Breast cancer proteomics reveals a positive correlation between glyoxalase 1 expression and high tumor grade.

abstract：:This study examined whether the soluble tumor-associated antigens (sTAA) of 66 kDa and 51 kDa could promote suppression of chemically-induced rat mammary tumorigenesis by the hormone-related anticancer drug tamoxifen and prevent the drug's toxic side-effects. Dimethylbenzanthracene (DMBA, 10 mg/rat, 3 administrations)...

journal_title：International journal of oncology

authors： Ben-Hur H,Kossoy G,Zusman I

更新日期：2002-02-01 00:00:00

abstract：:A precise diagnosis of peritoneal dissemination is necessary to determine the appropriate treatment strategy for colorectal cancer. However, small peritoneal dissemination is difficult to diagnose. 5-aminolevulinic acid (5-ALA) is an intermediate substrate of heme metabolism. The administration of 5-ALA to cancer pati...

journal_title：International journal of oncology

authors： Kondo Y,Murayama Y,Konishi H,Morimura R,Komatsu S,Shiozaki A,Kuriu Y,Ikoma H,Kubota T,Nakanishi M,Ichikawa D,Fujiwara H,Okamoto K,Sakakura C,Takahashi K,Inoue K,Nakajima M,Otsuji E

更新日期：2014-07-01 00:00:00

abstract：:Despite recent advances in understanding colorectal tumour biology, there is still a need to improve the 5-year survival rate of patients with colorectal cancer as approximately 40% of patients presenting with advanced disease will remain resistant to therapy. One of the major contributing factors in resistance to the...

journal_title：International journal of oncology

authors： Patsos HA,Greenhough A,Hicks DJ,Al Kharusi M,Collard TJ,Lane JD,Paraskeva C,Williams AC

更新日期：2010-07-01 00:00:00

abstract：:The tumor suppressor protein p53 is one of the most important manipulators of the cell cycle. By interaction with targets such as WAF1/CIP1, mdm2 or GADD45 p53 functions as a negative or positive regulator of the cell cycle. After DNA damage p53 is implicated in growth arrest of cells in the G(1) phase of the cell cyc...

journal_title：International journal of oncology

authors： Gotz C,Montenarh M

更新日期：1995-05-01 00:00:00

abstract：:To compare the oncosuppressive activity of integrated and episomal adeno-associated virus (AAV), two Epstein-Barr virus (EBV) derived episomal form vectors, p205 and p220, were used to generate plasmids containing episomal AAV. HeLa cells transfected with p205, p220, and the plasmids with forward (pA205-1, pA220-1) an...

journal_title：International journal of oncology

authors： Wu FY,Wu CY,Lin CH,Wu CH

更新日期：1999-07-01 00:00:00

abstract：:The objective of the present study was to establish the individual and combined chemopreventive potential of a widely used non-steroidal anti-inflammatory drug, ibuprofen (IBU), encapsulated in solid lipid nanoparticles (SLNs) for the chemoprevention of pancreatic cancer. The IBU SLNs were optimized using various lipi...

journal_title：International journal of oncology

authors： Thakkar A,Chenreddy S,Wang J,Prabhu S

更新日期：2015-04-01 00:00:00

abstract：:Macrophages activated by lipopolysaccharide or interferon-gamma have been shown to be cytotoxic to tumor cells by releasing nitric oxide. Here, we report that unstimulated rat alveolar macrophages cultured with certain tumor cells produce nitric oxide and are cytotoxic to these tumor cells. Alveolar macrophages were t...

journal_title：International journal of oncology

authors： Nozaki Y,Isobe K,Nakashima I,Shimokata K

更新日期：1993-06-01 00:00:00

abstract：:Drug-resistance is a major contributing factor for the poor prognosis in patients with pancreatic cancer. We have shown previously that the irreversible ErbB family blocker afatinib, is more effective than the reversible EGFR tyrosine kinase inhibitor erlotinib in inhibiting the growth of human pancreatic cancer cells...

