Regulation of cell-growth and apoptosis in synchronized agf cells - involvement of oncogenes and cell-cycle regulatory proteins.

abstract：:Targeted cancer therapies are used to inhibit the growth, progression, and metastasis of the tumor by interfering with specific molecular targets and are currently the focus of anticancer drug development. Protein kinase B, also known as Akt, plays a central role in many types of cancer and has been validated as a the...

journal_title：International journal of oncology

authors： Nitulescu GM,Margina D,Juzenas P,Peng Q,Olaru OT,Saloustros E,Fenga C,Spandidos DΑ,Libra M,Tsatsakis AM

更新日期：2016-03-01 00:00:00

abstract：:Gap junctional intercellular communication (GJIC) has been shown to be involved in the bystander effect through herpes simplex virus thymidine kinase/ganciclovir (HSV-tk/GCV) gene therapy. In this study, we examined the expression of connexins, the components of gap junction, and the degree of GJIC in esophageal cance...

journal_title：International journal of oncology

authors： Matono S,Tanaka T,Sueyoshi S,Yamana H,Fujita H,Shirouzu K

更新日期：2003-11-01 00:00:00

abstract：:To examine the possibility that chemical inducers of cytochrome P450 may have effects on the expression of oncogenes and a tumor suppressor gene, human colon LS174T cells were treated with different cytochrome P450 inducers such as benzanthracene (Ba), pyrazole (Pyr) and phenobarbital-hydrocortisone (Pb-Hc). Three for...

journal_title：International journal of oncology

authors： Vasquez H,Strobel H

更新日期：1996-09-01 00:00:00

abstract：:Hypericin is a potent agent in the photodynamic therapy of cancers and accumulates to a large extent in tumor tissue. To better understand the impact of hypericin aggregates present in the delivery vehicle on the biodistribution of the compound, we compared the in vivo tissue accumulation after administering hypericin...

journal_title：International journal of oncology

authors： Van De Putte M,Roskams T,Bormans G,Verbruggen A,De Witte PA

更新日期：2006-03-01 00:00:00

abstract：:Adrenomedullin (AM) is a multifunctional 52-amino acid peptide. AM has several effects and acts as a growth factor in several types of cancer cells. Our previous study revealed that an AM antagonist (AMA) suppressed the growth of pancreatic tumors in mice, although its mechanism was not elucidated. In this study, we c...

journal_title：International journal of oncology

authors： Tsuchiya K,Hida K,Hida Y,Muraki C,Ohga N,Akino T,Kondo T,Miseki T,Nakagawa K,Shindoh M,Harabayashi T,Shinohara N,Nonomura K,Kobayashi M

更新日期：2010-06-01 00:00:00

abstract：:Bile duct carcinoma patients generally have a poor prognosis. Understanding this cancer at the biological, genetic, molecular, and cellular level in ways relevant to clinical management is essential for developing effective preventive and therapeutic regimens. However, the currently established bile duct cancer cell l...

journal_title：International journal of oncology

authors： Ghosh M,Koike N,Tsunoda S,Hirano T,Kaul S,Kashiwagi H,Kawamoto T,Ohkohchi N,Saijo K,Ohno T,Miwa M,Todoroki T

更新日期：2005-02-01 00:00:00

abstract：:Estrogens act through interactions with estrogen receptors (ERs) to play diverse roles in various pathophysiological conditions. A number of synthetic selective estrogen receptor modulators (SERMs), such as tamoxifen and raloxifene, have been developed and used to treat ER-related diseases, including breast cancer and...

journal_title：International journal of oncology

authors： Kim HI,Kim T,Kim JE,Lee J,Heo J,Lee NR,Kim NJ,Inn KS

更新日期：2015-07-01 00:00:00

abstract：:Prostaglandin E2 (PGE2) can stimulate tumor progression by both direct and indirect mechanisms. However, its influence on cell proliferation is still unclear. The present study characterized expression of subtypes of PGE2 receptors in oral squamous cell carcinomas, while also investigating the effects of EP3 and EP4 s...

