Abstract:
:We studied the expresssion of estrogen (ER), progesterone (PgR), and androgen receptors (AR) in hepatocellular carcinoma (HCC) and found expression in (7/36), 3.2% (1/31), 16.7% (4/24) of cases, respectively. The expression of ER did not correlate with histological grade, tumor size, or stage of disease. On the other hand, all the patients with AR-positive tumors had stage IV disease, and only 25% of the patients with AR-negative tumors had stage IV disease. The survival was not influenced by the expression pattern of ER, however, the survival of the patients with AR-positive tumors tended to be worse than that of patients with AR-negative tumors. We suggest that the AR expression correlates better with poor outcome in HCC than the ER expression.
journal_name
Int J Oncoljournal_title
International journal of oncologyauthors
Ishizu H,Une Y,Gondo H,Kameda H,Uchino Jdoi
10.3892/ijo.4.6.1349subject
Has Abstractpub_date
1994-06-01 00:00:00pages
1349-52issue
6eissn
1019-6439issn
1791-2423journal_volume
4pub_type
杂志文章abstract::In a retrospective analysis of 91 consecutive oral carcinomas we reviewed all patient records and weighed clinicopathological parameters against the results of image DNA cytometry and p53 immunhistochemical staining of the initial diagnostic biopsies. Eighty-seven percent of the biopsies were either aneuploid or nondi...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.5.4.915
更新日期:1994-10-01 00:00:00
abstract::Although strong evidence is available suggesting that microenvironmental parameters play a role in lymphogenic or hematogenic metastasis, the underlying mechanisms are still unclear and further investigations of this topic are needed. For such a study however, an appropriate model of metastasis for in vivo analysis of...
journal_title:International journal of oncology
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abstract::Although epidemiological studies have suggested a positive correlation between environmental radon exposure and prostate cancer, the mechanism involved is not clear. In the present study, we examined the oncogenic transforming potency of alpha-particles using non-tumorigenic, telomerase-immortalized human benign prost...
journal_title:International journal of oncology
pub_type: 杂志文章
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abstract::Telomerase activity (TA) is associated with most malignant human tumors but is not detected in normal somatic cells with a few exceptions. Three major subunits (hTR, hTP1 and hTERT) of telomerase have been identified. To investigate the clinical implications of the mRNA detection of these components as useful diagnost...
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更新日期:2001-11-01 00:00:00
abstract::Recently, the compilation of massive amounts of genetic and genomic information on a wide variety of human cancer types, collectively known as The Cancer Genome Atlas (TCGA), has revealed a wealth of descriptive classification schemes both within and between different types and sources of cancer. In endometrial cancer...
journal_title:International journal of oncology
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abstract::Whether elderly patients with metastatic esophageal, gastroesophageal, and gastric cancer do as well with chemotherapy as their younger counterparts was investigated in this pooled analysis. In total, 367 patients from 8 consecutive, first-line trials were included: i) etoposide + cisplatin; ii) 5-fluorourucil + leuco...
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更新日期:2010-03-01 00:00:00
abstract::Serial analysis of gene expression (SAGE) is a sequence-based tool that enables quantitative study of comprehensive gene expression profiles. In this study, we generated a SAGE library of hepatitis B virus (HBV)-associated small hepatocellular carcinoma (HCC) and compared it with libraries of normal liver and other or...
journal_title:International journal of oncology
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更新日期:2009-07-01 00:00:00
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doi:10.3892/ijo.2013.1905
更新日期:2013-06-01 00:00:00
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journal_title:International journal of oncology
pub_type: 杂志文章,评审
doi:
更新日期:2002-11-01 00:00:00
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更新日期:2015-09-01 00:00:00
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更新日期:1994-03-01 00:00:00
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doi:
更新日期:2006-05-01 00:00:00
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pub_type: 杂志文章,评审
doi:10.3892/ijo.2013.2047
更新日期:2013-10-01 00:00:00
abstract::Functional defects in DNA mismatch repair genes have been shown to be associated mainly with hereditary human malignancies. We examined genomic DNA from 88 sporadic transitional cell carcinomas (TCCs) of the urinary tract for mutations in hMSH6 gene by polymerase chain reaction and direct sequencing analysis. Mutation...
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doi:
更新日期:2000-03-01 00:00:00
abstract::Three major, fast developing lines of research are elucidating the biology of the mammary gland and its malignant transformation: phenotypical analyses of epithelial cells and mammary proliferative lesions, the identification, purification and characterization of mammary stem cells and breast cancer-initiating cells, ...
journal_title:International journal of oncology
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更新日期:2004-08-01 00:00:00
abstract::Resveratrol and other polyphenols have anti-carcinogenic and anti-tumorigenic activities in various carcinomas. However, such studies are limited in endometrial cancer. We hypothesize that resveratrol suppresses cancer growth through modulation of cell cycle and cell growth regulatory genes. To test this hypothesis, w...
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更新日期:2003-10-01 00:00:00
abstract::Angiogenesis is a prerequisite for the growth and metastasis of solid tumors. Studies have confirmed that in the absence of angiogenesis, tumors rarely have the ability to develop beyond a few millimeters in diameter. Tumor-associated endothelium is activated by the production of soluble factors by tumor and stromal c...
journal_title:International journal of oncology
pub_type: 杂志文章,评审
doi:
更新日期:2004-08-01 00:00:00
abstract::Our study reviews the central role of androgens for the development of androgen-insensitive growth in prostatic carcinoma using an individual dynamic model which emulates aspects of proliferation control. Our aim is the identification of individually proliferating cells from prostate carcinoma. Short-term cultured cel...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.7.6.1339
更新日期:1995-12-01 00:00:00
abstract::The Drosophila argos protein is a natural ligand antagonist of Drosophila EGF receptor (DER), but does not interact with the human EGF receptor (EGFR). With a view to generating a corresponding EGFR antagonist, we, have designed five chimeric proteins featuring selected characteristic parts of argos within the framewo...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.10.4.677
更新日期:1997-04-01 00:00:00
abstract::The expression of RNA for interleukin (IL) -9, -10 and -12, interferon gamma (IFN-gamma), transforming growth factor beta one (TGF-beta1), macrophage inflammatory protein one alpha (MIP-1alpha) and granulocyte-macrophage colony-stimulating factor (GM-CSF) in a panel of human T leukemia cell lines at various stages of ...
journal_title:International journal of oncology
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doi:10.3892/ijo.4.3.633
更新日期:1994-03-01 00:00:00
abstract::Periostin (POSTN) is a protein involved in multiple processes important for cancer development, both at the stage of cancer initiation and progression, as well as metastasis. The aim of this study was to determine the expression of POSTN in the cells of non-invasive ductal breast carcinoma in situ (DCIS) and invasive ...
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journal_title:International journal of oncology
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doi:10.3892/ijo.4.3.567
更新日期:1994-03-01 00:00:00
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abstract::Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is promising for cancer treatment owing to its selective cytotoxicity against malignant cells. However, some cancer cell types, including malignant melanoma cells, are resistant to TRAIL-induced apoptosis. Therefore, dr...
journal_title:International journal of oncology
pub_type: 杂志文章
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journal_title:International journal of oncology
pub_type: 杂志文章
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更新日期:2014-09-01 00:00:00
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pub_type: 杂志文章
doi:10.3892/ijo.5.6.1419
更新日期:1994-12-01 00:00:00
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journal_title:International journal of oncology
pub_type: 杂志文章
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更新日期:2006-12-01 00:00:00
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journal_title:International journal of oncology
pub_type: 临床试验,杂志文章
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更新日期:2004-12-01 00:00:00