journal_title：International journal of oncology

authors： Ioannou N,Seddon AM,Dalgleish A,Mackintosh D,Solca F,Modjtahedi H

更新日期：2016-03-01 00:00:00

abstract：:MLL gene at human chromosome 11q23.3 is frequently rearranged or amplified in hematological malignancies, while PHLDB1, BCL9L, FOXN5 (FOXR1), RNF26, and MFRP genes linked to MLL gene are deleted in neuroblastoma. Here, we characterized the TMEM24 gene family by using bioinformatics. KIAA0285 gene within the 11q23.3 co...

journal_title：International journal of oncology

authors： Katoh M,Katoh M

更新日期：2004-09-01 00:00:00

abstract：:The tyrosine kinase inhibitor imatinib has been reported to inhibit CD8+ T lymphocytes. Little is known about its effects on CD4+CD25+ regulatory T cells (T(reg) cells) which might regulate the graft-vs.-leukemia (GVL) reaction after allogeneic stem cell transplantation (allo-SCT) and donor lymphocyte infusion (DLI). ...

journal_title：International journal of oncology

authors： Chen J,Schmitt A,Giannopoulos K,Chen B,Rojewski M,Döhner H,Bunjes D,Schmitt M

更新日期：2007-11-01 00:00:00

abstract：:Diagnostic features of 102 consecutive cases of cancer reoccurrence in the conserved breast are reported. The sensitivity of palpation, mammography, cytology or ultrasonography was 75.5%, 58.7%, 77.4% and 77.8%, respectively. Mammography failures were not due to natural breast density and could probably be explained b...

journal_title：International journal of oncology

authors： Ciatto S,Cataliotti L,Pacini P,Distante V,Bianchi S,Simoncini R,Cardona G,Rontini M,Falli F,Elbetti C

更新日期：1993-08-01 00:00:00

abstract：:Human breast epithelial MCF10AT cells injected with Matrigel into the subcutis of nude/beige mice form simple ducts which, with time, resemble human proliferative breast disease and sporadically progress to carcinoma. Basement membrane was visualized with a silver stain and myoepithelial cells detected by their reacti...

journal_title：International journal of oncology

authors： Tait L,Dawson P,Wolman S,Galea K,Miller F

更新日期：1996-08-01 00:00:00

abstract：:Neuroblastoma is a childhood malignancy originating from cells of the sympathetic nervous system, exhibiting a marked diversity in outcome, with spontaneous regression at one end of the spectrum and severe disease and death at the other end. Features associated with frequent recurrence, a poor prognosis, and high tumo...

journal_title：International journal of oncology

authors： Jögi A,Abel F,Sjöberg RM,Toftgård R,Zaphiropoulos PG,Påhlman S,Martinsson T,Axelson H

更新日期：2000-05-01 00:00:00

abstract：:Following the publication of the above paper, an interested reader drew to the authors' attention that, in Fig. 2D, the si‑ITGB3/E‑cadherin image appeared to show an overlap with the Scr/MDA231+CCL18/N‑cadherin image from Fig. 4E in a paper published in 2013 that shared some of the same authors [Zhang B, Yin C, Li H, ...

journal_title：International journal of oncology

authors： Li W,Liu C,Zhao C,Zhai L,Lv S

更新日期：2021-01-11 00:00:00

abstract：:Smac/DIABLO promotes apoptosis by antagonizing inhibitor of apoptosis proteins. The expression of Smac/DIABLO in tissues has been reported in various cancers; however, little is known about circulating levels of Smac/DIABLO. The present study was designed to first determine if Smac/...

journal_title：International journal of oncology

authors： Mizutani Y,Katsuoka Y,Bonavida B

更新日期：2012-04-01 00:00:00

abstract：:Telomeres, repeated DNA sequences (T2AG3)n that guard the ends of chromosomes, serve as a checkpoint for cell-cycle progression and regulate cell senescence and apoptosis. Loss of the telomeric repeats promotes genomic instability, which is the hallmark of most cancer cells. Whether this loss differs among tumor cells...