journal_title：International journal of oncology

authors： Hoshikawa H,Goto R,Mori T,Mitani T,Mori N

更新日期：2009-03-01 00:00:00

abstract：:Oxygen tension measurements were made in three tumors: (i) the murine FSaII fibrosarcoma, (ii) the rat 9L gliosarcoma and (iii) the rat 13672 mammary adenocarcinoma using a pO2 histograph. Tumor oxygenation measurements were made while the animals breathed air or breathed carbogen (95% oxygen/5% carbon dioxide). Pento...

journal_title：International journal of oncology

authors： Teicher B,Sotomayor E,Robinson M,Dupuis N,Schwartz G,Frei E

更新日期：1993-01-01 00:00:00

abstract：:Although CD138 expression is a hallmark of plasma cells and myeloma cells, reduced CD138 expression is occasionally found. However, the mechanisms underlying CD138 downregulation in myeloma cells remain unclear. Previous reports suggest that the bone marrow microenvironment may contribute to CD138 downregulation. Amon...

journal_title：International journal of oncology

authors： Kawano Y,Kikukawa Y,Fujiwara S,Wada N,Okuno Y,Mitsuya H,Hata H

更新日期：2013-12-01 00:00:00

abstract：:WNT signals are transduced to the planar cell polarity (PCP) pathway or the beta-catenin pathway. Drosophila Frizzled (Fz), Starry night (Stan), Van Gogh (Vang), Dishevelled (Dsh), Prickle (Pk), Diego (Dgo) and Nemo (Nmo) are implicated in the PCP signaling pathway. Choi and Benzer identified Drosophila Nmo in 1994, a...

journal_title：International journal of oncology

authors： Katoh M,Katoh M

更新日期：2005-06-01 00:00:00

abstract：:Long non-coding RNAs (lncRNAs) are involved in cancer progression. In the present study, we analyzed the lncRNA profiles in adriamycin-resistant and -sensitive breast cancer cells and found a group of dysregulated lncRNAs in the adriamycin-resistant cells. Expression of the dysregulated lncRNAs was correlated with dys...

journal_title：International journal of oncology

authors： He DX,Zhang GY,Gu XT,Mao AQ,Lu CX,Jin J,Liu DQ,Ma X

更新日期：2016-10-01 00:00:00

abstract：:The transcription factor E2F4 plays a critical role in cell cycle progression of normal and cancerous intestinal epithelial cells. Contrary to other E2Fs, the coding region of the E2F4 gene contains a longer spacer segment of a CAG trinucleotide repeat sequence encoding 13 consecutive serine residues, which is highly ...

journal_title：International journal of oncology

authors： Paquin MC,Leblanc C,Lemieux E,Bian B,Rivard N

更新日期：2013-12-01 00:00:00

abstract：:We have previously reported that Insulin-like growth factor (IGF-I) is a cellular growth factor of human transformed T-lymphocytes. To evaluate the role of IGF-I for nontransformed T-cells we investigated synthesis of IGF-I and the influence of an IGF-I antiserum, UBK487, during proliferation process. IGF-I is synthes...

journal_title：International journal of oncology

authors： Hartmann K,Teckentrup R,Nixdorf D,Meuer S,Papa V,Heinrich U

更新日期：1993-06-01 00:00:00

abstract：:Hsp90α is a molecular chaperone protein involved in the structural maturation of oncogenic signaling proteins. Hsp90 was recently identified as an anticancer target; various studies are ongoing to find ways for managing cancer through Hsp90α. However, this approach is limited by reported side-effects. Hypoxia is a hal...

journal_title：International journal of oncology

authors： Pak SH,Joung YH,Park JH,Lim EJ,Darvin P,Na YM,Hong DY,Lee B,Hwang TS,Park T,Ye SK,Moon ES,Cho BW,Park KD,Lee HK,Chung IM,Yang YM

