Abstract:
:Interleukin (IL)-4 and IL-10 have a wide variety of activities in the immune system. We re-evaluated the action of IL-4 and IL-10 on human blood monocytes, myeloid dendritic cell (DC1) precursors, using a serum-free culture system. Both IL-4 and IL-10 inhibited the survival of CD14+ monocytes supported by granulocyte-macrophage colony-stimulating factor in a dose-dependent manner. When IL-4 and IL-10 were combined, they had synergistic effects at low doses and induced a profound suppression of CD14+ monocyte survival. When the optimal timing was determined, the exposure to IL-4 and IL-10 for the initial 2 days was essential for suppression of survival of CD14+ monocytes. Annexin V/propidium iodide staining indicates that the suppression of CD14+ monocyte survival induced by IL-4 and IL-10 results from apoptosis. Tumor necrosis factor-alpha and lipopolysaccharide abrogated the effects of IL-4 and IL-10 on CD14+ monocytes, albeit incompletely. Thus, IL-4 in synergy with IL-10 negatively regulates the survival of DC1 precursor monocytes by inducing their apoptosis, which is modulated by factors such as tumor necrosis factor-alpha and lipopolysaccharide. Our data suggest the primary activities of IL-4 and IL-10 in DC1-mediated immune responses.
journal_name
Int J Oncoljournal_title
International journal of oncologyauthors
Miyashita H,Katayama N,Fujieda A,Shibasaki T,Yamamura K,Sugimoto Y,Miyata E,Ohishi K,Nishii K,Masuya M,Shiku Hkeywords:
subject
Has Abstractpub_date
2005-03-01 00:00:00pages
731-5issue
3eissn
1019-6439issn
1791-2423journal_volume
26pub_type
杂志文章abstract::Cholangiocarcinoma (CC) is an aggressive liver tumor with limited therapeutic options. Natrium‑iodide symporter (NIS) mediates the uptake of iodine by the thyroid, representing a key component in metabolic radiotherapy using iodine‑131 (131I) for the treatment of thyroid cancer. NIS expression is increased in CC, prov...
journal_title:International journal of oncology
pub_type: 杂志文章
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更新日期:2020-03-01 00:00:00
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journal_title:International journal of oncology
pub_type: 杂志文章
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journal_title:International journal of oncology
pub_type: 杂志文章
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journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2015.3123
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journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2012.1599
更新日期:2012-11-01 00:00:00
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journal_title:International journal of oncology
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doi:
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journal_title:International journal of oncology
pub_type: 杂志文章
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更新日期:2014-09-01 00:00:00
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journal_title:International journal of oncology
pub_type: 临床试验,杂志文章
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journal_title:International journal of oncology
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pub_type: 杂志文章
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journal_title:International journal of oncology
pub_type: 杂志文章
doi:
更新日期:2002-07-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:International journal of oncology
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journal_title:International journal of oncology
pub_type: 杂志文章
doi:
更新日期:2009-01-01 00:00:00
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journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2011.1031
更新日期:2011-07-01 00:00:00
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pub_type: 杂志文章
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更新日期:2018-05-01 00:00:00
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journal_title:International journal of oncology
pub_type: 杂志文章
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journal_title:International journal of oncology
pub_type: 杂志文章
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更新日期:2005-03-01 00:00:00
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journal_title:International journal of oncology
pub_type: 已发布勘误
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journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2014.2498
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journal_title:International journal of oncology
pub_type: 杂志文章
doi:
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journal_title:International journal of oncology
pub_type: 杂志文章
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journal_title:International journal of oncology
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