journal_title：International journal of oncology

authors： Multani AS,Ozen M,Sen S,Mandal AK,Price JE,Fan D,Radinsky R,Ali-Osman F,Von Eschenbach AC,Fidler IJ,Pathak S

更新日期：1999-09-01 00:00:00

abstract：:Natural antisense transcripts (NATs) constitute a class of non-coding RNAs that have emerged as important regulators of gene expression. However, involvement of NATs in colorectal cancer (CRC) development has not been reported to date. In the present study, the up- and down-regulation of NATs were investigated in huma...

journal_title：International journal of oncology

authors： Kohno K,Chiba M,Murata S,Pak S,Nagai K,Yamamoto M,Yanagisawa K,Kobayashi A,Yasue H,Ohkohchi N

更新日期：2010-12-01 00:00:00

abstract：:Neuroblastoma is a childhood malignancy of the sympathetic nervous system. The tumor exhibits two different phenotypes: favorable and unfavorable. MYCN amplification is associated with rapid tumor progression and the worst neuroblastoma disease outcome. We have previously reported that inhibitors of histone deacetylas...

journal_title：International journal of oncology

authors： Torres J,Regan PL,Edo R,Leonhardt P,Jeng EI,Rappaport EF,Ikegaki N,Tang XX

更新日期：2010-10-01 00:00:00

abstract：:This review focuses on two chemotherapeutic agents belonging to the family of purine analogs, 9-beta-D-arabinosyl-2-fluoroadenine-5'-monophosphate (F-ara-AMP, fludarabine), which is the soluble form of F-ara-A, and 2-chloro-2'-deoxyadenosine (CdA, cladribine). Both compounds display remarkable activity in malignancies...

journal_title：International journal of oncology

authors： Van den Neste E,Cardoen S,Offner F,Bontemps F

更新日期：2005-10-01 00:00:00

abstract：:Cholangiocarcinoma (CCA) is a lethal malignancy which occurs with relatively high incidence in Thailand. This cancer is often difficult to diagnose and associated with high mortality. The secretome, containing the secreted proteins from cells, are potentially useful as biomarkers of cancers. Since three-dimensional (3...

journal_title：International journal of oncology

authors： Tit-Oon P,Chokchaichamnankit D,Khongmanee A,Sawangareetrakul P,Svasti J,Srisomsap C

更新日期：2014-11-01 00:00:00

abstract：:Hedgehog (HH) pathway Smoothened (Smo) inhibitors are active against Gorlin syndrome-associated basal cell carcinoma (BCC) and medulloblastoma where Patched (Ptch) mutations occur. We interrogated 705 epithelial cancer cell lines for growth response to the Smo inhibitor cyclopamine ...

journal_title：International journal of oncology

authors： Galimberti F,Busch AM,Chinyengetere F,Ma T,Sekula D,Memoli VA,Dragnev KH,Liu F,Johnson KC,Guo Y,Freemantle SJ,Andrew AS,Greninger P,Robbins DJ,Settleman J,Benes C,Dmitrovsky E

更新日期：2012-11-01 00:00:00

abstract：:RhKGF is developed for prevention and treatment of chemotherapy- and radiation-induced epithelial damage in cancer patients. Little information exists on growth modulation of malignant cells by KGF. We have tested the anchorage-independent clonal growth of 35 human tumor and 22 lymphoma and leukemia cell lines in semi...

journal_title：International journal of oncology

authors： Oelmann E,Haghgu S,Kulimova E,Mesters RM,Kienast J,Herbst H,Schmitmann C,Kolkmeyer A,Serve H,Berdel WE