更新日期：2012-07-01 00:00:00

abstract：:Cytokines of the TGF beta family are thought to be involved in cellular growth control and are therefore likely candidates to regulate homeostasis of the prostate. We have analyzed immunohistochemically the expression of TGF-beta 3 in normal prostate (NP), benign prostate hyperplasia (BPH) and prostate cancer (PCa). I...

journal_title：International journal of oncology

authors： Djonov V,Andres A,Altermatt H,Merz V

更新日期：1997-12-01 00:00:00

abstract：:Hypericin is used as a powerful naturally occurring photosensitizer in photodynamic therapy (PDT). Activated by visible light, it kills tumour cells and tissues via generation of reactive oxygen species (ROS). Depending on the protocol, apoptotic cell death can be achieved very effectively by hypericin-PDT. To analyze...

journal_title：International journal of oncology

authors： Sanovic R,Krammer B,Grumboeck S,Verwanger T

更新日期：2009-10-01 00:00:00

abstract：:Chemotherapy is an established treatment modality for bone sarcomas such as osteosarcoma (OS). However, the use of chemotherapy in high-grade soft tissue sarcomas remains controversial, with the most active chemotherapeutic agent, doxorubicin (DOX), reported to have a response rate of, at best only 34% and most studie...

journal_title：International journal of oncology

authors： Bouralexis S,Clayer M,Atkins GJ,Labrinidis A,Hay S,Graves S,Findlay DM,Evdokiou A

更新日期：2004-05-01 00:00:00

abstract：:We investigated the expression and promoter methylation of dbpA in human hepatocellular carcinoma (HCC) and examined their correlation with clinicopathological features. In 96 paired samples of HCC and adjacent non-tumorous liver, and 10 normal liver specimens, dbpA mRNA was quantif...

journal_title：International journal of oncology

authors： Yasen M,Obulhasim G,Kajino K,Mogushi K,Mizushima H,Tanaka S,Tanaka H,Hino O,Arii S

更新日期：2012-03-01 00:00:00

abstract：:The purpose of this study was to test the hypothesis that cooperative interaction between cutaneous fatty acid-binding protein (C-FABP) and peroxisome proliferator-activated receptors (PPAR) promotes the malignant progression of human prostate cancer. The expression of C-FABP, PPARβ/δ and PPARγ was measured by western...

journal_title：International journal of oncology

authors： Forootan FS,Forootan SS,Malki MI,Chen D,Li G,Lin K,Rudland PS,Foster CS,Ke Y

更新日期：2014-01-01 00:00:00

abstract：:Activation of the Wingless (Wnt)/ß-catenin signaling pathway contributes to prostate tumorigenesis and metastasis. Depending of the stage of prostate cancer development, current drug therapies are of limited efficiency, so that prevention with natural compounds appears as an attractive strategy especially due to the s...

journal_title：International journal of oncology

authors： Teiten MH,Gaascht F,Cronauer M,Henry E,Dicato M,Diederich M

更新日期：2011-03-01 00:00:00

abstract：:This study evaluated the effects of a combination of opioid growth factor (OGF) and paclitaxel on squamous cell carcinoma of the head and neck (SCCHN) using a tissue culture model of human SCCHN. The combination of OGF and paclitaxel was markedly inhibitory to SCCHN proliferation, reducing growth from control levels b...

journal_title：International journal of oncology

authors： McLaughlin PJ,Jaglowski JR,Verderame MF,Stack BC,Leure-Dupree AE,Zagon IS

更新日期：2005-03-01 00:00:00

abstract：:Thermal ablation of solid tumors using conductive interstitial thermal therapy (CITT) produces coagulative necrosis in the center of ablation. Local changes in homeostasis for surviving tumor and systemic changes in circulation and distant organs must be understood and monitored in order to prevent tumor re-growth and...

