HER2 testing in gastric cancer: molecular morphology and storage time-related changes in archival samples.

abstract：:The mitogen-activated protein kinase (MAPK) cascade is a critical component in the regulation of cell survival and proliferation decisions. In breast carcinoma cells, activation of the p38-MAPK member of this family occurs in response to pro-inflammatory cytokines and cellular stress. The involvement of p38-MAPK in th...

journal_title：International journal of oncology

authors： Weldon CB,Parker AP,Patten D,Elliott S,Tang Y,Frigo DE,Dugan CM,Coakley EL,Butler NN,Clayton JL,Alam J,Curiel TJ,Beckman BS,Jaffe BM,Burow ME

更新日期：2004-06-01 00:00:00

abstract：:Bcl-xL is an apoptosis inhibitor that is upregulated in bladder cancer (BCa) and provides an attractive target for molecular therapies. Treatment with specific antisense oligodeoxynucleotides (AS‑ODNs) or small interfering RNAs (siRNAs) were able to sensitize BCa cells to conventional chemotherapeutics. Ten new Bcl‑xL...

journal_title：International journal of oncology

authors： Rieger C,Huebner D,Temme A,Wirth MP,Fuessel S

更新日期：2015-09-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is the third most common cause of cancer-related mortality worldwide. We have previously reported that LASP-1 is a downstream protein of the urokinase type plasminogen activator (uPA). Here we investigated the role of LASP-1 in HCC by a molecular and biological characterization of LASP-1...

journal_title：International journal of oncology

authors： Salvi A,Bongarzone I,Ferrari L,Abeni E,Arici B,De Bortoli M,Scuri S,Bonini D,Grossi I,Benetti A,Baiocchi G,Portolani N,De Petro G

更新日期：2015-05-01 00:00:00

abstract：:Gene amplification is a frequent event in lung cancer, specifically in squamous cell lung carcinoma. Recently, we reported amplifications on chromosomal bands 3q26.1-q26.3 with the genes BCHE and SLC2A2 amplified in 40% of squamous cell lung carcinomas. Here, we identified an amplified domain within chromosomal bands ...

journal_title：International journal of oncology

authors： Rácz A,Brass N,Höfer M,Sybrecht GW,Remberger K,Meese EU

更新日期：2000-07-01 00:00:00

abstract：:Breast cancer (BC) continues to affect the lives of millions of women worldwide. Several members of the carcinoembryonic antigen-related cell adhesion molecule (CEACAM) subfamily are involved in tumor progression. Notably, the CEACAM subfamily harbors the already established cancer biomarker CEA, as well as other pote...

journal_title：International journal of oncology

authors： Michaelidou K,Tzovaras A,Missitzis I,Ardavanis A,Scorilas A

更新日期：2013-05-01 00:00:00

abstract：:The exact mechanism behind the effect of hypoxia-inducible factor-1alpha (HIF-1alpha) on the proliferation and/or apoptosis of carcinoma cells is still a matter of debate. We treated a human gastric carcinoma cell line, MKN-1 (mutant P53), with 500 microM CoCl(2). A dual-phase pattern of HIF-1alpha expression with an ...

journal_title：International journal of oncology

authors： Ardyanto TD,Osaki M,Tokuyasu N,Nagahama Y,Ito H

更新日期：2006-09-01 00:00:00

abstract：:Cancer stem cells (CSCs), which have the potential for self-renewal, differentiation and de-differentiation, undergo epigenetic, epithelial-mesenchymal, immunological and metabolic reprogramming to adapt to the tumor microenvironment and survive host defense or therapeutic insults. Intra-tumor heterogeneity and cancer...

journal_title：International journal of oncology

authors： Katoh M

更新日期：2017-11-01 00:00:00

abstract：:Neuroblastoma is a childhood malignancy of the sympathetic nervous system. The tumor exhibits two different phenotypes: favorable and unfavorable. MYCN amplification is associated with rapid tumor progression and the worst neuroblastoma disease outcome. We have previously reported that inhibitors of histone deacetylas...

journal_title：International journal of oncology

authors： Torres J,Regan PL,Edo R,Leonhardt P,Jeng EI,Rappaport EF,Ikegaki N,Tang XX

更新日期：2010-10-01 00:00:00

abstract：:Macrophages activated by lipopolysaccharide or interferon-gamma have been shown to be cytotoxic to tumor cells by releasing nitric oxide. Here, we report that unstimulated rat alveolar macrophages cultured with certain tumor cells produce nitric oxide and are cytotoxic to these tumor cells. Alveolar macrophages were t...

journal_title：International journal of oncology

authors： Nozaki Y,Isobe K,Nakashima I,Shimokata K

更新日期：1993-06-01 00:00:00

abstract：:Paclitaxel (taxol) has been used for the treatment of various human tumors and is an exceedingly efficient chemotherapy agent against esophageal cancer. However, the precise molecular mechanisms of paclitaxel effects on human esophageal adenocarcinoma cells are not well understood. MTT assay and cell cycle analysis we...

