Abstract:
:Understanding the link between chemoresistance and cancer progression may identify future targeted therapy for breast cancer. One of the mechanisms by which chemoresistance is attained in cancer cells is mediated through the expression of multidrug resistance proteins (MRPs). Acquiring drug resistance has been correlated to the emergence of metastasis, accounting for the progression of the disease. One of the diagnostic markers of metastatic progression is the overexpression of a transmembrane protein called Mucin 1 (MUC1) which has been implicated in reduced survival rate. The objective of this study was to understand the relationship between MUC1 and MRP1 using natural phenolic compound isolated from Magnolia grandiflora, honokiol, in mammary carcinoma cells. We provide evidence that honokiol suppresses the expression level of MUC1 and MRP1 in mammary carcinoma cells. In a time-dependent manner, honokiol-mediated reduction of MUC1 is followed by a reduction of MRP1 expression in the breast cancer cells. Additionally, silencing MUC1 suppresses the expression level of MRP1 and enhances the efficacy of doxorubicin, an MRP1 substrate. Taken together, these findings suggest MUC1 regulates the expression of MRP1 and provides a direct link between cancer progression and chemoresistance in mammary carcinoma cells.
journal_name
Int J Oncoljournal_title
International journal of oncologyauthors
Thulasiraman P,Johnson ABdoi
10.3892/ijo.2016.3534subject
Has Abstractpub_date
2016-08-01 00:00:00pages
479-86issue
2eissn
1019-6439issn
1791-2423journal_volume
49pub_type
杂志文章abstract::We have previously shown that the combination of allogeneic intra-bone marrow-bone marrow transplantation (IBM-BMT) and donor lymphocyte infusion (DLI) using CD4+ cell-depleted spleen cells is effective in suppressing tumor growth, but that this does not induce graft-versus-host disease (GVHD) in mice. In this report,...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:
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journal_title:International journal of oncology
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journal_title:International journal of oncology
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doi:
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journal_title:International journal of oncology
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journal_title:International journal of oncology
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journal_title:International journal of oncology
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journal_title:International journal of oncology
pub_type: 杂志文章
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journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2013.2166
更新日期:2014-01-01 00:00:00
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journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.15.6.1137
更新日期:1999-12-01 00:00:00
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journal_title:International journal of oncology
pub_type: 杂志文章
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doi:10.3892/ijo.2014.2568
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journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2018.4315
更新日期:2018-05-01 00:00:00
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journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2018.4274
更新日期:2018-04-01 00:00:00
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journal_title:International journal of oncology
pub_type: 杂志文章
doi:
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journal_title:International journal of oncology
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doi:
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journal_title:International journal of oncology
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pub_type: 共识发展会议,杂志文章
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journal_title:International journal of oncology
pub_type: 杂志文章
doi:
更新日期:1996-01-01 00:00:00
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journal_title:International journal of oncology
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journal_title:International journal of oncology
pub_type: 杂志文章
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