journal_title：International journal of oncology

authors： Przybyla BD,Shafirstein G,Vishal SJ,Dennis RA,Griffin RJ

更新日期：2014-02-01 00:00:00

abstract：:A p53 functional analysis system, which can identify the types of abnormality of p53, such as loss of function, dominant negative function, or gain of oncogenic function, is now required. In this study, we examined the functional diversity of several mutations of p53 derived from human head and neck cancer cells. The ...

journal_title：International journal of oncology

authors： Kawamata H,Omotehara F,Nakashiro K,Uchida D,Shinagawa Y,Tachibana M,Imai Y,Fujimori T

更新日期：2007-05-01 00:00:00

abstract：:Breast cancer ranks as the second most common cause of cancer death among women in the United States. Anticancer agents are an important component of breast cancer therapy. Drugs frequently used to treat breast cancer include methotrexate, 5-fluorouracil (5-FU), cyclophosphamide, anthracyclines, taxanes, trastuzumab, ...

journal_title：International journal of oncology

authors： Navolanic PM,McCubrey JA

更新日期：2005-11-01 00:00:00

abstract：:We showed in our previous study that cancer upregulated gene (CUG) 2, a novel oncogene, confers resistance to infection of oncolytic vesicular stomatitis virus (VSV) by activating Stat1-mediated signal transduction. Since many studies have reported that autophagy is involved in virus replication, we investigated wheth...

journal_title：International journal of oncology

authors： Malilas W,Koh SS,Lee S,Srisuttee R,Cho IR,Moon J,Kaowinn S,Johnston RN,Chung YH

更新日期：2014-04-01 00:00:00

abstract：:Linear accelerator-based radiotherapy has little effect on tumors such as malignant melanoma, various types of sarcoma, and most locally-advanced neoplasms that have grown to several centimeters or more. These tumors contain many hypoxic cancer cells or large amounts of anti-oxidative enzymes, and are therefore resist...

journal_title：International journal of oncology

authors： Ogawa Y,Kubota K,Ue H,Tadokoro M,Matsui R,Yamanishi T,Hamada N,Kariya S,Nishioka A,Nakajima H,Tarutani M,Sano S

更新日期：2011-09-01 00:00:00

abstract：:Ionizing radiation (IR) is frequently unsuccessful in the treatment of cancer because of local failure or distant metastases. The efficacy of systemically administered cytokines for cancer therapy is often limited by toxicity. We report that intratumoral injection of an adenoviral vector with interleukin-12 (IL-12) en...

journal_title：International journal of oncology

authors： Seetharam S,Staba MJ,Schumm LP,Schreiber K,Schreiber H,Kufe DW,Weichselbaum RR

更新日期：1999-10-01 00:00:00

abstract：:High-mobility group AT-hook protein 2 (HMGA 2) is a transcription factor associated with malignancy and poor prognosis in a variety of human cancers. We correlated HMGA 2 expression with clinical parameters, survival, and O-6-methylguanine-DNA methyltransferase methylation status (MGMT) in glioblastoma patients. HMGA ...

journal_title：International journal of oncology

authors： Schwarm FP,Uhle F,Schänzer A,Acker T,Stein M,Reinges MH,Weischer C,Weigand MA,Uhl E,Kolodziej MA

更新日期：2016-04-01 00:00:00

abstract：:This study was designed to identify epigenetically regulated genes and to clarify the contribution of epige-netic alteration to acquired resistance to epidermal growth factor receptor‑tyrosine kinase inhibitors (EGFR‑TKIs). We established a gefitinib‑resistant lung cancer cell line, PC9, which was originally gefitinib...

journal_title：International journal of oncology

authors： Terai H,Soejima K,Yasuda H,Sato T,Naoki K,Ikemura S,Arai D,Ohgino K,Ishioka K,Hamamoto J,Kanai Y,Betsuyaku T

更新日期：2015-01-01 00:00:00