journal_title：International journal of oncology

authors： Kim SJ,Chung MJ,Kim JS,Kim B,Park WH,Kim SH,Kim SZ,Lee JS,Kim SM

更新日期：2011-12-01 00:00:00

abstract：:A relevant animal model is critical for investigating the pathogenic mechanisms underlying hepatitis B virus (HBV)-induced hepatocellular carcinoma (HCC). Mice are not naturally infected by HBV, presumably due to the lack of HBV receptors on mouse hepatocytes. To bypass this entry step of HBV infection, we report gene...

journal_title：International journal of oncology

authors： Huang YH,Fang CC,Tsuneyama K,Chou HY,Pan WY,Shih YM,Wu PY,Chen Y,Leung PS,Gershwin ME,Tao MH

更新日期：2011-12-01 00:00:00

abstract：:Three genes on the short arm of chromosome 11 (WT1, IGF2 and HRAS) were hypomethylated in Wilms' tumour tissue compared to normal kidney tissue, and one (CALCA) was hypermethylated. IGF2 and HRAS showed evidence of allele-specific methylation, which may indicate genomic imprinting of the 11p15 region in some kidney ce...

journal_title：International journal of oncology

authors： Williams J,Maitland N,Mott M,Brown K

更新日期：1992-12-01 00:00:00

abstract：:Cytogenetic analyses of peripheral blood cells of breast cancer patients unveiled in one case a grossly enlarged G-band in one copy of chromosome 16 (16qh+), which scored also strongly positive in C-banding. Fluorescence in situ hybridization with both a total chromosome 16 library and with probe pHuR195 detecting loc...

journal_title：International journal of oncology

authors： Savelyeva L,Schneider B,Finke L,Schlag P,Schwab M

更新日期：1994-02-01 00:00:00

abstract：:Thymidylate synthase (TS) is an essential enzyme for DNA biosynthesis that is an important target of fluoropyrimidine anti-cancer drugs such as 5-fluorouracil (5-FU), which is frequently used against human colon adenocarcinomas. Because levels of TS in such tumors may be predictive of chemotherapeutic response to 5-FU...

journal_title：International journal of oncology

authors： Weitz S,Wildrick D,Boman B

更新日期：1993-02-01 00:00:00

abstract：:We established a new lymphoma cell line, designated CTB-1, from pericardial effusion of a patient with diffuse large B-cell lymphoma. This cell line showing vigorous growth ability has undergone 260 passages over a period of 34 months in suspension culture, and is heterotransplantable to nude mice. The cultured cells ...

journal_title：International journal of oncology

authors： Uchida Y,Miyazawa K,Yaguchi M,Gotoh A,Iwase O,Ohyashiki K,Toyama K

更新日期：1997-06-01 00:00:00

abstract：:The MyD118/Gadd45/CR6 gene family (also termed Gadd45beta/alpha/gamma) has been identified as genes which are rapidly induced by genotoxic agents, during terminal differentiation, as well as by apoptotic cytokines. In recent years, evidence has emerged that the proteins encoded by these genes play pivotal roles in neg...

journal_title：International journal of oncology

authors： Zhang W,Hoffman B,Liebermann DA

更新日期：2001-04-01 00:00:00

abstract：:Autocrine fibroblast growth factor (FGF) signaling was genetically manipulated in human gliomas by an adenovirus-mediated strategy. Antisense inhibition of endogenous basic FGF (bFGF) expression showed inhibition of the proliferation of human glioma cells (U251MG, NMC-G1) without promoting apoptosis. The reduction in ...

journal_title：International journal of oncology

authors： Aoki T,Kato S,Fox JC,Okamoto K,Sakata K,Morimatsu M,Shigemori M

更新日期：2002-09-01 00:00:00

abstract：:Although a number of recent studies have reported the involvement of leptin in colorectal carcinogenesis, findings are contradictory and difficult to interpret. Our group has previously reported that leptin signaling might have an important role in the development of colorectal adenomas. In this study, we investigated...

journal_title：International journal of oncology

authors： Uchiyama T,Takahashi H,Endo H,Sugiyama M,Sakai E,Hosono K,Nagashima Y,Inayama Y,Wada K,Hippo Y,Nakajima A

更新日期：2011-10-01 00:00:00

abstract：:Hematopoietic disorders can be used as a suitable tool of additional information on the actual resolving power of comparative genomic hybridization (CGH). Therefore, CGH examination was performed of DNA extracted from 23 acute and 15 chronic myeloproliferative disorders which had just been analyzed using classical cyt...

journal_title：International journal of oncology

authors： Gebhart E,Verdorfer I,Saul W,Trautmann U,Brecevic L

更新日期：2000-06-01 00:00:00

abstract：:By setting the cut-off line at the level as used in a negative control study without primary antibody in the same sample, the Ki-67 labeling rate was calculated by the Ki67-DNA dual fluorescence analysis. The mean Ki-67 labeling rate of 28 advanced gastric cancer was 45.1% (13.9-76.3%). The Ki-67 labeling rates were s...

