor suppressor gene. To elucidate the potential role of MDM2 in benign and malignant hyperproliferative conditions in the pancreas, we studied MDM2 expression in cultured human pancreatic cancer...
journal_title:International journal of oncology
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abstract::Radiotherapy (RT) is one of the major modalities for non‑small cell lung cancer (NSCLC), but its efficacy is often compromised by cellular resistance caused by various mechanisms including the overexpression of epidermal growth factor receptor (EGFR). Although cis‑diamminedichloroplatinum(Ⅱ) (cisplatin, CDDP) has been...
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pub_type: 杂志文章
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更新日期:2001-05-01 00:00:00