更新日期：2004-10-01 00:00:00

abstract：:Twenty-one patients with isolated colorectal liver metastases underwent hepatic artery infusion (HAI) port implantation for regional chemotherapy with bolus injections of 5-FU, LV and fast drip of cisplatin. Ten of the 21 patients had previously failed systemic chemotherapy before HAI. Toxicity was moderate and no nee...

journal_title：International journal of oncology

authors： Lyass S,Lyass O,Gabizon A,Peretz T,Eid A,Muggiasullam M,Durst A,Shiloni E

更新日期：1996-12-01 00:00:00

abstract：:Reports of the metabolomic characteristics of esophageal cancer are limited. In the present study, we thus conducted metabolome analysis of paired tumor tissues (Ts) and non-tumor esophageal tissues (NTs) using capillary electrophoresis time-of-flight mass spectrometry (CE-TOFMS). The Ts and surrounding NTs were surgi...

journal_title：International journal of oncology

authors： Tokunaga M,Kami K,Ozawa S,Oguma J,Kazuno A,Miyachi H,Ohashi Y,Kusuhara M,Terashima M

更新日期：2018-06-01 00:00:00

abstract：:Although the incidence of brain metastasis in gastric cancer is relatively low, its prevalence may increase with improved therapy and longer survival tumors. The molecular mechanisms underlying brain metastases are not well understood. To gain insight into the mechanism of brain metastasis, we studied differences in m...

journal_title：International journal of oncology

authors： Minn YK,Lee DH,Hyung WJ,Kim JE,Choi J,Yang SH,Song H,Lim BJ,Kim SH

更新日期：2014-12-01 00:00:00

abstract：:Globally, breast cancer in women is the leading cause of cancer death. This fact has generated an interest to obtain insight into breast tumorigenesis and also to develop drugs to control the disease. Ras is a proto-oncogene that is activated as a response to extracellular signals. As a member of the Ras GTPase superf...

journal_title：International journal of oncology

authors： Ponce-Cusi R,Calaf GM

更新日期：2016-02-01 00:00:00

abstract：:The P-glycoprotein (P-gp) multidrug transporter is present at the luminal face of the brain capillary endothelial cells that contribute to the blood-brain barrier. To study its role in transendothelial anticancer drug transport, we made use of a co-culture system formed of bovine brain capillary endothelial cells and ...

journal_title：International journal of oncology

authors： Joly B,Lecureur V,Puozzo C,Guillouzo A,Fardel O

更新日期：1996-11-01 00:00:00

abstract：:Docetaxel is one of the most commonly used chemotherapeutic agents in breast cancer. To avert from significant toxicities with no clinical benefit, identification of predictive markers for response is one of the most important unsolved clinical needs. Therefore, the potential associ...

journal_title：International journal of oncology

authors： Gil EY,Jo UH,Jeong H,Whang YM,Woo OH,Cho KR,Seo JH,Kim A,Lee ES,Koh I,Kim YH,Park KH

更新日期：2012-08-01 00:00:00

abstract：:Most cancer cells trigger thrombin generation (TG) to various extent. In the present study, we dissected the mechanisms responsible for the procoagulant activity of pancreatic adenocarcinoma cells (BXPC3), a highly thrombogenic cancer type, and breast cancer cells (MCF7), a less thombogenic tumor type. TG of normal pl...

journal_title：International journal of oncology

authors： Rousseau A,Larsen AK,Van Dreden P,Sabbah M,Elalamy I,Gerotziafas GT

更新日期：2017-12-01 00:00:00

abstract：:All p53 family members are expressed in several isoforms through alternative promoters and alternative splicing. However, the significance of these isoforms is not yet well understood in cholangiocarcinoma (CCA). In this study, we investigated the expression of p53, p63, p73 and their isoforms at the mRNA and protein ...

journal_title：International journal of oncology

authors： Nutthasirikul N,Limpaiboon T,Leelayuwat C,Patrakitkomjorn S,Jearanaikoon P

更新日期：2013-04-01 00:00:00