journal_title：International journal of oncology

authors： Kimura H,Yonemura Y,Miyazaki I

更新日期：1992-08-01 00:00:00

abstract：:Extracellular matrix breakdown as well as increased expression in cancer cells and tumor microvascular endothelial cells make matrix metalloproteinase 2 (MMP2) an attractive target for cancer treatment. By taking advantage of MMP2's properties, an MMP2 cleavable melittin/avidin conjugate was designed. Melittin alone i...

journal_title：International journal of oncology

authors： Holle L,Song W,Holle E,Wei Y,Wagner T,Yu X

更新日期：2003-01-01 00:00:00

abstract：:To overcome the poor tumor transduction efficiency of adenovirus serotype 5 (Ad5) observed in several types of cancer, the fiber region of Ad5, apart from its tail, was replaced by adenovirus serotype 35 (Ad35). The chimeric Ad5/F35 adenoviral vector did not exhibit any significant enhancement of transduction efficien...

journal_title：International journal of oncology

authors： Kim SY,Kang S,Song JJ,Kim JH

更新日期：2013-04-01 00:00:00

abstract：:Approximately 90% of all pancreatic cancers are pancreatic ductal adenocarcinomas (PDAC). PDAC is a highly aggressive malignancy and is one of the deadliest. This poor clinical outcome is due to the prominent resistance of pancreatic cancer to drug and radiation therapies. Regucalcin plays a pivotal role as a suppress...

journal_title：International journal of oncology

authors： Yamaguchi M,Osuka S,Weitzmann MN,El-Rayes BF,Shoji M,Murata T

更新日期：2016-05-01 00:00:00

abstract：:Nonsteroidal anti-inflammatory drugs (NSAIDs) are known to induce apoptosis in a variety of cancer cells, including colon, prostate, breast and leukemia. Among them, aspirin, a classical NSAID, shows promise in cancer therapy in certain types of cancers. We hypothesized that aspirin...

journal_title：International journal of oncology

authors： Hossain MA,Kim DH,Jang JY,Kang YJ,Yoon JH,Moon JO,Chung HY,Kim GY,Choi YH,Copple BL,Kim ND

更新日期：2012-04-01 00:00:00

abstract：:Midkine (MK) expression has been documented to be inversely correlated with the prognosis of patients with various tumors, but the mechanism of this relationship has not been well characterized. Recent studies have also correlated p53 expression with prognosis of patients with oral squamous cell carcinoma (OSCC). We e...

journal_title：International journal of oncology

authors： Ota K,Fujimori H,Ueda M,Jono H,Shinriki S,Ota T,Sueyoshi T,Taura M,Taguma A,Kai H,Shinohara M,Ando Y

更新日期：2010-10-01 00:00:00

abstract：:Invasiveness and metastatic potential are the two most important properties defining malignancy. The adeno-virus E1A (Ad-E1A) gene has a dual effect as a proliferative gene and as a tumor-suppressor gene, decreasing tumor growth and the metastatic potential of malignant cells. In order to study genes related with the ...

journal_title：International journal of oncology

authors： Fernández-Soria V,Lleonart ME,Diaz-Fuertes M,Villuendas R,Sánchez-Prieto R,Fabra A,Ramón Y Cajal S

更新日期：2006-01-01 00:00:00

abstract：:Stromal cells isolated from lymph nodes of adult T-cell leukemia/lymphoma (ATL) patients were cultured. Such lymph node stromal cells (LNSC) could be maintained for more than one year, whereas LNSC from other lymphoproliferative disorders ceased to proliferate within months. The rate of human T lymphotropic virus type...

journal_title：International journal of oncology

authors： Joh T,Yamada Y,Seto M,Nakamura S,Ohmoto Y,Kamihira S,Tomonaga M,Shiku H

更新日期：1996-10-01 00:00:00

abstract：:Increasing evidence suggests that microRNAs (miRNAs) play a critical role in tumorigenesis. Decreased expression of miR‑382 has been observed in various types of cancers. However, the biological function of miRNA-382 in ovarian cancer is still largely unknown. Here, we found miR‑382 was downregulated in human ovarian ...

journal_title：International journal of oncology

authors： Tan H,He Q,Gong G,Wang Y,Li J,Wang J,Zhu D,Wu X

更新日期：2016-01-01 00:00:00

abstract：:Telomerase activity (TA) is associated with most malignant human tumors but is not detected in normal somatic cells with a few exceptions. Three major subunits (hTR, hTP1 and hTERT) of telomerase have been identified. To investigate the clinical implications of the mRNA detection of these components as useful diagnost...

journal_title：International journal of oncology

authors： Lee BK,Diebel E,Neukam FW,Wiltfang J,Ries J

更新日期：2001-11-01 00:00:00

abstract：:The protease-activated receptor-2 (PAR-2) is a G protein-coupled receptor that is cleaved and activated by trypsin and tryptase. The purpose of this study was to clarify the role of PAR-2 in proliferation of human pancreatic cancer cells. PAR-2 mRNA and protein expression were detected by RT-PCR and Western blotting i...

journal_title：International journal of oncology

authors： Shimamoto R,Sawada T,Uchima Y,Inoue M,Kimura K,Yamashita Y,Yamada N,Nishihara T,Ohira M,Hirakawa K

更新日期：2004-06-01 00:00:00